LOCUS       NM_009349               1023 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus indolethylamine N-methyltransferase (Inmt), mRNA.
ACCESSION   NM_009349
VERSION     NM_009349.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1023)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1023)
  AUTHORS   Zieman,A.G., Poll,B.G., Ma,J. and Coulombe,P.A.
  TITLE     Altered keratinocyte differentiation is an early driver of keratin
            mutation-based palmoplantar keratoderma
  JOURNAL   Hum Mol Genet 28 (13), 2255-2270 (2019)
   PUBMED   31220272
REFERENCE   3  (bases 1 to 1023)
  AUTHORS   Huang,J., Liu,Y., Oltean,A. and Beebe,D.C.
  TITLE     Bmp4 from the optic vesicle specifies murine retina formation
  JOURNAL   Dev Biol 402 (1), 119-126 (2015)
   PUBMED   25792196
REFERENCE   4  (bases 1 to 1023)
  AUTHORS   Alpern,D., Langer,D., Ballester,B., Le Gras,S., Romier,C.,
            Mengus,G. and Davidson,I.
  TITLE     TAF4, a subunit of transcription factor II D, directs promoter
            occupancy of nuclear receptor HNF4A during post-natal hepatocyte
            differentiation
  JOURNAL   Elife 3, e03613 (2014)
   PUBMED   25209997
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1023)
  AUTHORS   Im,S.K., Jeong,H., Jeong,H.W., Kim,K.T., Hwang,D., Ikegami,M. and
            Kong,Y.Y.
  TITLE     Disruption of sorting nexin 5 causes respiratory failure associated
            with undifferentiated alveolar epithelial type I cells in mice
  JOURNAL   PLoS One 8 (3), e58511 (2013)
   PUBMED   23526992
REFERENCE   6  (bases 1 to 1023)
  AUTHORS   Ding,M. and Toth,L.A.
  TITLE     mRNA expression in mouse hypothalamus and basal forebrain during
            influenza infection: a novel model for sleep regulation
  JOURNAL   Physiol Genomics 24 (3), 225-234 (2006)
   PUBMED   16403846
REFERENCE   7  (bases 1 to 1023)
  AUTHORS   Thompson,M.A., Moon,E., Kim,U.J., Xu,J., Siciliano,M.J. and
            Weinshilboum,R.M.
  TITLE     Human indolethylamine N-methyltransferase: cDNA cloning and
            expression, gene cloning, and chromosomal localization
  JOURNAL   Genomics 61 (3), 285-297 (1999)
   PUBMED   10552930
REFERENCE   8  (bases 1 to 1023)
  AUTHORS   Takenaka,M., Imai,E., Kaneko,T., Ito,T., Moriyama,T., Yamauchi,A.,
            Hori,M., Kawamoto,S. and Okubo,K.
  TITLE     Isolation of genes identified in mouse renal proximal tubule by
            comparing different gene expression profiles
  JOURNAL   Kidney Int 53 (3), 562-572 (1998)
   PUBMED   9507200
REFERENCE   9  (bases 1 to 1023)
  AUTHORS   Warner,D.R., Mozier,N.M., Pearson,J.D. and Hoffman,J.L.
  TITLE     Cloning and base sequence analysis of a cDNA encoding mouse lung
            thioether S-methyltransferase
  JOURNAL   Biochim Biophys Acta 1246 (2), 160-166 (1995)
   PUBMED   7819283
REFERENCE   10 (bases 1 to 1023)
  AUTHORS   Mozier,N.M., McConnell,K.P. and Hoffman,J.L.
  TITLE     S-adenosyl-L-methionine:thioether S-methyltransferase, a new enzyme
            in sulfur and selenium metabolism
  JOURNAL   J Biol Chem 263 (10), 4527-4531 (1988)
   PUBMED   3350800
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC079243.7.
            
            On Apr 27, 2007 this sequence version replaced NM_009349.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M88694.1, AK002281.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               AC079243.7         138528-138691       c
            165-372             AC079243.7         136987-137194       c
            373-1023            AC079243.7         134328-134978       c
FEATURES             Location/Qualifiers
     source          1..1023
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 27.38 cM"
     gene            1..1023
                     /gene="Inmt"
                     /gene_synonym="Temt"
                     /note="indolethylamine N-methyltransferase"
                     /db_xref="GeneID:21743"
                     /db_xref="MGI:MGI:102963"
     exon            1..164
                     /gene="Inmt"
                     /gene_synonym="Temt"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..802
                     /gene="Inmt"
                     /gene_synonym="Temt"
                     /EC_number="2.1.1.49"
                     /EC_number="2.1.1.96"
                     /note="thioether S-methyltransferase; aromatic alkylamine
                     N-methyltransferase; arylamine N-methyltransferase; amine
                     N-methyltransferase; nicotine N-methyltransferase;
                     indolamine N-methyltransferase"
                     /codon_start=1
                     /product="indolethylamine N-methyltransferase"
                     /protein_id="NP_033375.1"
                     /db_xref="CCDS:CCDS20163.1"
                     /db_xref="GeneID:21743"
                     /db_xref="MGI:MGI:102963"
                     /translation="MEGKVYIGGEDYEKEFTPKDYLTTYYSFHSGPVAEQEIVKFSLQ
                     NLYQTFSTGGVGGDVLIDIGSGPTIYQLLSACEVFREIIVTDYTPQNLQELQKWLKKE
                     PGAYDWSSIVQHACELEGDRSRWQEKEAKLRRTVTRVLRCDVTKTPPLGSAQVPLADC
                     VLTFLAMECACPDIDTYRAALRRLAGLLKPGGHLVTLVTLRFQHYMVGPKKFSGVYLE
                     KEVVEKAIQDAGCQVLKCNCVSLSYSEAYCSHDGLCFVVARKGPSA"
     exon            165..372
                     /gene="Inmt"
                     /gene_synonym="Temt"
                     /inference="alignment:Splign:2.1.0"
     exon            373..1023
                     /gene="Inmt"
                     /gene_synonym="Temt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctagaatg gagggcaagg tatacatagg aggtgaggac tatgaaaaag agttcactcc
       61 caaagactac ctgaccacct actacagctt ccactctggc cctgtggcag agcaggaaat
      121 cgtaaagttt agcctgcaga acctctacca gaccttctct acaggaggtg tagggggcga
      181 cgtcctgatc gacattggct ctggccctac catctaccag ctgctttcag catgcgaggt
      241 cttccgggag atcattgtca ctgactacac cccgcagaac ctgcaggagc tgcagaagtg
      301 gctgaagaaa gagccaggag cctacgactg gtcctccata gtgcaacatg catgtgagct
      361 ggagggagac agaagcaggt ggcaggagaa ggaagccaag ctcagaagga cagtcactcg
      421 tgtcctgagg tgtgatgtga ccaagacacc cccgctgggg tcagctcagg tgcctctggc
      481 tgactgcgtg ctgacctttc tggccatgga gtgtgcctgc cctgatatag atacctaccg
      541 ggcagccttg cgcagactgg ccggcctgct gaaaccagga gggcacctgg tgaccctggt
      601 tactctgcgc ttccagcact atatggtggg ccccaagaag ttctctgggg tctacctaga
      661 gaaggaggtg gtggagaagg ctattcaaga tgctggctgt caggtgctga agtgcaactg
      721 cgtctccctc agctactcgg aggcttactg ctcccacgac ggtttgtgct ttgtggtggc
      781 ccggaagggt cccagtgcct gaggccactg gcagcgaatc gccttccctg ggaaagttat
      841 agcaatcatt tgtaaagcct tgctccacag ctttctaaca cggaccatgt tgcttctatc
      901 taatacctgg tcacagtcac aagggaaaac ccaaggttct ctattttcag caccaacatc
      961 catccccttt gctcttattg taccctgttg aaagttcatt ttaaaataaa gtggcctatc
     1021 tgg
//
