LOCUS       NM_175398               4701 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus inka box actin regulator 2 (Inka2), transcript variant
            1, mRNA.
ACCESSION   NM_175398
VERSION     NM_175398.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4701)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4701)
  AUTHORS   Yamada,S., Tokunaga,A. and Sakakibara,S.I.
  TITLE     Inka2 expression in smooth muscle cells and its involvement in cell
            migration
  JOURNAL   Biochem Biophys Res Commun 643, 55-60 (2023)
   PUBMED   36586159
  REMARK    GeneRIF: Inka2 expression in smooth muscle cells and its
            involvement in cell migration.
REFERENCE   3  (bases 1 to 4701)
  AUTHORS   Yamada,S., Mizukoshi,T., Tokunaga,A. and Sakakibara,S.I.
  TITLE     Inka2, a novel Pak4 inhibitor, regulates actin dynamics in neuronal
            development
  JOURNAL   PLoS Genet 18 (10), e1010438 (2022)
   PUBMED   36301793
  REMARK    GeneRIF: Inka2, a novel Pak4 inhibitor, regulates actin dynamics in
            neuronal development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4701)
  AUTHORS   Ohayon,D., Aguirrebengoa,M., Escalas,N., Jungas,T. and Soula,C.
  TITLE     Transcriptome profiling of the Olig2-expressing astrocyte subtype
            reveals their unique molecular signature
  JOURNAL   iScience 24 (7), 102806 (2021)
   PUBMED   34296073
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4701)
  AUTHORS   Akiyama,H., Iwasaki,Y., Yamada,S., Kamiguchi,H. and Sakakibara,S.I.
  TITLE     Control of cell migration by the novel protein phosphatase-2A
            interacting protein inka2
  JOURNAL   Cell Tissue Res 380 (3), 527-537 (2020)
   PUBMED   31975032
  REMARK    GeneRIF: Control of cell migration by the novel protein
            phosphatase-2A interacting protein inka2.
REFERENCE   6  (bases 1 to 4701)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4701)
  AUTHORS   Iwasaki,Y., Yumoto,T. and Sakakibara,S.
  TITLE     Expression profiles of inka2 in the murine nervous system
  JOURNAL   Gene Expr Patterns 19 (1-2), 83-97 (2015)
   PUBMED   26292052
  REMARK    GeneRIF: In the present study, we identified a novel gene,
            designated as inka2, which is related to inka1
REFERENCE   8  (bases 1 to 4701)
  AUTHORS   Quintens,R., Verreet,T., Janssen,A., Neefs,M., Leysen,L.,
            Michaux,A., Verslegers,M., Samari,N., Pani,G., Verheyde,J.,
            Baatout,S. and Benotmane,M.A.
  TITLE     Identification of novel radiation-induced p53-dependent transcripts
            extensively regulated during mouse brain development
  JOURNAL   Biol Open 4 (3), 331-344 (2015)
   PUBMED   25681390
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4701)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY290400.1, AK078368.1 and AC139316.4.
            
            On Jul 17, 2009 this sequence version replaced NM_175398.3.
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052371.1, AK033558.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-237               BY290400.1         3-239
            238-1872            AK078368.1         91-1725
            1873-4701           AC139316.4         45359-48187
FEATURES             Location/Qualifiers
     source          1..4701
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.44 cM"
     gene            1..4701
                     /gene="Inka2"
                     /gene_synonym="6530418L21Rik; Fam212b"
                     /note="inka box actin regulator 2"
                     /db_xref="GeneID:109050"
                     /db_xref="MGI:MGI:1923497"
     exon            1..227
                     /gene="Inka2"
                     /gene_synonym="6530418L21Rik; Fam212b"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1073
                     /gene="Inka2"
                     /gene_synonym="6530418L21Rik; Fam212b"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM212B; MInca-r; induced in neural crest by
                     AP2-alpha protein-related homolog; PAK4-inhibitor INKA2;
                     family with sequence similarity 212, member B"
                     /codon_start=1
                     /product="PAK4-inhibitor INKA2 isoform 1"
                     /protein_id="NP_780607.2"
                     /db_xref="CCDS:CCDS17710.1"
                     /db_xref="GeneID:109050"
                     /db_xref="MGI:MGI:1923497"
                     /translation="MTKESKDMDCYLRRLKQELMSMKEVGDGLQDQMNCMMGALQELK
                     LLQVQTALEQLEISGGTPTFSCPESSQEQPECPRWQGSGGPAGPAAWTSSSQPSFDSS
                     PKLPCRRSVCGKELAVLPKTQLPEEHQSCTQQGTEWVEPDDWTSTLMSRGRNRQPLVL
                     GDNVFADLVGNWLDLPELEKGGEKGETGGSIEPKGEKGQSRELGRKFALTANIFRKFL
                     RSVRPDRDRLLKEKPGWMTPMVSESRAGRSKKVKKRSLSKGSGRFPFSSTGEPRHIET
                     PATSSPKALEPSCRGFDINTAVWV"
     exon            228..4701
                     /gene="Inka2"
                     /gene_synonym="6530418L21Rik; Fam212b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3101..3106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Inka2"
                     /gene_synonym="6530418L21Rik; Fam212b"
                     /note="hexamer: ATTAAA"
     polyA_site      3121
                     /gene="Inka2"
                     /gene_synonym="6530418L21Rik; Fam212b"
                     /note="major polyA site"
     regulatory      4680..4685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Inka2"
                     /gene_synonym="6530418L21Rik; Fam212b"
                     /note="hexamer: AATAAA"
     polyA_site      4701
                     /gene="Inka2"
                     /gene_synonym="6530418L21Rik; Fam212b"
ORIGIN      
        1 ttggctgctg cacttttcct ccgcccctat cccgggcatt gagcggcagc agcggggaac
       61 gccgctctaa gtccccacgc tggagctgag gctcggctca gcgcggataa gggcgcggag
      121 cgcactgaga accctacttt ctcgtgagcc cgagcccagc aaatgggcga atgacaaagg
      181 agagcaagga catggactgc tatctgcgtc gcctcaaaca ggagctgatg tccatgaagg
      241 aggtggggga tggcttgcag gatcagatga actgcatgat gggcgcactt caggaactga
      301 agctcctaca agtgcagacg gcattggaac agctggagat ctcgggaggc acgcccacct
      361 tcagctgccc tgagagctca caggaacagc ctgagtgccc tcgctggcag ggtagtggag
      421 ggcctgctgg gcctgctgcc tggacctcct ccagccaacc atcttttgac agtagcccca
      481 agttgccatg ccgtaggagt gtctgtggga aggagctggc tgtccttcct aaaacccagc
      541 tgccggagga gcaccagagc tgtacccaac aggggacaga gtgggtggag ccagatgact
      601 ggacctccac gttgatgtca cggggcagaa atcggcagcc tctggtgttg ggggacaatg
      661 tttttgcaga cctggtgggt aactggctag atttaccaga actggaaaag ggcggggaaa
      721 agggtgagac tgggggatcc attgaaccca aaggagaaaa aggccagtcc agagagctgg
      781 gtcgtaagtt tgccctaacc gcaaacattt ttaggaagtt cttgcgtagc gtgcggcccg
      841 acagagaccg gctgctcaag gagaagcctg gctggatgac tcccatggtc tctgagtcac
      901 gagcaggacg ctcgaagaaa gtcaagaaga ggagcctttc taagggctca ggacggttcc
      961 ctttctcaag cacaggagag cccagacata ttgaaacccc cgccacaagc agccccaagg
     1021 ccttagaacc ctcctgtagg ggctttgaca ttaacacagc tgtttgggtc tgagagatgc
     1081 tcactgaacc taaaatgcag actggtgagg gccctggggg agagggaggg cagatggcat
     1141 ggtcttcaga ccagatgcaa gttcccatcc tcagaaagaa agaaagagtt ctcagtcagg
     1201 cctcagtaga accaagtgga gagaggctgt ctgtcacagg tcaggctgag ctgagtccct
     1261 agagagaatg tgtgtatttg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgat
     1321 ggtggtggtg gtggtggtgt tctttgaggc tggatgtgac aataattggg agaggcagga
     1381 gaggagtcca ggaagcctgt gttactcctc cactacttcc caagacctca tttgaacatc
     1441 ctatatggaa aggggcattg agccctcagg tttcccagag gaacttccaa taaagaccag
     1501 tctcagggac ccgcaaccat tttaatggtc tgcttcctga caaggcactg ctacaggcaa
     1561 ggggttttca tttgtaaagg gttggtatca cagaccttac taggaccaag attttagccc
     1621 atagctgggt actggggacc cagaacaagc aggtgtgtgt gtgtgtgtgt gtgtgtgtgt
     1681 gtgtgtgtgt gtgtgtgtgt tgaggaagcc tgagaagccc taggtctcca aagagcagag
     1741 gagaagcaac gtgctttcac gcaggcactg tctcatgagt ccaagtaggc gtgcccaacc
     1801 agcatggtat ttcataaagc agcaagctct gagaacacac tcggctgcca ggagacaaaa
     1861 cagggcaggc cgatctcatg gttataaatg gaccctagag tcacacacgg cctggtccag
     1921 cagtgagagc ccatcctgac ccctgttgcc tgccataatg ctcctgcagg gcagcagatg
     1981 gttggggtga acctagaaat aatacccata tatttagaaa aattcttagt ctacatctca
     2041 tagtcatgcg gtgagctgga cacatctatc ctcatcaacc tggaagtcaa caggggaccc
     2101 gcagggtggg gttgatgcca ggcactttat atagtgagca ggcatgcaag cctgggtcca
     2161 taaggaatcc atctcagccc ccacccctta gccaggagag aacaaagtag gcccctgttc
     2221 aagcccagct atcccggagg gtgccttagc tcctccctca ccccctccgg cagacctagc
     2281 tcagcttgat ggggtgtgac aactgcaatt agaggcaagc cgcctgctgc ccccagagca
     2341 ttaagagcaa attggagaag aaaaataaca agagaagctc ttctgcctgc agtctagact
     2401 cccaagggac tgagaggagg aagggagagc ttaggggaca gggatgggga ggtaacagta
     2461 agattgggaa gggttgccca caagttccca tcaagttaaa tgagagatgg ctttatttat
     2521 ttatttttag agtggggatt ttttaaaaaa atctgtagct ttttgctagg caatgtacct
     2581 atctcagaac gattaatcaa tggggtcaaa gggtcctggc atgcacgttg cccccatcaa
     2641 gctgctcaaa aaggaaagca gttcccagct caaatctgtg ggcatcaggc ttatctactt
     2701 tggcctggtg tttgtcagct gagctcactc tttctggtca agcatgtcct tgtccatcct
     2761 gtctccgttg aacttctgtc tctggtgaag gaagataacg gtagctccct ctgatggccg
     2821 ctgtgatgtg tgtgaagaag gaccatgtga aaaccccaca ccctgactcc tgaagggtgg
     2881 cacactcaac agatgatcca agaggacatg gactttgatg gcataggaag ccaggtcacc
     2941 tcctcaccat ccatggacaa ctctcttggc ttgtggacca gtcatagttc acatcattta
     3001 aatcaactaa catgtgctgg aaccatggct cagtggttaa gagtactgac tgtggttcca
     3061 aaggtcccaa gttcaaaccc cagcagccac ttttacagcc attaaatcaa ctaacatgac
     3121 agactccttg cttgtctggg cactgtaata gaaggtgaga actcaatgat aggaaaggaa
     3181 ccagctgctg gcctccacat ctaccaaggc acacaaagaa atgcagtgaa cagagtcagg
     3241 ggaccaatac aaaacaacta ggaagtaatt tgtgcatcta agataataca tatgtgtcag
     3301 gcacctttgc ctttattttt cttatttcct tccttccttc cttccttcct tccttccttc
     3361 cttccttcct tccttccttc ctttctttct acacctggga aatggttgct cattttaccc
     3421 aaataggctc agagaagtta actctttcaa ggtcacacag tacaaagctg ggattgaatc
     3481 agtttgtaat tgacttccaa tcttacattc atgctacctg gcaaactgtc tacatttgct
     3541 ccacagccag atcaagaata acatttgtct tctgagatta ttcatgtctc ttcatgattg
     3601 acaagtggca tgctaattac cctttggagg aattttgcct gggtctcaga gtggctgata
     3661 taatgtccca actactaggt catgcttggt tgatgaaagc ttatggtgac tcaacctcat
     3721 ataactttta ctttcctgtc catatccttg gctcttgctg agacagtaat ggagagtgtg
     3781 tcactgaagt gaagaggtgc atagaaatgc tctggcagtc atgggaagag atggtgataa
     3841 taggcagaga gaaattgaca gctaaattct gccccttggg ctcattttat ggttaattag
     3901 gacaagtaaa taagctggaa gctcatttaa tacccttcct ggcatagagg cctgccccac
     3961 agctggccta attccttggc aggcctctag ttggcctagg tatcttctcg gagatctacc
     4021 tgcctctctg catccctgtc tgtggtcagc ctgtagatat tttccaacca cagtatctac
     4081 tggaagtgcc tctccctgct gggcacggtt ggtagaggcg gccagatctc tgtttcctct
     4141 ttcttctctc ctctatgctc ttctgtagcc taccctcagg gtgatctcta acccaaacta
     4201 atcccgagga acagacactt ggctcagctc cacctactac ctggctcacc tgttcccaga
     4261 atctccatag aagagggcac tttctttctc aagttaccct aacattctct gcaggataaa
     4321 atcatgagtc cagcctgtct gtggaactgg ggcctgtctg cagcttccct gcagaagtgt
     4381 ccattcactt tgggtgatct tcccgaccaa gatacttagg tgttttggcc agcaccagta
     4441 tttctatgaa ttcctgatct ggagttgaat agacaggaat caagacctag gcttttcact
     4501 gtgtgaacct gagcatgtgg cctgacctgc tggaagctcc tctgctcttg tgtgaagcag
     4561 gaatgctgtc aggcacacag cacaacacac cagtggtgga gaacgctaat cccaacacac
     4621 aaattccaca gaaatggcac tatcctcggg tctcctgcct aaccatggac aaagctgaga
     4681 ataaacagtg ctttactttg a
//
