LOCUS       NM_027918               2275 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus inhibitor of carbonic anhydrase (Inhca), mRNA.
ACCESSION   NM_027918
VERSION     NM_027918.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2275)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2275)
  AUTHORS   Simmonds,C.S., Karsenty,G., Karaplis,A.C. and Kovacs,C.S.
  TITLE     Parathyroid hormone regulates fetal-placental mineral homeostasis
  JOURNAL   J Bone Miner Res 25 (3), 594-605 (2010)
   PUBMED   19968565
REFERENCE   3  (bases 1 to 2275)
  AUTHORS   Mason,A.B., Judson,G.L., Bravo,M.C., Edelstein,A., Byrne,S.L.,
            James,N.G., Roush,E.D., Fierke,C.A., Bobst,C.E., Kaltashov,I.A. and
            Daughtery,M.A.
  TITLE     Evolution reversed: the ability to bind iron restored to the N-lobe
            of the murine inhibitor of carbonic anhydrase by strategic
            mutagenesis
  JOURNAL   Biochemistry 47 (37), 9847-9855 (2008)
   PUBMED   18712936
REFERENCE   4  (bases 1 to 2275)
  AUTHORS   Wang,F., Lothrop,A.P., James,N.G., Griffiths,T.A., Lambert,L.A.,
            Leverence,R., Kaltashov,I.A., Andrews,N.C., MacGillivray,R.T. and
            Mason,A.B.
  TITLE     A novel murine protein with no effect on iron homoeostasis is
            homologous with transferrin and is the putative inhibitor of
            carbonic anhydrase
  JOURNAL   Biochem J 406 (1), 85-95 (2007)
   PUBMED   17511619
  REMARK    GeneRIF: Murine inhibitor of carbonic anhydrase was a glycoprotein
            that associated with carbonic anhydrase in a 1:1
            stoichiometry.[ICA]
REFERENCE   5  (bases 1 to 2275)
  AUTHORS   Grant,G.R., Robinson,S.W., Edwards,R.E., Clothier,B., Davies,R.,
            Judah,D.J., Broman,K.W. and Smith,A.G.
  TITLE     Multiple polymorphic loci determine basal hepatic and splenic iron
            status in mice
  JOURNAL   Hepatology 44 (1), 174-185 (2006)
   PUBMED   16799992
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK005035.1.
            
            On Apr 5, 2007 this sequence version replaced NM_027918.1.
            
            Summary: This gene is a member of the transferrin gene family.
            Unlike many members of that gene family it does not play a
            significant role in iron homeostasis but rather is an inhibitor of
            carbonic anhydrase. This gene arose as a tandem duplicate of the
            adjacent transferrin gene sometime after the divergence of
            monotremes and therian mammals but before the diversification of
            placental mammals. This gene subsequently became a pseudogene in
            monkeys and apes. In lemurs and other strepsirrhine primates it
            possibly remains a protein coding gene. [provided by RefSeq, Oct
            2021].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005035.1, BC021390.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2275              AK005035.1         2-2276
FEATURES             Location/Qualifiers
     source          1..2275
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 55.1 cM"
     gene            1..2275
                     /gene="Inhca"
                     /gene_synonym="1300017J02Rik; Ica; mICA"
                     /note="inhibitor of carbonic anhydrase"
                     /db_xref="GeneID:71775"
                     /db_xref="MGI:MGI:1919025"
     exon            1..117
                     /gene="Inhca"
                     /gene_synonym="1300017J02Rik; Ica; mICA"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..2177
                     /gene="Inhca"
                     /gene_synonym="1300017J02Rik; Ica; mICA"
                     /codon_start=1
                     /product="inhibitor of carbonic anhydrase precursor"
                     /protein_id="NP_082194.1"
                     /db_xref="CCDS:CCDS23452.1"
                     /db_xref="GeneID:71775"
                     /db_xref="MGI:MGI:1919025"
                     /translation="MRLLICALLCLGTLGLCLALPEKTIRWCVVSDHEATKCSSFRDN
                     MKKVLPAGGPAVTCVRKMSHPECIRDISANKVDAVTVDGALVAEADLPHHSLKPIMAE
                     YYGSKDDPKTHYYVVAMAKKGTGFQLNQLRGKKSCHTGLGWSAGWYVPLSTLLPSGSR
                     ETAAATFFSSSCVPCADGKMFPSLCQLCAGKGTDKCACSSREPYFGSWGALKCLQDGT
                     ADVSFVKHLTVFEAMPTKADRDQYELLCMDNTRRPVEEYEQCYLARVPSHVVVARSVD
                     GKEDSIQELLRVAQEHFGKDKSSPFQLFGSPHGEDLLFTDAAHGLLRVPRKIDISLYL
                     GYEFLSAFRNLKRGLEDSQRVKWCAVGQQERTKCDQWSAVSGGALACATEETPEDCIA
                     ATMKGEADAMSLDGGFAYVAGHCGLVPVLAENYLSTHSSGRLGSKCVNAPLEGYYVVA
                     VVKKSDVGITWKSLQGKKSCHTAVGTSEGWNVPMGLIYNQTGSCKFDAFFSRSCAPGS
                     DPDSPLCALCVGGNNPAHMCAANNAEGYHGSSGALRCLVEKGDVAFMKHPTVLQNTDG
                     KNPEPWAKGLKHEDFELLCLDGTRKPVTEAQSCHLARVPNRAVFSRKDKADFVRRILF
                     NQQELFGRNGFEYMMFQMFESSAKDLLFSDDTECLSNLQNKTTYKTYLGPQYLTLMDN
                     FRQCLSSELLDACTFHKY"
     exon            118..290
                     /gene="Inhca"
                     /gene_synonym="1300017J02Rik; Ica; mICA"
                     /inference="alignment:Splign:2.1.0"
     exon            291..399
                     /gene="Inhca"
                     /gene_synonym="1300017J02Rik; Ica; mICA"
                     /inference="alignment:Splign:2.1.0"
     exon            400..561
                     /gene="Inhca"
                     /gene_synonym="1300017J02Rik; Ica; mICA"
                     /inference="alignment:Splign:2.1.0"
     exon            562..709
                     /gene="Inhca"
                     /gene_synonym="1300017J02Rik; Ica; mICA"
                     /inference="alignment:Splign:2.1.0"
     exon            710..765
                     /gene="Inhca"
                     /gene_synonym="1300017J02Rik; Ica; mICA"
                     /inference="alignment:Splign:2.1.0"
     exon            766..944
                     /gene="Inhca"
                     /gene_synonym="1300017J02Rik; Ica; mICA"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1116
                     /gene="Inhca"
                     /gene_synonym="1300017J02Rik; Ica; mICA"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1259
                     /gene="Inhca"
                     /gene_synonym="1300017J02Rik; Ica; mICA"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1350
                     /gene="Inhca"
                     /gene_synonym="1300017J02Rik; Ica; mICA"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1407
                     /gene="Inhca"
                     /gene_synonym="1300017J02Rik; Ica; mICA"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1563
                     /gene="Inhca"
                     /gene_synonym="1300017J02Rik; Ica; mICA"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1705
                     /gene="Inhca"
                     /gene_synonym="1300017J02Rik; Ica; mICA"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1770
                     /gene="Inhca"
                     /gene_synonym="1300017J02Rik; Ica; mICA"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1955
                     /gene="Inhca"
                     /gene_synonym="1300017J02Rik; Ica; mICA"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2142
                     /gene="Inhca"
                     /gene_synonym="1300017J02Rik; Ica; mICA"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2275
                     /gene="Inhca"
                     /gene_synonym="1300017J02Rik; Ica; mICA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcaacact gccttctggg taaagtgcac ctaggctggg ggagagcaag cagaacgcag
       61 ttccacagtt gaaaatgagg ctgctcatct gcgcccttct atgcttgggg accctagggc
      121 tgtgcctggc tcttcctgag aagaccatac gatggtgcgt tgtgtcagat catgaggcca
      181 ctaagtgttc tagtttccgt gacaatatga agaaagtcct tcctgcaggt ggcccagctg
      241 ttacctgtgt aaggaaaatg tctcaccctg agtgcatccg ggacatctcg gccaataaag
      301 tagatgctgt gactgttgac ggagctttgg tggctgaagc tgacctgcct caccacagcc
      361 tgaaacctat catggcagaa tactatggat caaaagatga tccaaaaacc cattattatg
      421 ttgtggccat ggcaaagaag ggaacaggct tccaactgaa ccagctccgg ggcaagaagt
      481 cctgccatac tggcctgggc tggtctgctg ggtggtacgt tcccctcagc accctgcttc
      541 cttctggctc tcgggaaaca gcggcagcca cgttcttctc cagcagctgt gtgccctgtg
      601 cggatggaaa gatgttcccc agcctgtgcc aactgtgtgc ggggaagggg acagacaagt
      661 gtgcctgctc ctcccgggaa ccatactttg gctcctgggg agccttaaaa tgtctgcagg
      721 atggcacggc ggatgtgagc ttcgtgaagc acctgacagt gtttgaggcc atgccaacaa
      781 aggccgacag ggaccaatac gagctgctct gcatggacaa cacccgcagg ccagtggagg
      841 aatatgaaca gtgctacctg gcccgggtcc cttctcatgt tgtggtggct cgaagtgtgg
      901 atggcaagga ggactccatc caagagcttc tcagagtggc ccaggaacat tttggaaaag
      961 acaagtcatc acccttccag ctctttggct cccctcacgg ggaggacctg ctgtttactg
     1021 atgctgctca tgggctccta agggtccctc gaaagataga catcagtctg tacttgggat
     1081 atgagtttct ttctgccttt cggaatctta aaagaggtct ggaagactcc cagagggtga
     1141 agtggtgtgc agtgggccag caggagagga ccaaatgtga ccagtggagt gctgtgagcg
     1201 gtggtgcttt ggcgtgtgcc acggaggaga cccctgagga ctgcatcgct gccaccatga
     1261 aaggagaagc ggacgccatg agcctggatg gagggtttgc ctacgtcgca ggccactgcg
     1321 gcctggtacc tgtcctggca gagaactact tgtctaccca cagcagtggg aggctggggt
     1381 ctaagtgtgt gaacgcacct ttggaaggtt attatgttgt ggctgtggtt aagaaatcgg
     1441 atgttggcat cacctggaaa tctctgcaag gcaagaagtc ctgccacacg gccgttggca
     1501 cttctgaagg ctggaacgtc cccatgggtt taatatacaa ccaaactggg tcttgcaaat
     1561 ttgatgcatt cttcagtcgc agctgtgccc cagggtctga ccctgactct cctctctgcg
     1621 ctctgtgtgt tgggggtaac aacccagccc acatgtgtgc tgccaacaac gctgaggggt
     1681 atcacggctc cagcggagct ctcaggtgtc tggttgagaa gggggacgtg gccttcatga
     1741 agcaccctac agttctacag aacactgatg gaaagaaccc tgagccttgg gctaagggtc
     1801 tgaaacacga agactttgag ctgctctgcc ttgatggcac caggaagcct gtgactgagg
     1861 ctcagagctg ccacctggcc agagtgccaa accgtgctgt gttctccagg aaagataagg
     1921 ctgactttgt tcgaagaata ctcttcaacc aacaggagct ctttggaaga aatggatttg
     1981 aatatatgat gttccagatg tttgaatcct cagctaagga cctgcttttc agtgatgaca
     2041 cagaatgttt atctaacctt cagaacaaaa caacatataa aacataccta ggaccacagt
     2101 atcttacctt gatggataac tttagacagt gcttgtcctc tgaactgctg gatgcctgca
     2161 catttcataa atattaaaca ccattcagct ggggggggcg gtaacccagg ggctggggac
     2221 ccaactgctt gcctccatgt ggacttgtgc agaatgaata aaagtatctt cccag
//
