LOCUS       NM_008382               2211 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus inhibin beta-E (Inhbe), mRNA.
ACCESSION   NM_008382
VERSION     NM_008382.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2211)
  AUTHORS   Cao,J., Zhong,Q., Huang,Y., Zhu,M., Wang,Z. and Xiong,Z.
  TITLE     Identification and validation of INHBE and P4HA1 as hub genes in
            non-alcoholic fatty liver disease
  JOURNAL   Biochem Biophys Res Commun 686, 149180 (2023)
   PUBMED   37922570
  REMARK    GeneRIF: Identification and validation of INHBE and P4HA1 as hub
            genes in non-alcoholic fatty liver disease.
REFERENCE   2  (bases 1 to 2211)
  AUTHORS   Hashimoto,O., Funaba,M., Sekiyama,K., Doi,S., Shindo,D., Satoh,R.,
            Itoi,H., Oiwa,H., Morita,M., Suzuki,C., Sugiyama,M., Yamakawa,N.,
            Takada,H., Matsumura,S., Inoue,K., Oyadomari,S., Sugino,H. and
            Kurisaki,A.
  TITLE     Activin E Controls Energy Homeostasis in Both Brown and White
            Adipose Tissues as a Hepatokine
  JOURNAL   Cell Rep 25 (5), 1193-1203 (2018)
   PUBMED   30380411
  REMARK    GeneRIF: a function of activin E to stimulate energy expenditure
            through brown and beige adipocyte activation, is reported.
REFERENCE   3  (bases 1 to 2211)
  AUTHORS   Sugiyama,M., Kikuchi,A., Misu,H., Igawa,H., Ashihara,M.,
            Kushima,Y., Honda,K., Suzuki,Y., Kawabe,Y., Kaneko,S. and
            Takamura,T.
  TITLE     Inhibin betaE (INHBE) is a possible insulin resistance-associated
            hepatokine identified by comprehensive gene expression analysis in
            human liver biopsy samples
  JOURNAL   PLoS One 13 (3), e0194798 (2018)
   PUBMED   29596463
  REMARK    GeneRIF: INHBE functions as a possible hepatokine to alter the
            whole-body metabolic status under obese insulin-resistant condition
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2211)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 2211)
  AUTHORS   Suragani,R.N., Cadena,S.M., Cawley,S.M., Sako,D., Mitchell,D.,
            Li,R., Davies,M.V., Alexander,M.J., Devine,M., Loveday,K.S.,
            Underwood,K.W., Grinberg,A.V., Quisel,J.D., Chopra,R.,
            Pearsall,R.S., Seehra,J. and Kumar,R.
  TITLE     Transforming growth factor-beta superfamily ligand trap ACE-536
            corrects anemia by promoting late-stage erythropoiesis
  JOURNAL   Nat Med 20 (4), 408-414 (2014)
   PUBMED   24658078
REFERENCE   6  (bases 1 to 2211)
  AUTHORS   Fang,J., Wang,S.Q., Smiley,E. and Bonadio,J.
  TITLE     Genes coding for mouse activin beta C and beta E are closely linked
            and exhibit a liver-specific expression pattern in adult tissues
  JOURNAL   Biochem Biophys Res Commun 231 (3), 655-661 (1997)
   PUBMED   9070865
REFERENCE   7  (bases 1 to 2211)
  AUTHORS   Fang,J., Yin,W., Smiley,E., Wang,S.Q. and Bonadio,J.
  TITLE     Molecular cloning of the mouse activin beta E subunit gene
  JOURNAL   Biochem Biophys Res Commun 228 (3), 669-674 (1996)
   PUBMED   8941337
REFERENCE   8  (bases 1 to 2211)
  AUTHORS   Lau,A.L., Nishimori,K. and Matzuk,M.M.
  TITLE     Structural analysis of the mouse activin beta C gene
  JOURNAL   Biochim Biophys Acta 1307 (2), 145-148 (1996)
   PUBMED   8679697
REFERENCE   9  (bases 1 to 2211)
  AUTHORS   Schmitt,J., Hotten,G., Jenkins,N.A., Gilbert,D.J., Copeland,N.G.,
            Pohl,J. and Schrewe,H.
  TITLE     Structure, chromosomal localization, and expression analysis of the
            mouse inhibin/activin beta C (Inhbc) gene
  JOURNAL   Genomics 32 (3), 358-366 (1996)
   PUBMED   8838799
REFERENCE   10 (bases 1 to 2211)
  AUTHORS   Lu,R.Z., Matsuyama,S., Nishihara,M. and Takahashi,M.
  TITLE     Developmental expression of activin/inhibin beta A, beta B, and
            alpha subunits, and activin receptor-IIB genes in preimplantation
            mouse embryos
  JOURNAL   Biol Reprod 49 (6), 1163-1169 (1993)
   PUBMED   8286599
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC114678.20, BY139130.1,
            AI452079.1 and CJ238406.1.
            
            On Sep 3, 2016 this sequence version replaced NM_008382.2.
            
            Summary: This gene encodes a member of the TGF-beta (transforming
            growth factor-beta) superfamily of proteins. The encoded
            preproprotein is proteolytically processed to generate an inhibin
            beta subunit. Inhibins have been implicated in regulating numerous
            cellular processes including cell proliferation, apoptosis, immune
            response and hormone secretion. This gene may be upregulated under
            conditions of endoplasmic reticulum stress, and this protein may
            inhibit cellular proliferation and growth in pancreas and liver.
            [provided by RefSeq, Sep 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U96386.1, BC010404.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AC114678.20        105602-105630
            30-374              BY139130.1         2-346
            375-601             AC114678.20        105976-106202
            602-960             AC114678.20        106439-106797
            961-1293            AI452079.1         1-333
            1294-1931           CJ238406.1         1-638
            1932-2211           AC114678.20        107769-108048
FEATURES             Location/Qualifiers
     source          1..2211
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 74.5 cM"
     gene            1..2211
                     /gene="Inhbe"
                     /note="inhibin beta-E"
                     /db_xref="GeneID:16326"
                     /db_xref="MGI:MGI:109269"
     exon            1..601
                     /gene="Inhbe"
                     /inference="alignment:Splign:2.1.0"
     CDS             304..1356
                     /gene="Inhbe"
                     /note="inhibin beta E chain; activin beta-E chain"
                     /codon_start=1
                     /product="inhibin beta E chain preproprotein"
                     /protein_id="NP_032408.2"
                     /db_xref="CCDS:CCDS24239.1"
                     /db_xref="GeneID:16326"
                     /db_xref="MGI:MGI:109269"
                     /translation="MKLPKAQLWLILLWALVWVQSTRSACPSCGGPTLAPQGERALVL
                     ELAKQQILEGLHLTSRPRITRPLPQAALTRALRRLQPKSMVPGNREKVISFATIIDKS
                     TSTYRSMLTFQLSPLWSHHLYHARLWLHVPPSFPGTLYLRIFRCGTTRCRGFRTFLAE
                     HQTTSSGWHALTLPSSGLRSEDSGVVKLQLEFRPLDLNSTAAGLPRLLLDTAGQQRPF
                     LELKIRANEPGAGRARRRTPTCEPETPLCCRRDHYVDFQELGWRDWILQPEGYQLNYC
                     SGQCPPHLAGSPGIAASFHSAVFSLLKANNPWPAGSSCCVPTARRPLSLLYLDHNGNV
                     VKTDVPDMVVEACGCS"
     exon            602..2211
                     /gene="Inhbe"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1945..1950
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Inhbe"
                     /note="hexamer: AATAAA"
     polyA_site      1970
                     /gene="Inhbe"
                     /note="major polyA site"
ORIGIN      
        1 caagcaactg gctctaaaga ggccctgcca gtagttagtc atgaactgtg agggtcacac
       61 atagctaccc caccaggcga tctactctca gtcttcctga gtcctaggct attgaggaca
      121 agtagcttgg tctgctcttt gtcaagggta gctgtgacac tggtttgctg ttgctgctgc
      181 tgctgctgct gctgctgctg ctgctgctgc tgctgctgct gcttctgtat cctctttggg
      241 aaatcagact cataaaactg ccacccattc gaggttctca aagcagagcc atctacctgg
      301 agcatgaagc ttccaaaagc ccagctctgg ctaatactgc tgtgggcatt ggtgtgggtg
      361 cagagtacaa gatctgcgtg cccgtcctgt gggggcccaa cactggcacc ccaaggagaa
      421 cgcgctctgg tcctggagct agccaagcag caaatcctgg agggactgca cctaaccagc
      481 cgtcccagaa taactcggcc tctgccccag gcagcactga ccagagccct ccggagactg
      541 cagcccaaga gcatggtccc tggcaaccga gagaaagtca tcagctttgc taccatcata
      601 gacaaatcca cttcaaccta ccgctccatg ctcaccttcc agctgtcccc tctttggtcc
      661 caccacctgt accatgcccg cctctggctg catgtgcctc cctcttttcc gggcactctg
      721 tacctgagga tcttccgttg cggcaccact aggtgccgag gattccgcac cttcctagct
      781 gagcaccaaa ccacttcctc tggctggcac gccctgactc tgccctctag cggcttgcgg
      841 agtgaggact ctggcgtcgt gaaactccaa ctggaattta gacccctgga ccttaacagc
      901 accgctgcgg gactgccacg gctgctcttg gacacagcgg gacagcaacg tcccttcttg
      961 gaacttaaga tccgagctaa tgaacctgga gcaggtcggg ccaggaggag gactcccacc
     1021 tgtgagcctg agaccccctt atgttgtagg cgagaccact atgtagactt ccaggagctg
     1081 gggtggcggg attggatcct gcagccggag ggataccagc tgaattactg cagtgggcag
     1141 tgcccgcccc acctggctgg cagtcctggc attgctgcct ccttccattc tgccgtcttt
     1201 agcctcctca aagccaacaa cccttggcct gcgggttctt cctgctgtgt ccccactgca
     1261 cgaaggcctc tctctctcct ctaccttgac cataatggca atgtggtcaa gaccgatgtg
     1321 ccagacatgg tagtagaggc ctgtggctgc agctagcaac agggcctgaa ggttctgggt
     1381 gaagttcaag gttcaagttg ggggttccca cgtgtctgga agctcgagtt ccggatccat
     1441 actgacaccc aataagctgt gtagcagtat gcctgggttt gacccctatg gaacttaaat
     1501 gggcgttttc ttgtcccaga ttctggccta tttcaggctg tttcaaatgt ggacagatgg
     1561 gtaaagcgtt gcctttcaag ggactgcctg gccagcacca ttttctacat caagccctgt
     1621 tccaggacag cagggatgcc gtgggaggga aggaagaaca cagggagaaa ctatttagtc
     1681 tctcccgaga aagaagttcc tcaagtaatg aaggcggaag tagaagggtg ggcagattag
     1741 gaaaagacaa acatacaggc taagaacagg gtgcattgcc tgctttgaca aggtcaagag
     1801 gaagaggagc aggcgccgag gaaggagggg tgtcggggtc cctggaatcg agaatcagta
     1861 aaaaggggtg ctgaactcgt aagttcttag gcttccccct cgaggacagg acccacgcgg
     1921 gtgacataca ttttatattt tcttaataaa aaggagaaag aaaagcacca gagaattgtg
     1981 taaggggttg ttaaaatggg ccagaagcga agtgtggttt ggggacctct gtgccccagc
     2041 gggtttctga gactttctca ggggttttca agactatttt cataatcaca ctgagatgtt
     2101 atttatcatt tgctaccatt atctttacat tgtacagtgg gaacagggtg tggtggctta
     2161 cacttataac tacagcaccg tgagttcaag accggccttc atagtgaatt c
//
