LOCUS       NM_010565               1976 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus inhibin beta-C (Inhbc), mRNA.
ACCESSION   NM_010565
VERSION     NM_010565.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1976)
  AUTHORS   Gold,E., Zellhuber-McMillan,S., Risbridger,G. and Marino,F.E.
  TITLE     Regional localization of activin-betaA, activin-betaC, follistatin,
            proliferation, and apoptosis in adult and developing mouse prostate
            ducts
  JOURNAL   Gene Expr Patterns 23-24, 70-79 (2017)
   PUBMED   28363632
  REMARK    GeneRIF: Results showed activin-C and follistatin are
            differentially expressed during prostate development and suggested
            that the antagonistic property of follistatin is secondary to the
            action of activin-C. Study provides evidence to support a role of
            activin-C in prostate development and provides new insights in the
            spatiotemporal localization of activins and their antagonists
            during mouse prostate development.
REFERENCE   2  (bases 1 to 1976)
  AUTHORS   Marino,F.E., Risbridger,G. and Gold,E.
  TITLE     Activin-betaC modulates gonadal, but not adrenal tumorigenesis in
            the inhibin deficient mice
  JOURNAL   Mol Cell Endocrinol 409, 41-50 (2015)
   PUBMED   25869398
  REMARK    GeneRIF: Data reinforces the importance of activin-betaC in
            reproductive biology and suggests that activin-betaC is a tumor
            modulator with gonadal specificity.
REFERENCE   3  (bases 1 to 1976)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 1976)
  AUTHORS   Boroviak,T., Loos,R., Bertone,P., Smith,A. and Nichols,J.
  TITLE     The ability of inner-cell-mass cells to self-renew as embryonic
            stem cells is acquired following epiblast specification
  JOURNAL   Nat Cell Biol 16 (6), 516-528 (2014)
   PUBMED   24859004
REFERENCE   5  (bases 1 to 1976)
  AUTHORS   Suragani,R.N., Cadena,S.M., Cawley,S.M., Sako,D., Mitchell,D.,
            Li,R., Davies,M.V., Alexander,M.J., Devine,M., Loveday,K.S.,
            Underwood,K.W., Grinberg,A.V., Quisel,J.D., Chopra,R.,
            Pearsall,R.S., Seehra,J. and Kumar,R.
  TITLE     Transforming growth factor-beta superfamily ligand trap ACE-536
            corrects anemia by promoting late-stage erythropoiesis
  JOURNAL   Nat Med 20 (4), 408-414 (2014)
   PUBMED   24658078
REFERENCE   6  (bases 1 to 1976)
  AUTHORS   Fang,J., Wang,S.Q., Smiley,E. and Bonadio,J.
  TITLE     Genes coding for mouse activin beta C and beta E are closely linked
            and exhibit a liver-specific expression pattern in adult tissues
  JOURNAL   Biochem Biophys Res Commun 231 (3), 655-661 (1997)
   PUBMED   9070865
REFERENCE   7  (bases 1 to 1976)
  AUTHORS   Fang,J., Yin,W., Smiley,E., Wang,S.Q. and Bonadio,J.
  TITLE     Molecular cloning of the mouse activin beta E subunit gene
  JOURNAL   Biochem Biophys Res Commun 228 (3), 669-674 (1996)
   PUBMED   8941337
REFERENCE   8  (bases 1 to 1976)
  AUTHORS   Lau,A.L., Nishimori,K. and Matzuk,M.M.
  TITLE     Structural analysis of the mouse activin beta C gene
  JOURNAL   Biochim Biophys Acta 1307 (2), 145-148 (1996)
   PUBMED   8679697
REFERENCE   9  (bases 1 to 1976)
  AUTHORS   Schmitt,J., Hotten,G., Jenkins,N.A., Gilbert,D.J., Copeland,N.G.,
            Pohl,J. and Schrewe,H.
  TITLE     Structure, chromosomal localization, and expression analysis of the
            mouse inhibin/activin beta C (Inhbc) gene
  JOURNAL   Genomics 32 (3), 358-366 (1996)
   PUBMED   8838799
REFERENCE   10 (bases 1 to 1976)
  AUTHORS   Lu,R.Z., Matsuyama,S., Nishihara,M. and Takahashi,M.
  TITLE     Developmental expression of activin/inhibin beta A, beta B, and
            alpha subunits, and activin receptor-IIB genes in preimplantation
            mouse embryos
  JOURNAL   Biol Reprod 49 (6), 1163-1169 (1993)
   PUBMED   8286599
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC114678.20 and AK131946.1.
            
            On Aug 4, 2016 this sequence version replaced NM_010565.3.
            
            Summary: This gene encodes a member of the TGF-beta (transforming
            growth factor-beta) superfamily of proteins. The encoded
            preproprotein is proteolytically processed to generate a subunit of
            homodimeric and heterodimeric activin complexes. The heterodimeric
            complex may function in the inhibition of activin A signaling.
            Transgenic mice overexpressing this gene exhibit defects in testis,
            liver and prostate. [provided by RefSeq, Aug 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026140.1, AK131946.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-462               AC114678.20        86902-87363
            463-1610            AK131946.1         59-1206
            1611-1611           AC114678.20        100763-100763
            1612-1970           AK131946.1         1208-1566
            1971-1976           AC114678.20        101123-101128
FEATURES             Location/Qualifiers
     source          1..1976
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 74.5 cM"
     gene            1..1976
                     /gene="Inhbc"
                     /note="inhibin beta-C"
                     /db_xref="GeneID:16325"
                     /db_xref="MGI:MGI:105932"
     exon            1..468
                     /gene="Inhbc"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1211
                     /gene="Inhbc"
                     /note="inhibin beta C chain; activin beta-C chain"
                     /codon_start=1
                     /product="inhibin beta C chain preproprotein"
                     /protein_id="NP_034695.1"
                     /db_xref="CCDS:CCDS24240.1"
                     /db_xref="GeneID:16325"
                     /db_xref="MGI:MGI:105932"
                     /translation="MASSLLLALLFLTPTTVVNPKTEGPCPACWGAIFDLESQRELLL
                     DLAKKSILDKLHLSQRPILSRPVSRGALKTALQRLRGPRRETLLEHDQRQEEYEIISF
                     ADTDLSSINQTRLEFHFSGRMASGMEVRQTRFMFFVQFPHNATQTMNIRVLVLRPYDT
                     NLTLTSQYVVQVNASGWYQLLLGPEAQAACSQGHLTLELVPESQVAHSSLILGWFSHR
                     PFVAAQVRVEGKHRVRRRGIDCQGASRMCCRQEFFVDFREIGWNDWIIQPEGYAMNFC
                     TGQCPLHVAGMPGISASFHTAVLNLLKANAAAGTTGRGSCCVPTSRRPLSLLYYDRDS
                     NIVKTDIPDMVVEACGCS"
     exon            469..1976
                     /gene="Inhbc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1952..1957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Inhbc"
                     /note="hexamer: AGTAAA"
     polyA_site      1973
                     /gene="Inhbc"
                     /note="major polyA site"
ORIGIN      
        1 ggccgctgta tctctgacaa aaaggagtca tgccagtcgg aggtcagtca cattcctccc
       61 agggtccctg gtgcccagga cagagttgaa gccactcccg ttgagaccct gaatataggc
      121 tttgggtcct ttaaggaggc tatcctccag caatggcctc ctccttgctc ctggctcttc
      181 tgttcctgac tccaaccaca gtagtgaacc ccaaaactga gggtccatgc ccagcatgtt
      241 ggggtgccat ctttgacctg gagagccagc gggagctgct tctcgatttg gccaagaaaa
      301 gtatcctgga caagctgcac ctcagccagc gccccatact cagtcggcca gtgtccagag
      361 gggctctcaa gaccgcgctg cagcgcctcc gcgggcctcg acgggaaacc ctgttggagc
      421 atgaccagag acaagaagaa tatgagatca tcagctttgc tgacacagac ctctccagca
      481 tcaaccagac ccggctcgag ttccacttct ctggtagaat ggccagcggc atggaggtcc
      541 ggcagacccg cttcatgttc ttcgtacagt tcccccacaa tgccacccag accatgaata
      601 taagagttct tgtgctaaga ccatatgaca ccaacctcac cttgacaagt cagtacgtgg
      661 tgcaggtgaa tgccagtggc tggtaccagc ttctcctggg acctgaagct caagctgctt
      721 gcagccaggg acaccttact ctggagctgg taccagaaag ccaggtggcc cacagttcct
      781 tgatcctggg ctggttttcc cacaggcctt ttgtggcagc ccaggtaagg gttgagggca
      841 agcatcgggt tcgccggcga ggtatcgatt gccagggggc gtccaggatg tgctgtcgac
      901 aagagttctt cgtagacttc cgtgagattg gctggaatga ctggatcatc cagcctgaag
      961 gctatgccat gaacttctgc actgggcagt gcccactaca tgtggcaggc atgcctggca
     1021 tctctgcctc ctttcacact gcagtgctga atctgctcaa agccaacgca gctgctggca
     1081 ccactggcag gggctcgtgc tgcgtgccta catctcggcg ccctctgtct ttgctctact
     1141 atgacaggga cagcaacatt gtcaagacgg atatacctga catggtggtc gaggcctgcg
     1201 ggtgtagtta gcttatgggt gatacaggct gcctgaggta gaatggcctt cctcaggaag
     1261 gggaaactct gttcccactt ctgtccagaa tggaaacacc tttctaagca tgcagacatc
     1321 cctctgtgga cttcagggga tccacctcta aagagagtca ctagtgacca acagcctttc
     1381 tctctcctgg gacatggttg acccagtaca cccatcctca gccttaagct agaggctaat
     1441 cgactgccta ccacaagcaa tgtcattttg ttcctggcaa acacaccctt agctctccct
     1501 tagtcaacta tgtaatctac tctgcctccc tgaccctgcc accggaaggt tcctattcca
     1561 cgatgatatg ccttagtgtc tccccttgaa ttctgtggct ctccgaagaa ccccttcatc
     1621 agggtcactg aagattatat tgctgccttc caaagaaagg ctcatctctc aaatctggag
     1681 acccgagccc agatgtgcta ctaaatagtg ttctctgccc tcttctgccc tcgggggtga
     1741 cataccaagt ctcattggtt ggacattcct ctagtttcca gctgaatttg accaaaagga
     1801 gactccagtt ggaaactaaa gcctaggata acacagaaaa actccatcag gcatagtggc
     1861 tcacatggac aagtccagcc ctgcacacga gagactgagg ccagctagct ctaggctagc
     1921 ctgggttatg ccattaagac ctttgtcaca aagtaaaaga aggaagaatg aaagaa
//
