LOCUS       NM_008381               4279 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus inhibin beta-B (Inhbb), mRNA.
ACCESSION   NM_008381 XM_148966
VERSION     NM_008381.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4279)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4279)
  AUTHORS   Souali-Crespo,S., Condrea,D., Vernet,N., Feret,B., Klopfenstein,M.,
            Grandgirard,E., Alunni,V., Cerciat,M., Jung,M., Mayere,C., Nef,S.,
            Mark,M., Chalmel,F. and Ghyselinck,N.B.
  TITLE     Loss of NR5A1 in mouse Sertoli cells after sex determination
            changes cellular identity and induces cell death by anoikis
  JOURNAL   Development 150 (24) (2023)
   PUBMED   38078651
REFERENCE   3  (bases 1 to 4279)
  AUTHORS   Li,R., Wang,T., Marquardt,R.M., Lydon,J.P., Wu,S.P. and DeMayo,F.J.
  TITLE     TRIM28 modulates nuclear receptor signaling to regulate uterine
            function
  JOURNAL   Nat Commun 14 (1), 4605 (2023)
   PUBMED   37528140
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4279)
  AUTHORS   Xie,X., Sun,L., Duan,Y., Lv,Z., Yao,X., Wang,C., Chen,X., Tian,S.,
            Yan,L., Shao,Y., Luo,H. and Liu,J.
  TITLE     SRSF2 in Sertoli cells is essential for testicular development and
            spermatogenesis in mice
  JOURNAL   FASEB J 37 (5), e22918 (2023)
   PUBMED   37039821
REFERENCE   5  (bases 1 to 4279)
  AUTHORS   Smith,K.S., Bihannic,L., Gudenas,B.L., Haldipur,P., Tao,R., Gao,Q.,
            Li,Y., Aldinger,K.A., Iskusnykh,I.Y., Chizhikov,V.V., Scoggins,M.,
            Zhang,S., Edwards,A., Deng,M., Glass,I.A., Overman,L.M.,
            Millman,J., Sjoboen,A.H., Hadley,J., Golser,J., Mankad,K.,
            Sheppard,H., Onar-Thomas,A., Gajjar,A., Robinson,G.W.,
            Hovestadt,V., Orr,B.A., Patay,Z., Millen,K.J. and Northcott,P.A.
  TITLE     Unified rhombic lip origins of group 3 and group 4 medulloblastoma
  JOURNAL   Nature 609 (7929), 1012-1020 (2022)
   PUBMED   36131015
REFERENCE   6  (bases 1 to 4279)
  AUTHORS   van den Eijnden-van Raaij,A.J., Feijen,A., Lawson,K.A. and
            Mummery,C.L.
  TITLE     Differential expression of inhibin subunits and follistatin, but
            not of activin receptor type II, during early murine embryonic
            development
  JOURNAL   Dev Biol 154 (2), 356-365 (1992)
   PUBMED   1330789
REFERENCE   7  (bases 1 to 4279)
  AUTHORS   Manova,K., Paynton,B.V. and Bachvarova,R.F.
  TITLE     Expression of activins and TGF beta 1 and beta 2 RNAs in early
            postimplantation mouse embryos and uterine decidua
  JOURNAL   Mech Dev 36 (3), 141-152 (1992)
   PUBMED   1373953
REFERENCE   8  (bases 1 to 4279)
  AUTHORS   Lazarini,F., Deslys,J.P. and Dormont,D.
  TITLE     Regulation of the glial fibrillary acidic protein, beta actin and
            prion protein mRNAs during brain development in mouse
  JOURNAL   Brain Res Mol Brain Res 10 (4), 343-346 (1991)
   PUBMED   1681406
REFERENCE   9  (bases 1 to 4279)
  AUTHORS   Barton,D.E., Yang-Feng,T.L., Mason,A.J., Seeburg,P.H. and
            Francke,U.
  TITLE     Mapping of genes for inhibin subunits alpha, beta A, and beta B on
            human and mouse chromosomes and studies of jsd mice
  JOURNAL   Genomics 5 (1), 91-99 (1989)
   PUBMED   2767687
REFERENCE   10 (bases 1 to 4279)
  AUTHORS   Mason,A.J., Niall,H.D. and Seeburg,P.H.
  TITLE     Structure of two human ovarian inhibins
  JOURNAL   Biochem Biophys Res Commun 135 (3), 957-964 (1986)
   PUBMED   3754442
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK132352.1, CB245693.1 and
            BP771405.1.
            
            On Aug 4, 2016 this sequence version replaced NM_008381.3.
            
            Summary: This gene encodes a member of the TGF-beta (transforming
            growth factor-beta) superfamily of proteins. The encoded
            preproprotein is proteolytically processed to generate a subunit of
            the dimeric activin and inhibin protein complexes. These complexes
            activate and inhibit, respectively, follicle stimulating hormone
            secretion from the pituitary gland. Homozygous knockout mice for
            this gene exhibit eyelid defects. [provided by RefSeq, Aug 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048845.1, AK132352.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AK132352.1         2-35
            35-318              AK132352.1         37-320
            319-319             CB245693.1         276-276
            320-4255            AK132352.1         322-4257
            4256-4279           BP771405.1         28-51               c
FEATURES             Location/Qualifiers
     source          1..4279
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 52.29 cM"
     gene            1..4279
                     /gene="Inhbb"
                     /note="inhibin beta-B"
                     /db_xref="GeneID:16324"
                     /db_xref="MGI:MGI:96571"
     exon            1..1622
                     /gene="Inhbb"
                     /inference="alignment:Splign:2.1.0"
     CDS             1163..2398
                     /gene="Inhbb"
                     /note="inhibin beta B chain; activin beta-B chain"
                     /codon_start=1
                     /product="inhibin beta B chain preproprotein"
                     /protein_id="NP_032407.1"
                     /db_xref="CCDS:CCDS15224.1"
                     /db_xref="GeneID:16324"
                     /db_xref="MGI:MGI:96571"
                     /translation="MDGLPGRALGAACLLLLVAGWLGPEAWGSPTPPPSPAAPPPPPP
                     PGAPGGSQDTCTSCGGGGGGFRRPEELGRVDGDFLEAVKRHILSRLQLRGRPNITHAV
                     PKAAMVTALRKLHAGKVREDGRVEIPHLDGHASPGADGQERVSEIISFAETDGLASSR
                     VRLYFFVSNEGNQNLFVVQASLWLYLKLLPYVLEKGSRRKVRVKVYFQEQGHGDRWNV
                     VEKKVDLKRSGWHTFPITEAIQALFERGERRLNLDVQCDSCQELAVVPVFVDPGEESH
                     RPFVVVQARLGDSRHRIRKRGLECDGRTSLCCRQQFFIDFRLIGWNDWIIAPTGYYGN
                     YCEGSCPAYLAGVPGSASSFHTAVVNQYRMRGLNPGPVNSCCIPTKLSSMSMLYFDDE
                     YNIVKRDVPNMIVEECGCA"
     exon            1623..4257
                     /gene="Inhbb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4234..4239
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Inhbb"
                     /note="hexamer: AATAAA"
     polyA_site      4257
                     /gene="Inhbb"
                     /note="major polyA site"
ORIGIN      
        1 gattgtgcgg cttttttacc cctcgggaaa aaaagaacag ggagtggaaa ggaagagaag
       61 gcaaagcgaa gaactcctcg ggcgcgctct gcactccgag ccacggctgg gcgcggggac
      121 gctgctgcca ccgccaccgc cgactcgctc tctccccggc cctgcagcgt gtgccagtgg
      181 gagcgcgagc cagggcactc gattctgggg acacagagag acttttggcc gccactgccg
      241 cggcaggcag aagagacagc ggcgagaagg gccctgccac cgcctttccc tcctccgccg
      301 ccccggccgg cccgctcagg cggccaggca cagggaagca gggaggagca gaggcccagg
      361 agaagcgcgc cgcggctcgc ccgcccgtgg atgcggcgcc cgggggagcc tggagacaac
      421 tttgccgggt gacgcgctgg gaggactgca gggcccgccg cccaggaggg ctcggcacct
      481 cctgtaagaa gggcccgcgc agcggcgctc ccccgcacag ctctctctcc tcccgccggc
      541 ccggagcagg ggagaaggac ctgcccatca ccgccgctgc ctcgggcggc cgtgtcctcg
      601 ctgcgagcag cgacagggcg aggcgctcag gtgcggtcgc ggggccccag ccgcagcgcc
      661 ctccgcagcg ccgcgcccgg ggtctccggc accttcgctt cagtctccag agcgacttgc
      721 gcccgctgcc gcctcttccc tccacctttc cagcccggcc gagccaagcc accgtgccag
      781 caccgctgct gccgctcctc gctttcgctt caccccgatc agggggctgc ggtggccctc
      841 gacgcggaga ggatgggcag gctgcagatg cctaggcgcc ccgagtcgtc agcgcgccac
      901 tgacccggcg gtccccccca ccccctcacc gccagcccgc gttcccttct ggtccccgcg
      961 gcgccccttc tcggccgcgc gggaaccccc gcggcccggc cggccccctc cccctgcgag
     1021 ccggcggcgg cgctcccggc aggcgggcgg gcggaggccc gggcgggggc ggggcggggc
     1081 ggtgcgccca gagcccggag cccggccctg agctcgcttc gcctcgcctc gcggcgggcg
     1141 ccctcgtcgc cagcggcgca ccatggacgg gctgcccggt cgggcgttgg gggccgcctg
     1201 ccttctgctc ctggtggccg gctggttggg acccgaggcc tggggctctc ccacaccccc
     1261 gccgtcgccc gctgcgccgc ccccgccccc gccacccgga gctccgggtg gctcgcagga
     1321 cacctgtacg tcgtgcggtg gcggcggcgg cggcttccgg cggccggagg agctgggccg
     1381 ggtggacggt gacttcctgg aggcggtgaa gagacacatc ttgagccgcc tgcagttgcg
     1441 gggccggccc aacatcacgc acgctgtccc caaggccgcc atggtcacgg ccctgcgcaa
     1501 gctgcacgcc ggcaaggtgc gcgaggacgg ccgcgtggag atcccgcacc tcgacggcca
     1561 cgccagcccg ggcgccgacg gccaggagcg cgtctccgag atcatcagct ttgcagagac
     1621 agatggcctc gcctcctccc gggtccgcct gtacttcttc gtctctaatg aaggcaacca
     1681 gaacctattc gtggtgcagg ccagcctgtg gctgtacctg aaactgctcc cctatgtcct
     1741 ggagaagggc agcaggagga aggtacgggt caaggtgtac ttccaagaac agggtcacgg
     1801 agacaggtgg aatgtggtgg agaagaaggt ggacctgaaa cgtagcggct ggcatacctt
     1861 tcccatcaca gaggccatcc aggccttgtt tgagcgaggg gagagacgcc ttaacctgga
     1921 tgtgcagtgt gacagctgcc aggagctggc cgtggtgcct gtgttcgtgg accccggtga
     1981 ggagtcacac aggccctttg tagtggtgca ggcccgcctg ggcgatagca gacatcgcat
     2041 ccgcaaacgg ggcctagagt gtgatgggcg gaccagcctc tgttgcaggc aacagttctt
     2101 catcgacttt cggctcatcg gctggaacga ctggatcatt gcgcccactg gctactacgg
     2161 gaactactgt gagggcagct gcccggccta tctggccggg gtccctggct cagcttcctc
     2221 cttccacaca gccgtggtga accagtaccg catgcgtggc ctgaaccctg ggcccgtgaa
     2281 ctcttgctgc atccctacca agctgagctc catgtccatg ctctactttg atgacgagta
     2341 caacattgtc aagcgggatg tgcccaacat gatcgtggag gagtgtggct gcgcctgaca
     2401 gaggcaacgg gggcggagca caggcccatg ggtctttgag ggagcaggag aggcaggtgg
     2461 gctgagtgtg gttgttccat tgggccgtga agagtgccag ggtgaggcct gaaataatgt
     2521 tctcccgctt tgtagaaaac cagtcaggac cagagggaga atccctctgt ggcacgagag
     2581 actcctaact gcacacatag acacgcatag ccagactcac gcagtctgcc acccacacag
     2641 cagcctctgg gataccagca aacggatgcg gtgacaaatg gcaccaatgc ctgtcagtct
     2701 gaaagaatgg ggtgagcagc caccattccc accagctggc cgggcactct gaattgcgcc
     2761 ttctgagcac acataaaagc acacaaagac agaggacaca gagagagtga gccagagagc
     2821 caccaagagg aaaagcaggg tgggagcaca ggcgggtgga gggccatgtg tccctgactt
     2881 gtcccaggtt cttcaccgaa gcgcctggca cagtcctgcc tgctcactgc ccgcctggca
     2941 tcctccatgc tttgaggcca gcagagctgt gccacccctg ttcttggaga gggcaagtag
     3001 cccaggagcg actcacctgt cacagagacc atggagcagg gacagtgacc ctttgatggt
     3061 ctgtcacttg cgtcccccat gtgacttata tatgtgtgta tgtgtgtttg ttttcggggg
     3121 tgttggggga gggagagaag aagggtctta attttatgct ttaaattcat ctccaacaac
     3181 tgacaggtca ctggtgccag ttgcagaatt gaaaagagcc tatcagctat ggcctttgaa
     3241 gcggaaaggc caaacgattc gaagtgagaa ggaaagaaaa atgttgcaat cggtgccctt
     3301 tgctggggac ttcctcctgg tgttatgctt agaggggagg gccactggca agggggagag
     3361 acaggggagg cagtggcaga gtgaggctgt tctgaggagc tgctcagctg ggcttggaga
     3421 gagagggaga gcttttggtt gctttgcaga agttgttccc gagggtgagc cctggcttca
     3481 gggttgtccg tggacatgtc ccctgcccag ttcacttgcc ctcccgcctg ctccacaatg
     3541 cacttgcggt cctgagtgaa tgcacaccac aatagcactt gcaggtctac gtgtgtccag
     3601 aagtggccct ggggcgagag cttgacgtgg ctgtcctcgt ggatgtccaa gtgccacgtg
     3661 aactatgcaa tttaaagggt tgacccacac taggcgaaac tggactcgta cgactctttt
     3721 atatttttat acttgaaatg aaatcttttg cttcttttct aagcgaatga ttgctttcaa
     3781 tgtttgcact gatctagttg catggttagt cagaaactgc catttgaaaa aaaaagttat
     3841 ttttatagct gcagaaaaat gaatacagtt aaatgtatta tacataattt tggaaccaaa
     3901 gaggccagcg gatcagtttt aatttttatt agatggtgag gccatcttct atgaggtaga
     3961 tgttctaaac aatccttcga gtggcctgcc agtgtttcag ggtataaatg attttttttt
     4021 tattcagttg atgtgtcttt tctgtccgta cacacccaga aggtagagta aaataaatga
     4081 ctggtggagt gaaggtgtgt gctgtaagtc ctcaccttta gtttatttaa taaatccctc
     4141 cttaggttct gtttcataat aacttaaaac caaacaattt tcccccacag actggctgtc
     4201 ttaagtattt tacgttcatg tacagtataa gacaataaaa gatggagtgc cacgggcaaa
     4261 aaaaaaaaaa aaaaaaaaa
//
