LOCUS       NM_008380               6403 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus inhibin beta-A (Inhba), mRNA.
ACCESSION   NM_008380
VERSION     NM_008380.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6403)
  AUTHORS   Koo,H.Y., Oh,J.H., Duran Alonso,M.B., Hernandez,I.L.,
            Gonzalez-Vallinas,M., Alonso,M.T., Tena,J.J., Gil-Galvez,A.,
            Giraldez,F., Bok,J. and Schimmang,T.
  TITLE     Analysis of Meis2 knockout mice reveals Sonic hedgehog-mediated
            patterning of the cochlear duct
  JOURNAL   Dev Dyn (2024) In press
   PUBMED   39351969
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 6403)
  AUTHORS   Yan,F., Suzuki,A., Iwaya,C., Pei,G., Chen,X., Yoshioka,H., Yu,M.,
            Simon,L.M., Iwata,J. and Zhao,Z.
  TITLE     Single-cell multiomics decodes regulatory programs for mouse
            secondary palate development
  JOURNAL   Nat Commun 15 (1), 821 (2024)
   PUBMED   38280850
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6403)
  AUTHORS   Liu,H., Zhou,R., Li,S., Dong,J., Fang,Y., Luo,Y., Su,H., Lai,B.,
            Liang,L., Zhang,D., Zhang,Y., Shyy,J.Y., Zhou,B., Yuan,Z. and
            Wang,Y.
  TITLE     Epigenetic repression of Cend1 by lysine-specific demethylase 1 is
            essential for murine heart development
  JOURNAL   iScience 27 (1), 108722 (2023)
   PUBMED   38226173
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6403)
  AUTHORS   Yao,L., Lu,J., Zhong,L., Wei,Y., Gui,T., Wang,L., Ahn,J.,
            Boerckel,J.D., Rux,D., Mundy,C., Qin,L. and Pacifici,M.
  TITLE     Activin A marks a novel progenitor cell population during fracture
            healing and reveals a therapeutic strategy
  JOURNAL   Elife 12, e89822 (2023)
   PUBMED   38079220
  REMARK    GeneRIF: Activin A marks a novel progenitor cell population during
            fracture healing and reveals a therapeutic strategy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6403)
  AUTHORS   Dali,O., D'Cruz,S., Legoff,L., Diba Lahmidi,M., Heitz,C.,
            Merret,P.E., Kernanec,P.Y., Pakdel,F. and Smagulova,F.
  TITLE     Transgenerational epigenetic effects imposed by neonicotinoid
            thiacloprid exposure
  JOURNAL   Life Sci Alliance 7 (2), e202302237 (2023)
   PUBMED   37973188
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6403)
  AUTHORS   Matzuk,M.M., Kumar,T.R., Vassalli,A., Bickenbach,J.R., Roop,D.R.,
            Jaenisch,R. and Bradley,A.
  TITLE     Functional analysis of activins during mammalian development
  JOURNAL   Nature 374 (6520), 354-356 (1995)
   PUBMED   7885473
REFERENCE   7  (bases 1 to 6403)
  AUTHORS   van den Eijnden-van Raaij,A.J., Feijen,A., Lawson,K.A. and
            Mummery,C.L.
  TITLE     Differential expression of inhibin subunits and follistatin, but
            not of activin receptor type II, during early murine embryonic
            development
  JOURNAL   Dev Biol 154 (2), 356-365 (1992)
   PUBMED   1330789
REFERENCE   8  (bases 1 to 6403)
  AUTHORS   Manova,K., Paynton,B.V. and Bachvarova,R.F.
  TITLE     Expression of activins and TGF beta 1 and beta 2 RNAs in early
            postimplantation mouse embryos and uterine decidua
  JOURNAL   Mech Dev 36 (3), 141-152 (1992)
   PUBMED   1373953
REFERENCE   9  (bases 1 to 6403)
  AUTHORS   Mathews,L.S. and Vale,W.W.
  TITLE     Expression cloning of an activin receptor, a predicted
            transmembrane serine kinase
  JOURNAL   Cell 65 (6), 973-982 (1991)
   PUBMED   1646080
REFERENCE   10 (bases 1 to 6403)
  AUTHORS   Albano,R.M., Godsave,S.F., Huylebroeck,D., Van Nimmen,K.,
            Isaacs,H.V., Slack,J.M. and Smith,J.C.
  TITLE     A mesoderm-inducing factor produced by WEHI-3 murine myelomonocytic
            leukemia cells is activin A
  JOURNAL   Development 110 (2), 435-443 (1990)
   PUBMED   2133547
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK134991.1, AC161586.5,
            AC154742.2 and BP759054.1.
            
            On Aug 2, 2016 this sequence version replaced NM_008380.1.
            
            Summary: This gene encodes a member of the TGF-beta (transforming
            growth factor-beta) superfamily of proteins. The encoded
            preproprotein is proteolytically processed to generate a subunit of
            the dimeric activin and inhibin protein complexes. These complexes
            activate and inhibit, respectively, follicle stimulating hormone
            secretion from the pituitary gland. The encoded protein also plays
            a role in eye, tooth and testis development. Homozygous knockout
            mice for this gene lack whiskers and exhibit tooth and palate
            defects, leading to neonatal lethality. [provided by RefSeq, Aug
            2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134991.1, SRR10662774.708831.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AK134991.1         1-61
            62-62               AC161586.5         135727-135727
            63-1957             AK134991.1         63-1957
            1958-5841           AC154742.2         35976-39859
            5842-6403           BP759054.1         27-588              c
FEATURES             Location/Qualifiers
     source          1..6403
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 5.85 cM"
     gene            1..6403
                     /gene="Inhba"
                     /note="inhibin beta-A"
                     /db_xref="GeneID:16323"
                     /db_xref="MGI:MGI:96570"
     exon            1..240
                     /gene="Inhba"
                     /inference="alignment:Splign:2.1.0"
     exon            241..427
                     /gene="Inhba"
                     /inference="alignment:Splign:2.1.0"
     exon            428..509
                     /gene="Inhba"
                     /inference="alignment:Splign:2.1.0"
     exon            510..1011
                     /gene="Inhba"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..6378
                     /gene="Inhba"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6354..6359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Inhba"
                     /note="hexamer: AATAAA"
     polyA_site      6378
                     /gene="Inhba"
                     /note="major polyA site"
ORIGIN      
        1 ggggttcgct agtggctgct cctccaggca gcaccgggcc agcgtggagt tggagctttg
       61 tgaagtagcc agtaaatcag aacgcctccg ctaggtgcag agcgcggtgg cagcgggcca
      121 ctctgccagt gcggtagtcg gtgggaccga actctacact cgggaagggg cagtctgcgg
      181 gtgcggggcc tgagctgccg ctcgcctccg ttggccagga gaccggcagc cccactgcag
      241 ctgccaaaag ggggggaaaa atcaagagct gcgcttttaa acgaagttgc ccttgctggt
      301 gttcagggta aaaatagagg cggccgcttg gaccagcttg gcccctgagt ccaggcgtcc
      361 cgcgagccgg gctggagctg cgcattcggg agtgatccct ggaaactgcc agcaggtgct
      421 gctcaagtgc caataccatg aagaggaatt cagacagctc tgacctcatg agacaagagc
      481 cggctgacaa aacagaaggg acccgaaaga gaatttgctg aagaggagaa ggaaaaaaaa
      541 agtccaaaaa aacctgtgcg tgaggggtgg ggaggaaaag cagggccttt aaagaaggca
      601 accacacgac ttttgctgcc aggatgccct tgctttggct gagaggattt ctgttggcaa
      661 gttgctggat tatagtgagg agttccccca ccccaggatc cgaggggcac ggctcagccc
      721 cggactgccc gtcctgtgcg ctggccaccc ttccgaagga tggacctaac tctcagccag
      781 agatggtaga ggctgtcaag aagcacatct taaacatgct gcacttgaag aagagacccg
      841 atgtcaccca gccggtgccc aaggcggcgc ttctcaacgc gatcagaaag cttcatgtgg
      901 gtaaagtggg ggagaacggg tatgtggaga tagaggacga cattggcagg agggccgaaa
      961 tgaatgaact catggagcag acctcggaga tcatcacctt tgccgagtca ggcacagcca
     1021 ggaagacact gcactttgag atttccaagg aaggcagtga cctgtcagta gtggagcgtg
     1081 cagaagtgtg gctcttcctg aaagtcccca aggctaacag aaccaggacc aaagtcacca
     1141 tccgtctatt tcagcagcag aagcacccac agggcagctt ggacacgggg gatgaggccg
     1201 aggaaatggg cttaaagggg gagaggagtg aactgttgct atcagagaaa gtagttgatg
     1261 ctcggaagag tacctggcac atctttccag tgtccagcag catccagcgc ctgctggacc
     1321 agggaaagag ttccctggac gtgcggattg cttgtgagca gtgccaggag agtggtgcca
     1381 gtctagtgct tctgggcaag aagaagaaga aagaggtgga tggagatggg aagaagaaag
     1441 atgggagtga cggagggctg gaagaggaaa aggaacagtc acatagacct ttcctcatgc
     1501 tgcaggctag gcagtccgaa gaccaccctc atcgcaggcg taggcggggc ttggagtgcg
     1561 acggcaaggt caacatttgc tgtaagaaac agttctttgt cagcttcaag gacattggct
     1621 ggaatgactg gatcattgct ccctctggct atcacgccaa ttattgtgag ggggagtgcc
     1681 caagccacat agcaggcacc tctgggtcct cgctctcctt ccactcaaca gtcattaacc
     1741 actaccgcat gaggggtcac agcccctttg ccaaccttaa gtcatgctgt gtgcccacca
     1801 agctgagacc catgtccatg ctgtattacg atgatggtca aaacatcatc aaaaaggaca
     1861 ttcaaaacat gattgtggag gagtgtggct gctcctagag tcgccaggtc ccagagaaaa
     1921 tggatctaga gagtccagag aagacagtgg caaaatgaag aaaaaaatat aagatttatg
     1981 aactaaacaa aacaaccaga aaaatagaaa taataataat aaaaaaccca caaaaaaaaa
     2041 acaaaaacaa aaatcaaaaa ctaaactgaa aacaagacct aatgaaacag atgaaggaag
     2101 atgtggaaaa atatcctaag gcagggctca gagatgaagc agtaaaggag acagggattg
     2161 ggggggggga ggggggagaa gagagaatgg tgtaccttca tttcttccaa aaccaaactg
     2221 attgcatcag ttttatccaa actgggtatt gtcctctctc ctgcctcttg cggttccctt
     2281 gcgagcctgg aagtctactt gtctattctg cagtaatgtg ggttagcaca acccaaataa
     2341 taatgtctag aaagccatga gttttaaagg gccagtccca cccacttacc caggttataa
     2401 gtatgtctat gtgacactat ctctgtgtat ttcaacacac acacacacac acacacactc
     2461 acacacacac acacacacac acacacacac acacacgccc ccccacacac acacacactc
     2521 acacacacac acacacacac acacacacac acacacacac tcacacacac acacacacac
     2581 acacacgccc acacacacaa acacagaggt gtttccacac accacatgca tacacatact
     2641 ggtaaaagaa caattctgtg caggtggtca cattttcttt tctgtaccac ttttgccacc
     2701 agacaaaacc aacataaaac attgagaaca agagtggaaa gaatgaaaga ccaagggaag
     2761 aagaatacca agttacattt cgttaaggtg cttttgatcc tagaactatg caacctaata
     2821 ggtttgaaac tgtttacctg aaagaggaca aaaagagaga cttttttgta ttggaagtaa
     2881 cctgattaat ttttattttc ttcaaggaga gatacttgaa aggaatatgt ttgtccatct
     2941 gttggattca aacatttcta tattttgtaa atgttgtttt ttttatcgtt tactatttgc
     3001 actacgatgg tgtttgacct gtctaatcct tatttaacaa gtattttctt tgggtggggg
     3061 tgggggtggg gtttaagagc tgcacttcat gtgagctata aaagaactgc tacagcacac
     3121 aaaatagcta tttttattat tataattata attattatta ttattttgta ccttaaaaat
     3181 agacacatac accaaagaca tttgtgtgag cctttaaaca gtctgtctgt ggttggtatt
     3241 gttcaccatc aatgagtcag gggtacagat ttaaggttga gttaggtaga ttgtgttcag
     3301 gcttaaaaga cctgagaggt ttgggttttg actcttttac atccatgaaa caggacattt
     3361 catactggat gtacagtagt gtacactgtt ggattatcaa gttcaaattc atgagactac
     3421 atgcttgtat gtgtatatat acattgcttg tgcatatgca tatctgtatg tatatataca
     3481 tgtattgtac catgtccata cacattttaa gcacttcagg ctgtcatttt aaaaatgttc
     3541 ttaaaacaat gaatgtttgt gtgcaaaaca cagtattttt aagaaggata agtgatagat
     3601 tttttttttt cttgctttta ctctgtagta cgtgggtaca tttcaaatgt taggatgggg
     3661 aaagactgaa aatcccagtg agtatccagc caggccctct ttaaatgtac aggatgaaat
     3721 cccctctttc atatcccccc tgctccctac aagttatccc ctgtggggaa aaatgggatg
     3781 ttactttaaa aacaaaatgg gctgattttt tcaacttata tttattattt attggaatca
     3841 atcttaaatc agaaacattt ttggaaaaaa tctttaggct agaataattt tttgaatagt
     3901 gttattacta cttaaataat aaaataagca ggaaagtatt taagacagtg agagttaagg
     3961 gagagagcac tcaggagcca gggagttgta caaatctcta atattctatt ttgcagccaa
     4021 aaaacttgct gtgtatgttt gtactttttc agaggcaaaa ctgaaaagat tgtcttacga
     4081 atatcaaaat acacacttaa cccaagttcc taatttaacc cagtgttggc ttgtctaaaa
     4141 cagctaatca gttattcatt tacatattta aaatatagag ccttattttt acggacttgt
     4201 ttgaagtttg aaaaacttta taaaagtgaa aaactctaat tgaaaaaaaa tctatattcc
     4261 tcagtatttt gtaaaatatt gaagctttta gcattaagtc agtccataga ttaaagtcat
     4321 tgtaggaaaa tgaaatacaa aggagaaatt aaatcttaaa aaagctggtt taactcttaa
     4381 aaaaataaac taactcaata tgtattaaat ataccgtcaa tataccttat cacattaggc
     4441 tgtgtgtagg caaactactt tagtcttgtt actgggcaaa catatttact gtgttccagg
     4501 ggccctccct gtcttatgca ggaaatgcat gtactgcata agaaatgaat tataattaag
     4561 gtctaatgac cttgaagatc tcgcatgcga ggacagatgg catgttgagg acacagaggt
     4621 gaggtggatg tccaggttca gctttgccaa tttttgtgaa aaacctttag cgccctctga
     4681 actgtttctt tagtattgga gctaatgccg aggcctagag aaatagtggg caagagatct
     4741 aactgtgcca tatcagagat gatctagacc atgggaagag caggatttat gtaactacta
     4801 attatagttc tcattcatct gagatgaatc tgcaatcttc ttaagccctt taaattctag
     4861 atgttttgag ggtaagcttg ggtttaatta gtagccatag taattaaatc tagaaagaaa
     4921 tgaaattcca caggacagtg tatttactgg agaccaagtg acttggttgt cacataaacc
     4981 tcatcagaac tcatcaaatt tgtatggcct tgcaatagaa tttaaattgc taatatttta
     5041 acaatattag atattgttaa caatttagaa aacatgaagt cttgtgaact ggtctttcta
     5101 cataagtgct taatccaaaa tttgaaaagc ctttaatgct taagatctta gtttcttcat
     5161 ggtgtgcttt ccctagtgtt aaagtggctc tgtctggtct ccccactttc tctaggataa
     5221 ttcttaaata cctgcccaca caagttctag atgctctgaa gagcatttgt agttagtatc
     5281 tctttaatac ttgtaagctt cattgacact tttccttccc aaaataagtc aaatttcagc
     5341 acagcaatgg ggattttctt atcttagaag accagccaat tctatgttca tttaagattg
     5401 attccacact ccattttcaa ggagaggcct tgtgttttct taaaaggcag aataagtaaa
     5461 attgggagct atgccagact gaacgcaaga cgtgactttg tgattccaga acaaacatgc
     5521 ctcagttata gtaacatgca ttcaaatgat tgtgtcactt gaaaaatatg atttcctgtg
     5581 ggccttttgg caacttctct ttttagtatc gagaaaaatg taatcacccc aaaacccgca
     5641 taagtgtgac ttgtagatgt gggcaggagg ttgggggatg gacattgtat gtgtttaaat
     5701 taaaccctgt atcactgaga agctattgga ggggtcagag ataatgaatg catagatgct
     5761 gttcacatct tcaagagcaa aagcaaatca cgtgtctcag ctatattatt atttattttt
     5821 atgcataaag tgaatcattt cttctgtatt aattttcagt ggggtttgcc ctctatttaa
     5881 atgctttgaa aaacagtgca ttgacaatgg ttgatatttt tctttaaaag aaaaatataa
     5941 ttatgaaagc caagataatc tgaaatctgt tttgatctaa aactttttat gttatgtggt
     6001 tgatgttgtt tgtttgtttt ttatttttat tttgtgagtt cctttgcata ctacatgcaa
     6061 ttctttaacc aatgtctggc taatgtaatt aaagttgtta atttatatga gtgcatttca
     6121 actatgtcaa tggtttctta atatttattt tgtagaagtg ctggtaattt tttatttacg
     6181 atatgtttaa agagataacg gttggatatg ttttcatgtg tttatagcag aagttattta
     6241 tttctattcc attccagcgg atattctgat gtttgcgagg catgcagtca atactttgta
     6301 cagttagtag gcagtattca gcaatgcccg atagcttctt tggccttatg ttaaataaaa
     6361 agacctgttt gggatgtaaa aaaaaaaaaa aaaaaaaaaa aaa
//
