LOCUS       NM_010564               1491 bp    mRNA    linear   ROD 24-DEC-2022
DEFINITION  Mus musculus inhibin alpha (Inha), transcript variant 1, mRNA.
ACCESSION   NM_010564
VERSION     NM_010564.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1491)
  AUTHORS   Talpur HS, Rehman ZU, Gouda M, Liang A, Bano I, Hussain MS,
            FarmanUllah F and Yang L.
  TITLE     Molecular Genomic Study of Inhibin Molecule Production through
            Granulosa Cell Gene Expression in Inhibin-Deficient Mice
  JOURNAL   Molecules 27 (17), 5595 (2022)
   PUBMED   36080362
  REMARK    GeneRIF: Molecular Genomic Study of Inhibin Molecule Production
            through Granulosa Cell Gene Expression in Inhibin-Deficient Mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1491)
  AUTHORS   Moody SC, Whiley PAF, Western PS and Loveland KL.
  TITLE     The Impact of Activin A on Fetal Gonocytes: Chronic Versus Acute
            Exposure Outcomes
  JOURNAL   Front Endocrinol (Lausanne) 13, 896747 (2022)
   PUBMED   35721752
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1491)
  AUTHORS   Wen Y, Ma X, Wang X, Wang F, Dong J, Wu Y, Lv C, Liu K, Zhang Y,
            Zhang Z and Yuan S.
  TITLE     hnRNPU in Sertoli cells cooperates with WT1 and is essential for
            testicular development by modulating transcriptional factors Sox8/9
  JOURNAL   Theranostics 11 (20), 10030-10046 (2021)
   PUBMED   34815802
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1491)
  AUTHORS   St-Jean G, Tsoi M, Abedini A, Levasseur A, Rico C, Morin M,
            Djordjevic B, Miinalainen I, Kaarteenaho R, Paquet M, Gevry N,
            Boyer A, Vanderhyden B and Boerboom D.
  TITLE     Lats1 and Lats2 are required for the maintenance of multipotency in
            the Mullerian duct mesenchyme
  JOURNAL   Development 146 (20) (2019)
   PUBMED   31575647
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1491)
  AUTHORS   Makanji Y, Zhu J, Mishra R, Holmquist C, Wong WP, Schwartz NB, Mayo
            KE and Woodruff TK.
  TITLE     Inhibin at 90: from discovery to clinical application, a historical
            review
  JOURNAL   Endocr Rev 35 (5), 747-794 (2014)
   PUBMED   25051334
  REMARK    Review article
REFERENCE   6  (bases 1 to 1491)
  AUTHORS   van den Eijnden-van Raaij AJ, Feijen A, Lawson KA and Mummery CL.
  TITLE     Differential expression of inhibin subunits and follistatin, but
            not of activin receptor type II, during early murine embryonic
            development
  JOURNAL   Dev Biol 154 (2), 356-365 (1992)
   PUBMED   1330789
REFERENCE   7  (bases 1 to 1491)
  AUTHORS   Matzuk MM, Finegold MJ, Su JG, Hsueh AJ and Bradley A.
  TITLE     Alpha-inhibin is a tumour-suppressor gene with gonadal specificity
            in mice
  JOURNAL   Nature 360 (6402), 313-319 (1992)
   PUBMED   1448148
REFERENCE   8  (bases 1 to 1491)
  AUTHORS   Nakamura T, Sugino K, Kurosawa N, Sawai M, Takio K, Eto Y, Iwashita
            S, Muramatsu M, Titani K and Sugino H.
  TITLE     Isolation and characterization of activin receptor from mouse
            embryonal carcinoma cells. Identification of its
            serine/threonine/tyrosine protein kinase activity
  JOURNAL   J Biol Chem 267 (26), 18924-18928 (1992)
   PUBMED   1326537
REFERENCE   9  (bases 1 to 1491)
  AUTHORS   Vidal SM, Epstein DJ, Malo D, Weith A, Vekemans M and Gros P.
  TITLE     Identification and mapping of six microdissected genomic DNA probes
            to the proximal region of mouse chromosome 1
  JOURNAL   Genomics 14 (1), 32-37 (1992)
   PUBMED   1358796
REFERENCE   10 (bases 1 to 1491)
  AUTHORS   Barton DE, Yang-Feng TL, Mason AJ, Seeburg PH and Francke U.
  TITLE     Mapping of genes for inhibin subunits alpha, beta A, and beta B on
            human and mouse chromosomes and studies of jsd mice
  JOURNAL   Genomics 5 (1), 91-99 (1989)
   PUBMED   2767687
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC115011.27, CX211461.1,
            X55957.1 and AW046749.1.
            
            [WARNING] On Apr 27, 2023 this sequence was replaced by
            NM_010564.6.
            
            On Aug 2, 2016 this sequence version replaced NM_010564.4.
            
            Summary: This gene encodes a member of the TGF-beta (transforming
            growth factor-beta) superfamily of proteins. The encoded
            preproprotein is proteolytically processed to generate multiple
            peptide products, including the alpha subunit of the inhibin A and
            B protein complexes. These complexes negatively regulate follicle
            stimulating hormone secretion from the pituitary gland. Inhibins
            have also been implicated in regulating numerous cellular processes
            including cell proliferation, apoptosis, immune response and
            hormone secretion. Mice in which this gene has been ablated exhibit
            sex cord-stromal tumors and symptoms that mimic the human cancer
            cachexia syndrome. [provided by RefSeq, Aug 2016].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056627.1, X55957.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AC115011.27        77193-77253         c
            62-358              CX211461.1         1-297
            359-1095            X55957.1           45-781
            1096-1491           AW046749.1         1-396               c
FEATURES             Location/Qualifiers
     source          1..1491
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 39.16 cM"
     gene            1..1491
                     /gene="Inha"
                     /note="inhibin alpha"
                     /db_xref="GeneID:16322"
                     /db_xref="MGI:MGI:96569"
     exon            1..442
                     /gene="Inha"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..1272
                     /gene="Inha"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; inhibin alpha chain"
                     /codon_start=1
                     /product="inhibin alpha chain isoform 1 preproprotein"
                     /protein_id="NP_034694.3"
                     /db_xref="CCDS:CCDS15078.1"
                     /db_xref="GeneID:16322"
                     /db_xref="MGI:MGI:96569"
                     /translation="MVSQRSLLLLLLLTLRDVDSCQGPELVRELVLAKVKALFLDALG
                     PPAMDGEGGDPGIRRLPRRHAVGGFMHRTSEPEEEDVSQAILFPATGATCEDQPAARG
                     LAQEAEEGLFTYVFRPSQHIRSHQVTSAQLWFHTGLGRKSTAAANSSAPLLDLLVLSS
                     GGPMAVPVSLGQGPPRWAVLHLAASAFPLLTHPILVLLLRCPLCSCSGRPETTPFLVA
                     HTRARAPSAGERARRSTPSVPWPWSPAALRLLQRPPEEPAAHAFCHRAALNISFQELG
                     WDRWIVHPPSFIFHYCHGSCGMPTSDLPLPVPGVPPTPVQPLFLVPGAKPCCAALPGS
                     MRSLRVRTTSDGGYSFKYEMVPNLITQHCACI"
     exon            443..1475
                     /gene="Inha"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccatgggca ggggcgactg ggactgtggg gcgtgggaag gactggggga gactggggtg
       61 agaagggtag aagaaggcca gcagtgggat ggggagggga cagtggggag gtcctagaca
      121 gaaagggcac agggcagcgt gtgggttccc tgtcatcagg gcaagtgaac tatggtgagc
      181 cagcggtctc tgctgctcct tttgctgttg accctacggg atgtggacag ctgccaggga
      241 cccgaacttg tccgggagct cgtcctggcc aaggtgaagg ctctattcct agatgccttg
      301 gggcccccag caatggatgg ggaaggtggg gatcctggaa taaggcgtct gcctcgaaga
      361 catgccgttg ggggtttcat gcacaggacc tctgaaccag aggaggaaga tgtctcccag
      421 gctatccttt tcccagctac aggtgccacc tgtgaggacc agccagctgc cagagggctt
      481 gcccaggagg ctgaggaagg cctcttcact tatgtattcc ggccatccca acacatacgc
      541 agccaccagg tgacttcagc ccagctgtgg ttccacacag gcctaggcag gaagagcaca
      601 gcagccgcca atagctctgc gcccctgcta gatcttctgg tgctatcatc tggggggccc
      661 atggctgtgc ctgtgtcctt gggacagggc ccgccacgct gggctgtact gcacctggcg
      721 gcgtctgctt tccctctgct gacccacccc atcctggtgt tgctgctgcg atgcccactc
      781 tgttcctgct cgggccggcc tgagaccact cctttcctgg tagcccacac tagggctcga
      841 gcacccagtg cgggggagag ggcccggcgt tcaactccct ccgtgccttg gccttggtct
      901 cctgcggctt tgcgcttgct gcagaggcct cccgaggaac ccgctgcgca tgccttctgc
      961 catcgagctg ctctcaatat ctccttccaa gagctgggct gggaccgctg gatcgtacac
     1021 cctcccagtt tcatcttcca ctactgccat ggtagctgcg ggatgcccac atctgacctg
     1081 cccctgccag tccctggggt gccccctacc ccggttcagc ccctgttttt ggtgccaggg
     1141 gccaagccct gctgtgctgc tcttccgggg agcatgaggt ccctacgcgt ccgaaccacc
     1201 tcagatggag gttactcttt caagtatgag atggtaccca accttattac tcaacactgt
     1261 gcttgtatct aaaagcacct ccgcctcctc ctcccatagc cgatggccac agtcaattca
     1321 ccaccccagg gtcctcagct aggaggagga cagagtgtgg aaagtagaca gtttccactt
     1381 ccttttccct acatctttca gtatgaggga tccatatcct gctccaccca ggtcctgtgg
     1441 ataacaataa aaaaggaagt gtgtgtgcct ttgtaaaaaa aaaaaaaaaa a
//
