LOCUS       NM_025454               4539 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus inhibitor of growth family, member 5 (Ing5), mRNA.
ACCESSION   NM_025454
VERSION     NM_025454.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4539)
  AUTHORS   Mah,S.Y.Y., Vanyai,H.K., Li-Wai-Suen,C.S.N., Garnham,A.L., Wynn,J.,
            Bergamasco,M.I., Malelang,S., Wilcox,S., Biben,C., Smyth,G.K.,
            Thomas,T. and Voss,A.K.
  TITLE     ING4 and ING5 are essential for histone H3 lysine 14 acetylation
            and epicardial cell lineage development
  JOURNAL   Development 151 (5) (2024)
   PUBMED   38446206
  REMARK    GeneRIF: ING4 and ING5 are essential for histone H3 lysine 14
            acetylation and epicardial cell lineage development.
REFERENCE   2  (bases 1 to 4539)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4539)
  AUTHORS   Mah,S.Y.Y., Vanyai,H.K., Yang,Y., Voss,A.K. and Thomas,T.
  TITLE     The chromatin reader protein ING5 is required for normal
            hematopoietic cell numbers in the fetal liver
  JOURNAL   Front Immunol 14, 1119750 (2023)
   PUBMED   37275850
  REMARK    GeneRIF: The chromatin reader protein ING5 is required for normal
            hematopoietic cell numbers in the fetal liver.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4539)
  AUTHORS   Wang,C., Cao,H., Gu,S., Shi,C., Chen,X. and Han,X.
  TITLE     Expression analysis of microRNAs and mRNAs in myofibroblast
            differentiation of lung resident mesenchymal stem cells
  JOURNAL   Differentiation 112, 10-16 (2020)
   PUBMED   31838455
  REMARK    GeneRIF: Expression analysis of microRNAs and mRNAs in
            myofibroblast differentiation of lung resident mesenchymal stem
            cells.
REFERENCE   5  (bases 1 to 4539)
  AUTHORS   Zhang,G.J., Zhao,J., Jiang,M.L. and Zhang,L.C.
  TITLE     ING5 inhibits cell proliferation and invasion in esophageal
            squamous cell carcinoma through regulation of the
            Akt/NF-kappaB/MMP-9 signaling pathway
  JOURNAL   Biochem Biophys Res Commun 496 (2), 387-393 (2018)
   PUBMED   29326045
  REMARK    GeneRIF: ING5 inhibits cell proliferation and invasion in
            esophageal squamous cell carcinoma through regulation of the
            Akt/NF-kappaB/MMP-9 signaling pathway.
REFERENCE   6  (bases 1 to 4539)
  AUTHORS   Zhang,F., Baumer,N., Rode,M., Ji,P., Zhang,T., Berdel,W.E. and
            Muller-Tidow,C.
  TITLE     The inhibitor of growth protein 5 (ING5) depends on INCA1 as a
            co-factor for its antiproliferative effects
  JOURNAL   PLoS One 6 (7), e21505 (2011)
   PUBMED   21750715
REFERENCE   7  (bases 1 to 4539)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   8  (bases 1 to 4539)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   9  (bases 1 to 4539)
  AUTHORS   Doyon,Y., Cayrou,C., Ullah,M., Landry,A.J., Cote,V., Selleck,W.,
            Lane,W.S., Tan,S., Yang,X.J. and Cote,J.
  TITLE     ING tumor suppressor proteins are critical regulators of chromatin
            acetylation required for genome expression and perpetuation
  JOURNAL   Mol Cell 21 (1), 51-64 (2006)
   PUBMED   16387653
REFERENCE   10 (bases 1 to 4539)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK028397.1, AK007536.1 and CAAA01224355.1.
            
            On Jul 20, 2005 this sequence version replaced NM_025454.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145695.1, SRR1660811.101963.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AK028397.1         2-52
            52-830              AK007536.1         43-821
            831-4539            CAAA01224355.1     7326-11034          c
FEATURES             Location/Qualifiers
     source          1..4539
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 47.34 cM"
     gene            1..4539
                     /gene="Ing5"
                     /gene_synonym="1700001C14Rik; 1700027H23Rik;
                     1810018M11Rik"
                     /note="inhibitor of growth family, member 5"
                     /db_xref="GeneID:66262"
                     /db_xref="MGI:MGI:1922816"
     exon            1..75
                     /gene="Ing5"
                     /gene_synonym="1700001C14Rik; 1700027H23Rik;
                     1810018M11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..761
                     /gene="Ing5"
                     /gene_synonym="1700001C14Rik; 1700027H23Rik;
                     1810018M11Rik"
                     /codon_start=1
                     /product="inhibitor of growth protein 5"
                     /protein_id="NP_079730.1"
                     /db_xref="CCDS:CCDS35673.1"
                     /db_xref="GeneID:66262"
                     /db_xref="MGI:MGI:1922816"
                     /translation="MATAMYLEHYLDSIENLPCELQRNFQLMRELDQRTEDKKAEIDI
                     LAAEYISTVKTLSSAQRVEHLQKIQSAYSKCKEYSDDKVQLAMQTYEMVDKHIRRLDA
                     DLARFEADLKDRMDGSDFESTGARSLKKGRSQKEKRSSRGRGRRTSEEDTPKKKKHKS
                     GSEFTDSILSVHPSDVLDMPVDPNEPTYCLCHQVSYGEMIGCDNPDCPIEWFHFACVD
                     LTTKPKGKWFCPRCVQEKRKKK"
     exon            76..147
                     /gene="Ing5"
                     /gene_synonym="1700001C14Rik; 1700027H23Rik;
                     1810018M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            148..314
                     /gene="Ing5"
                     /gene_synonym="1700001C14Rik; 1700027H23Rik;
                     1810018M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            315..426
                     /gene="Ing5"
                     /gene_synonym="1700001C14Rik; 1700027H23Rik;
                     1810018M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            427..520
                     /gene="Ing5"
                     /gene_synonym="1700001C14Rik; 1700027H23Rik;
                     1810018M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            521..656
                     /gene="Ing5"
                     /gene_synonym="1700001C14Rik; 1700027H23Rik;
                     1810018M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            657..718
                     /gene="Ing5"
                     /gene_synonym="1700001C14Rik; 1700027H23Rik;
                     1810018M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            719..4539
                     /gene="Ing5"
                     /gene_synonym="1700001C14Rik; 1700027H23Rik;
                     1810018M11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      797..802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ing5"
                     /gene_synonym="1700001C14Rik; 1700027H23Rik;
                     1810018M11Rik"
                     /note="hexamer: AATATA"
     polyA_site      845
                     /gene="Ing5"
                     /gene_synonym="1700001C14Rik; 1700027H23Rik;
                     1810018M11Rik"
     regulatory      4517..4522
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ing5"
                     /gene_synonym="1700001C14Rik; 1700027H23Rik;
                     1810018M11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4539
                     /gene="Ing5"
                     /gene_synonym="1700001C14Rik; 1700027H23Rik;
                     1810018M11Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcccgctcgc gcagaccccg agcgtggccg aggcgaagat ggcgactgcc atgtacttgg
       61 agcactatct ggacagcatt gagaaccttc cctgtgaact tcagaggaac ttccagctga
      121 tgcgagagct agaccagaga acagaagata agaaagcaga gatcgacatc ctggctgcag
      181 agtatatttc cacagtgaag actctctcgt cagcccagcg tgtggagcac ctccagaaga
      241 tccagagcgc ctacagcaag tgcaaggagt acagtgatga caaggtgcag ctggccatgc
      301 agacctacga gatggtggat aaacacatcc gaagacttga tgctgacctg gcgcgctttg
      361 aggctgacct gaaggacagg atggatggaa gtgactttga gagcactgga gcacggagct
      421 tgaaaaaagg ccggagtcag aaagaaaaaa gaagctcccg gggccgaggc cggcggacgt
      481 cagaagagga taccccaaag aagaagaaac ataaaagcgg gtctgagttt actgacagta
      541 tcctatctgt gcacccctct gatgtgctgg acatgcctgt ggatccgaat gagcctacat
      601 actgcttgtg ccaccaggtg tcctacgggg agatgatcgg ctgtgacaat ccagattgtc
      661 ccattgagtg gtttcacttt gcctgcgtgg atctcaccac aaagcccaaa ggaaagtggt
      721 tttgtccacg atgtgttcag gaaaagagga agaagaagta aagaagaggc tgttgtgcca
      781 gactgaagag caagctaata tatttcctca ctcatgttgc aatatgatct ttcattttaa
      841 aactacctta ttttgactga tatttaataa ttcagtggcc agttgtaatt ttggatattt
      901 cctaaaacaa gaagccgctg caccatttgc acagaacaat ctcacaggga cttgccacag
      961 tgactttagg agcaggctcc cccatcccac aacctcccag cactgggaat ggccacacca
     1021 tcagtgatgt gtgtcagttt gagctgtagg caaagtgcat ggtgcagggt gaacgcattt
     1081 taacctgtta cactgccact gctttgtgac tagagggtca gccttgcgtg tccacggttt
     1141 ccaggactgt ctgtggcagc atggaagcac agctggtgct ctgtgagtaa agtattgtca
     1201 ggcactgccc catgctgtgc tctgaccctt actggagacc aggcactctt ggccaagatc
     1261 cctctgacgt gtctggaagg gaccgggggc tcttcccagg tggaagtacc ctctgtcgtt
     1321 ttgtgcacca ccttttcctg tgaacttacg gccctccctg gagattgagc ttccgttagc
     1381 cttggactgt cagttaccac agccagcact gcccagcagc ggacagccag acagccaggc
     1441 tgagcttcca gctctctggg gattcccgcc tatatttttt tactgtgaag atgaaattat
     1501 tgtactagca tgaaggtcat gggtctgtgt gtctatgaag tgagtctgtc tactgtgagc
     1561 tgatcgtaag aactctgctg tgctgcatcc cactaggcca gcagcttatg ttcaagggga
     1621 cgatgattat gtgacatgat ttgtgactct gtgcccaata gcagttctgg aatgaaggta
     1681 ggaaactgga gtgtactctt tgtttgacca ctgtccacaa aaccagtgtt gaactgtctt
     1741 gaaatattgg ggggatgtct acccggggcc tgttgagatg catctgtggt gttccttaag
     1801 agcgacaggc tcctgaaagc cacggttgac ttagaactcc tctggcatgt tcttcagtaa
     1861 ctcaggctct ctgagaagaa ttaaaagagt ccaaccggta cctggcctca cctcagaaaa
     1921 agacctgcaa gacagagctg ggttatgcaa tttctgatgt aagaagaggc cggctcttta
     1981 tataatgaca ggcacattgt tttcttctga tggtcacaaa caaagcagaa gggtgttgtc
     2041 tctgccccat acctgtgtca ccatggtcat gttcttactg gacaatgtct tgcacagcct
     2101 atcctagtga aagaggaaga caggagtggc ttgtgtttgt gctactgaat atgttggtct
     2161 gcgttgacct ttcctgggct gtaggtacca ggcaggttag ctgtcgttga taggcaagtg
     2221 cacaagattg tctctaggct aggaagagct ttgggaatgg ggctggcatt cttcttgggg
     2281 acccctctca gggtcagatt agatagacat aacttagcct ttaaaaattg tgagggaccc
     2341 ccctccccca aagaccagat ctcatgtatc ctaggcaggc tttgaactca caatgtagct
     2401 gagaataacg ttcatctttt ggtctttctt cacctcccaa atgctgaggt tataggtgtg
     2461 caccaatagg tctgtctggt tttgcaatgg tagggaccaa acccagaact tttttttttt
     2521 tttttttggt ttttcaagac aagatttctc tgtgtagctc tggctgtcct ggaacccact
     2581 gtgtatatga ctaggctgaa ctccaactca gagattctcc tgcctctgcc ttccaagtgc
     2641 taggactaga gaagcatgcc ccaccaccgc cagctccaac ccagaactct tgagtgttag
     2701 gtaagccttc tgcagattga gtcacacccc agccttctct ttattcttct accatttgtt
     2761 ctctttcttc agtgcttggg gtcaggcctc atgcttcctt ttaatcttaa attttagatt
     2821 atttatttat ttattgggag gcagggcttt attatgtaaa agactagctt tgaacttgca
     2881 gtcatcttgc tggagctagg caatgctggg accacagatg gccgccactg tgtctggact
     2941 gctttttaca gtttctgtaa ctacaggacg tttttaatca gatcttgctt ggtaatgcct
     3001 tagaagctgg gttactatgt gagattcagc ctgaggcagc tgagtccttt gatgatcagg
     3061 aagaagtggc gtttactggt ggcggtgtta gaggctggat gagttccatc ttctggcttc
     3121 ctgaggtcat gctggctctt tccctgaggt cttctacctg gggccaccct acatactggc
     3181 ttctgatttt tatttatttt gtgagttcct atgattatct cctttttgac agttataatg
     3241 tcatgaaaat aagatgcata tagcttggca aaaaaaaaaa aacagaattc gtgagtttgg
     3301 ggatttacct ccatggtgga aaaccatgcc taacaagtgt gaagtgtaat gtggtattgg
     3361 ctgtatgtag gtgaacaaag ctgccttcca aaagtgatgg tctaggttag atccctggca
     3421 acaaaatggg gggaaaacag aaaggaaaat ctgtgggttg tggctggtat tctgatggaa
     3481 ggcttgttcc cactgcttct gtgtgtaagc aaagagggaa cttcaggaga cgcgttccgg
     3541 caccagctcc gcctcagatg tggagaagcc acgagcacac ccctcagccc tgctccagaa
     3601 gcctgagtgt ctccatcgct ggatcagaca ctctcatgcc tgctggtcga gacctggctc
     3661 ttaagctgtc cttgcttcat caacagactg gcagctgctt tgcctgagcc aaggctgggt
     3721 cttccctgtg taattcccct tgtaagtaca ggagtgtttt gctgagagga ggggtcatct
     3781 ttcttgtttt ctgtgcacat tatcaatagt ttattataga agaagcatga tgaattagta
     3841 aaaaattgag cccctagatc tgtgaacatg ttagtggtgt aatgggtcca agcagcactg
     3901 accattcgcc tatccagcag gtgggatcag taggaggcag gctgccagcc gtgtcttcca
     3961 ctctacagtg aagagccctg tagtgtgagg ttttgtggat ggctggggaa gtgggcacct
     4021 gcttgctcct gtgtatacag catcttgcct tctatccctc atttgacccc agaaggcctt
     4081 ggcggggatg cttcatccag agagcaactt ctccatgtga tcacggtgcc agggttggcc
     4141 ctgttagagg gctgggaggt taggtaagtc ttaagggttt gaaatcaaac agcgaggaac
     4201 ctttgtttca ggctttgaaa ctctgttttc tatgaacaga gattgattgg tcttcactgc
     4261 ctatgcccaa aggagcttta aagcagggga ggtctaagaa gtgtcttttc cctcagaatg
     4321 tgctgtggtc gttgctcttc gccacactcc atccatcagg atgatccagc tttaacatga
     4381 atgtcacatt ttattttcaa ggaattatta cctatgtccc ctttgtaaag gagagatact
     4441 atggtaaatc tttttattaa ataatgtaaa gatgtatatc tgtatttttg gatcatggat
     4501 tatggatata ttgtttaata aagtattttt gggaagaaa
//
