LOCUS       NM_133345               1617 bp    mRNA    linear   ROD 06-AUG-2024
DEFINITION  Mus musculus inhibitor of growth family, member 4 (Ing4),
            transcript variant 1, mRNA.
ACCESSION   NM_133345
VERSION     NM_133345.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1617)
  AUTHORS   Tsutsumi,E., Macy,A.M., LoBello,J., Hastings,K.T. and Kim,S.
  TITLE     Tumor immune microenvironment permissive to metastatic progression
            of ING4-deficient breast cancer
  JOURNAL   PLoS One 19 (7), e0304194 (2024)
   PUBMED   38968186
  REMARK    GeneRIF: Tumor immune microenvironment permissive to metastatic
            progression of ING4-deficient breast cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1617)
  AUTHORS   Mah,S.Y.Y., Vanyai,H.K., Li-Wai-Suen,C.S.N., Garnham,A.L., Wynn,J.,
            Bergamasco,M.I., Malelang,S., Wilcox,S., Biben,C., Smyth,G.K.,
            Thomas,T. and Voss,A.K.
  TITLE     ING4 and ING5 are essential for histone H3 lysine 14 acetylation
            and epicardial cell lineage development
  JOURNAL   Development 151 (5) (2024)
   PUBMED   38446206
  REMARK    GeneRIF: ING4 and ING5 are essential for histone H3 lysine 14
            acetylation and epicardial cell lineage development.
REFERENCE   3  (bases 1 to 1617)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1617)
  AUTHORS   Cui,Z., Sun,S., Li,J., Li,J., Sha,T., He,J. and Zuo,L.
  TITLE     Inhibitor of Growth 4 (ING4) Plays a Tumor-repressing Role in Oral
            Squamous Cell Carcinoma via Nuclear Factor Kappa-B (NF-kB)/DNA
            Methyltransferase 1 (DNMT1) Axis-mediated Regulation of Aldehyde
            Dehydrogenase 1A2 (ALDH1A2)
  JOURNAL   Curr Cancer Drug Targets 22 (9), 771-783 (2022)
   PUBMED   35388759
  REMARK    GeneRIF: Inhibitor of Growth 4 (ING4) Plays a Tumor-repressing Role
            in Oral Squamous Cell Carcinoma via Nuclear Factor Kappa-B
            (NF-kB)/DNA Methyltransferase 1 (DNMT1) Axis-mediated Regulation of
            Aldehyde Dehydrogenase 1A2 (ALDH1A2).
REFERENCE   5  (bases 1 to 1617)
  AUTHORS   Yang,Y., Liu,Y., He,X., Yang,F., Han,S., Qin,A., Wu,G., Liu,M.,
            Li,Z., Wang,J., Yang,X. and Hu,D.
  TITLE     ING4 alleviated lipopolysaccharide-induced inflammation by
            regulating the NF-kappaB pathway via a direct interaction with
            SIRT1
  JOURNAL   Immunol Cell Biol 98 (2), 127-137 (2020)
   PUBMED   31811786
  REMARK    GeneRIF: ING4 alleviated lipopolysaccharide-induced inflammation by
            regulating the NF-kappaB pathway via a direct interaction with
            SIRT1.
REFERENCE   6  (bases 1 to 1617)
  AUTHORS   McClive,P.J., Hurley,T.M., Sarraj,M.A., van den Bergen,J.A. and
            Sinclair,A.H.
  TITLE     Subtractive hybridisation screen identifies sexually dimorphic gene
            expression in the embryonic mouse gonad
  JOURNAL   Genesis 37 (2), 84-90 (2003)
   PUBMED   14595844
REFERENCE   7  (bases 1 to 1617)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 1617)
  AUTHORS   Ha,S., Lee,S., Chung,M. and Choi,Y.
  TITLE     Mouse ING1 homologue, a protein interacting with A1, enhances cell
            death and is inhibited by A1 in mammary epithelial cells
  JOURNAL   Cancer Res 62 (5), 1275-1278 (2002)
   PUBMED   11888890
REFERENCE   9  (bases 1 to 1617)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   10 (bases 1 to 1617)
  AUTHORS   Bassett,D.E. Jr., Boguski,M.S., Spencer,F., Reeves,R., Goebl,M. and
            Hieter,P.
  TITLE     Comparative genomics, genome cross-referencing and XREFdb
  JOURNAL   Trends Genet 11 (9), 372-373 (1995)
   PUBMED   7482790
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK009267.1.
            
            On Apr 6, 2007 this sequence version replaced NM_133345.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK009267.1, AK050522.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1617              AK009267.1         2-1618
FEATURES             Location/Qualifiers
     source          1..1617
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.17 cM"
     gene            1..1617
                     /gene="Ing4"
                     /gene_synonym="D6Wsu147e; D6Xrf92; p29ING4"
                     /note="inhibitor of growth family, member 4"
                     /db_xref="GeneID:28019"
                     /db_xref="MGI:MGI:107307"
     exon            1..50
                     /gene="Ing4"
                     /gene_synonym="D6Wsu147e; D6Xrf92; p29ING4"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..760
                     /gene="Ing4"
                     /gene_synonym="D6Wsu147e; D6Xrf92; p29ING4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ING1-like protein; inhibitor of growth protein 4"
                     /codon_start=1
                     /product="inhibitor of growth protein 4 isoform 1"
                     /protein_id="NP_579923.1"
                     /db_xref="CCDS:CCDS39632.1"
                     /db_xref="GeneID:28019"
                     /db_xref="MGI:MGI:107307"
                     /translation="MAAGMYLEHYLDSIENLPFELQRNFQLMRDLDQRTEDLKAEIDK
                     LATEYMSSARSLSSEEKLALLRQIQEAYGKCKEFGDDKVQLAMQTYEMVDKHIRRLDT
                     DLARFEADLKEKQIESSDYDSSSSKGKKSRTQKEKKAARARSKGKNSDEEAPKAAQKK
                     LKLVRTSPEYGMPSVTFGSVHPSDVLDMPVDPNEPTYCLCHQVSYGEMIGCDNPDCSI
                     EWFHFACVGLTTKPRGKWFCPRCSQERKKK"
     exon            51..122
                     /gene="Ing4"
                     /gene_synonym="D6Wsu147e; D6Xrf92; p29ING4"
                     /inference="alignment:Splign:2.1.0"
     exon            123..289
                     /gene="Ing4"
                     /gene_synonym="D6Wsu147e; D6Xrf92; p29ING4"
                     /inference="alignment:Splign:2.1.0"
     exon            290..404
                     /gene="Ing4"
                     /gene_synonym="D6Wsu147e; D6Xrf92; p29ING4"
                     /inference="alignment:Splign:2.1.0"
     exon            405..510
                     /gene="Ing4"
                     /gene_synonym="D6Wsu147e; D6Xrf92; p29ING4"
                     /inference="alignment:Splign:2.1.0"
     exon            511..658
                     /gene="Ing4"
                     /gene_synonym="D6Wsu147e; D6Xrf92; p29ING4"
                     /inference="alignment:Splign:2.1.0"
     exon            659..720
                     /gene="Ing4"
                     /gene_synonym="D6Wsu147e; D6Xrf92; p29ING4"
                     /inference="alignment:Splign:2.1.0"
     exon            721..1617
                     /gene="Ing4"
                     /gene_synonym="D6Wsu147e; D6Xrf92; p29ING4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1336..1341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ing4"
                     /gene_synonym="D6Wsu147e; D6Xrf92; p29ING4"
                     /note="hexamer: AATAAA"
     polyA_site      1355
                     /gene="Ing4"
                     /gene_synonym="D6Wsu147e; D6Xrf92; p29ING4"
                     /note="major polyA site"
ORIGIN      
        1 gttttgcttc aagatggctg ctgggatgta tttggaacat tatctggaca gtattgaaaa
       61 cctcccgttt gaattacaga gaaactttca gctcatgagg gacctagacc aaaggacaga
      121 ggacctgaag gctgaaattg acaagttggc cactgaatat atgagtagcg cccgcagcct
      181 gagctccgag gagaagctgg cccttctcag acagatccag gaggcctatg gcaagtgcaa
      241 ggaatttggt gacgacaagg tgcagctggc catgcagacc tatgagatgg tagacaaaca
      301 cattcggcgg ctggacacag acctggcccg ttttgaggct gatctgaagg agaaacagat
      361 cgagtccagt gactatgaca gctcttctag caaaggcaaa aagagccgga cccaaaagga
      421 gaaaaaagct gccagagccc gttccaaagg gaaaaactca gatgaagaag cccccaaggc
      481 tgcccagaag aagttaaaac ttgtgcgcac aagtcctgag tatgggatgc cctcagtgac
      541 ctttggcagt gtccacccct ctgatgtgtt ggatatgcct gtggatccca acgaacccac
      601 atattgcctt tgtcaccagg tctcctatgg agagatgatt ggctgtgaca acccggattg
      661 ttccatcgag tggttccact tcgcctgtgt ggggctgaca accaaacctc gagggaaatg
      721 gttttgccca cgctgctccc aagaacggaa gaagaaatag gtttccctgg attccattac
      781 agacttctgc atccccctga cctgggctag tggacagagt ggaaggcctg tgctggggac
      841 ggggggccca gggagatgtg gacagtgcgg taccgtcatc cctctccctc ctccccactc
      901 ggtgctgagg ctgcatccaa accccagtag ggagggtgct gcagccagtg acggtatgtg
      961 ctctcctccc gcctctccca gagggaagta atctcactca ctgtcctttt gcctccttgg
     1021 tgaggttggt gctgtatttc agagggaggg tcctcttcat tccccttgct ttgacttaag
     1081 gactggggca gtggagtggg gcactttccc agtcccctca ctcctccttc ccccattggg
     1141 agctaggcag gacagactgc cttctctgca ctcttcctgt tctccatggg gaggggtctt
     1201 ctaggtcatt tgggcagtgg cctagttaag tggttactcc aacctctatg gcccggggat
     1261 ttatgctgac tctgaatggg agaggggcaa ggtagaccgc aggttactca catgtaaaag
     1321 gagttggggt aggtaaataa aagctatcca tgctagcctg ctgtgtttat tgtagagact
     1381 gtttaagtat atgtggtaag cattcttttc gcatcctctg gattggatga gaggcaggaa
     1441 gatggcttgc cagaaatagg acaagacata aaacccaaaa tggtcctgtc ctgtggtgtc
     1501 cacagcttct ccacctggag gagtgccttg catcggggga ctcagaattt tgtaattacg
     1561 aatctcctct ccgtgaaaca cctttaaccc aattccaata aatcatgtat ttgcttt
//
