LOCUS       NM_023626               3755 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus inhibitor of growth family, member 3 (Ing3),
            transcript variant 1, mRNA.
ACCESSION   NM_023626
VERSION     NM_023626.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3755)
  AUTHORS   Fink,D., Yau,T., Nabbi,A., Wagner,B., Wagner,C., Hu,S.M., Lang,V.,
            Handschuh,S., Riabowol,K. and Rulicke,T.
  TITLE     Loss of Ing3 Expression Results in Growth Retardation and Embryonic
            Death
  JOURNAL   Cancers (Basel) 12 (1), 80 (2019)
   PUBMED   31905726
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3755)
  AUTHORS   Fisher,C.L., Marks,H., Cho,L.T., Andrews,R., Wormald,S.,
            Carroll,T., Iyer,V., Tate,P., Rosen,B., Stunnenberg,H.G.,
            Fisher,A.G. and Skarnes,W.C.
  TITLE     An efficient method for generation of bi-allelic null mutant mouse
            embryonic stem cells and its application for investigating
            epigenetic modifiers
  JOURNAL   Nucleic Acids Res 45 (21), e174 (2017)
   PUBMED   28981838
REFERENCE   3  (bases 1 to 3755)
  AUTHORS   Jacquet,K., Fradet-Turcotte,A., Avvakumov,N., Lambert,J.P.,
            Roques,C., Pandita,R.K., Paquet,E., Herst,P., Gingras,A.C.,
            Pandita,T.K., Legube,G., Doyon,Y., Durocher,D. and Cote,J.
  TITLE     The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1
            through Direct H4K20me Binding and H2AK15 Acetylation
  JOURNAL   Mol Cell 62 (3), 409-421 (2016)
   PUBMED   27153538
REFERENCE   4  (bases 1 to 3755)
  AUTHORS   Nabbi,A., Almami,A., Thakur,S., Suzuki,K., Boland,D., Bismar,T.A.
            and Riabowol,K.
  TITLE     ING3 protein expression profiling in normal human tissues suggest
            its role in cellular growth and self-renewal
  JOURNAL   Eur J Cell Biol 94 (5), 214-222 (2015)
   PUBMED   25819753
  REMARK    GeneRIF: ING3 levels may serve as a surrogate for growth rate, and
            suggest possible roles for ING3 in growth and self renewal and
            related diseases such as cancer.
REFERENCE   5  (bases 1 to 3755)
  AUTHORS   Shimizu,H., Kubo,A., Uchibe,K., Hashimoto,M., Yokoyama,S.,
            Takada,S., Mitsuoka,K. and Asahara,H.
  TITLE     The AERO system: a 3D-like approach for recording gene expression
            patterns in the whole mouse embryo
  JOURNAL   PLoS One 8 (10), e75754 (2013)
   PUBMED   24146773
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3755)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   7  (bases 1 to 3755)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   8  (bases 1 to 3755)
  AUTHORS   Mugford,J.W., Yu,J., Kobayashi,A. and McMahon,A.P.
  TITLE     High-resolution gene expression analysis of the developing mouse
            kidney defines novel cellular compartments within the nephron
            progenitor population
  JOURNAL   Dev Biol 333 (2), 312-323 (2009)
   PUBMED   19591821
REFERENCE   9  (bases 1 to 3755)
  AUTHORS   Millien,G., Beane,J., Lenburg,M., Tsao,P.N., Lu,J., Spira,A. and
            Ramirez,M.I.
  TITLE     Characterization of the mid-foregut transcriptome identifies genes
            regulated during lung bud induction
  JOURNAL   Gene Expr Patterns 8 (2), 124-139 (2008)
   PUBMED   18023262
REFERENCE   10 (bases 1 to 3755)
  AUTHORS   Doyon,Y., Selleck,W., Lane,W.S., Tan,S. and Cote,J.
  TITLE     Structural and functional conservation of the NuA4 histone
            acetyltransferase complex from yeast to humans
  JOURNAL   Mol Cell Biol 24 (5), 1884-1896 (2004)
   PUBMED   14966270
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117213.3 and AK080787.1.
            
            On Apr 4, 2007 this sequence version replaced NM_023626.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK080787.1, SRR1660811.163444.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AC117213.3         28414-28447
            35-3755             AK080787.1         4-3724
FEATURES             Location/Qualifiers
     source          1..3755
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 8.81 cM"
     gene            1..3755
                     /gene="Ing3"
                     /gene_synonym="1300013A07Rik; P47ING3"
                     /note="inhibitor of growth family, member 3"
                     /db_xref="GeneID:71777"
                     /db_xref="MGI:MGI:1919027"
     exon            1..179
                     /gene="Ing3"
                     /gene_synonym="1300013A07Rik; P47ING3"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1417
                     /gene="Ing3"
                     /gene_synonym="1300013A07Rik; P47ING3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     inhibitor of growth protein 3; p47 regulator protein"
                     /codon_start=1
                     /product="inhibitor of growth protein 3 isoform 1"
                     /protein_id="NP_076115.3"
                     /db_xref="CCDS:CCDS39434.1"
                     /db_xref="GeneID:71777"
                     /db_xref="MGI:MGI:1919027"
                     /translation="MLYLEDYLEMIEQLPMDLRDRFTEMREMDLQVQNAMDQLEQRVS
                     EFFMNAKKNKPEWREEQMASIKKDYYKALEDADEKVQLANQIYDLVDRHLRKLDQELA
                     KFKMELEADNAGITEILERRSLELDAPSQPVNNHHAHSHTPVEKRKYNPTSHHAAADH
                     IPEKKFKSEALLSTLTSDASKENTLGCRNNNSTASCNNAYNVNSSQPLASYNIGSLSS
                     GAGAGAITMAAAQAVQATAQMKEGRRTSSLKASYEAFKNNDFQLGKEFSIPRETAGYS
                     SSSALMTTLTQNASSSATDSRSGRKSKNNTKSSSQQSSSSSSSSSSSSLSLCSSSSTV
                     VQEVSQQATVVPESDSNSQVDWTYDPNEPRYCICNQVSYGEMVGCDNQDCPIEWFHYG
                     CVGLTEAPKGKWFCPQCTAAMKRRGSRHK"
     exon            180..251
                     /gene="Ing3"
                     /gene_synonym="1300013A07Rik; P47ING3"
                     /inference="alignment:Splign:2.1.0"
     exon            252..352
                     /gene="Ing3"
                     /gene_synonym="1300013A07Rik; P47ING3"
                     /inference="alignment:Splign:2.1.0"
     exon            353..418
                     /gene="Ing3"
                     /gene_synonym="1300013A07Rik; P47ING3"
                     /inference="alignment:Splign:2.1.0"
     exon            419..515
                     /gene="Ing3"
                     /gene_synonym="1300013A07Rik; P47ING3"
                     /inference="alignment:Splign:2.1.0"
     exon            516..587
                     /gene="Ing3"
                     /gene_synonym="1300013A07Rik; P47ING3"
                     /inference="alignment:Splign:2.1.0"
     exon            588..707
                     /gene="Ing3"
                     /gene_synonym="1300013A07Rik; P47ING3"
                     /inference="alignment:Splign:2.1.0"
     exon            708..865
                     /gene="Ing3"
                     /gene_synonym="1300013A07Rik; P47ING3"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1059
                     /gene="Ing3"
                     /gene_synonym="1300013A07Rik; P47ING3"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1261
                     /gene="Ing3"
                     /gene_synonym="1300013A07Rik; P47ING3"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1300
                     /gene="Ing3"
                     /gene_synonym="1300013A07Rik; P47ING3"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..3755
                     /gene="Ing3"
                     /gene_synonym="1300013A07Rik; P47ING3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2236..2241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ing3"
                     /gene_synonym="1300013A07Rik; P47ING3"
                     /note="hexamer: AATAAA"
     polyA_site      2257
                     /gene="Ing3"
                     /gene_synonym="1300013A07Rik; P47ING3"
                     /note="major polyA site"
     regulatory      2596..2601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ing3"
                     /gene_synonym="1300013A07Rik; P47ING3"
                     /note="hexamer: AATATA"
     polyA_site      2622
                     /gene="Ing3"
                     /gene_synonym="1300013A07Rik; P47ING3"
ORIGIN      
        1 cctttgcttt tttttttttt tttttccttt gccggagtcg agcgggtgct gctagcggag
       61 gcgccatatt ggaagggaca aaactccggc gacagcgagt gacacaaata aacccctgga
      121 cccgttcgtc cccgcaacag tcagggccgc gatgttgtac ctagaggact atttggaaat
      181 gattgagcag cttccgatgg acctacggga ccgcttcacg gagatgcgcg agatggatct
      241 gcaggtgcag aatgcaatgg atcaactaga acaaagagtc agtgagttct ttatgaatgc
      301 aaagaagaat aaacccgagt ggcgagaaga acagatggca tccatcaaaa aagactacta
      361 taaagctttg gaagatgcag atgagaaagt acagttggca aaccagattt atgatttggt
      421 agatcgccac ttgagaaagc tggatcagga actggccaag tttaaaatgg agctggaagc
      481 cgataatgct ggaattacag aaatactaga gaggcgatct ttggaattag atgctccttc
      541 gcagccagtg aacaatcacc acgctcattc acatactccc gtggaaaaaa ggaaatataa
      601 tccaacttct caccatgcag cagcagacca tatccctgag aagaaattca aatctgaagc
      661 gctgctgtcc acccttacat ctgacgcttc caaggagaac acgctgggtt gtcggaacaa
      721 taattccaca gcttcctgca acaatgctta caatgtgaac tcgtcccagc ccctggcctc
      781 ctataacatt ggttcattat cttcaggggc tggcgcaggg gccatcacca tggcggcagc
      841 acaggccgtg caagcgacag cacagatgaa agaagggcga agaacatcga gtttaaaagc
      901 cagttacgaa gcatttaaga acaatgactt ccagctggga aaagaatttt ccatacccag
      961 agaaacagct ggctactcct cctcatcggc actcatgaca accttaaccc agaatgccag
     1021 ttcctccgcc acggactcgc ggagtggcag gaagagcaaa aacaacacca agtcttcaag
     1081 ccagcagtcg tcgtcctcct cctcctcgtc gtcctcttcc tccttatctc tgtgttcatc
     1141 gtcttcaact gtagtacaag aagtttccca gcaagcaact gtagtgcccg aatctgactc
     1201 caacagtcaa gtcgattgga cttacgaccc aaatgaacct cggtattgca tctgtaatca
     1261 ggtatcctat ggagagatgg tgggatgtga taaccaagat tgtccaatag agtggttcca
     1321 ctatgggtgt gttggcttga ccgaagcgcc gaaggggaag tggttctgtc cgcagtgcac
     1381 cgctgccatg aagagaagag gcagtcggca caaatagaga gggactctat tgtcactgca
     1441 ggaaggagga actccagctc gccattttat acaggacgct aggaggaaag acacgaggac
     1501 gaagaagcag ctcatctcca ggccaccact tagaggatta cagagacaat cctataagat
     1561 cttgaacttg aattttatga gttgtatttt aataatgtaa gtaaattatt tatgcactcc
     1621 tggtgtgcta tgaatattat tccagttagc cttggattat ttctgtggcc aacatatgca
     1681 gacatttgta ctccaaccat tttctcaaag taatgggcat tctataattt aaacttcaaa
     1741 gaattccaac gatgaagatt ttaagaaagt attttatatt caacaggtat attcagctgc
     1801 atgtactgta ctccagagct gttatgttac actgtatata aatggttgca aaaaacaaaa
     1861 acaaaaaaca aaatacaaac aaaaaaagtc agtccttcta aaaaggattt aagataatgg
     1921 tttttaagat gcctttataa taagctttgt ttctttgtga aactcattca gcaggctgaa
     1981 ggaattggtt tatgtggtaa agtgggctgg tgtcctctag agtacctggg tacataaaca
     2041 gaaactcctg taggtaaaac ctgatccgtg ccattagtct ctatgtttct gcatccagat
     2101 agagtgcagc tcacgctcaa gggggtgggg gcgggggctc cgggggaaag ggcgttaaag
     2161 tgatacattt ttataccaaa tgtgtttatt tttttgtgcg agtaatcctt aaattggaat
     2221 tgtattaggt gttaaaataa agttttttaa aaaataactt gtatttatac tttacacact
     2281 taattatgaa aatttcttaa ttgcaattta ttcctaattt tcataatcca aaaaagatta
     2341 gaggttagca tgcagaatgc tatgtaatct atgatttcta taatgatggc tggaaattgt
     2401 gttatgagga taaggaaaga acattttaaa tgtaaatttg aagtgtcaaa tgtatttttc
     2461 tagaatattt ctctggcttt gctttgaatc taagggatat aaaaagaacc taattacagt
     2521 agatacaatg aaaataatgg ctatagatgt ttggactgga agcagtgtgg ccaatatgac
     2581 ttaaagagac cttaaaatat aattttgttt ttaattctct gacatcgtga tgtggcagtt
     2641 aattaactct taaatcactc tgggctttgt gaaaccaaaa taatgcaggt tgtgggatgt
     2701 cttcaaaaca ctcctaagga cttgttctat aggtgctatt taggtgatgg actttacata
     2761 gtggagactt cacttaatag atgttcagta gatgggtaga aaaattgatg aaacttcaaa
     2821 gatcagactt cctctacatt gaaatatatg aaatccacat atgctttaat gaagcccact
     2881 tctgaatctt ttagaactta cccagaaggc agtgttaaat ctacgtaatg ctacctacgt
     2941 aatgatttga cagattttcg gagcctcatc cagctgtaag atcctggaac gctgaactgc
     3001 cataggctta cttgatgact gttgtcagcc ccagagatgg gttcatacag ttcttaggat
     3061 ttcagctcgt caggagtgtg atgacctcac gatattttta agcctttaag cagtgtatat
     3121 agttgagctc tgtcagctca gtcgcatgct ctctggagat gcttggatga gaggcgttta
     3181 cgtgctgtaa tcacacagtg tgactcttct aaactcatcc accctttgaa ctggctggag
     3241 gaagtcacct tattttaaga gaaagttcct tgtcaggtca gggccagggg cattcctgtg
     3301 ttcagtcgct atagctcctc cctcttgtgt tctacttact gagtctctta gaaagaaagc
     3361 acagaagcaa gctttgagct caaacgttga ctttcttaca aactatacat gaagaaatac
     3421 accaaaattt tacattaaag atttagaaat tagtagaacc tgtccctaaa ttagatagct
     3481 atatgtaaat gtgtatgcat acataccata tatggccaaa catggaacta cctcactaaa
     3541 gcaacatttc cagcaattac tattctttgt tacatttaca ccaagatatt cagaatcttt
     3601 gttgtacaaa agttctgtaa cagtgggtgg cggaaaaagg cccaagtgtg agttcacagt
     3661 ttataggtgg tgaaaacgag gccttactgc tgtagtctat atttaaatgt tcatggtaac
     3721 acatttgaag caataaatgg cttaattaaa tgcct
//
