LOCUS       NM_023503               2813 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus inhibitor of growth family, member 2 (Ing2), mRNA.
ACCESSION   NM_023503 XM_992381
VERSION     NM_023503.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2813)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2813)
  AUTHORS   Ma,Y., Yan,R., Wan,Q., Lv,B., Yang,Y., Lv,T. and Xin,W.
  TITLE     Inhibitor of growth 2 regulates the high glucose-induced cell cycle
            arrest and epithelial-to-mesenchymal transition in renal proximal
            tubular cells
  JOURNAL   J Physiol Biochem 76 (3), 373-382 (2020)
   PUBMED   32424454
  REMARK    GeneRIF: Inhibitor of growth 2 regulates the high glucose-induced
            cell cycle arrest and epithelial-to-mesenchymal transition in renal
            proximal tubular cells.
            Erratum:[J Physiol Biochem. 2020 Aug;76(3):483. doi:
            10.1007/s13105-020-00752-2.. PMID: 32562166]
REFERENCE   3  (bases 1 to 2813)
  AUTHORS   Streubel,G., Fitzpatrick,D.J., Oliviero,G., Scelfo,A., Moran,B.,
            Das,S., Munawar,N., Watson,A., Wynne,K., Negri,G.L., Dillon,E.T.,
            Jammula,S., Hokamp,K., O'Connor,D.P., Pasini,D., Cagney,G. and
            Bracken,A.P.
  TITLE     Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells
            required for self-renewal
  JOURNAL   EMBO J 36 (15), 2216-2232 (2017)
   PUBMED   28554894
REFERENCE   4  (bases 1 to 2813)
  AUTHORS   Zhao,S., Yang,X.F., Gou,W.F., Lu,H., Li,H., Zhu,Z.T., Sun,H.Z. and
            Zheng,H.C.
  TITLE     Expression profiles of inhibitor of growth protein 2 in normal and
            cancer tissues: An immunohistochemical screening analysis
  JOURNAL   Mol Med Rep 13 (2), 1881-1887 (2016)
   PUBMED   26717876
  REMARK    GeneRIF: ING2 may be involved in the repair and regeneration of
            organs or tissues and is associated with breast and gynecological
            carcinogenesis.
REFERENCE   5  (bases 1 to 2813)
  AUTHORS   Zhou,L., Wang,P., Zhang,J., Heng,B.C. and Tong,G.Q.
  TITLE     ING2 (inhibitor of growth protein-2) plays a crucial role in
            preimplantation development
  JOURNAL   Zygote 24 (1), 89-97 (2016)
   PUBMED   25672483
  REMARK    GeneRIF: ING2 may play a crucial role in the process of
            preimplantation embryo development through chromatin regulation.
REFERENCE   6  (bases 1 to 2813)
  AUTHORS   Unoki,M., Kumamoto,K., Robles,A.I., Shen,J.C., Zheng,Z.M. and
            Harris,C.C.
  TITLE     A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell
            cycle arrest and apoptosis
  JOURNAL   FEBS Lett 582 (28), 3868-3874 (2008)
   PUBMED   18951897
REFERENCE   7  (bases 1 to 2813)
  AUTHORS   Pena,P.V., Davrazou,F., Shi,X., Walter,K.L., Verkhusha,V.V.,
            Gozani,O., Zhao,R. and Kutateladze,T.G.
  TITLE     Molecular mechanism of histone H3K4me3 recognition by plant
            homeodomain of ING2
  JOURNAL   Nature 442 (7098), 100-103 (2006)
   PUBMED   16728977
  REMARK    GeneRIF: 2.0 A resolution structure of the mouse ING2 PHD finger in
            complex with a histone H3 peptide trimethylated at lysine 4
REFERENCE   8  (bases 1 to 2813)
  AUTHORS   Watanabe-Fukunaga,R., Iida,S., Shimizu,Y., Nagata,S. and
            Fukunaga,R.
  TITLE     SEI family of nuclear factors regulates p53-dependent
            transcriptional activation
  JOURNAL   Genes Cells 10 (8), 851-860 (2005)
   PUBMED   16098148
REFERENCE   9  (bases 1 to 2813)
  AUTHORS   Wagner,M.J., Gogela-Spehar,M., Skirrow,R.C., Johnston,R.N.,
            Riabowol,K. and Helbing,C.C.
  TITLE     Expression of novel ING variants is regulated by thyroid hormone in
            the Xenopus laevis tadpole
  JOURNAL   J Biol Chem 276 (50), 47013-47020 (2001)
   PUBMED   11600495
REFERENCE   10 (bases 1 to 2813)
  AUTHORS   Zhang,Y., Sun,Z.W., Iratni,R., Erdjument-Bromage,H., Tempst,P.,
            Hampsey,M. and Reinberg,D.
  TITLE     SAP30, a novel protein conserved between human and yeast, is a
            component of a histone deacetylase complex
  JOURNAL   Mol Cell 1 (7), 1021-1031 (1998)
   PUBMED   9651585
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC107236.8.
            
            On Jan 26, 2010 this sequence version replaced NM_023503.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083144.1, AK012716.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN02146467, SAMN02146468
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-654               AC107236.8         191157-191810       c
            655-2813            AC107236.8         183829-185987       c
FEATURES             Location/Qualifiers
     source          1..2813
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 26.87 cM"
     gene            1..2813
                     /gene="Ing2"
                     /gene_synonym="2810011M06Rik; Ing1l; Ing2b; P33ING2"
                     /note="inhibitor of growth family, member 2"
                     /db_xref="GeneID:69260"
                     /db_xref="MGI:MGI:1916510"
     exon            1..654
                     /gene="Ing2"
                     /gene_synonym="2810011M06Rik; Ing1l; Ing2b; P33ING2"
                     /inference="alignment:Splign:2.1.0"
     CDS             480..1325
                     /gene="Ing2"
                     /gene_synonym="2810011M06Rik; Ing1l; Ing2b; P33ING2"
                     /note="inhibitor of growth 1-like protein"
                     /codon_start=1
                     /product="inhibitor of growth protein 2"
                     /protein_id="NP_075992.2"
                     /db_xref="CCDS:CCDS22298.1"
                     /db_xref="GeneID:69260"
                     /db_xref="MGI:MGI:1916510"
                     /translation="MLGQQQQQQLYSSAALLTGERSRLLSCYVQDYLECVESLPHDMQ
                     RNVSVLRELDNKYQETLKEIDDVYEKYKKEDDSNQKKRLQQHLQRALINSQELGDEKI
                     QIVTQMLELVENRARQMELHSQCFQDPAESERASDKSKMDSSQPERSSRRPRRQRTSE
                     SRDLCHMTNGIDDCDDQPPKEKRSKSAKKKKRSKAKQEREASPVEFAIDPNEPTYCLC
                     NQVSYGEMIGCDNEQCPIEWFHFSCVSLTYKPKGKWYCPKCRGDNEKTMDKSTEKTKK
                     ERRAR"
     exon            655..2813
                     /gene="Ing2"
                     /gene_synonym="2810011M06Rik; Ing1l; Ing2b; P33ING2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1447..1452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ing2"
                     /gene_synonym="2810011M06Rik; Ing1l; Ing2b; P33ING2"
                     /note="hexamer: ATTAAA"
     polyA_site      1467
                     /gene="Ing2"
                     /gene_synonym="2810011M06Rik; Ing1l; Ing2b; P33ING2"
                     /note="major polyA site"
     polyA_site      1762
                     /gene="Ing2"
                     /gene_synonym="2810011M06Rik; Ing1l; Ing2b; P33ING2"
     regulatory      2623..2628
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ing2"
                     /gene_synonym="2810011M06Rik; Ing1l; Ing2b; P33ING2"
                     /note="hexamer: AAGAAA"
     polyA_site      2648
                     /gene="Ing2"
                     /gene_synonym="2810011M06Rik; Ing1l; Ing2b; P33ING2"
ORIGIN      
        1 ggactagtcc tgtgagactc cgacaggcac ggaggctgat agagaggcga gagggtagcg
       61 aggggcttgt cacggggatc cgggcgaccg ggcagccccg gtagtgtctg gggagtcccc
      121 gggggggaca gccagcgtcg ctgcctggga gccccggcgc catcggccgc ggggaacccc
      181 gctgctcgct ctcctagaga gggagggggc cggagggagc cccggtctcg ccccgcccct
      241 gggcttgtta ccgcgggggc ggggagtaag ggcttcttct tgggggagtg gagatcgggg
      301 gactcggcgg tgccctctcg agcggcggcc gtgtccccgc ggcgccgggc tgccgagcgg
      361 aggagcggcg gtcgtggctg ttgcatgtgt ggctgctgga tgcggaggcg gcggcggcgg
      421 cggcggcgag gagcagcagc agcggcggcg gcggcggtgg tggtggtggc ggcggcagga
      481 tgttagggca gcagcagcag cagcagctgt actcgtcggc cgcgctcctg accggagagc
      541 ggagccggct gctctcctgc tacgtgcagg actacctgga gtgtgtggag tcgctgcccc
      601 acgacatgca gaggaacgtg tcggtgctgc gggagctgga caacaaatac caagaaacgt
      661 taaaggaaat tgatgatgtc tatgaaaaat ataagaaaga agatgattcc aaccagaaaa
      721 aacgcctaca gcagcatctc cagagagcgt taatcaatag ccaagaattg ggagatgaaa
      781 aaattcagat tgtcacccag atgctcgaat tggtggagaa ccgagcgaga caaatggagc
      841 tgcattcaca gtgtttccag gatcctgctg aaagtgagcg agcctcagac aagtcgaaga
      901 tggattccag tcaaccggaa agatcttcta gaagacctcg aagacagagg accagtgaga
      961 gccgtgactt atgtcacatg acaaacggga ttgacgactg tgatgatcaa ccaccgaaag
     1021 aaaagagatc caagtccgcc aagaagaaga agcgctccaa ggccaagcag gagagggagg
     1081 catcccctgt cgagtttgcc atcgatccca atgagcccac ctactgcttg tgtaaccaag
     1141 tgtcctacgg ggagatgata ggctgtgaca atgaacagtg tcccattgaa tggtttcact
     1201 tttcatgtgt ttcactcacc tataaaccca aggggaaatg gtattgccca aagtgtaggg
     1261 gagacaatga gaaaaccatg gacaaaagta ccgaaaagac aaaaaaggag agaagagcga
     1321 ggtagtgaag gccatcggtt ttaaagggtt ctttgtcttt tatagaattg ctttactttc
     1381 agaaaatgtt ttagggtaac tgcataagac tatgcaataa tttttaatca ttagtattga
     1441 tggtgtatta aaagttgttg tactttgtct gtgaccttaa ttttctgcac tgaattacca
     1501 aatattttca gccaggtagt ctctgtgagg acctaatgaa aggagcaggc agagaggcgt
     1561 atgaacgaac tgcaagcagc ttcccaagcc acgcctattc cacccccacc ttcaactctc
     1621 atgctgtttg ggggtggggg gtaaacccaa aaagttttgc taacatttta ttttagttct
     1681 gtgtgcttaa gaattttatg tattgttgga tttctgtgtc aaattctctt ggtgatttca
     1741 aacatgaaca ctattctgtt tagagattct tattgcctcc atgtcttcag acacttgtta
     1801 aatctctagt ctcccagaaa ttccaggaac tagagacaac agtacccatg ctcccacatg
     1861 gactagtgcg ctcttcctgg agtgtccact gcgtattttc ttggtagctt ttgttacctg
     1921 tcagttgtag cgtctgtaaa agcccctgct tcttcagaac agacacacct catctagtgt
     1981 ttaataaggg actcattttg atcaggacac gtaagactag ttagaaatac caaataatgt
     2041 tgccgctgcc tcatattggc aagatgtgga ttattcagca tcatggttca aggttgaaca
     2101 atttaaaggt gtgtcttaat attttctatg tgacccactg ctgggatgtt tagccacaga
     2161 cccgtcagtg ggaaaagggc atagattagt ctttaaataa tgccttttct gtcaaacagt
     2221 tattttaaat agttcttttc tgggggctag agtttatttt taccccccaa tgagtaatta
     2281 tacattattt taaataatag tatatttacc ttaacctcct ggtattggtg ctgtttgatg
     2341 ttttcatgtt tattgaacta atttcattat aataatacga ttaataatgt atttgtaaat
     2401 tgaattttcc aagattttga tattttaagg ttaagcatct tggtggagct gtgaccatgt
     2461 gtgggagcag tttttggtta tggagagcag cagacggact agtcctttaa cctctcatgc
     2521 agcttctgtc ttagttgtca tcttttcttc ctaatctgat aatcttggtt cttgttgatt
     2581 aacatgtgaa aaatcctatc tgcttgtttg gaaaaaaaaa aaaagaaaga tgtttttttc
     2641 ctcttcaagc tctctgtgtg acttaggccc tgtcatttca ccttacctga atgttgggtg
     2701 atggatcaac ctagaaaatg agttggctta accatctgca agggcctttt gaaatttcag
     2761 tgttgtgccg tggtgaacga ttttaacaat gaaatggctt gcttttctct ttc
//
