LOCUS       NM_011919               2433 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus inhibitor of growth family, member 1 (Ing1),
            transcript variant 1, mRNA.
ACCESSION   NM_011919 XM_906800
VERSION     NM_011919.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2433)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2433)
  AUTHORS   Schafer,A., Mekker,B., Mallick,M., Vastolo,V., Karaulanov,E.,
            Sebastian,D., von der Lippen,C., Epe,B., Downes,D.J., Scholz,C. and
            Niehrs,C.
  TITLE     Impaired DNA demethylation of C/EBP sites causes premature aging
  JOURNAL   Genes Dev 32 (11-12), 742-762 (2018)
   PUBMED   29884649
REFERENCE   3  (bases 1 to 2433)
  AUTHORS   Leighton,L.J., Zhao,Q., Li,X., Dai,C., Marshall,P.R., Liu,S.,
            Wang,Y., Zajaczkowski,E.L., Khandelwal,N., Kumar,A., Bredy,T.W. and
            Wei,W.
  TITLE     A Functional Role for the Epigenetic Regulator ING1 in
            Activity-induced Gene Expression in Primary Cortical Neurons
  JOURNAL   Neuroscience 369, 248-260 (2018)
   PUBMED   29158107
  REMARK    GeneRIF: ING1 knockdown leads to decreased expression of genes
            related to synaptic plasticity, including the regulatory subunit of
            calcineurin, Ppp3r1. In addition, ING1 binding at a site upstream
            of the transcription start site (TSS) of Ppp3r1 depends on yet
            another group of neuroepigenetic regulatory proteins, the Piwi-like
            family, which are also involved in DNA repair.
REFERENCE   4  (bases 1 to 2433)
  AUTHORS   Streubel,G., Fitzpatrick,D.J., Oliviero,G., Scelfo,A., Moran,B.,
            Das,S., Munawar,N., Watson,A., Wynne,K., Negri,G.L., Dillon,E.T.,
            Jammula,S., Hokamp,K., O'Connor,D.P., Pasini,D., Cagney,G. and
            Bracken,A.P.
  TITLE     Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells
            required for self-renewal
  JOURNAL   EMBO J 36 (15), 2216-2232 (2017)
   PUBMED   28554894
REFERENCE   5  (bases 1 to 2433)
  AUTHORS   Esmaeili,M., Pungsrinont,T., Schaefer,A. and Baniahmad,A.
  TITLE     A novel crosstalk between the tumor suppressors ING1 and ING2
            regulates androgen receptor signaling
  JOURNAL   J Mol Med (Berl) 94 (10), 1167-1179 (2016)
   PUBMED   27305909
  REMARK    GeneRIF: Taken together, our findings provide evidence for a novel
            crosstalk and a crossregulation between ING1 and ING2 in regulating
            androgen receptor-mediated transactivation and suggest that ING2
            acts as a novel corepressor that inhibits AR signaling, prostate
            cancer cell growth, and migration.
REFERENCE   6  (bases 1 to 2433)
  AUTHORS   Wagner,M.J., Gogela-Spehar,M., Skirrow,R.C., Johnston,R.N.,
            Riabowol,K. and Helbing,C.C.
  TITLE     Expression of novel ING variants is regulated by thyroid hormone in
            the Xenopus laevis tadpole
  JOURNAL   J Biol Chem 276 (50), 47013-47020 (2001)
   PUBMED   11600495
REFERENCE   7  (bases 1 to 2433)
  AUTHORS   Cheung,K.J. Jr., Bush,J.A., Jia,W. and Li,G.
  TITLE     Expression of the novel tumour suppressor p33(ING1)is independent
            of p53
  JOURNAL   Br J Cancer 83 (11), 1468-1472 (2000)
   PUBMED   11076655
REFERENCE   8  (bases 1 to 2433)
  AUTHORS   Zeremski,M., Hill,J.E., Kwek,S.S., Grigorian,I.A., Gurova,K.V.,
            Garkavtsev,I.V., Diatchenko,L., Koonin,E.V. and Gudkov,A.V.
  TITLE     Structure and regulation of the mouse ing1 gene. Three alternative
            transcripts encode two phd finger proteins that have opposite
            effects on p53 function
  JOURNAL   J Biol Chem 274 (45), 32172-32181 (1999)
   PUBMED   10542254
REFERENCE   9  (bases 1 to 2433)
  AUTHORS   Zhang,Y., Sun,Z.W., Iratni,R., Erdjument-Bromage,H., Tempst,P.,
            Hampsey,M. and Reinberg,D.
  TITLE     SAP30, a novel protein conserved between human and yeast, is a
            component of a histone deacetylase complex
  JOURNAL   Mol Cell 1 (7), 1021-1031 (1998)
   PUBMED   9651585
REFERENCE   10 (bases 1 to 2433)
  AUTHORS   Helbing,C.C., Veillette,C., Riabowol,K., Johnston,R.N. and
            Garkavtsev,I.
  TITLE     A novel candidate tumor suppressor, ING1, is involved in the
            regulation of apoptosis
  JOURNAL   Cancer Res 57 (7), 1255-1258 (1997)
   PUBMED   9102209
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124475.3, CA320790.1, AA407185.1, AK076482.1 and BX528243.1.
            
            On Oct 22, 2014 this sequence version replaced NM_011919.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016573.1, SRR7345562.1011125.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC124475.3         168883-168902
            21-430              CA320790.1         1-410
            431-840             AA407185.1         1-410
            841-1988            AK076482.1         284-1431
            1989-2433           BX528243.1         2-446
FEATURES             Location/Qualifiers
     source          1..2433
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 5.73 cM"
     gene            1..2433
                     /gene="Ing1"
                     /gene_synonym="2610028J21Rik; mING1h; p33Ing1; p37Ing1b"
                     /note="inhibitor of growth family, member 1"
                     /db_xref="GeneID:26356"
                     /db_xref="MGI:MGI:1349481"
     exon            1..589
                     /gene="Ing1"
                     /gene_synonym="2610028J21Rik; mING1h; p33Ing1; p37Ing1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             454..1293
                     /gene="Ing1"
                     /gene_synonym="2610028J21Rik; mING1h; p33Ing1; p37Ing1b"
                     /note="isoform 1 is encoded by transcript variant 1;
                     inhibitor of growth protein 1"
                     /codon_start=1
                     /product="inhibitor of growth protein 1 isoform 1"
                     /protein_id="NP_036049.2"
                     /db_xref="CCDS:CCDS22097.1"
                     /db_xref="GeneID:26356"
                     /db_xref="MGI:MGI:1349481"
                     /translation="MLSPANGEQIHLVNYVEDYLDSIESLPFDLQRNVSLMREIDAKY
                     QEILKELDDYYEKFKRETDGTQKRRVLHCIQRALIRSQELGDEKIQIVSQMVELVENR
                     SRQVDSHVELFEAHQDISDGTGGSGKAGQDKSKSEAITQADKPNNKRSRRQRNNENRE
                     NASNNHDHDDITSGTPKEKKAKTSKKKKRSKAKAEREASPADLPIDPNEPTYCLCNQV
                     SYGEMIGCDNDECPIEWFHFSCVGLNHKPKGKWYCPKCRGESEKTMDKALEKSKKERA
                     YNR"
     exon            590..2423
                     /gene="Ing1"
                     /gene_synonym="2610028J21Rik; mING1h; p33Ing1; p37Ing1b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2048..2053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ing1"
                     /gene_synonym="2610028J21Rik; mING1h; p33Ing1; p37Ing1b"
                     /note="hexamer: AATAAA"
     polyA_site      2069
                     /gene="Ing1"
                     /gene_synonym="2610028J21Rik; mING1h; p33Ing1; p37Ing1b"
                     /note="major polyA site"
ORIGIN      
        1 tttcccaagt gtttgaaact ggtatttggg ttttccacgt tggacaagtg cggcgaggcg
       61 ggcggcggag cgcgcccttc ccgcagccgg ccccgctctc tccgctctcc acgctggtgg
      121 cgggtgggcg gcggtggccg gccctctttg ggtgtgtgcg cgctagtacg cacggccccc
      181 cgcgccgccc gccgcccggg agggggcctg cacggccggc ggggtgtgcg cttgagcttc
      241 ggccgccgcg gcccgcgcct gcaggcgccg gggtccccgc ggccccggag gcggcgcggc
      301 aggcgccaga tgtagccgcc ggccagcccg gccggagcgg cgggggggcg cggaagggcg
      361 agagagcttt gcattttgca gtgctgtttg aggggggcgg ggggtggagg aagcggaaag
      421 ccgccgaatc gccggggacc tccggggtga accatgttga gtcctgccaa cggggagcag
      481 atccacctgg tgaactatgt ggaggattac ctggactcaa tcgagtcact gcctttcgac
      541 ctgcagagga acgtctcgct gatgcgggag atcgacgcca aataccaaga gatcctgaag
      601 gagctggacg actactatga gaagttcaaa cgggagacag acggcaccca gaagcgccgg
      661 gtactgcact gcatccagag ggccctgatc cgcagccagg agctaggcga tgagaagatc
      721 cagatcgtga gtcagatggt ggagctggtg gagaaccgca gcagacaggt ggacagtcac
      781 gtggagctct tcgaagcaca ccaggacatc agtgacggca ctggtggcag cggcaaggcg
      841 ggccaggaca agtcgaagag tgaggccatc acacaggcag ataagccgaa taacaagcgg
      901 tccaggaggc agcgaaacaa tgagaatcga gagaacgcgt cgaataatca cgaccatgat
      961 gacatcacct caggaacgcc caaggagaag aaagcaaaaa cctcaaagaa gaagaaacgc
     1021 tccaaggcca aagcagagag ggaagcgtct cctgccgacc ttcccatcga ccccaacgag
     1081 cccacgtact gtctgtgcaa ccaggtctcc tacggggaga tgatcggctg tgacaacgac
     1141 gaatgcccca tcgagtggtt ccacttctcc tgcgtggggc tcaaccataa accaaagggc
     1201 aagtggtact gccccaagtg ccgtggggag agcgagaaga ccatggacaa agccctggag
     1261 aagtccaaga aagagagggc ttacaacagg tagtgagtgg acactcaccc gtggtcagtg
     1321 acacagccac cagtgtgttt atggtatcgc tgccttcgtg gaagtccgag ggcagtcaga
     1381 tgagtatttt agagaatgtt agccgtgcct cctctcctcg gatggcggag acagcctgcg
     1441 tcttcatggt gtaccttgtt cccagactgg gtctgcagag ccgcaattta gaaactacaa
     1501 atacaggttc gaattaacca tgtcagcgag tgtcagactg attttggggg ttggggagtg
     1561 acttggaagt aagctaacag ctgtataaag aagagatttc atttggctgt tttgacaaaa
     1621 atgttacggt ttacaaaaaa aaaaaaaaat tagccaggtt gctgaagtac aacaagcgtg
     1681 cttcttgcta ccataatgta tatccacacg acaagttggt ggtctaaagt ctaaatatta
     1741 ttatttttta aagaggtaaa tgggtaaatt ttacatgaca tattttatac atggcctatt
     1801 ccctaactgg ccatttttaa tgactgggta catttttaat aggtcagaca caagtggtcc
     1861 aggcagtggg tccgagtctt gcctttgcta ccctaggtca tggtgtagcc acctttaact
     1921 tatatgaagt gtataaatgt acatcttgcc cctgctgtat cataaccgga agtgcagcct
     1981 ggtgctgtta tgaagccaag gtgtgcatcc tgctgcgtgt gtgagctgta tagatgttgc
     2041 gtcaagaaat aaatgaaact tggccagttt gtttctttag catttaattt taacatacaa
     2101 ataattttaa atttttgtct taaaaattta tacaccagca gtttagacaa agccttaagc
     2161 aaattgtata ttattgatct cacgtaataa ggaagtaggc attatgtcca tgccagcaaa
     2221 tacatgtcaa aggtgtttag atcagaggtt aggacgtgac tgtgcttgtg aggtccagcc
     2281 ccaccatctg tttttgtatg gcctgtgagc taagaatggt ctctatgttt ctgagtggtt
     2341 tttaaaatca catttcatga tacacgaaag tcctatgaaa tgaagatttg cgtgtctata
     2401 aataaagact cattggaaca ccaaaaaaaa aaa
//
