LOCUS       NM_198411               4618 bp    mRNA    linear   ROD 11-OCT-2023
DEFINITION  Mus musculus inverted formin, FH2 and WH2 domain containing (Inf2),
            transcript variant 1, mRNA.
ACCESSION   NM_198411 XM_153742
VERSION     NM_198411.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4618)
  AUTHORS   Nutter CA, Kidd BM, Carter HA, Hamel JI, Mackie PM, Kumbkarni N,
            Davenport ML, Tuyn DM, Gopinath A, Creigh PD, Sznajder LJ, Wang ET,
            Ranum LPW, Khoshbouei H, Day JW, Sampson JB, Prokop S and Swanson
            MS.
  TITLE     Choroid plexus mis-splicing and altered cerebrospinal fluid
            composition in myotonic dystrophy type 1
  JOURNAL   Brain 146 (10), 4217-4232 (2023)
   PUBMED   37143315
REFERENCE   2  (bases 1 to 4618)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4618)
  AUTHORS   Sun H, Perez-Gill C, Schlondorff JS, Subramanian B and Pollak MR.
  TITLE     Dysregulated Dynein-Mediated Trafficking of Nephrin Causes
            INF2-related Podocytopathy
  JOURNAL   J Am Soc Nephrol 32 (2), 307-322 (2021)
   PUBMED   33443052
  REMARK    GeneRIF: Dysregulated Dynein-Mediated Trafficking of Nephrin Causes
            INF2-related Podocytopathy.
REFERENCE   4  (bases 1 to 4618)
  AUTHORS   A M, Fung TS, Kettenbach AN, Chakrabarti R and Higgs HN.
  TITLE     A complex containing lysine-acetylated actin inhibits the formin
            INF2
  JOURNAL   Nat Cell Biol 21 (5), 592-602 (2019)
   PUBMED   30962575
  REMARK    GeneRIF: we purified an INF2 inhibitor from mouse brain tissue, and
            identified it as a complex of lysine-acetylated actin (KAc-actin)
            and cyclase-associated protein (CAP). Inhibition of INF2 by
            CAP-KAc-actin is dependent on the INF2 diaphanous inhibitory domain
            (DID).
REFERENCE   5  (bases 1 to 4618)
  AUTHORS   Zhang Z and Yu J.
  TITLE     Nurr1 exacerbates cerebral ischemia-reperfusion injury via
            modulating YAP-INF2-mitochondrial fission pathways
  JOURNAL   Int J Biochem Cell Biol 104, 149-160 (2018)
   PUBMED   30267803
  REMARK    GeneRIF: the pathogenesis of cerebral ischemia-reperfusion injury
            is associated with Nurr1 upregulation followed by augmented
            mitochondrial fission via an abnormal YAP-INF2 pathways
REFERENCE   6  (bases 1 to 4618)
  AUTHORS   Korobova F, Ramabhadran V and Higgs HN.
  TITLE     An actin-dependent step in mitochondrial fission mediated by the
            ER-associated formin INF2
  JOURNAL   Science 339 (6118), 464-467 (2013)
   PUBMED   23349293
REFERENCE   7  (bases 1 to 4618)
  AUTHORS   Ramabhadran V, Korobova F, Rahme GJ and Higgs HN.
  TITLE     Splice variant-specific cellular function of the formin INF2 in
            maintenance of Golgi architecture
  JOURNAL   Mol Biol Cell 22 (24), 4822-4833 (2011)
   PUBMED   21998196
  REMARK    GeneRIF: Splice variant-specific cellular function of the formin
            INF2 in maintenance of Golgi architecture.
REFERENCE   8  (bases 1 to 4618)
  AUTHORS   Sun H, Schlondorff JS, Brown EJ, Higgs HN and Pollak MR.
  TITLE     Rho activation of mDia formins is modulated by an interaction with
            inverted formin 2 (INF2)
  JOURNAL   Proc Natl Acad Sci U S A 108 (7), 2933-2938 (2011)
   PUBMED   21278336
REFERENCE   9  (bases 1 to 4618)
  AUTHORS   Chhabra ES, Ramabhadran V, Gerber SA and Higgs HN.
  TITLE     INF2 is an endoplasmic reticulum-associated formin protein
  JOURNAL   J Cell Sci 122 (Pt 9), 1430-1440 (2009)
   PUBMED   19366733
REFERENCE   10 (bases 1 to 4618)
  AUTHORS   Chhabra ES and Higgs HN.
  TITLE     INF2 Is a WASP homology 2 motif-containing formin that severs actin
            filaments and accelerates both polymerization and depolymerization
  JOURNAL   J Biol Chem 281 (36), 26754-26767 (2006)
   PUBMED   16818491
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY330473.1, BY335782.1, AC124373.4, CD347830.1, BC060610.1 and
            BC115422.1.
            
            [WARNING] On Jan 17, 2024 this sequence was replaced by
            NM_198411.3.
            
            On Sep 6, 2006 this sequence version replaced NM_198411.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ834374.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               BY330473.1         1-117
            118-328             BY335782.1         88-298
            329-367             AC124373.4         67828-67866
            368-950             CD347830.1         1-583
            951-964             AC124373.4         70827-70840
            965-1106            AC124373.4         71330-71471
            1107-1749           AC124373.4         71632-72274
            1750-3852           BC060610.1         1-2103
            3853-4063           BC115422.1         2074-2284
            4064-4618           BC060610.1         2258-2812
FEATURES             Location/Qualifiers
     source          1..4618
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 61.2 cM"
     gene            1..4618
                     /gene="Inf2"
                     /gene_synonym="2610204M08Rik; EG629699"
                     /note="inverted formin, FH2 and WH2 domain containing"
                     /db_xref="GeneID:70435"
                     /db_xref="MGI:MGI:1917685"
     exon            1..112
                     /gene="Inf2"
                     /gene_synonym="2610204M08Rik; EG629699"
                     /inference="alignment:Splign:2.1.0"
     exon            113..512
                     /gene="Inf2"
                     /gene_synonym="2610204M08Rik; EG629699"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..3937
                     /gene="Inf2"
                     /gene_synonym="2610204M08Rik; EG629699"
                     /note="isoform 1 is encoded by transcript variant 1;
                     formin, inverted; inverted formin-2"
                     /codon_start=1
                     /product="inverted formin-2 isoform 1"
                     /protein_id="NP_940803.2"
                     /db_xref="CCDS:CCDS36571.1"
                     /db_xref="GeneID:70435"
                     /db_xref="MGI:MGI:1917685"
                     /translation="MSVKEGAQRKWAALKEKLGPQDSDPTEANLESAEPELCIRLLQM
                     PSVVNYSGLRKRLESSDGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCI
                     SCVRAVMNSQQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHAL
                     TLDALDHYKMVCSQQYRFSVIMSELSDSDNVPYVVTLLSVINAIILGPEDLRSRAQLR
                     SEFIGLQLLDILTRLRDLEDADLLIQLEAFEEAKAEDEEELQRISDGINMNSHQEVFA
                     SLFHKVSCSPASAQLLSVLQGLMHLEPAGRSGQLLWEALENLVNRAVLLASDAQACTL
                     EEVVERLLSIKGRPRPSPLDKAHKSVQTNSVQNQGSSSQNTTTPTTKVEGQQPVVASP
                     CQHVGSIQSSSVDIAPQPVALEQCITALPLPTPPLSSSTPVLPPTPPPLPGPGATSPL
                     PPPPPPLPPPLPGSGTTSPPPPPPPPPPLPPPLPGSGTISPPPPPPPPPLPGTGAVSP
                     PPPPPLPSLPDSHKTQPPPPPPLPGMCPVPPPPPLPRAGQIPPPPPLPGFSVPSMMGG
                     VEEIIVAQVDHSLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVARERNSMWATLGSPC
                     TAAVEPDFSSIEQLFSFPTAKPKEPSAAPARKEPKEVTFLDSKKSLNLNIFLKQFKCS
                     NEEVTSMIQAGDTSKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLSNADQFYVLLL
                     DIPCYPLRVECMMLCEGTAIVLDMVRPKAQLVLTACESLLTSQRLPVFCQLILKIGNF
                     LNYGSHTGDADGFKISTLLKLTETKSQQSRVTLLHHVLEEVEKSHPDLLQLSRDLEPP
                     SQAAGINVEIIHSEASANLKKLLEAERKVSASIPEVQKQYAERLQASIEASQELDKVF
                     DAIEQKKLELADYLCEDPQQLSLEDTFSTMKTFRDLFTRALKENKDRKEQMAKAERRK
                     QQLAEEEARRPRDEDGKPIRKGPGKQEEVCVIDALLADIRKGFQLRKTARGRGDTEAS
                     GRVAPADPPKATEPATASNPTQGTNHPASEPLDTTAADEPQGWDLVDAVTPSPQPSKE
                     EDGPPALERRSSWYVDAIDFLDPEDTPDAQPSEGVWPVTLGDGQALNPLEFSSNKPPG
                     VKSSHQDATDPEALWGVHRTEADSTSEGPEDEAQRGQSTHLPRTGPGEDEDGEDTAPE
                     SALDTSLDRSFSEDAVTDSSGSGTLPRVQGRVSKGTSKRRKKRPSRNQEEFVPDSDDI
                     KAKRLCVIQ"
     exon            513..628
                     /gene="Inf2"
                     /gene_synonym="2610204M08Rik; EG629699"
                     /inference="alignment:Splign:2.1.0"
     exon            629..788
                     /gene="Inf2"
                     /gene_synonym="2610204M08Rik; EG629699"
                     /inference="alignment:Splign:2.1.0"
     exon            789..822
                     /gene="Inf2"
                     /gene_synonym="2610204M08Rik; EG629699"
                     /inference="alignment:Splign:2.1.0"
     exon            823..964
                     /gene="Inf2"
                     /gene_synonym="2610204M08Rik; EG629699"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1106
                     /gene="Inf2"
                     /gene_synonym="2610204M08Rik; EG629699"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1955
                     /gene="Inf2"
                     /gene_synonym="2610204M08Rik; EG629699"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2101
                     /gene="Inf2"
                     /gene_synonym="2610204M08Rik; EG629699"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2163
                     /gene="Inf2"
                     /gene_synonym="2610204M08Rik; EG629699"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2266
                     /gene="Inf2"
                     /gene_synonym="2610204M08Rik; EG629699"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2352
                     /gene="Inf2"
                     /gene_synonym="2610204M08Rik; EG629699"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2453
                     /gene="Inf2"
                     /gene_synonym="2610204M08Rik; EG629699"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2524
                     /gene="Inf2"
                     /gene_synonym="2610204M08Rik; EG629699"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2632
                     /gene="Inf2"
                     /gene_synonym="2610204M08Rik; EG629699"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2703
                     /gene="Inf2"
                     /gene_synonym="2610204M08Rik; EG629699"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..2824
                     /gene="Inf2"
                     /gene_synonym="2610204M08Rik; EG629699"
                     /inference="alignment:Splign:2.1.0"
     exon            2825..2989
                     /gene="Inf2"
                     /gene_synonym="2610204M08Rik; EG629699"
                     /inference="alignment:Splign:2.1.0"
     exon            2990..3092
                     /gene="Inf2"
                     /gene_synonym="2610204M08Rik; EG629699"
                     /inference="alignment:Splign:2.1.0"
     exon            3093..3254
                     /gene="Inf2"
                     /gene_synonym="2610204M08Rik; EG629699"
                     /inference="alignment:Splign:2.1.0"
     exon            3255..3881
                     /gene="Inf2"
                     /gene_synonym="2610204M08Rik; EG629699"
                     /inference="alignment:Splign:2.1.0"
     exon            3882..3938
                     /gene="Inf2"
                     /gene_synonym="2610204M08Rik; EG629699"
                     /inference="alignment:Splign:2.1.0"
     exon            3939..4601
                     /gene="Inf2"
                     /gene_synonym="2610204M08Rik; EG629699"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcgcggtt agactgtgcg gaaagcagcc gcgaggccgc cgcccgcagc cccagacgct
       61 ccggcgccgg gacacagcac tctgcaccat ctctcggctg tacccccacc cgtttgacaa
      121 gatgtctgta aaggaaggcg ctcaacgcaa gtgggcggcg ctgaaggaga agctggggcc
      181 gcaggactca gaccccacgg aagccaacct ggagagcgcc gagcctgagc tgtgcatccg
      241 gctgctgcag atgccctcgg tggtcaacta ctcgggcctg cgcaagcgcc tggagagcag
      301 cgatggcggc tggatggtgc agttcctgga gcagagcggc ctggacctgc tgctggaggc
      361 gctggcacgg ctgtcagggc gtggcgtggc ccgcatctcg gatgccctgc tgcagctcac
      421 ctgcatcagc tgtgtgcgtg ctgtcatgaa ttcacagcag ggcatcgaat acatcctcag
      481 caaccagggt tatgtgcgcc agctctccca ggctctggat acctccaatg taatggtcaa
      541 gaagcaggtg tttgaattgc tggctgctct gtgcatctat tcgcctgagg gccacgcact
      601 gacgctcgat gccctggacc attacaagat ggtgtgcagc cagcagtacc gcttcagcgt
      661 catcatgagt gagctctcgg acagtgacaa cgtgccctat gtggtcaccc tgctcagtgt
      721 gatcaacgcc atcattctgg gtcccgagga cctccgctct cgtgcccagc tgcggagtga
      781 gttcataggg ctacagctgc tggatattct gacccggcta cgagacttgg aggatgcgga
      841 tctgctgatc cagctggaag ccttcgaaga ggccaaagcg gaggacgagg aggaacttca
      901 gcgaattagc gatgggatca acatgaacag ccaccaggaa gtctttgcgt ccctgttcca
      961 caaggtgagc tgttctccag cgtcggccca gctgctgtca gtattgcagg gtctcatgca
     1021 cctggagcct gctggccgct caggccaact gctctgggag gccctggaaa acctggtgaa
     1081 ccgggctgtg ctcctggcca gtgatgccca ggcttgcacc ctggaggagg tggttgaacg
     1141 actgctgtcc atcaaagggc ggccccgacc aagccccctg gacaaggccc acaagagtgt
     1201 ccagaccaac tcagtccaga atcagggcag ttcctcccaa aacactacta ctcccacaac
     1261 taaagtggaa ggccagcagc cagtagtggc ttctccctgc caacacgtgg gcagcatcca
     1321 gagctccagt gttgacatag cgccacagcc agtagccctt gagcagtgca taacagcctt
     1381 acctctacct accccaccac tctccagctc cacccctgtg ctccctccaa ccccaccccc
     1441 cctgccaggc ccaggggcca catctcccct tccccctccc cctccccctt tgcctccccc
     1501 tttgccaggc tcagggacca catctccccc tccccctcct cctccccctc cccccttgcc
     1561 accccctctg ccaggctcag ggaccatatc tccccctcca cccccacccc cacctcccct
     1621 accaggtaca ggggctgtgt ctcccccacc ccctccgcca cttccatctc tgcctgattc
     1681 ccacaagacc cagcccccgc ccccaccccc actccctggc atgtgcccag ttcctccccc
     1741 tcccccacta cccagagcag gccagatacc tccacctcct cccctgcctg gtttctctgt
     1801 cccctccatg atgggtggtg tggaggagat cattgtggcc caggtcgacc acagcctggg
     1861 ctcagcctgg gtccccagtc accgcagagt gaatccaccc acactgagaa tgaagaagct
     1921 gaactggcag aagctgccat ccaatgtggc acgagagcgc aactccatgt gggccacact
     1981 gggcagcccc tgcacagccg cagtggagcc cgacttctcc agcattgagc agctgttctc
     2041 cttccccacg gctaagccca aggagccctc tgctgccccc gccaggaagg agcccaaaga
     2101 agtcactttt ctggactcca agaagagcct gaacctcaac atcttcctga agcaatttaa
     2161 atgttccaat gaagaagtca ccagcatgat ccaggctgga gacaccagca agtttgatgt
     2221 ggaggtcctc aaacagcttc taaagcttct tccagagaag catgagattg agaacctacg
     2281 ggcgttcact gaggagcgag ccaagttgtc caatgctgac cagttctatg ttctgctcct
     2341 ggacattccc tgctacccgc tgcgggtgga gtgcatgatg ctgtgtgagg gaacggccat
     2401 cgtcctggac atggtgcggc ccaaggccca gctggtgctc actgcctgcg agagcctgct
     2461 caccagccag cggttgccag tcttctgtca gctgatcctc aaaatcggga atttcctcaa
     2521 ctacggcagc cacacgggag atgcagatgg tttcaagatt agcaccttgc tgaagctcac
     2581 agagaccaag tcccagcaga gtcgcgtgac gctgctgcac cacgtgctgg aggaagtgga
     2641 gaagagccac ccggacctcc tacagctatc ccgggacctg gagccaccct ctcaagctgc
     2701 aggaatcaac gtggagatca tccactcaga ggccagtgcc aacctgaaga agcttctaga
     2761 agcggagcgg aaggtgtccg cttccatccc tgaggtgcag aagcagtacg ctgagcgcct
     2821 ccaggccagc attgaggcct ctcaggagct ggacaaggta ttcgacgcca ttgagcaaaa
     2881 gaaactggag ctggctgact acctgtgcga agacccccag cagctgtccc tagaggacac
     2941 gttcagcacc atgaagacct tccgagacct cttcacccgt gccctgaagg agaacaagga
     3001 ccggaaggaa cagatggcaa aagcggaaag gaggaaacag cagctggcgg aggaggaggc
     3061 ccggaggccg agggacgagg atgggaagcc tatcaggaag gggcctggga agcaagaaga
     3121 ggtgtgcgtc atcgatgccc tgctggccga catcaggaag ggcttccagc tacggaagac
     3181 agcccggggc cggggagaca ctgaagcaag tggcagagtg gcccccgcag atcctccaaa
     3241 ggccacagag cctgcaactg ccagcaatcc tacccagggc acaaaccacc ctgcttcaga
     3301 gcccttggat accacagcag ctgacgagcc gcagggctgg gaccttgtgg atgctgtaac
     3361 ccccagcccc cagccctcca aggaggaaga tggtcctcca gccctggaga ggcgctcctc
     3421 ctggtatgtg gatgccattg acttcctgga ccctgaagat accccggatg cccagccctc
     3481 tgagggggtc tggccagtga ctctgggaga tggtcaagct ctgaatcccc tcgagttctc
     3541 tagcaataag cctcctggag tcaagagctc gcaccaggac gctacggatc ctgaagcctt
     3601 gtggggcgtc caccgaaccg aggcagacag caccagtgag ggaccagagg atgaagctca
     3661 gcgaggacag agcacccacc taccccgcac aggccccgga gaggatgagg atggagagga
     3721 cacagcccca gaatctgcac ttgacacgtc cctggacagg tccttctctg aggacgcagt
     3781 gacagattcc tcagggtctg gcaccctccc cagggtccaa ggccgggtct caaaggggac
     3841 gagcaagcgg aggaagaaac gtccctcaag gaaccaagaa gagtttgtcc ctgattctga
     3901 tgatattaag gcaaaaaggc tgtgtgtgat ccagtgaggc ctcaggtcca ggcccaaagc
     3961 caagtgagtg ctctcgtcgg ctcagcacat cggctggatg tgttgcctgg agaggctctt
     4021 cggggccagg ctgggactgg gcccccgaga aacccaaact ccgtgcctta cccagccagg
     4081 atccttggga gccttgggca ttgatgctgg gacctggcct ggcaccctgg gccacctgca
     4141 cgctcttagc ccctgctttt gcaaaccact cccaccccct atcgcatgca ccacaggggt
     4201 ggacgggagc ctcctgcctg gctctaggga gatggatcac agacacctgc actggggctg
     4261 aaacatcccc tctcccccaa cccccatggc tcagttgatt tttagctgag tgctgttttc
     4321 tgcatcttta ttctgctatg gctgagttga ggttagtgag ggactgaggg aatgctcgtt
     4381 ggaagtgctg tgggtaggac ctggcaggta ggctctaggg aacaaataaa caaaaagttc
     4441 atgtgcacaa tgagtggtga ccagaccact gcagctgtca tctcccttgg tgtgtgccca
     4501 gtggggaaca agctgcccct gctcagcccc tctcatgtgt gcactgttga gtctgcaggc
     4561 cagcagggat tttaaccaat aaagagcaac cttgtctgtc aaaaaaaaaa aaaaaaaa
//
