LOCUS       NM_001369356            3187 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus inner centromere protein (Incenp), transcript variant
            1, mRNA.
ACCESSION   NM_001369356 XM_006526712
VERSION     NM_001369356.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3187)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3187)
  AUTHORS   Ray,J.P., Staron,M.M., Shyer,J.A., Ho,P.C., Marshall,H.D.,
            Gray,S.M., Laidlaw,B.J., Araki,K., Ahmed,R., Kaech,S.M. and
            Craft,J.
  TITLE     The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling,
            Differentiation, and Metabolism of T Helper 1 and Follicular B
            Helper T Cells
  JOURNAL   Immunity 43 (4), 690-702 (2015)
   PUBMED   26410627
REFERENCE   3  (bases 1 to 3187)
  AUTHORS   Fernandez-Miranda,G., Trakala,M., Martin,J., Escobar,B.,
            Gonzalez,A., Ghyselinck,N.B., Ortega,S., Canamero,M., Perez de
            Castro,I. and Malumbres,M.
  TITLE     Genetic disruption of aurora B uncovers an essential role for
            aurora C during early mammalian development
  JOURNAL   Development 138 (13), 2661-2672 (2011)
   PUBMED   21613325
REFERENCE   4  (bases 1 to 3187)
  AUTHORS   Sharif,B., Na,J., Lykke-Hartmann,K., McLaughlin,S.H., Laue,E.,
            Glover,D.M. and Zernicka-Goetz,M.
  TITLE     The chromosome passenger complex is required for fidelity of
            chromosome transmission and cytokinesis in meiosis of mouse oocytes
  JOURNAL   J Cell Sci 123 (Pt 24), 4292-4300 (2010)
   PUBMED   21123620
REFERENCE   5  (bases 1 to 3187)
  AUTHORS   Trivedi,C.M., Zhu,W., Wang,Q., Jia,C., Kee,H.J., Li,L.,
            Hannenhalli,S. and Epstein,J.A.
  TITLE     Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic
            cardiac myocyte proliferation
  JOURNAL   Dev Cell 19 (3), 450-459 (2010)
   PUBMED   20833366
REFERENCE   6  (bases 1 to 3187)
  AUTHORS   Uren,A.G., Wong,L., Pakusch,M., Fowler,K.J., Burrows,F.J.,
            Vaux,D.L. and Choo,K.H.
  TITLE     Survivin and the inner centromere protein INCENP show similar
            cell-cycle localization and gene knockout phenotype
  JOURNAL   Curr Biol 10 (21), 1319-1328 (2000)
   PUBMED   11084331
REFERENCE   7  (bases 1 to 3187)
  AUTHORS   Cutts,S.M., Fowler,K.J., Kile,B.T., Hii,L.L., O'Dowd,R.A.,
            Hudson,D.F., Saffery,R., Kalitsis,P., Earle,E. and Choo,K.H.
  TITLE     Defective chromosome segregation, microtubule bundling and nuclear
            bridging in inner centromere protein gene (Incenp)-disrupted mice
  JOURNAL   Hum Mol Genet 8 (7), 1145-1155 (1999)
   PUBMED   10369859
REFERENCE   8  (bases 1 to 3187)
  AUTHORS   Saffery,R., Irvine,D.V., Kile,B.T., Hudson,D.F., Cutts,S.M. and
            Choo,K.H.
  TITLE     Cloning, expression, and promoter structure of a mammalian inner
            centromere protein (INCENP)
  JOURNAL   Mamm Genome 10 (4), 415-418 (1999)
   PUBMED   10087305
REFERENCE   9  (bases 1 to 3187)
  AUTHORS   Craig,J.M., Earnshaw,W.C. and Vagnarelli,P.
  TITLE     Mammalian centromeres: DNA sequence, protein composition, and role
            in cell cycle progression
  JOURNAL   Exp Cell Res 246 (2), 249-262 (1999)
   PUBMED   9925740
  REMARK    Review article
REFERENCE   10 (bases 1 to 3187)
  AUTHORS   Fowler,K.J., Saffery,R., Kile,B.T., Irvine,D.V., Hudson,D.F.,
            Trowell,H.E. and Choo,K.H.
  TITLE     Genetic mapping of mouse centromere protein (Incenp and Cenpe)
            genes
  JOURNAL   Cytogenet Cell Genet 82 (1-2), 67-70 (1998)
   PUBMED   9763662
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132253.5.
            
            On Apr 5, 2019 this sequence version replaced XM_006526712.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AB100433.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               AC132253.5         128718-128868       c
            152-302             AC132253.5         124700-124850       c
            303-416             AC132253.5         124218-124331       c
            417-1153            AC132253.5         122652-123388       c
            1154-1205           AC132253.5         116054-116105       c
            1206-1263           AC132253.5         115086-115143       c
            1264-1378           AC132253.5         114852-114966       c
            1379-1430           AC132253.5         113817-113868       c
            1431-1545           AC132253.5         113284-113398       c
            1546-1680           AC132253.5         113078-113212       c
            1681-1692           AC132253.5         112571-112582       c
            1693-1802           AC132253.5         107698-107807       c
            1803-1923           AC132253.5         107507-107627       c
            1924-2043           AC132253.5         107056-107175       c
            2044-2270           AC132253.5         105969-106195       c
            2271-2349           AC132253.5         104477-104555       c
            2350-2457           AC132253.5         104195-104302       c
            2458-2608           AC132253.5         103599-103749       c
            2609-3187           AC132253.5         101674-102252       c
FEATURES             Location/Qualifiers
     source          1..3187
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 6.1 cM"
     gene            1..3187
                     /gene="Incenp"
                     /gene_synonym="2700067E22Rik; C130081E20"
                     /note="inner centromere protein"
                     /db_xref="GeneID:16319"
                     /db_xref="MGI:MGI:1313288"
     exon            1..151
                     /gene="Incenp"
                     /gene_synonym="2700067E22Rik; C130081E20"
                     /inference="alignment:Splign:2.1.0"
     exon            152..302
                     /gene="Incenp"
                     /gene_synonym="2700067E22Rik; C130081E20"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..2805
                     /gene="Incenp"
                     /gene_synonym="2700067E22Rik; C130081E20"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="inner centromere protein isoform 1"
                     /protein_id="NP_001356285.1"
                     /db_xref="CCDS:CCDS89338.1"
                     /db_xref="GeneID:16319"
                     /db_xref="MGI:MGI:1313288"
                     /translation="MGTTAPGPICLLDLCDQKLLDFVCNVDNKDFMWLKEIEEEAERM
                     FIREFSNEPELMPKTPSQKNRRKKRRVSNIQDENRDPVRKRLSRRKSRSSQVGTRHLR
                     SKPVTIVEENGFPVLQRITRATAAAAAAAAAASVASASSSSTAGSPTVLTKKAVVEIS
                     TSERLSAELQLTKLKGSLPPSPVSQGTLTSEEELTPKKSEAGKLDSVTVNSLKATPQS
                     PKNRGVGEGRSVSKLKIARASWGLQDSPGSTDSPWQERVLSPILLNNILPTTAKSPLG
                     NIRSVRRSLISQDSQVPLASKYNLVAKQENGSRRSSRRIAKKAGKEPEASARIICHSY
                     LERLLNVEVPQNVGLEQEPVEVAEPEEAEEEQEVSKNSGCPSKPRSATKIAISTPTSK
                     PAAAGQTTTVEEQEAELDQTDGHREPPQSVRRKRSYKQAISEPDEEQLEDEELQPCQN
                     KTPSPPCPANKVVRPLRTFLHTVQKNQMLMTPTLASRSSVMKSFIKRNTPLRVDPKCS
                     FVEKERQRLESLRRKEEAEQRRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQM
                     KEEKKKQIEQKFAQIDEKTEKAKEERLAEKAKKKATAKKMEEVEARRKQEEEARRLRW
                     LQQEEEERRHQEMLQRKKEEEQERRKAAEARRLAEQREQERRREQERREQERREQERR
                     EQERKEQERREQEQERLRAKREMQEREKALRLQKERLQKELEEKKRKEEQQRLAEQQL
                     QEEQAKKAKEVAAARKVLNMTVDVQSPVCTSYQMTPQGPKSIPKISVDDYGMDLNSDD
                     STDDESHPRKPIPSWAKGTQLSQAIVHQYYHPPNILELFGSILPLDLEDIFKKRKTRY
                     HKRTSSAVWNSPPLKATMVPSSGD"
     exon            303..416
                     /gene="Incenp"
                     /gene_synonym="2700067E22Rik; C130081E20"
                     /inference="alignment:Splign:2.1.0"
     exon            417..1153
                     /gene="Incenp"
                     /gene_synonym="2700067E22Rik; C130081E20"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1205
                     /gene="Incenp"
                     /gene_synonym="2700067E22Rik; C130081E20"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1263
                     /gene="Incenp"
                     /gene_synonym="2700067E22Rik; C130081E20"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1378
                     /gene="Incenp"
                     /gene_synonym="2700067E22Rik; C130081E20"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1430
                     /gene="Incenp"
                     /gene_synonym="2700067E22Rik; C130081E20"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1545
                     /gene="Incenp"
                     /gene_synonym="2700067E22Rik; C130081E20"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1680
                     /gene="Incenp"
                     /gene_synonym="2700067E22Rik; C130081E20"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1692
                     /gene="Incenp"
                     /gene_synonym="2700067E22Rik; C130081E20"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1802
                     /gene="Incenp"
                     /gene_synonym="2700067E22Rik; C130081E20"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1923
                     /gene="Incenp"
                     /gene_synonym="2700067E22Rik; C130081E20"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2043
                     /gene="Incenp"
                     /gene_synonym="2700067E22Rik; C130081E20"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2270
                     /gene="Incenp"
                     /gene_synonym="2700067E22Rik; C130081E20"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2349
                     /gene="Incenp"
                     /gene_synonym="2700067E22Rik; C130081E20"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2457
                     /gene="Incenp"
                     /gene_synonym="2700067E22Rik; C130081E20"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2608
                     /gene="Incenp"
                     /gene_synonym="2700067E22Rik; C130081E20"
                     /inference="alignment:Splign:2.1.0"
     exon            2609..3187
                     /gene="Incenp"
                     /gene_synonym="2700067E22Rik; C130081E20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3058..3063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Incenp"
                     /gene_synonym="2700067E22Rik; C130081E20"
                     /note="hexamer: AATAAA"
     polyA_site      3080
                     /gene="Incenp"
                     /gene_synonym="2700067E22Rik; C130081E20"
                     /note="major polyA site"
     regulatory      3121..3126
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Incenp"
                     /gene_synonym="2700067E22Rik; C130081E20"
                     /note="hexamer: AATAAA"
     polyA_site      3140
                     /gene="Incenp"
                     /gene_synonym="2700067E22Rik; C130081E20"
                     /note="major polyA site"
     polyA_site      3181
                     /gene="Incenp"
                     /gene_synonym="2700067E22Rik; C130081E20"
ORIGIN      
        1 gtagattcgc ccgcgctctt cgcccggtag gtcctcgcct gcggcgagct cgcggtactg
       61 ggagtccagc cggtccggcg tggcgggaag cttaatctgc ggaagccgcg gactggaaaa
      121 ggagtggtcc gggaagacgc ggcgccgccg gacagtgcca ccatggggac cacagcccca
      181 gggcctattt gccttctgga tctatgtgac cagaaactcc tggactttgt ctgcaatgtg
      241 gacaacaagg acttcatgtg gctcaaggag attgaggagg aggctgagcg catgtttatc
      301 agagaattca gcaatgagcc agagctgatg cccaaaactc cttctcagaa aaaccgtcgg
      361 aagaagaggc gggtgtctaa cattcaggat gaaaacagag atcccgtgag gaaaaggtta
      421 tcccgcagaa agtctcggag cagtcaggtg ggtacccggc acctccgcag caagcccgtt
      481 actattgttg aggagaatgg cttccctgtg ttgcagcgga taacccgggc cacagctgca
      541 gcagcggcag cagcagcggc agcgtctgtg gcatcagctt cttcctcttc cactgctggg
      601 tctcccacag tgctgaccaa gaaagcagtg gtggagataa gcactagtga acgactgagt
      661 gcagaactac aactcactaa gctcaaaggt agccttcctc catctccagt ttcccaaggc
      721 accctgacat cagaggagga actaacaccc aagaaatcag aggctggaaa gctggactct
      781 gtcacagtga actccctcaa ggctacccct cagagcccca agaaccgagg ggttggggaa
      841 ggacgttctg tttccaagct caagattgct cgggcctcct gggggctgca ggactctcct
      901 ggctctacag actcaccatg gcaagagcgg gtgctttctc ctatcctgct gaataacatc
      961 ttgcccacaa cagccaagag ccctcttggg aatattcggt cagtgcggcg aagcctgatt
     1021 tcccaggatt cccaagtgcc actagcctcg aagtataatt tggtggccaa acaagaaaat
     1081 ggcagtcgca gatcaagcag aaggattgcc aagaaggctg gcaaagagcc agaggcctct
     1141 gctcgaatca tttgtcacag ttacctggag aggctcctga atgttgaagt gcctcagaat
     1201 gttggcctgg agcaggagcc tgtcgaggtg gccgaacctg aggaggcaga agaggagcaa
     1261 gaggtctcca agaacagtgg gtgtccctcc aaaccccgca gtgccaccaa gattgcgatt
     1321 agtacgccca cctcgaagcc tgcggccgct ggtcagacaa caactgttga agagcaagaa
     1381 gctgagcttg accaaacaga tggacacaga gaaccacccc agagtgtcag gaggaaacgc
     1441 agttacaaac aggcaataag tgaaccggat gaggagcaac tggaagatga agaactgcag
     1501 ccctgccaga ataagacccc ttccccaccc tgtccagcca acaaggtggt acggcccctc
     1561 cggactttcc tgcacacagt gcagaagaac cagatgctca tgacccccac actggcctcc
     1621 cgcagcagtg tcatgaagtc ctttattaaa cgcaacactc cgcttcgtgt ggaccctaag
     1681 tgcagctttg ttgagaagga gcgccagcgc ctagagagcc tgcgacggaa ggaggaggcc
     1741 gagcagcggc gcagacagaa ggtagaggaa gacaagcggc ggcgactgga ggaggtgaag
     1801 ctgaagcgtg aagagcgcct ccgcaaggtg ttgcaggccc gtgagagggt ggaacagatg
     1861 aaggaggaaa agaagaagca gattgagcag aagtttgctc agattgatga gaagacagaa
     1921 aaggctaagg aggagcgtct ggcagagaag gcaaagaaga aggcaactgc caagaagatg
     1981 gaagaggtag aggcacgaag gaagcaggag gaggaggcac gcaggctcag gtggctccaa
     2041 caggaggaag aggagcggcg gcatcaagaa atgctacaac ggaagaagga ggaagaacag
     2101 gagcgccgca aagcagctga ggccaggcgc ctggcagaac agcgggagca agagaggcga
     2161 agggagcagg agcggcggga gcaggagcgg agggaacagg agcggaggga acaggaacgg
     2221 aaggagcagg agcggcggga gcaggagcag gagcgtcttc gggccaagag ggagatgcag
     2281 gagagagaga aagccctgcg actccaaaag gaacgacttc agaaggaact ggaggagaag
     2341 aagaggaagg aagagcaaca gcgcctggct gagcagcaac tgcaggagga gcaggcaaag
     2401 aaagctaagg aggtggcagc agccaggaaa gtcctgaaca tgactgtgga tgtgcagtct
     2461 cctgtttgta cctcatatca aatgactcca caaggaccca aatccatccc caagatcagc
     2521 gtagacgatt atgggatgga cctaaatagt gatgactcca cagatgatga gtcccacccc
     2581 cggaaaccca tcccttcctg ggccaaaggc acccaactca gccaggccat tgtccaccag
     2641 tactaccacc ctccaaacat tctagagctc ttcggatcta ttctcccact ggacttggag
     2701 gacatcttta agaagaggaa gactcgctac cacaagcgca ctagctctgc tgtttggaac
     2761 tcaccacccc tgaaagccac catggtcccc agcagtgggg actagactat ctagcctgaa
     2821 gagtccatga ggcaggccct cagtcatttt ggagcacagg gcccatgtgt gtctttctgt
     2881 ttgtttctct gtctgttttg atgttgggct ggtgcacttc tgcctgatat gccattgttc
     2941 aggtggctat cagtgtcctc tgtttgtcag gtattcccag acctgttggg aggatgggct
     3001 tcatgcctgg ggaagaacca ggttgagcac tgatggctct gtaggcagta ctctgtaaat
     3061 aaatagattg ttacagttca gttgaatgac ttttagtttc tagggtttgt gaggtagttt
     3121 aataaagtgt atagcccaaa gtctgctgtg gatattgtga agactagagg cttcattgga
     3181 atattgg
//
