LOCUS       NM_001419091            1310 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus inhibitor of CDK, cyclin A1 interacting protein 1
            (Inca1), transcript variant 7, mRNA.
ACCESSION   NM_001419091
VERSION     NM_001419091.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1310)
  AUTHORS   Baumer,N., Baumer,S., Berkenfeld,F., Stehling,M., Kohler,G.,
            Berdel,W.E., Muller-Tidow,C. and Tschanter,P.
  TITLE     Maintenance of leukemia-initiating cells is regulated by the CDK
            inhibitor Inca1
  JOURNAL   PLoS One 9 (12), e115578 (2014)
   PUBMED   25525809
  REMARK    GeneRIF: Results showed that absence of Inca1 mildly affects normal
            hematopoiesis under homeostatic conditions but controls
            hematopoiesis after induction of cytotoxic stress and plays a role
            in the maintenance of leukemia development in acute myeloid
            leukemia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1310)
  AUTHORS   Baumer,N., Tickenbrock,L., Tschanter,P., Lohmeyer,L.,
            Diederichs,S., Baumer,S., Skryabin,B.V., Zhang,F.,
            Agrawal-Singh,S., Kohler,G., Berdel,W.E., Serve,H., Koschmieder,S.
            and Muller-Tidow,C.
  TITLE     Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin
            A1 (INCA1) regulates proliferation and is repressed by oncogenic
            signaling
  JOURNAL   J Biol Chem 286 (32), 28210-28222 (2011)
   PUBMED   21540187
  REMARK    GeneRIF: Inhibitor of cyclin-dependent kinase (CDK) interacting
            with cyclin A1 (INCA1) regulates proliferation and is repressed by
            oncogenic signaling
REFERENCE   3  (bases 1 to 1310)
  AUTHORS   Zhang,F., Baumer,N., Rode,M., Ji,P., Zhang,T., Berdel,W.E. and
            Muller-Tidow,C.
  TITLE     The inhibitor of growth protein 5 (ING5) depends on INCA1 as a
            co-factor for its antiproliferative effects
  JOURNAL   PLoS One 6 (7), e21505 (2011)
   PUBMED   21750715
REFERENCE   4  (bases 1 to 1310)
  AUTHORS   Diederichs,S., Baumer,N., Ji,P., Metzelder,S.K., Idos,G.E.,
            Cauvet,T., Wang,W., Moller,M., Pierschalski,S., Gromoll,J.,
            Schrader,M.G., Koeffler,H.P., Berdel,W.E., Serve,H. and
            Muller-Tidow,C.
  TITLE     Identification of interaction partners and substrates of the cyclin
            A1-CDK2 complex
  JOURNAL   J Biol Chem 279 (32), 33727-33741 (2004)
   PUBMED   15159402
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596117.19.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189682.22106.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               AL596117.19        67284-67516         c
            234-413             AL596117.19        63228-63407         c
            414-527             AL596117.19        57803-57916         c
            528-567             AL596117.19        57547-57586         c
            568-761             AL596117.19        57110-57303         c
            762-921             AL596117.19        56349-56508         c
            922-1310            AL596117.19        55725-56113         c
FEATURES             Location/Qualifiers
     source          1..1310
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 43.21 cM"
     gene            1..1310
                     /gene="Inca1"
                     /note="inhibitor of CDK, cyclin A1 interacting protein 1"
                     /db_xref="GeneID:103844"
                     /db_xref="MGI:MGI:2144284"
     exon            1..233
                     /gene="Inca1"
                     /inference="alignment:Splign:2.1.0"
     exon            234..413
                     /gene="Inca1"
                     /inference="alignment:Splign:2.1.0"
     CDS             370..1065
                     /gene="Inca1"
                     /note="isoform 1 is encoded by transcript variant 7;
                     protein INCA1; inhibitor of CDK interacting with cyclin
                     A1"
                     /codon_start=1
                     /product="protein INCA1 isoform 1"
                     /protein_id="NP_001406020.1"
                     /db_xref="GeneID:103844"
                     /db_xref="MGI:MGI:2144284"
                     /translation="MQGQEDGDSILPFAKCSRVVSRFSPCSLPPQNRRPMPQPYGDAF
                     WENLSQRSSSNWMVEQYIPPILRATDCSRPSLHPLEGLPPPEKLWRRKRKKLHLERMQ
                     KGPGSIPARVRAVTYHLEDLRRRQGIINELKRAQWGSSDATPELPALEEGFELLSTTK
                     YFDVEEERATYPQKETYSVTPRDQLLWTPWTPVGQQGTYASGQLSSLTYSTATARKNP
                     VYDPQAMELESEE"
     exon            414..527
                     /gene="Inca1"
                     /inference="alignment:Splign:2.1.0"
     exon            528..567
                     /gene="Inca1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..761
                     /gene="Inca1"
                     /inference="alignment:Splign:2.1.0"
     exon            762..921
                     /gene="Inca1"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1310
                     /gene="Inca1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1285..1290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Inca1"
                     /note="hexamer: ATTAAA"
     polyA_site      1302
                     /gene="Inca1"
                     /note="major polyA site"
ORIGIN      
        1 aggcgagcca ggcaagtggg gcgaccgggc tcactacgga gctgctcctt cctgcccgac
       61 ctgaggttcc agaactcgct tcgcagttgc ctcaggtgat ggggccaaat gcagagacgt
      121 cgccgacata gccgcacgga cgctctcttc tcagatagcc ttctggtttg actcccggac
      181 cgccgcctca gcccgtcagc cccagtcagc cccagtcagc ccctcaggct caggatgttc
      241 agtccccttc cagtctctag atttgttgat ggtctggtcc ccacagccat tatacgagtg
      301 aatgactcat tgcccattat cctcccagca ccaaggagat ccagtcttgc tacctagcca
      361 agtccagtca tgcagggtca ggaagatgga gacagcatcc ttccttttgc caagtgttcc
      421 agagtggtca gccgattttc accctgcagc ctgcctcccc agaatcgcag accaatgcct
      481 cagccgtatg gagatgcctt ctgggagaat cttagccaaa ggtctagctc caattggatg
      541 gtagaacagt acattccacc aattctgagg gccactgatt gctcccggcc tagcctgcac
      601 cctcttgagg ggctccctcc tcctgagaag ctttggagaa gaaagagaaa gaagctgcat
      661 ttggaaagaa tgcagaaggg acctggaagc attccagccc gagttagagc agttacttat
      721 catctggagg acctgagaag gcgccaggga atcatcaatg aactgaagag ggcccagtgg
      781 ggcagctctg atgctacacc tgaacttcca gcacttgaag agggctttga actcctaagc
      841 actacaaaat actttgacgt ggaagaagag agggcaacct atccacagaa agagacttat
      901 tctgtcactc ccagagatca gctgctttgg actccctgga ctcctgtagg ccagcagggg
      961 acttatgcct ctgggcagct aagctctttg acctacagca ctgctacagc cagaaagaac
     1021 cccgtttacg atccccaggc gatggagttg gagtctgagg agtagtggga aatcatccag
     1081 gcccaagcta cgggacccaa gatcaattca aacatcagga ctccctagtg ctggcttcag
     1141 agcggatgtt ttctatctct gttgtctcca tcccatagcg taggcattca cagcccactt
     1201 gagttcctat ctaactgccc agtacactcg cagccgggtt tttctctagg ccagaacctg
     1261 gtcttgtgtt ctctctgttc tgttattaaa gagcaccaaa tagtcttgtt
//
