LOCUS       NM_028872               2853 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus innate immunity activator (Inava), transcript variant
            1, mRNA.
ACCESSION   NM_028872 XM_283644
VERSION     NM_028872.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2853)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2853)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2853)
  AUTHORS   Mohanan,V., Nakata,T., Desch,A.N., Levesque,C., Boroughs,A.,
            Guzman,G., Cao,Z., Creasey,E., Yao,J., Boucher,G., Charron,G.,
            Bhan,A.K., Schenone,M., Carr,S.A., Reinecker,H.C., Daly,M.J.,
            Rioux,J.D., Lassen,K.G. and Xavier,R.J.
  TITLE     C1orf106 is a colitis risk gene that regulates stability of
            epithelial adherens junctions
  JOURNAL   Science 359 (6380), 1161-1166 (2018)
   PUBMED   29420262
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124550.4.
            
            On Apr 20, 2022 this sequence version replaced NM_028872.3.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is more supported by the available
            transcript and conservation data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053100.1, SRR13948564.5539928.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               AC124550.4         156460-156676       c
            218-366             AC124550.4         150071-150219       c
            367-491             AC124550.4         149337-149461       c
            492-608             AC124550.4         148709-148825       c
            609-831             AC124550.4         147893-148115       c
            832-885             AC124550.4         143629-143682       c
            886-1096            AC124550.4         142688-142898       c
            1097-1270           AC124550.4         142280-142453       c
            1271-1955           AC124550.4         138313-138997       c
            1956-2853           AC124550.4         136078-136975       c
FEATURES             Location/Qualifiers
     source          1..2853
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 59.61 cM"
     gene            1..2853
                     /gene="Inava"
                     /gene_synonym="1700034M08Rik; 4933426C09Rik;
                     5730559C18Rik; D1Mgi54"
                     /note="innate immunity activator"
                     /db_xref="GeneID:67313"
                     /db_xref="MGI:MGI:1921579"
     exon            1..217
                     /gene="Inava"
                     /gene_synonym="1700034M08Rik; 4933426C09Rik;
                     5730559C18Rik; D1Mgi54"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..2048
                     /gene="Inava"
                     /gene_synonym="1700034M08Rik; 4933426C09Rik;
                     5730559C18Rik; D1Mgi54"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C1orf106 homolog; innate immunity
                     activator protein"
                     /codon_start=1
                     /product="innate immunity activator protein isoform 1"
                     /protein_id="NP_083148.4"
                     /db_xref="CCDS:CCDS15325.2"
                     /db_xref="GeneID:67313"
                     /db_xref="MGI:MGI:1921579"
                     /translation="MLQMPKLNEIPPGRGGPGEPWGEGRWAGPTGPEAARPARGARGQ
                     ARGARARWDSWEHSRLPTHPGPGWDQCSPSFLCAPSSQKLIMESKDEVSDSDSGIILQ
                     SGPDSPVSPMKELTNAVRKQQRALEARLEACLEELRRLCLREAELTGTLPAEYPLKPG
                     EKAPKVRRRIGAAYKLDEWALHREDPLSSLERQLALQLQITEAARRLCAEENLSRQAR
                     RQRKHAALQEEKKLRDLQRCLGDRRRNSEPPPTTVPSLGRELSASDDSSLSDGLLLEE
                     EDSQAPKPPPESPAPPSRPLPPQSLEGLQPTGPESGGQERAPIQNSPWKETSLDHPYE
                     KPRKSSELSSESSSPATTPQDQPNPSSLWVLDAASYHVVPIRNVPGQRQGRTSAPATP
                     EMQGRRGQSQSLRVDSFRAGAEGRGRSAFPRRRPTHYTVTVPDSCFTPGKPPLPHPAC
                     HSCSEDSGSDVSSISHPTSPGSSSPDISFLRPLCLPEPPRHRGAWGPACGRELAPHYS
                     KLLLPAGYFPTGRYVMVAEGHLPPGEWELCRAAVGAAYDEEGAPLRYQRLVPSHSRIV
                     RTPSLKDSPAGRGLSKAAVSEELKWWHERARLRSSRPHSLDRQGAFRVRSLPPGRESF
                     GRASGPRTQVPPVYVLRRSTDGAPVQVFVPENGEIISQV"
     exon            218..366
                     /gene="Inava"
                     /gene_synonym="1700034M08Rik; 4933426C09Rik;
                     5730559C18Rik; D1Mgi54"
                     /inference="alignment:Splign:2.1.0"
     exon            367..491
                     /gene="Inava"
                     /gene_synonym="1700034M08Rik; 4933426C09Rik;
                     5730559C18Rik; D1Mgi54"
                     /inference="alignment:Splign:2.1.0"
     exon            492..608
                     /gene="Inava"
                     /gene_synonym="1700034M08Rik; 4933426C09Rik;
                     5730559C18Rik; D1Mgi54"
                     /inference="alignment:Splign:2.1.0"
     exon            609..831
                     /gene="Inava"
                     /gene_synonym="1700034M08Rik; 4933426C09Rik;
                     5730559C18Rik; D1Mgi54"
                     /inference="alignment:Splign:2.1.0"
     exon            832..885
                     /gene="Inava"
                     /gene_synonym="1700034M08Rik; 4933426C09Rik;
                     5730559C18Rik; D1Mgi54"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1096
                     /gene="Inava"
                     /gene_synonym="1700034M08Rik; 4933426C09Rik;
                     5730559C18Rik; D1Mgi54"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1270
                     /gene="Inava"
                     /gene_synonym="1700034M08Rik; 4933426C09Rik;
                     5730559C18Rik; D1Mgi54"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1955
                     /gene="Inava"
                     /gene_synonym="1700034M08Rik; 4933426C09Rik;
                     5730559C18Rik; D1Mgi54"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2853
                     /gene="Inava"
                     /gene_synonym="1700034M08Rik; 4933426C09Rik;
                     5730559C18Rik; D1Mgi54"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2819..2824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Inava"
                     /gene_synonym="1700034M08Rik; 4933426C09Rik;
                     5730559C18Rik; D1Mgi54"
                     /note="hexamer: AATAAA"
     polyA_site      2853
                     /gene="Inava"
                     /gene_synonym="1700034M08Rik; 4933426C09Rik;
                     5730559C18Rik; D1Mgi54"
                     /note="major polyA site"
ORIGIN      
        1 actgggcctt tggtatgccc caggggacag atgtcttggg atctttaaca tttgggatgc
       61 tgcaaatgcc gaagttaaat gaaatacctc cggggagggg aggcccgggg gagccttggg
      121 gagagggaag atgggcggga ccaacaggtc ctgaagctgc gcgaccggcg cggggggcgc
      181 gggggcaggc gcgaggcgcc agagctcggt gggacagctg ggaacactcc agactaccta
      241 cacatcctgg cccaggctgg gaccagtgca gcccctcctt cctctgtgcc ccctcttccc
      301 agaaactcat catggagagt aaggatgaag tcagtgactc cgacagcggc atcatcctgc
      361 agtctggccc ggacagccct gtctctccaa tgaaagagct gaccaatgca gtacgcaagc
      421 agcagagggc tctggaagcg aggctggagg cctgcctgga ggagctgcgc agactctgcc
      481 tgagggaggc ggagctgact gggactttgc cggcagagta tccccttaag cctggtgaga
      541 aggcccccaa ggtccggcgc aggatcggag cagcgtacaa gctggatgag tgggccctcc
      601 acagagagga ccccctgagc agcctagagc gccagttggc tctgcagctt cagatcaccg
      661 aggcggctcg aaggctgtgt gcagaggaga acctcagcag acaggcacgc aggcagcgga
      721 agcacgctgc gctgcaggag gagaagaagc tgcgggacct tcagcgttgc ctgggtgatc
      781 ggcggcggaa cagtgagccc cctcctacca ctgtgccctc cctgggcaga gaactcagtg
      841 cctctgacga cagctccctg tctgatgggc tgctcctgga ggaagaagac tcccaagcgc
      901 caaaacctcc cccagagtca ccggcaccac cttcgcggcc tctcccaccc cagagccttg
      961 agggcctaca gccaacagga cctgagtctg gcggccagga acgggctccc atccaaaaca
     1021 gtccctggaa ggagaccagc ctggaccacc cctatgagaa gcccaggaag tcttctgagc
     1081 tcagtagcga gtccagcagc ccggccacca ctcctcagga ccagcccaac ccttccagcc
     1141 tgtgggtgct ggatgctgcc tcttaccacg tggtccccat ccgaaatgtt cccggccagc
     1201 gtcagggccg caccagtgcc ccagccaccc ctgagatgca gggcaggagg ggccagtcac
     1261 agtctctgag ggtggactcc ttccgagcag gcgcggaggg ccgaggtcgc agtgcctttc
     1321 cccgccgccg ccccactcat tacacagtga cagtgccaga ctcctgcttc acacccggca
     1381 agcccccact gccacaccct gcctgccatt cctgctctga agacagtggc tctgatgtct
     1441 ccagcatctc ccatcccacc tcacctggca gcagcagtcc agacatctcc tttctgaggc
     1501 ccctctgtct ccctgagcca cctcgccacc gtggggcctg gggcccagcc tgtggcagag
     1561 agctggcccc tcattactct aaacttctgc tacccgctgg atacttccca acggggcgct
     1621 atgtgatggt ggccgagggc cacctgccgc cgggcgagtg ggagctgtgt cgtgcagccg
     1681 tgggtgctgc ctatgacgag gaaggtgcac ccctgcgtta ccagcgactg gtaccctccc
     1741 acagccgcat tgtgcgcaca ccctcactaa aggacagtcc tgcgggccgg ggactcagca
     1801 aggcagcagt ctcggaggag ctcaagtggt ggcatgaacg cgcacgtctc cggagcagcc
     1861 gcccccactc gctcgaccgc caaggggcgt tccgtgttag gagtctgcct cctgggaggg
     1921 agagcttcgg gcgggcctca ggacccagga cacaggtgcc ccccgtgtac gtactccgga
     1981 ggtcgacgga cggggcccca gtgcaagtct ttgtgcctga gaacggagag attatcagcc
     2041 aagtgtaact cttctgaacg ccttgcctcg tgcgggaaaa gacttttcta ttggagctgg
     2101 ggtcgaggac cccctcaccc ttaagtgctt ctttcatctc ccctcccctc atcgcaggcc
     2161 gatgatgcag agctgagacc tttcggtttt tttacatgtg tttcccagaa gtcctgacct
     2221 gaggatttat atctgtgatt tgtcttattc tttaataaca tgattatgct ttatccccca
     2281 gagtctggcc ttttggacta atgtcgagct ggactaatcg acagcatttg tctccttatg
     2341 taggacaagt ggcatagagg gccccttgag acgtcccata tgctctgggc cctctttctg
     2401 agatacctgt tgcttcttaa ggctggaggc cggatgtggg actccctcaa cagggactct
     2461 tcccttgttt cccagatgct gggcagaact ctcctctccc cttcagggca caggcatttc
     2521 tgtcatggtg ttcttcccat accctacagt agtcccaacc tccacttgcc atattgtatg
     2581 gcttctgagc cccttcccca gtgcatagat gccccccccc caacccagtg tattctctgg
     2641 atccctaagt gccttagatc ctgagccaca gagctgagag acttctgagt gctagtgcct
     2701 ccccacacct gagcatcctt cacattaatt aacttattgg tcttacctaa cagctatctc
     2761 gtgtggttgc accgtggcgg tgccctccgt tacagggcaa ccttgtgcca aatacttcaa
     2821 taaaatctga ttggcccagc tgaggatgaa gga
//
