LOCUS       NM_146100               3273 bp    mRNA    linear   ROD 11-OCT-2024
DEFINITION  Mus musculus internexin neuronal intermediate filament protein,
            alpha (Ina), mRNA.
ACCESSION   NM_146100 NM_010563
VERSION     NM_146100.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3273)
  AUTHORS   Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L.,
            Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D.,
            Chen,J., Cui,G., Suo,S. and Peng,G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3273)
  AUTHORS   Zhao,L., Song,W. and Chen,Y.G.
  TITLE     Mesenchymal-epithelial interaction regulates gastrointestinal tract
            development in mouse embryos
  JOURNAL   Cell Rep 40 (2), 111053 (2022)
   PUBMED   35830795
REFERENCE   3  (bases 1 to 3273)
  AUTHORS   Lee,D.R., Rhodes,C., Mitra,A., Zhang,Y., Maric,D., Dale,R.K. and
            Petros,T.J.
  TITLE     Transcriptional heterogeneity of ventricular zone cells in the
            ganglionic eminences of the mouse forebrain
  JOURNAL   Elife 11, e71864 (2022)
   PUBMED   35175194
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3273)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3273)
  AUTHORS   Morandell,J., Schwarz,L.A., Basilico,B., Tasciyan,S., Dimchev,G.,
            Nicolas,A., Sommer,C., Kreuzinger,C., Dotter,C.P., Knaus,L.S.,
            Dobler,Z., Cacci,E., Schur,F.K.M., Danzl,J.G. and Novarino,G.
  TITLE     Cul3 regulates cytoskeleton protein homeostasis and cell migration
            during a critical window of brain development
  JOURNAL   Nat Commun 12 (1), 3058 (2021)
   PUBMED   34031387
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3273)
  AUTHORS   Chan,S.O. and Chiu,F.C.
  TITLE     The 66-kDa neurofilament protein (NF-66): sequence analysis and
            evolution
  JOURNAL   Neurochem Res 21 (4), 449-455 (1996)
   PUBMED   8734438
REFERENCE   7  (bases 1 to 3273)
  AUTHORS   Chien,C.L. and Liem,R.K.
  TITLE     The neuronal intermediate filament, alpha-internexin is transiently
            expressed in amacrine cells in the developing mouse retina
  JOURNAL   Exp Eye Res 61 (6), 749-756 (1995)
   PUBMED   8846847
REFERENCE   8  (bases 1 to 3273)
  AUTHORS   Dahlstrand,J., Lardelli,M. and Lendahl,U.
  TITLE     Nestin mRNA expression correlates with the central nervous system
            progenitor cell state in many, but not all, regions of developing
            central nervous system
  JOURNAL   Brain Res Dev Brain Res 84 (1), 109-129 (1995)
   PUBMED   7720210
REFERENCE   9  (bases 1 to 3273)
  AUTHORS   Chien,C.L. and Liem,R.K.
  TITLE     Characterization of the mouse gene encoding the neuronal
            intermediate filament protein alpha-internexin
  JOURNAL   Gene 149 (2), 289-292 (1994)
   PUBMED   7959004
REFERENCE   10 (bases 1 to 3273)
  AUTHORS   Ching,G.Y. and Liem,R.K.
  TITLE     Structure of the gene for the neuronal intermediate filament
            protein alpha-internexin and functional analysis of its promoter
  JOURNAL   J Biol Chem 266 (29), 19459-19468 (1991)
   PUBMED   1717465
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY735610.1, BC018383.1, CA321793.1 and BE986602.1.
            
            On Jul 25, 2018 this sequence version replaced NM_146100.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2323184.1,
                                           SRR7345562.3320323.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BY735610.1         499-515             c
            18-2288             BC018383.1         1-2271
            2289-2700           CA321793.1         196-607
            2701-3273           BE986602.1         1-573               c
FEATURES             Location/Qualifiers
     source          1..3273
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 39.07 cM"
     gene            1..3273
                     /gene="Ina"
                     /gene_synonym="alpha-Inx; NF-66; NF66"
                     /note="internexin neuronal intermediate filament protein,
                     alpha"
                     /db_xref="GeneID:226180"
                     /db_xref="MGI:MGI:96568"
     exon            1..1139
                     /gene="Ina"
                     /gene_synonym="alpha-Inx; NF-66; NF66"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1580
                     /gene="Ina"
                     /gene_synonym="alpha-Inx; NF-66; NF66"
                     /note="neurofilament-66; 66 kDa neurofilament protein"
                     /codon_start=1
                     /product="alpha-internexin"
                     /protein_id="NP_666212.3"
                     /db_xref="CCDS:CCDS38013.1"
                     /db_xref="GeneID:226180"
                     /db_xref="MGI:MGI:96568"
                     /translation="MSFGSEHYLCSASSYRKVFGDSSRLSARLSGPGGSGSFRSQSLS
                     RSNVASTAACSSASSLGLGLAYRRLPASDGLDLSQAAARTNEYKIIRTNEKEQLQGLN
                     DRFAVFIEKVHQLETQNRALEAELAALRQRHAEPSRVGELFQRELRELRAQLEEASSA
                     RAQALLERDGLAEEVQRLRARCEEESRGREGAERALKAQQRDVDGATLARLDLEKKVE
                     SLLDELAFVRQVHDEEVAELLATLQASSQAAAEVDVAVAKPDLTSALREIRAQYESLA
                     AKNLQSAEEWYKSKFANLNEQAARSTEAIRASREEIHEYRRQLQARTIEIEGLRGANE
                     SLERQILELEERHSAEVAGYQDSIGQLESDLRNTKSEMARHLREYQDLLNVKMALDIE
                     IAAYRKLLEGEETRFSTGGLSISGLNPLPNPSYLLPPRILSSTASKVSSAGLSLKKEE
                     EEEEEEASKEVSKKTSKVGEGFEETLGEAVISTKKTGKSATEESTSSSQKM"
     exon            1140..1264
                     /gene="Ina"
                     /gene_synonym="alpha-Inx; NF-66; NF66"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..3257
                     /gene="Ina"
                     /gene_synonym="alpha-Inx; NF-66; NF66"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3238..3243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ina"
                     /gene_synonym="alpha-Inx; NF-66; NF66"
                     /note="hexamer: ATTAAA"
     polyA_site      3257
                     /gene="Ina"
                     /gene_synonym="alpha-Inx; NF-66; NF66"
                     /note="major polyA site"
ORIGIN      
        1 acccagcctt gccgcacctt cgcgtcctcg ccaggtcccg ccgcagccgc gcacccggcc
       61 ccgaccccgg caccatgagc ttcggatcgg agcactattt gtgctccgcc tcctcctacc
      121 gcaaggtgtt cggggacagc tcgcgcctct ccgcgcgcct gtccgggccg ggaggctcgg
      181 gcagcttccg ctcgcagtcg ctgtcccgca gcaatgtggc ctccacggcc gcctgctcct
      241 cggcctcgtc cctcggcctg ggcctggcct accgccgcct gccggcctcc gacgggctgg
      301 acctgagcca ggcggcggcg cgcaccaacg agtacaagat catccgcact aacgagaagg
      361 agcagctgca gggcctcaac gaccgcttcg ccgtgttcat cgagaaggtg caccagctgg
      421 agacgcagaa ccgtgcgctc gaggccgagc tggccgcgct gcgccagcgc cacgccgagc
      481 cgtcgcgcgt cggcgagctc ttccagcgcg agctgcgcga gctgcgcgcg cagctggagg
      541 aggcgagctc ggcgcgcgcg caggccctgc tggagcgcga tgggctggcc gaggaggtgc
      601 agcgactgcg ggcgcgctgc gaggaggaga gccgcgggcg cgaaggcgcc gagcgcgccc
      661 tgaaggcgca gcagcgcgac gtggacggcg ccaccctggc ccgcctggat ctggagaaga
      721 aggtggagtc gctgctggac gagctggctt tcgtgcgcca ggtccacgac gaggaggtgg
      781 ccgagctcct ggccacgttg caggcgtctt cgcaagccgc cgccgaggtg gacgtggccg
      841 tggctaaacc agacctgact tcggcgctga gggagatccg cgcgcagtat gagtccctgg
      901 ccgctaagaa cctgcagtcc gccgaggagt ggtacaagtc caagttcgcc aacctaaacg
      961 agcaggctgc gcgcagcacc gaagccatcc gagccagccg agaggagatc cacgagtacc
     1021 ggcgccagct ccaggcacgt accattgaga tagagggtct gcgcggagcc aatgagtccc
     1081 tggagaggca gatcttggaa ctggaggagc ggcacagcgc tgaggtggcc ggctaccagg
     1141 acagcattgg gcagctggaa agtgacctga ggaacacaaa aagcgagatg gcacgccacc
     1201 ttcgggaata ccaggacttg ctcaatgtca aaatggccct tgacattgag atcgcagctt
     1261 acaggaagct cctggaaggt gaagagacgc ggtttagcac cggcgggtta agcatctcgg
     1321 ggctgaatcc actgcccaat cccagttatt tgctccctcc cagaatcctt agctctacag
     1381 cctccaaagt ctcctctgcc gggctgtccc tgaaaaagga ggaagaagag gaggaggaag
     1441 aggcctctaa ggaagtcagt aagaaaacat ccaaggtagg ggaaggtttc gaagagacac
     1501 tgggggaagc ggtaatatct acgaagaaaa ctggaaagtc ggctacagaa gaaagtacca
     1561 gttcaagcca aaaaatgtaa tgccgctgct tgagaaaaag tcgatgcctg ggagggaatg
     1621 cacttggctc attcacggca cactcctgaa ccacacccac caccgctata gaatgtctgc
     1681 aaggcttcag cgtcattgta ccgacccctt acgttctcca gtaggaaggc cactgtagac
     1741 gggcgcaagc tgcagtcctg gagcagagga ggagttctcc aagaacacag ctttctcacc
     1801 cacagttcag gcttcctggt gacaggtgac tcaggtgcag aggaagtgca aatgaaggtg
     1861 ctaaatctgc tcatccctca ctgggagctg aaacggaaac ctatgtttat ccactggacc
     1921 ccgccaggcc ccagccatag aaccttactg tagatgccta aaagcataca atcactgcag
     1981 aggacaagct agtgctccag acaccgctcc ccagccccct ccgatagagc cgagtcacca
     2041 cacacgtctc tcatgggcac atgccttcca ctcttcaatc ccataattcc tttctcgcac
     2101 ccaagaggaa ggaacagagt ttagtgtagc atccccttct agccacgcat agaacgtatg
     2161 ccctttagct agctcttctt cactctgtgg gtaaaattag ctgcatgctg gccatccctg
     2221 tgatttgtgt aactcacccc tgcccatttc atgtcctttc acatctgtag ctttaaaaaa
     2281 aaaaaaaaga aaaagattaa tgataacggc agtgattagt tttaaggatt ttcctaaaaa
     2341 taaataaata aataaacata aaagggatct ctaggcttta ggctttcagg ttgtccagat
     2401 ccacttaatt agaggggaaa aaatacctta aatgatgtag catttcactt taactgtaga
     2461 agcacggtga taattaccct gcgctgtgct ttagcgctga ccttagacct cgtagtgtaa
     2521 atagaggaag agtactctct gaaggggaag aacaaggtct cctctgtgtt gggttccatg
     2581 tagtggcgta gaattcgctt tctcgtaccc ttgccctaga atctacatag tccccttccc
     2641 attaggatag gtcctcaaga ggccttgctt ttttaagtat gctatgtata ggacatttta
     2701 tcaccagaca caatgctacc acccaaaagt gaaaaaacac acaaaaaaaa gccacatctg
     2761 gtcaatcaac accaccagca gatattaaag aaagaaagaa aaaagaaaca aacttttctt
     2821 cagagtcttt ccccaacagg gttacattgc ttcagttggt gggtgtccct cccccaaagg
     2881 aaaggcagaa acattcagga tccaggaggg gtatacacac ttctcccacc tcacggaggc
     2941 aggctggaaa gtcagctctt tctgcaccca actgcggcat ccacacgacc agtctgcctc
     3001 atgtgccaaa tcaggctttg ccctgtctct gctcacttcc accagagctc tggaactgtc
     3061 tgtcctgtcc ccgcccactc catcgcaagc tctgtgctgc caaggacatg acgcatctgt
     3121 tgaactcaca ttctagcacg tgcttcaata gctcaaggaa ccgaaaagac actttgcttt
     3181 tcctgaccca tccctctctc cctctaccct tactgtaaga cattagtaat ctaagaaatt
     3241 aaaagtcatt aatcctaaaa aaaaaaaaaa aaa
//
