LOCUS       NM_022016               3587 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus interphotoreceptor matrix proteoglycan 1 (Impg1),
            mRNA.
ACCESSION   NM_022016 XM_986383
VERSION     NM_022016.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3587)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3587)
  AUTHORS   Williams,B.N., Draper,A., Lang,P.F., Lewis,T.R., Smith,A.L.,
            Mayerl,S.J., Rougie,M., Simon,J.M., Arshavsky,V.Y., Greenwald,S.H.,
            Gamm,D.M., Pinilla,I. and Philpot,B.D.
  TITLE     Heterogeneity in the progression of retinal pathologies in mice
            harboring patient mimicking Impg2 mutations
  JOURNAL   Hum Mol Genet 33 (5), 448-464 (2024)
   PUBMED   37975905
  REMARK    Erratum:[Hum Mol Genet. 2024 Feb 18;33(5):475-476. doi:
            10.1093/hmg/ddae004.. PMID: 38217426]
REFERENCE   3  (bases 1 to 3587)
  AUTHORS   Mitchell,B., Coulter,C., Geldenhuys,W.J., Rhodes,S. and Salido,E.M.
  TITLE     Interphotoreceptor matrix proteoglycans IMPG1 and IMPG2 proteolyze
            in the SEA domain and reveal localization mutual dependency
  JOURNAL   Sci Rep 12 (1), 15535 (2022)
   PUBMED   36109576
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3587)
  AUTHORS   Olivier,G., Brabet,P., Pirot,N., Broyon,M., Guillou,L.,
            Cazevieille,C., Sar,C., Quiles,M., Sarzi,E., Pequignot,M.,
            Andreo,E., Roubertie,A., Meunier,I., Muller,A., Kalatzis,V. and
            Manes,G.
  TITLE     SPACR Encoded by IMPG1 Is Essential for Photoreceptor Survival by
            Interplaying between the Interphotoreceptor Matrix and the Retinal
            Pigment Epithelium
  JOURNAL   Genes (Basel) 13 (9), 1508 (2022)
   PUBMED   36140676
  REMARK    GeneRIF: SPACR Encoded by IMPG1 Is Essential for Photoreceptor
            Survival by Interplaying between the Interphotoreceptor Matrix and
            the Retinal Pigment Epithelium.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3587)
  AUTHORS   Salido,E.M. and Ramamurthy,V.
  TITLE     Proteoglycan IMPG2 Shapes the Interphotoreceptor Matrix and
            Modulates Vision
  JOURNAL   J Neurosci 40 (20), 4059-4072 (2020)
   PUBMED   32265257
  REMARK    Erratum:[J Neurosci. 2020 Aug 19;40(34):6660. doi:
            10.1523/JNEUROSCI.1846-20.2020.. PMID: 32737169]
REFERENCE   6  (bases 1 to 3587)
  AUTHORS   Zako,M., Iwaki,M., Yoneda,M., Miyaishi,O., Zhao,J., Suzuki,Y.,
            Takeuchi,M., Miyake,G., Ikagawa,H. and Kimata,K.
  TITLE     Molecular cloning and characterization of chick sialoprotein
            associated with cones and rods, a developmentally regulated
            glycoprotein of interphotoreceptor matrix
  JOURNAL   J Biol Chem 277 (28), 25592-25600 (2002)
   PUBMED   11991949
REFERENCE   7  (bases 1 to 3587)
  AUTHORS   Lee,J.W., Chen,Q., Rayborn,M.E., Shadrach,K.G., Crabb,J.W.,
            Rodriguez,I.R. and Hollyfield,J.G.
  TITLE     SPACR in the interphotoreceptor matrix of the mouse retina:
            molecular, biochemical and immunohistochemical characterization
  JOURNAL   Exp Eye Res 71 (4), 341-352 (2000)
   PUBMED   10995555
REFERENCE   8  (bases 1 to 3587)
  AUTHORS   Kuehn,M.H., Wietecki,D.T. and Hageman,G.S.
  TITLE     Molecular characterization of the murine orthologue of the human
            retinal proteoglycan IPM 150
  JOURNAL   Mol Vis 6, 148-156 (2000)
   PUBMED   10958699
  REMARK    GeneRIF: Murine orthologue of the human retinal glycoprotein IPM
            150 (IMPG1), involved in retinal adhesion and photoreceptor cell
            survival.  Analyses of IPM 150 and IPM 200 core proteins reveals
            the presence of multiple conserved domain of unknown function.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK020862.1, BC022970.1 and AC120388.11.
            
            On Oct 20, 2007 this sequence version replaced NM_022016.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF266478.1, BC022970.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849374,
                                           SAMN00849375 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AK020862.1         2-13
            13-2922             BC022970.1         1-2910
            2923-3587           AC120388.11        65990-66654
FEATURES             Location/Qualifiers
     source          1..3587
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 43.99 cM"
     gene            1..3587
                     /gene="Impg1"
                     /gene_synonym="A930015H12Rik; IMP150; SPACR"
                     /note="interphotoreceptor matrix proteoglycan 1"
                     /db_xref="GeneID:63859"
                     /db_xref="MGI:MGI:1926876"
     exon            1..216
                     /gene="Impg1"
                     /gene_synonym="A930015H12Rik; IMP150; SPACR"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..2546
                     /gene="Impg1"
                     /gene_synonym="A930015H12Rik; IMP150; SPACR"
                     /note="IPM-150; sialoprotein associated with cones and
                     rods; interphotoreceptor matrix proteoglycan of 150 kDa"
                     /codon_start=1
                     /product="interphotoreceptor matrix proteoglycan 1
                     precursor"
                     /protein_id="NP_071299.3"
                     /db_xref="CCDS:CCDS57685.1"
                     /db_xref="GeneID:63859"
                     /db_xref="MGI:MGI:1926876"
                     /translation="MNLQIKHAIFVLGIFLQVQGIKDTSIKIFSSEIKNIDKTPRIET
                     IESTSTVHKVSTMKRIFDLPKLRTKRSALFPAANICPQESLRQILASLQEYYRLRVCQ
                     EVVWEAYRIFLDRIPDTEEYQDWVSLCQKETFCLFDIGKNFSNSQEHLDLLQQRIKQR
                     SFPGRKDETASMETLEAPTEAPVVPTDVSRMSLGPFPLPSDDTDLKEILSVTLKDIQK
                     PTTESKTEPIHVSEFSSEEKVEFSISLPNHRFKAELTNSGSPYYQELVGQSQLQLQKI
                     FKKLPGFGEIRVLGFRPKKEEDGSSSTEIQLMAIFKRDHAEAKSPDSHLLSLDSNKIE
                     SERIHHGVIEDKQPETYLTATDLKKLIIQLLDGDLSLVEGKIPFGDEVTGTLFRPVTE
                     PDLPKPLADVTEDATLSPELPFVEPRLEAVDREGSELPGMSSKDSSWSPPVSASISRS
                     ENLPSFTPSIFSLDAQSPPPLMTTGPTALIPKPTLPTIDYSTIRQLPLESSHWPASSS
                     DRELITSSHDTIRDLDGMDVSDTPALSEISELSGYDSASGQFLEMTTPIPTVRFITTS
                     SETIATKGQELVVFFSLRVANMPFSYDLFNKSSLEYQALEQRFTDLLVPYLRSNLTGF
                     KQLEILSFRNGSVIVNSKVRFAKAVPYNLTQAVRGVLEDLRSTAAQGLNLEIESYSLD
                     IEPADQADPCKLLDCGKFAQCVKNEWTEEAECRCRQGHESHGTLDYQTLNLCPPGKTC
                     VAGREQATPCRPPDHSTNQAQEPGVKKLRQQNKVVKKRNSKLSAIGFEEFEDQDWEGN
                     "
     exon            217..447
                     /gene="Impg1"
                     /gene_synonym="A930015H12Rik; IMP150; SPACR"
                     /inference="alignment:Splign:2.1.0"
     exon            448..614
                     /gene="Impg1"
                     /gene_synonym="A930015H12Rik; IMP150; SPACR"
                     /inference="alignment:Splign:2.1.0"
     exon            615..643
                     /gene="Impg1"
                     /gene_synonym="A930015H12Rik; IMP150; SPACR"
                     /inference="alignment:Splign:2.1.0"
     exon            644..708
                     /gene="Impg1"
                     /gene_synonym="A930015H12Rik; IMP150; SPACR"
                     /inference="alignment:Splign:2.1.0"
     exon            709..812
                     /gene="Impg1"
                     /gene_synonym="A930015H12Rik; IMP150; SPACR"
                     /inference="alignment:Splign:2.1.0"
     exon            813..965
                     /gene="Impg1"
                     /gene_synonym="A930015H12Rik; IMP150; SPACR"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1024
                     /gene="Impg1"
                     /gene_synonym="A930015H12Rik; IMP150; SPACR"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1045
                     /gene="Impg1"
                     /gene_synonym="A930015H12Rik; IMP150; SPACR"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1290
                     /gene="Impg1"
                     /gene_synonym="A930015H12Rik; IMP150; SPACR"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1361
                     /gene="Impg1"
                     /gene_synonym="A930015H12Rik; IMP150; SPACR"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1440
                     /gene="Impg1"
                     /gene_synonym="A930015H12Rik; IMP150; SPACR"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1985
                     /gene="Impg1"
                     /gene_synonym="A930015H12Rik; IMP150; SPACR"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2205
                     /gene="Impg1"
                     /gene_synonym="A930015H12Rik; IMP150; SPACR"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2401
                     /gene="Impg1"
                     /gene_synonym="A930015H12Rik; IMP150; SPACR"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2468
                     /gene="Impg1"
                     /gene_synonym="A930015H12Rik; IMP150; SPACR"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..3587
                     /gene="Impg1"
                     /gene_synonym="A930015H12Rik; IMP150; SPACR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2542..2547
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Impg1"
                     /gene_synonym="A930015H12Rik; IMP150; SPACR"
                     /note="hexamer: ATTAAA"
     polyA_site      2576
                     /gene="Impg1"
                     /gene_synonym="A930015H12Rik; IMP150; SPACR"
                     /note="major polyA site"
ORIGIN      
        1 agcaccttca tagggtaaac cagggaggtc gtctgtactc agccggcacc tggatttgat
       61 tgtttttcat atttccgtca ccttatttct ttaagtgtga cttggtattg ctctgtgatt
      121 tttcagaatt accagtatac agaaccagaa tgaatttgca aattaaacat gctatctttg
      181 ttttggggat ttttctccaa gttcaaggaa tcaaagatac ctctattaaa atattcagtt
      241 ctgaaattaa aaacatagac aaaaccccaa gaatcgaaac aattgaaagt acttcaacag
      301 tgcacaaagt gtcaaccatg aaacgaatat tcgatttgcc aaagcttcga accaaaagat
      361 cagcactttt cccagctgct aacatctgtc cacaggaatc cttgagacag attttagcaa
      421 gtcttcaaga atattataga ctgagagtat gtcaagaagt cgtgtgggaa gcatatcgta
      481 tctttctgga ccgaattcct gacacagagg aatatcaaga ctgggtcagc ctctgccaga
      541 aagaaacctt ctgcctcttt gacattggga aaaacttcag caactcccag gagcacctag
      601 atcttcttca gcagagaata aaacagagaa gcttccctgg gaggaaagat gagacagcct
      661 ccatggagac actggaagca cctactgaag cccctgtggt acccacagat gtttccagga
      721 tgtccctggg gcccttccca cttccttctg atgacacaga cctcaaggag attctcagtg
      781 tcaccctcaa ggacattcaa aagcccacaa cagaaagtaa aacagaacct attcatgtgt
      841 ctgaattctc atcagaggag aaggtggaat tcagcatctc tctgccaaac cacaggttca
      901 aggcagagct caccaactct gggtcaccat actaccagga actggtggga cagtcccaac
      961 tgcagttgca aaagatattt aagaaacttc caggattcgg agaaatccgt gtattaggat
     1021 ttagaccaaa gaaagaagaa gatggttcaa gctccacaga aatacagctt atggccatct
     1081 ttaagaggga ccatgcagaa gcaaaaagcc ctgatagtca tctactgtct cttgattcca
     1141 acaaaattga aagtgaaaga atccatcatg gagtcataga agacaaacaa ccagaaacct
     1201 acctcacagc tacagacctc aaaaaactca tcatacaact actagatgga gacctgtcct
     1261 tggtagaagg gaaaattcca ttcggtgatg aagttactgg gacactcttc agacctgtca
     1321 ctgaaccaga tctgcccaag ccccttgctg atgtcacaga ggatgccact ttgagtccag
     1381 aacttccttt cgttgagcct aggcttgagg cagtggacag agaaggatct gagctgcctg
     1441 gaatgtcctc caaagacagt tcttggtctc cacctgtatc agcctcaatt tcccgatcag
     1501 aaaatctacc ttcgtttaca cctagcatct tctctctaga tgctcaaagc ccccctccct
     1561 tgatgaccac tggcccaaca gcactcatcc ccaagcccac tctccccact atcgattatt
     1621 ctaccatccg ccaattgcct ctggaatcgt cacattggcc tgcatcctcc agtgacagag
     1681 agctgatcac aagcagccat gacacaatcc gagacctaga tggcatggat gtgtctgaca
     1741 cgccagcctt gtcagaaata tcagaactga gtggatacga ttctgcctcg ggtcagttct
     1801 tggagatgac cacacccatc ccaacagtac ggttcatcac caccagctcc gagaccattg
     1861 ccaccaaggg ccaggagcta gtggtattct tcagcctgcg tgttgctaac atgccgttct
     1921 cctatgacct gttcaacaag agttctctgg agtatcaagc cctggaacaa cgattcacag
     1981 acctgctggt tccctatcta cgatcgaatc ttacgggatt taagcaactg gaaatactca
     2041 gcttcagaaa cggaagtgtg atcgtgaaca gcaaagtgcg gtttgcaaag gcggtaccct
     2101 acaacctcac ccaggccgtg cgcggggtct tggaggatct tcggtccacc gcagctcaag
     2161 ggctcaatct ggaaatcgaa agctactccc tcgacattga accagctgat caggcggatc
     2221 cctgcaaact cctagactgt ggcaaatttg cccagtgtgt aaagaatgag tggacagagg
     2281 aagcagagtg tcgctgcaga cagggacatg agagccacgg gaccctggac taccagaccc
     2341 tgaacctctg tccccctgga aagacttgtg tggccggccg agaacaagca actccatgca
     2401 ggccaccaga tcactctaca aaccaagctc aggaacctgg tgttaaaaag ctacgtcagc
     2461 aaaataaggt agtcaagaaa agaaattcta aactatcagc tataggattt gaagaatttg
     2521 aagaccagga ctgggaggga aattaaaagc tggaatcata tgcattatgt tgcaaactct
     2581 gttgaaagga aactttattt cttaaagaaa ggtgtatctg ttctgttaac ttctgaaaaa
     2641 cagagggaga gattcagtgg tcattggaat acaggcatgt aatcaacttt gagactcagc
     2701 atgcttgaac aagagcacag gcgtgtattt gatgacagtt aagcctggtt ggggcggggg
     2761 gcacatattt ttagtcaaaa ctcaaagcaa tcattggaac acatttgact atttttggac
     2821 agtactcaag tagcaaagat aaggttagct tttttctttc tttaaattat tacataaagc
     2881 ttatttcaaa taaatacaac ttgtttagtg ggttgtacaa tattgaggat ctgattcttt
     2941 tatatgttag aatatacagt taaaagatta tcatttgggc cagagagata gctaagtggt
     3001 taagagtata tactgctctt ccagaagccc tgggtttacg tcccaacagc cacattgact
     3061 ggctcacaca cacctgtaag tcaggctcca gagaacaaac accctcctct ggcctttgta
     3121 cccacgtgca cataaccgca aacagacaca cccacgctat ttttttagag tcattgattt
     3181 ttttaattag gggtggaaaa gcaggctgga gagatgactc cgtggttaag aacagttgtt
     3241 gttcttccag aggacccagg ttcagttccc agaacccaca aggcagtctc ccaactattc
     3301 ataattctag ttcaagtgga tccagcaccc tcttctaact gatactgcca gtaccaggca
     3361 gccatgtggt gcatatgcat ttgggcaggt aaaacactca gacacacaaa aaaattttaa
     3421 atctaaattt tgaaaatatt ttagttttaa ggatgatcac tgtgtgaggg tcaggtctct
     3481 tatgtatgaa tgtagtacca agaactgtga tgagtatatg tatgctccat tctatagtct
     3541 cctctctctc tctctctctc tctctctctc tctctctctc tctctct
//
