LOCUS       NM_011830               1701 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus inosine monophosphate dehydrogenase 2 (Impdh2),
            transcript variant 2, mRNA.
ACCESSION   NM_011830
VERSION     NM_011830.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1701)
  AUTHORS   Xu,C., Wei,Z., Lv,L., Dong,X., Xia,W., Xing,J., Liu,H., Zhao,X.,
            Liu,Y., Wang,W., Jiang,H., Gong,Y., Liu,C., Xu,K., Wang,S.,
            Akimoto,Y. and Hu,Z.
  TITLE     Impdh2 deficiency suppresses osteoclastogenesis through
            mitochondrial oxidative phosphorylation and alleviates
            ovariectomy-induced osteoporosis
  JOURNAL   Biochem Biophys Res Commun 727, 150317 (2024)
   PUBMED   38959733
  REMARK    GeneRIF: Impdh2 deficiency suppresses osteoclastogenesis through
            mitochondrial oxidative phosphorylation and alleviates
            ovariectomy-induced osteoporosis.
REFERENCE   2  (bases 1 to 1701)
  AUTHORS   Hu,J., Zheng,S., Hua,M., Ding,M., Hu,Z. and Jiang,H.
  TITLE     Deletion of Impdh2 in adipocyte precursors limits the expansion of
            white adipose tissue and enhances metabolic health with
            overnutrition
  JOURNAL   Biochem Biophys Res Commun 716, 149998 (2024)
   PUBMED   38692012
  REMARK    GeneRIF: Deletion of Impdh2 in adipocyte precursors limits the
            expansion of white adipose tissue and enhances metabolic health
            with overnutrition.
REFERENCE   3  (bases 1 to 1701)
  AUTHORS   Peng,M., Keppeke,G.D., Tsai,L.K., Chang,C.C., Liu,J.L. and
            Sung,L.Y.
  TITLE     The IMPDH cytoophidium couples metabolism and fetal development in
            mice
  JOURNAL   Cell Mol Life Sci 81 (1), 210 (2024)
   PUBMED   38717553
  REMARK    GeneRIF: The IMPDH cytoophidium couples metabolism and fetal
            development in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1701)
  AUTHORS   Toyoda,S., Handa,T., Yong,H., Takahashi,H. and Shiwaku,H.
  TITLE     IMPDH2 forms spots at branching sites and distal ends of astrocyte
            stem processes
  JOURNAL   Genes Cells 29 (2), 150-158 (2024)
   PUBMED   38009721
  REMARK    GeneRIF: IMPDH2 forms spots at branching sites and distal ends of
            astrocyte stem processes.
REFERENCE   5  (bases 1 to 1701)
  AUTHORS   Peng,M., Chang,C.C., Liu,J.L. and Sung,L.Y.
  TITLE     CTPS and IMPDH form cytoophidia in developmental thymocytes
  JOURNAL   Exp Cell Res 405 (1), 112662 (2021)
   PUBMED   34022203
REFERENCE   6  (bases 1 to 1701)
  AUTHORS   Takenaka,M., Imai,E., Kaneko,T., Ito,T., Moriyama,T., Yamauchi,A.,
            Hori,M., Kawamoto,S. and Okubo,K.
  TITLE     Isolation of genes identified in mouse renal proximal tubule by
            comparing different gene expression profiles
  JOURNAL   Kidney Int 53 (3), 562-572 (1998)
   PUBMED   9507200
REFERENCE   7  (bases 1 to 1701)
  AUTHORS   Lightfoot,T. and Snyder,F.F.
  TITLE     Gene amplification and dual point mutations of mouse IMP
            dehydrogenase associated with cellular resistance to mycophenolic
            acid
  JOURNAL   Biochim Biophys Acta 1217 (2), 156-162 (1994)
   PUBMED   7906545
REFERENCE   8  (bases 1 to 1701)
  AUTHORS   Tiedeman,A.A. and Smith,J.M.
  TITLE     Isolation and sequence of a cDNA encoding mouse IMP dehydrogenase
  JOURNAL   Gene 97 (2), 289-293 (1991)
   PUBMED   1671845
REFERENCE   9  (bases 1 to 1701)
  AUTHORS   Hodges,S.D., Fung,E., McKay,D.J., Renaux,B.S. and Snyder,F.F.
  TITLE     Increased activity, amount, and altered kinetic properties of IMP
            dehydrogenase from mycophenolic acid-resistant neuroblastoma cells
  JOURNAL   J Biol Chem 264 (30), 18137-18141 (1989)
   PUBMED   2572589
REFERENCE   10 (bases 1 to 1701)
  AUTHORS   Astrin,K.H. and Caskey,C.T.
  TITLE     Mutants of purine metabolism in cultured mouse and hamster cells
  JOURNAL   Arch Biochem Biophys 176 (2), 397-410 (1976)
   PUBMED   988789
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT010508.10.
            
            On Mar 13, 2020 this sequence version replaced NM_011830.4.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK169129.1, AK169788.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               CT010508.10        210199-210394
            197-245             CT010508.10        210797-210845
            246-347             CT010508.10        211360-211461
            348-422             CT010508.10        211546-211620
            423-629             CT010508.10        211937-212143
            630-717             CT010508.10        212555-212642
            718-917             CT010508.10        212899-213098
            918-1008            CT010508.10        213184-213274
            1009-1104           CT010508.10        213359-213454
            1105-1248           CT010508.10        214398-214541
            1249-1393           CT010508.10        214629-214773
            1394-1537           CT010508.10        214865-215008
            1538-1621           CT010508.10        215090-215173
            1622-1701           CT010508.10        215261-215340
FEATURES             Location/Qualifiers
     source          1..1701
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.5 cM"
     gene            1..1701
                     /gene="Impdh2"
                     /gene_synonym="IMPD; IMPD 2; IMPDH-II"
                     /note="inosine monophosphate dehydrogenase 2"
                     /db_xref="GeneID:23918"
                     /db_xref="MGI:MGI:109367"
     exon            1..196
                     /gene="Impdh2"
                     /gene_synonym="IMPD; IMPD 2; IMPDH-II"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1643
                     /gene="Impdh2"
                     /gene_synonym="IMPD; IMPD 2; IMPDH-II"
                     /EC_number="1.1.1.205"
                     /note="isoform 2 is encoded by transcript variant 2;
                     inosine-5'-monophosphate dehydrogenase 2; IMP
                     dehydrogenase 2; IMP dehydrogenase type II; inosine
                     5'-phosphate dehydrogenase 2"
                     /codon_start=1
                     /product="inosine-5'-monophosphate dehydrogenase 2 isoform
                     2"
                     /protein_id="NP_035960.2"
                     /db_xref="CCDS:CCDS40768.1"
                     /db_xref="GeneID:23918"
                     /db_xref="MGI:MGI:109367"
                     /translation="MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDF
                     TADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQAN
                     EVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISS
                     RDIDFLKEEEHDRFLEEIMTKREDLVVAPAGVTLKEANEILQRSKKGKLPIVNENDEL
                     VAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLALAGVDVVVLDSS
                     QGNSIFQINMIKYIKEKYPSLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQ
                     EVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAA
                     TTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDK
                     GSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHS
                     YEKRLF"
     exon            197..245
                     /gene="Impdh2"
                     /gene_synonym="IMPD; IMPD 2; IMPDH-II"
                     /inference="alignment:Splign:2.1.0"
     exon            246..347
                     /gene="Impdh2"
                     /gene_synonym="IMPD; IMPD 2; IMPDH-II"
                     /inference="alignment:Splign:2.1.0"
     exon            348..422
                     /gene="Impdh2"
                     /gene_synonym="IMPD; IMPD 2; IMPDH-II"
                     /inference="alignment:Splign:2.1.0"
     exon            423..629
                     /gene="Impdh2"
                     /gene_synonym="IMPD; IMPD 2; IMPDH-II"
                     /inference="alignment:Splign:2.1.0"
     exon            630..717
                     /gene="Impdh2"
                     /gene_synonym="IMPD; IMPD 2; IMPDH-II"
                     /inference="alignment:Splign:2.1.0"
     exon            718..917
                     /gene="Impdh2"
                     /gene_synonym="IMPD; IMPD 2; IMPDH-II"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1008
                     /gene="Impdh2"
                     /gene_synonym="IMPD; IMPD 2; IMPDH-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1104
                     /gene="Impdh2"
                     /gene_synonym="IMPD; IMPD 2; IMPDH-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1248
                     /gene="Impdh2"
                     /gene_synonym="IMPD; IMPD 2; IMPDH-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1393
                     /gene="Impdh2"
                     /gene_synonym="IMPD; IMPD 2; IMPDH-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1537
                     /gene="Impdh2"
                     /gene_synonym="IMPD; IMPD 2; IMPDH-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1621
                     /gene="Impdh2"
                     /gene_synonym="IMPD; IMPD 2; IMPDH-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1701
                     /gene="Impdh2"
                     /gene_synonym="IMPD; IMPD 2; IMPDH-II"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1675..1680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Impdh2"
                     /gene_synonym="IMPD; IMPD 2; IMPDH-II"
                     /note="hexamer: AATAAA"
     polyA_site      1701
                     /gene="Impdh2"
                     /gene_synonym="IMPD; IMPD 2; IMPDH-II"
                     /note="major polyA site"
ORIGIN      
        1 agtttatatt ggcgcggtcc ggacggcaga ggcctctgcg gcgcggtcct cggagcggcg
       61 cggttctcgg agccacgcgt ctgtcttcct ccgtggtcat ggcggactac ctgattagcg
      121 gaggcacctc ttacgtgccg gacgacgggc tcacagcgca gcagctcttc aactgcgggg
      181 acggcctcac ctacaatgat tttctcattc ttcctgggta tatcgacttc actgcagatc
      241 aggtggactt gacgtctgct ctaactaaga agattacact aaagacccca ttggtttcct
      301 cacccatgga cactgtcaca gaggctggaa tggccatcgc gatggcgctt acaggaggta
      361 ttggtttcat ccaccacaac tgcacacctg aattccaggc caatgaagtt cggaaagtga
      421 agaaatacga acagggattc atcactgacc ccgtggtcct tagccccaag gatcgtgtac
      481 gcgatgtttt tgaggccaaa gccaggcatg gcttctgtgg tatccccatc acagatacag
      541 gccggatggg gagtcgattg gtgggcatca tctcctcaag ggacattgat ttcctcaagg
      601 aggaagagca tgaccggttc ttggaagaga tcatgactaa gagggaagat ttggtggtcg
      661 cccctgccgg cgtcactctg aaagaggcaa atgagattct gcagcgaagt aaaaagggaa
      721 agttgcccat tgtgaatgaa aatgatgagc tggtagccat cattgcccgg acagacctaa
      781 agaagaatcg tgattacccc ctggcctcca aagatgccaa gaagcaactg ctgtgtgggg
      841 cagccattgg cactcatgag gatgacaagt ataggctgga cttactggcc cttgctggtg
      901 tggatgtagt ggttttggac tcttcccagg gaaactccat cttccaaatc aatatgatca
      961 aatacatcaa ggagaagtat cccagtctac aggtcattgg aggcaatgta gtcactgctg
     1021 cgcaagccaa gaacctcata gatgcaggtg tagatgcttt gcgagtcggc atgggaagtg
     1081 gttccatctg catcacccag gaagtgttgg cctgtgggcg gccccaagcc acagcagtgt
     1141 acaaggtctc tgagtatgcc cgtcgctttg gtgttcctgt tattgctgat ggaggaatcc
     1201 aaaatgtggg tcatattgcc aaagctttgg ctcttggggc ttccacagtc atgatgggct
     1261 ccctcctggc tgccaccact gaggcccctg gcgagtactt cttctcagat gggatccggc
     1321 tgaagaaata ccgaggtatg ggttctcttg atgccatgga caaacatctc agcagccaga
     1381 accgatactt cagtgaagct gacaaaatca aagtggccca aggagtttca ggggcagtgc
     1441 aggacaaggg gtctatccac aagttcgttc cttacctgat tgctggcatc cagcattcct
     1501 gtcaggacat tggtgccaag agtttaaccc aagtcagagc catgatgtac tcgggggagc
     1561 ttaaatttga gaagaggaca tcctctgctc aggtggaagg tggcgtccac agcctccatt
     1621 cgtacgagaa acggcttttc tgaaaacaga tccagtatat gccttgaatt tttcaataaa
     1681 agtttgggaa aaaaaaagtg a
//
