LOCUS       NM_001302933            2620 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus inosine monophosphate dehydrogenase 1 (Impdh1),
            transcript variant 1, mRNA.
ACCESSION   NM_001302933
VERSION     NM_001302933.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2620)
  AUTHORS   Nabi Afjadi,M., Yazdanparast,R. and Barzegari,E.
  TITLE     The Impact of Terminal Peptide Extensions of Retinal Inosine 5
            Monophosphate Dehydrogenase 1 Isoforms on their DNA-binding
            Activities
  JOURNAL   Protein J 43 (3), 592-602 (2024)
   PUBMED   38733555
  REMARK    GeneRIF: The Impact of Terminal Peptide Extensions of Retinal
            Inosine 5 Monophosphate Dehydrogenase 1 Isoforms on their
            DNA-binding Activities.
REFERENCE   2  (bases 1 to 2620)
  AUTHORS   Peng,M., Chang,C.C., Liu,J.L. and Sung,L.Y.
  TITLE     CTPS and IMPDH form cytoophidia in developmental thymocytes
  JOURNAL   Exp Cell Res 405 (1), 112662 (2021)
   PUBMED   34022203
REFERENCE   3  (bases 1 to 2620)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2620)
  AUTHORS   Plana-Bonamaiso,A., Lopez-Begines,S., Fernandez-Justel,D.,
            Junza,A., Soler-Tapia,A., Andilla,J., Loza-Alvarez,P., Rosa,J.L.,
            Miralles,E., Casals,I., Yanes,O., de la Villa,P., Buey,R.M. and
            Mendez,A.
  TITLE     Post-translational regulation of retinal IMPDH1 in vivo to adjust
            GTP synthesis to illumination conditions
  JOURNAL   Elife 9, e56418 (2020)
   PUBMED   32254022
  REMARK    GeneRIF: Post-translational regulation of retinal IMPDH1 in vivo to
            adjust GTP synthesis to illumination conditions.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2620)
  AUTHORS   Andashti,B., Yazdanparast,R., Barzegari,E. and Galehdari,H.
  TITLE     The functional impact of the C/N-terminal extensions of the mouse
            retinal IMPDH1 isoforms: a kinetic evaluation
  JOURNAL   Mol Cell Biochem 465 (1-2), 155-164 (2020)
   PUBMED   31838626
  REMARK    GeneRIF: The functional impact of the C/N-terminal extensions of
            the mouse retinal IMPDH1 isoforms: a kinetic evaluation.
REFERENCE   6  (bases 1 to 2620)
  AUTHORS   Gu,J.J., Tolin,A.K., Jain,J., Huang,H., Santiago,L. and
            Mitchell,B.S.
  TITLE     Targeted disruption of the inosine 5'-monophosphate dehydrogenase
            type I gene in mice
  JOURNAL   Mol Cell Biol 23 (18), 6702-6712 (2003)
   PUBMED   12944494
  REMARK    GeneRIF: We conclude that both IMPDH and HPRT activities contribute
            to normal T-lymphocyte activation and function
REFERENCE   7  (bases 1 to 2620)
  AUTHORS   Bowne,S.J., Sullivan,L.S., Blanton,S.H., Cepko,C.L., Blackshaw,S.,
            Birch,D.G., Hughbanks-Wheaton,D., Heckenlively,J.R. and Daiger,S.P.
  TITLE     Mutations in the inosine monophosphate dehydrogenase 1 gene
            (IMPDH1) cause the RP10 form of autosomal dominant retinitis
            pigmentosa
  JOURNAL   Hum Mol Genet 11 (5), 559-568 (2002)
   PUBMED   11875050
REFERENCE   8  (bases 1 to 2620)
  AUTHORS   Kennan,A., Aherne,A., Palfi,A., Humphries,M., McKee,A., Stitt,A.,
            Simpson,D.A., Demtroder,K., Orntoft,T., Ayuso,C., Kenna,P.F.,
            Farrar,G.J. and Humphries,P.
  TITLE     Identification of an IMPDH1 mutation in autosomal dominant
            retinitis pigmentosa (RP10) revealed following comparative
            microarray analysis of transcripts derived from retinas of
            wild-type and Rho(-/-) mice
  JOURNAL   Hum Mol Genet 11 (5), 547-557 (2002)
   PUBMED   11875049
  REMARK    GeneRIF: A mutation in this isozyme of Rho-/- mice was revealed in
            comparfative microarray analysis to be a homologue of the putative
            enzyme in human autosomal dominant retinitis pigmentosa.
REFERENCE   9  (bases 1 to 2620)
  AUTHORS   Dayton,J.S. and Mitchell,B.S.
  TITLE     Type I inosine monophosphate dehydrogenase: evidence for a single
            functional gene in mammalian species
  JOURNAL   Biochem Biophys Res Commun 195 (2), 897-901 (1993)
   PUBMED   7690562
REFERENCE   10 (bases 1 to 2620)
  AUTHORS   Astrin,K.H. and Caskey,C.T.
  TITLE     Mutants of purine metabolism in cultured mouse and hamster cells
  JOURNAL   Arch Biochem Biophys 176 (2), 397-410 (1976)
   PUBMED   988789
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY203859.1, AK047537.1, CK619435.1, BC053416.1 and AI844845.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK171139.1, SRR7345562.1139914.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                BY203859.1         2-15
            15-293              AK047537.1         2-280
            294-296             CK619435.1         252-254
            297-1692            AK047537.1         281-1676
            1693-2600           BC053416.1         1501-2408
            2601-2620           AI844845.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..2620
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.36 cM"
     gene            1..2620
                     /gene="Impdh1"
                     /gene_synonym="B930086D20Rik; IMPDH-I"
                     /note="inosine monophosphate dehydrogenase 1"
                     /db_xref="GeneID:23917"
                     /db_xref="MGI:MGI:96567"
     exon            1..293
                     /gene="Impdh1"
                     /gene_synonym="B930086D20Rik; IMPDH-I"
                     /inference="alignment:Splign:2.1.0"
     exon            294..395
                     /gene="Impdh1"
                     /gene_synonym="B930086D20Rik; IMPDH-I"
                     /inference="alignment:Splign:2.1.0"
     exon            396..444
                     /gene="Impdh1"
                     /gene_synonym="B930086D20Rik; IMPDH-I"
                     /inference="alignment:Splign:2.1.0"
     exon            445..546
                     /gene="Impdh1"
                     /gene_synonym="B930086D20Rik; IMPDH-I"
                     /inference="alignment:Splign:2.1.0"
     exon            547..621
                     /gene="Impdh1"
                     /gene_synonym="B930086D20Rik; IMPDH-I"
                     /inference="alignment:Splign:2.1.0"
     exon            622..828
                     /gene="Impdh1"
                     /gene_synonym="B930086D20Rik; IMPDH-I"
                     /inference="alignment:Splign:2.1.0"
     exon            829..916
                     /gene="Impdh1"
                     /gene_synonym="B930086D20Rik; IMPDH-I"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1116
                     /gene="Impdh1"
                     /gene_synonym="B930086D20Rik; IMPDH-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1207
                     /gene="Impdh1"
                     /gene_synonym="B930086D20Rik; IMPDH-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1303
                     /gene="Impdh1"
                     /gene_synonym="B930086D20Rik; IMPDH-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1447
                     /gene="Impdh1"
                     /gene_synonym="B930086D20Rik; IMPDH-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1592
                     /gene="Impdh1"
                     /gene_synonym="B930086D20Rik; IMPDH-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1736
                     /gene="Impdh1"
                     /gene_synonym="B930086D20Rik; IMPDH-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1820
                     /gene="Impdh1"
                     /gene_synonym="B930086D20Rik; IMPDH-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..2603
                     /gene="Impdh1"
                     /gene_synonym="B930086D20Rik; IMPDH-I"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2580..2585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Impdh1"
                     /gene_synonym="B930086D20Rik; IMPDH-I"
                     /note="hexamer: AATAAA"
     polyA_site      2602
                     /gene="Impdh1"
                     /gene_synonym="B930086D20Rik; IMPDH-I"
                     /note="major polyA site"
ORIGIN      
        1 agtagacccc gcccactacc ccgctccctc cgggagcgga ctggggctct tattgcctac
       61 gccggttcgg gagcctccac gcggagaggc tcccgccgcc tagagctgcg gcctccgcat
      121 ggcatggagg aaccgctctc acccccaccg gagtccgggc tgctctcgcc gctgctgcag
      181 ggaggtggag cggctgccgc tccagagccc ggagcccggc aacacccggg acatgagacc
      241 gcggcgcagc ggtacagcgc ccgcctgctg caggccggct acgagccgga gagcagcatg
      301 gcggactacc tgatcagcgg cggcaccggc tacgttcccg aggatgggct caccgcgcag
      361 cagctctttg ccaacgcgga tggcctcacc tacaacgact tcctgatcct cccaggattc
      421 atagacttca tagctgatga agtggacctg acatcagccc tgacccggaa gatcacactg
      481 aagacaccat tgatctcgtc tcccatggat acagtgacag aggctgatat ggccattgca
      541 atggctctca tgggaggaat tggtttcatt catcacaact gtaccccaga gttccaggcc
      601 aatgaagtac ggaaggtcaa gaagtttgag caaggcttca tcacagaccc tgtggtcctg
      661 agcccttcac atactgtggg tgatgttctg gaggccaaga tacagcatgg cttctctggt
      721 atccccatca ccgcgacggg caccatgggg agcaagctgg tgggcatcgt cacctcccga
      781 gacattgact tccttgctga gaaggaccac accaccctcc tcagtgaggt gatgactccg
      841 agggtcgagc tggtggtggc tccagcaggt gtgacattga aagaagcaaa tgagatcttg
      901 cagcgcagca agaaagggaa gctgcccata gtcaacgatc aagatgagct ggtagccatc
      961 attgcgcgca cagacctgaa gaagaacaga gactaccctc tggcctccaa ggactcccac
     1021 aaacagctgt tgtgtggggc agctgtgggc acccgtgagg atgacaaata ccgcctggac
     1081 ctgctcactc aggccggtgc tgacgtcata gtactagatt catcccaggg gaactcagtg
     1141 tatcagatcg ccatggtgca ctatatcaag cagaagtacc cccacctcca agtgattggg
     1201 ggaaatgtgg tgacagcagc ccaggccaag aacttgattg atgctggtgt ggacgggctt
     1261 cgtgtgggca tgggctgtgg ttccatctgc atcacccagg aagtgatggc ctgtggccga
     1321 ccccagggga ctgctgtcta caaggtggcc gagtacgccc gacgttttgg ggtgccggta
     1381 atagcggatg gtggcatcca gaccgtgggc catgtggtca aagccctggc acttggagcc
     1441 tctacagtaa tgatgggctc cctgctggct gccaccacgg aggcgcctgg tgaatacttc
     1501 ttctcagatg gggtgaggct gaagaagtac cggggcatgg gttctctgga cgccatggag
     1561 aagagcagca gcagccagaa aagatacttc agtgaggggg ataaggtgaa gatcgcacaa
     1621 ggtgtctccg gttccatcca ggataaaggc tccattcaga agtttgtgcc ctacctcata
     1681 gcagggatcc agcatggctg ccaggatatt ggggcccaaa gcctatctgt cctgcgatcc
     1741 atgatgtact caggagagct caagtttgag aagcggacca tgtcggccca gattgagggt
     1801 ggcgtgcacg gcctacactc ttacgagaag cggctgtact gaggacagcg gtggcggcca
     1861 aggcagtgga gggggcgaac cccggggccc ccctctagga acagcctccc tccagaacta
     1921 agtggtccat agatttgcac tacgggttcc ccagctcctt tccagggaga ggagtggagt
     1981 ccttgagggg cctgtggccc ctctcccggg caaccccaca gagtcaggta gccccccccc
     2041 cccgtgccag gctgccccat aagatcttcc gggttccccc ttcttcagtt ccctgagccc
     2101 agtcagcctt ggctctcagg ccctgtgcct gcctcaggtc tttctcactg cagcctgctc
     2161 tggcccaatg tccaactctg acccctgggg aaggtagccc ctcctggctt ctcctatagg
     2221 gcacctctct ctcttgctgc ccccttcctc ccaggaaatg gtgctctcct gaccctgcct
     2281 ctggcccgtc cctggagtgc tgtcctctca gccatgtggc actgtgggtt ctggacctag
     2341 gccaggggga ggtctctgcc cccttcctct ggcttgaggc tcccatgggg cctgctcctc
     2401 ggcttacttc cccatctctg agcccaggga gggcctgctg atgaccacct gcccttcatt
     2461 cctgattcac caccatcccc aagtgtaccg tccctgccct ctcttctcag ctgcagttga
     2521 aggctttaac tttgcacact ttggggtcac aattgtgtca ttgtatatta aataatctga
     2581 ataaatcaag cagttatcaa tgcaaaaaaa aaaaaaaaaa
//
