LOCUS       NM_008378               3779 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus impact, RWD domain protein (Impact), transcript
            variant 1, mRNA.
ACCESSION   NM_008378
VERSION     NM_008378.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3779)
  AUTHORS   Jiang,W., Shi,J., Zhao,J., Wang,Q., Cong,D., Chen,F., Zhang,Y.,
            Liu,Y., Zhao,J., Chen,Q., Gu,L., Zhou,W., Wang,C., Fang,Z.,
            Geng,S., Xie,W., Chen,L.N., Yang,Y., Bai,Y., Lin,H. and Li,X.
  TITLE     ZFP57 dictates allelic expression switch of target imprinted genes
  JOURNAL   Proc Natl Acad Sci U S A 118 (5) (2021)
   PUBMED   33500348
REFERENCE   2  (bases 1 to 3779)
  AUTHORS   Yamazaki,H., Kasai,S., Mimura,J., Ye,P., Inose-Maruyama,A.,
            Tanji,K., Wakabayashi,K., Mizuno,S., Sugiyama,F., Takahashi,S.,
            Sato,T., Ozaki,T., Cavener,D.R., Yamamoto,M. and Itoh,K.
  TITLE     Ribosome binding protein GCN1 regulates the cell cycle and cell
            proliferation and is essential for the embryonic development of
            mice
  JOURNAL   PLoS Genet 16 (4), e1008693 (2020)
   PUBMED   32324833
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3779)
  AUTHORS   Pereira,C.M., Filev,R., Dubiela,F.P., Brandao,B.B., Queiroz,C.M.,
            Ludwig,R.G., Hipolide,D., Longo,B.M., Mello,L.E., Mori,M.A. and
            Castilho,B.A.
  TITLE     The GCN2 inhibitor IMPACT contributes to diet-induced obesity and
            body temperature control
  JOURNAL   PLoS One 14 (6), e0217287 (2019)
   PUBMED   31166980
  REMARK    GeneRIF: results indicate that IMPACT contributes to GCN2-dependent
            and -independent mechanisms involved in the regulation of autonomic
            functions in response to energy availability.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3779)
  AUTHORS   Cambiaghi,T.D., Pereira,C.M., Shanmugam,R., Bolech,M., Wek,R.C.,
            Sattlegger,E. and Castilho,B.A.
  TITLE     Evolutionarily conserved IMPACT impairs various stress responses
            that require GCN1 for activating the eIF2 kinase GCN2
  JOURNAL   Biochem Biophys Res Commun 443 (2), 592-597 (2014)
   PUBMED   24333428
  REMARK    GeneRIF: This study extends our understanding of the roles played
            by GCN1 in GCN2 activation induced by a variety of stress
            arrangements and suggests that IMPACT and YIH1 use similar
            mechanisms for regulating this eIF2alpha kinase.
REFERENCE   5  (bases 1 to 3779)
  AUTHORS   Yamaguchi,S., Shen,L., Liu,Y., Sendler,D. and Zhang,Y.
  TITLE     Role of Tet1 in erasure of genomic imprinting
  JOURNAL   Nature 504 (7480), 460-464 (2013)
   PUBMED   24291790
REFERENCE   6  (bases 1 to 3779)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 3779)
  AUTHORS   Kosaki,K., Suzuki,T., Kosaki,R., Yoshihashi,H., Itoh,M., Goto,Y.
            and Matsuo,N.
  TITLE     Human homolog of the mouse imprinted gene Impact resides at the
            pericentric region of chromosome 18 within the critical region for
            bipolar affective disorder
  JOURNAL   Mol Psychiatry 6 (1), 87-91 (2001)
   PUBMED   11244491
REFERENCE   8  (bases 1 to 3779)
  AUTHORS   Okamura,K., Hagiwara-Takeuchi,Y., Li,T., Vu,T.H., Hirai,M.,
            Hattori,M., Sakaki,Y., Hoffman,A.R. and Ito,T.
  TITLE     Comparative genome analysis of the mouse imprinted gene impact and
            its nonimprinted human homolog IMPACT: toward the structural basis
            for species-specific imprinting
  JOURNAL   Genome Res 10 (12), 1878-1889 (2000)
   PUBMED   11116084
REFERENCE   9  (bases 1 to 3779)
  AUTHORS   Neidhardt,L., Gasca,S., Wertz,K., Obermayr,F., Worpenberg,S.,
            Lehrach,H. and Herrmann,B.G.
  TITLE     Large-scale screen for genes controlling mammalian embryogenesis,
            using high-throughput gene expression analysis in mouse embryos
  JOURNAL   Mech Dev 98 (1-2), 77-94 (2000)
   PUBMED   11044609
REFERENCE   10 (bases 1 to 3779)
  AUTHORS   Hagiwara,Y., Hirai,M., Nishiyama,K., Kanazawa,I., Ueda,T.,
            Sakaki,Y. and Ito,T.
  TITLE     Screening for imprinted genes by allelic message display:
            identification of a paternally expressed gene impact on mouse
            chromosome 18
  JOURNAL   Proc Natl Acad Sci U S A 94 (17), 9249-9254 (1997)
   PUBMED   9256468
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ056911.1, AK138136.1, AC131672.3 and BM899561.1.
            
            On Oct 26, 2017 this sequence version replaced NM_008378.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020524.1, SRR7345562.5042899.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-359               CJ056911.1         1-359
            360-1329            AK138136.1         2-971
            1330-3215           AC131672.3         122571-124456       c
            3216-3779           BM899561.1         1-564               c
FEATURES             Location/Qualifiers
     source          1..3779
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 6.87 cM"
     gene            1..3779
                     /gene="Impact"
                     /gene_synonym="E430016J11Rik"
                     /note="impact, RWD domain protein"
                     /db_xref="GeneID:16210"
                     /db_xref="MGI:MGI:1098233"
     exon            1..450
                     /gene="Impact"
                     /gene_synonym="E430016J11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             415..1371
                     /gene="Impact"
                     /gene_synonym="E430016J11Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein IMPACT; imprinted and ancient gene protein"
                     /codon_start=1
                     /product="protein IMPACT isoform 1"
                     /protein_id="NP_032404.1"
                     /db_xref="CCDS:CCDS29068.1"
                     /db_xref="GeneID:16210"
                     /db_xref="MGI:MGI:1098233"
                     /translation="MAEEEVGNSQRQSEEIEAMAAIYGEEWCVIDENAKIFCIRVTDF
                     MDDPKWTLCLQVMLPSEYPGTAPPSYQLNAPWLKGQERADLSNSLEEIYVHNMGESIL
                     YQWVEKIRDALIQKSQITEPDPDVKKKTEEVEVESEEDPILEHPPENPVKTLDLKISE
                     ETQPETEELPPVAHGVPITDRRSTFQAHVAPVVCPEQVKLVLAKLYENKKIASATHNI
                     YAYRIFCEDKQTFLQDCEDDGETAAGGRLLHLMEILNVKNVMVVVSRWYGGILLGPDR
                     FKHINNCARNILVEKNFTNTPDESTKNLGKKKVKKDKKKNDH"
     exon            451..579
                     /gene="Impact"
                     /gene_synonym="E430016J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            580..632
                     /gene="Impact"
                     /gene_synonym="E430016J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            633..695
                     /gene="Impact"
                     /gene_synonym="E430016J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            696..781
                     /gene="Impact"
                     /gene_synonym="E430016J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            782..907
                     /gene="Impact"
                     /gene_synonym="E430016J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1005
                     /gene="Impact"
                     /gene_synonym="E430016J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1079
                     /gene="Impact"
                     /gene_synonym="E430016J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1170
                     /gene="Impact"
                     /gene_synonym="E430016J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1305
                     /gene="Impact"
                     /gene_synonym="E430016J11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..3763
                     /gene="Impact"
                     /gene_synonym="E430016J11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3740..3745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Impact"
                     /gene_synonym="E430016J11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3763
                     /gene="Impact"
                     /gene_synonym="E430016J11Rik"
                     /note="major polyA site"
ORIGIN      
        1 tatcgagatg ccctcaaaaa catttaaaaa acaaaatgaa caaactatac aaatgaaaac
       61 tctgccttga aggatgagta tgagagtccc aatttggtaa tccaaactct cccatggctt
      121 ctaatggcat tggagcctca gtgcggcctg caaaaggccc tagccccatg actttgcaag
      181 aaacagaacc cagggcaagc tccccctacg tcactcccaa cactttcaga aagcctgtag
      241 ctggcagccg ctgcctgcac gcagggttgt tgacccggaa gcaattcagg aagtgggtgg
      301 tgttggctgt cagttccggt gcatcagtgc atcgcagttg cattcatttg ctgcttgcca
      361 gtcgtctctt tcggatttgg gcatttggag ctggtgtcgc agatcctgag caccatggct
      421 gaagaggaag tagggaacag ccagaggcag agtgaagaaa tcgaagcaat ggcagccatt
      481 tatggcgagg agtggtgtgt cattgatgaa aatgccaaaa tattttgtat tagagtcact
      541 gacttcatgg atgaccccaa atggacactt tgtttacagg tgatgttgcc aagtgagtac
      601 ccgggtacag caccgccttc ttatcagctg aacgctccct ggctgaaagg gcaagaacgc
      661 gcagacttat cgaacagcct tgaggagata tatgtccaca acatgggtga atctattctt
      721 taccagtggg tggagaaaat aagagatgct ctgatacaga aatctcagat aaccgagcca
      781 gacccagatg tcaagaagaa aactgaagag gttgaggttg agtccgaaga agaccctatt
      841 ctagagcacc cgccggaaaa tccagttaaa acattggacc tcaaaatcag tgaagaaact
      901 caaccagaaa ctgaagaatt gcctccagtt gctcatggcg ttcctattac tgaccgaagg
      961 agcacttttc aggctcatgt ggcccctgtc gtctgtcctg agcaggtgaa actggttctt
     1021 gccaagctgt acgagaataa gaagattgcc agcgccaccc acaacatcta tgcctacagg
     1081 atattctgtg aggataaaca gaccttcttg caggactgtg aagatgatgg agaaacagct
     1141 gctgggggcc gccttcttca cctcatggag attttgaatg tgaagaatgt catggtggtg
     1201 gtgtcccgct ggtatggagg gatcctgctg ggacctgacc gtttcaaaca catcaacaac
     1261 tgtgccagga acattctggt ggagaagaac ttcacgaaca ctcctgacga gtcaactaag
     1321 aatttgggga aaaagaaggt gaagaaagac aagaagaaga atgatcatta agacgtgaac
     1381 ctgtgtgaga ggttaacttc ccagccactg tggacacgtt cccagtggtc atgagtacat
     1441 taagatagca cactgacagc tcaagtcagc cagttcatca tggttccacc agcattgtgt
     1501 ttcctcctct ggttccacca tttgccagaa ctagagaatc tagaacatat tcacatgtgt
     1561 ttcacattta tttggaagaa cagctgtgag cttacttacc atttcatata atactaggaa
     1621 gtgacacatg cacagtgttt tcctgagcta aatgtcaatt tcagtattgt cgcgtgcctt
     1681 tgttaggcag ggaagacgtg tctccagagg aatagaaagg ccacatgtct tgcgatagaa
     1741 attgccatgc tgttaagtga gcattgcttt ttcagctccc agttgctttc agagtggggg
     1801 cgcatggaag acggaggtct tggggagtct ttctcttgtg atttcacaag tgagtcacgc
     1861 ttccttccat agtattcatc atggagtgat agtttacgtg aaaacccgag tattcatctg
     1921 tgatcatgtg ccaaagtgat agtttacaca tttgctagtc caagtgttac tcctcagttg
     1981 tttcaaattg gtgattgtgg aatttcaaaa agttactatt tcttagttgt tgccttttgt
     2041 tgtttgattc ctgtagtgac acacagtgac cattcagtct cagtagtcct tcccagtagt
     2101 ccttccgtcc catcccttac gtgtgttgag gtaacattcc ggtgtctctg aacgacctgg
     2161 aagcacttcc ctgtgctctt ccctgtgctc tggtcaactc acttgcagaa cgagatagag
     2221 gcagcaggac accagaggag caggctgccc actgcaccag tttgatatac atttgccatt
     2281 tgaactctgg ccagattttt ttttttttta gttctgtgat tttttttttt tttttttttt
     2341 tgaggagaga tagagggaca aatcttttga ttagattaaa aaaaaaacct ctttccctgc
     2401 ggaagttttt gtctaatctc cttttttaaa cacgtgttta atttattttt tacatgcata
     2461 ttacttgtaa gaaataagac aaaaattccc tttgtgtagg taagctgtac ctgttatctt
     2521 tcagaaataa tgccaacaat gactaaattg atcaacggat cgcagactag tttgattccc
     2581 ctcccgagga agaggcagcc ttgggagagt gctggagcac acatagacag cgtctgaggt
     2641 tgtgcaggtt ttttctctta gtttgtaagc ttgaaagatc cacatcctca cttggtattt
     2701 taaataggaa tccagtagcc agctttacac tagagtgggt tctgagacag aagtcttatt
     2761 ttcaacatta tttaatgttg taaattatca agagttatag gatgacctat atgtgtgttt
     2821 ggaacactta cctctgtttc catgaaatgc taagtatatc ctatgtatta attgttacag
     2881 agcttagaca gtatttgcta aagataatga tataatcttg acatttcaga cctgtgaaaa
     2941 gagattaaaa cactaagaat tttatgctgc agaaaaaagg agcataaaat attttcctag
     3001 cacactggat tagaatttct ttcctggagt tttgtctaaa atgtattagt gtttacagaa
     3061 gaaaagacaa ttttttatat ctctgatctc attttccttc acttaaaaat tacgtttccc
     3121 cattttacaa gattgctaac ctcattttgt gggttgagct ccttaacctt cgctgcaggt
     3181 gggaggggag accccagttc ctcacttcta actcctgaaa ttgcgtattt cacatgccat
     3241 tagtgcaaag taatgatagc atagttttct ctattgaagt agagaaaatc atatgtagag
     3301 aattttctag ttctcccaat tataactttg taaagccagg cgtctgctgt ggccttctct
     3361 atattttatt agttgacatg ttctccacat gccagtatct atgagcaaat ggcatccacg
     3421 tagacgggca gagcagaagc tgctagtgag gtgtctgtca gagacaggct gttggaagga
     3481 agcactgata caggacagat aaagcagata ctgtttacag ggcaggtgag tgatactgta
     3541 atcacttcag tgaattgtaa tcacatccag tccactaaag agatgaccat aaatggtgta
     3601 tacagttttt attttttatt atgcatgatt ttgtatatat ggctattttt ctttccgtaa
     3661 aaatggtatt aaaccgtata tactgttttg tatcctacat atttcatata gaagtatatt
     3721 gttaacattt tcccatatca ataaatattc ttctatggct taaaaaaaaa aaaaaaaaa
//
