LOCUS       NM_053261               1737 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus inositol monophosphatase 2 (Impa2), mRNA.
ACCESSION   NM_053261
VERSION     NM_053261.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1737)
  AUTHORS   Ohnishi,T., Murata,T., Watanabe,A., Hida,A., Ohba,H., Iwayama,Y.,
            Mishima,K., Gondo,Y. and Yoshikawa,T.
  TITLE     Defective craniofacial development and brain function in a mouse
            model for depletion of intracellular inositol synthesis
  JOURNAL   J Biol Chem 289 (15), 10785-10796 (2014)
   PUBMED   24554717
REFERENCE   2  (bases 1 to 1737)
  AUTHORS   Ohnishi,T., Tanizawa,Y., Watanabe,A., Nakamura,T., Ohba,H.,
            Hirata,H., Kaneda,C., Iwayama,Y., Arimoto,T., Watanabe,K., Mori,I.
            and Yoshikawa,T.
  TITLE     Human myo-inositol monophosphatase 2 rescues the nematode
            thermotaxis mutant ttx-7 more efficiently than IMPA1: functional
            and evolutionary considerations of the two mammalian myo-inositol
            monophosphatase genes
  JOURNAL   J Neurochem 124 (5), 685-694 (2013)
   PUBMED   23205734
REFERENCE   3  (bases 1 to 1737)
  AUTHORS   Cryns,K., Shamir,A., Van Acker,N., Levi,I., Daneels,G., Goris,I.,
            Bouwknecht,J.A., Andries,L., Kass,S., Agam,G., Belmaker,H.,
            Bersudsky,Y., Steckler,T. and Moechars,D.
  TITLE     IMPA1 is essential for embryonic development and lithium-like
            pilocarpine sensitivity
  JOURNAL   Neuropsychopharmacology 33 (3), 674-684 (2008)
   PUBMED   17460611
REFERENCE   4  (bases 1 to 1737)
  AUTHORS   Cryns,K., Shamir,A., Shapiro,J., Daneels,G., Goris,I., Van
            Craenendonck,H., Straetemans,R., Belmaker,R.H., Agam,G.,
            Moechars,D. and Steckler,T.
  TITLE     Lack of lithium-like behavioral and molecular effects in IMPA2
            knockout mice
  JOURNAL   Neuropsychopharmacology 32 (4), 881-891 (2007)
   PUBMED   16841073
REFERENCE   5  (bases 1 to 1737)
  AUTHORS   Ohnishi,T., Ohba,H., Seo,K.C., Im,J., Sato,Y., Iwayama,Y.,
            Furuichi,T., Chung,S.K. and Yoshikawa,T.
  TITLE     Spatial expression patterns and biochemical properties distinguish
            a second myo-inositol monophosphatase IMPA2 from IMPA1
  JOURNAL   J Biol Chem 282 (1), 637-646 (2007)
   PUBMED   17068342
  REMARK    GeneRIF: IMPA2 has a separate function in vivo from that of IMPA1
REFERENCE   6  (bases 1 to 1737)
  AUTHORS   Shamir,A., Sjoholt,G., Ebstein,R.P., Agam,G. and Steen,V.M.
  TITLE     Characterization of two genes, Impa1 and Impa2 encoding mouse
            myo-inositol monophosphatases
  JOURNAL   Gene 271 (2), 285-291 (2001)
   PUBMED   11418250
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154125.7.
            
            On Jul 20, 2018 this sequence version replaced NM_053261.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170962.1, AK154489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-260               AC154125.7         192498-192757       c
            261-394             AC154125.7         179695-179828       c
            395-499             AC154125.7         175229-175333       c
            500-545             AC154125.7         172907-172952       c
            546-654             AC154125.7         171249-171357       c
            655-763             AC154125.7         166276-166384       c
            764-915             AC154125.7         164971-165122       c
            916-1737            AC154125.7         162788-163609       c
FEATURES             Location/Qualifiers
     source          1..1737
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 39.92 cM"
     gene            1..1737
                     /gene="Impa2"
                     /gene_synonym="2210415D20Rik; IMP 2; IMPase 2"
                     /note="inositol monophosphatase 2"
                     /db_xref="GeneID:114663"
                     /db_xref="MGI:MGI:2149728"
     exon            1..260
                     /gene="Impa2"
                     /gene_synonym="2210415D20Rik; IMP 2; IMPase 2"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1031
                     /gene="Impa2"
                     /gene_synonym="2210415D20Rik; IMP 2; IMPase 2"
                     /EC_number="3.1.3.25"
                     /note="myo-inositol monophosphatase A2; inositol
                     (myo)-1(or 4)-monophosphatase 2"
                     /codon_start=1
                     /product="inositol monophosphatase 2"
                     /protein_id="NP_444491.1"
                     /db_xref="CCDS:CCDS29320.1"
                     /db_xref="GeneID:114663"
                     /db_xref="MGI:MGI:2149728"
                     /translation="MKPSSEEEGELVQGVGPWDECFEVAVQLALRAGQIIRKALTEEK
                     RVSTKTSAADLVTETDHRVEDLIVSELRKRFPSHRFIAEEATASGAKCVLTHSPTWII
                     DPIDGTCNFVHRFPTVAVSIGFAVHQELEFGVIHHCTEERLYTGRRGQGAFCNGQRLQ
                     VSRETDLAKALVLTEIGPKRDPDTLKVFLSNMERLLHAKAHGVRVIGSSTLALCYLAS
                     GAADAYYQFGLHCWDLAAATVIIREAGGIVIDTSGGPLDLMSCRVVAAGTREMAVLIA
                     QALQTINYGRDDEK"
     exon            261..394
                     /gene="Impa2"
                     /gene_synonym="2210415D20Rik; IMP 2; IMPase 2"
                     /inference="alignment:Splign:2.1.0"
     exon            395..499
                     /gene="Impa2"
                     /gene_synonym="2210415D20Rik; IMP 2; IMPase 2"
                     /inference="alignment:Splign:2.1.0"
     exon            500..545
                     /gene="Impa2"
                     /gene_synonym="2210415D20Rik; IMP 2; IMPase 2"
                     /inference="alignment:Splign:2.1.0"
     exon            546..654
                     /gene="Impa2"
                     /gene_synonym="2210415D20Rik; IMP 2; IMPase 2"
                     /inference="alignment:Splign:2.1.0"
     exon            655..763
                     /gene="Impa2"
                     /gene_synonym="2210415D20Rik; IMP 2; IMPase 2"
                     /inference="alignment:Splign:2.1.0"
     exon            764..915
                     /gene="Impa2"
                     /gene_synonym="2210415D20Rik; IMP 2; IMPase 2"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1737
                     /gene="Impa2"
                     /gene_synonym="2210415D20Rik; IMP 2; IMPase 2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1339..1344
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Impa2"
                     /gene_synonym="2210415D20Rik; IMP 2; IMPase 2"
                     /note="hexamer: AATAAA"
     polyA_site      1361
                     /gene="Impa2"
                     /gene_synonym="2210415D20Rik; IMP 2; IMPase 2"
                     /note="major polyA site"
     regulatory      1596..1601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Impa2"
                     /gene_synonym="2210415D20Rik; IMP 2; IMPase 2"
                     /note="hexamer: ATTAAA"
     polyA_site      1616
                     /gene="Impa2"
                     /gene_synonym="2210415D20Rik; IMP 2; IMPase 2"
     regulatory      1710..1715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Impa2"
                     /gene_synonym="2210415D20Rik; IMP 2; IMPase 2"
                     /note="hexamer: CATAAA"
     polyA_site      1733
                     /gene="Impa2"
                     /gene_synonym="2210415D20Rik; IMP 2; IMPase 2"
ORIGIN      
        1 cttcctgctg caacgcgcgc tggaggacgc acggcttggc gggaaggcga gggcactgtg
       61 cggagcctcc ggtgctggcg gcggccacga gtgggagccc gggtccggcc gcagcacgcg
      121 gaacagagca gaaggtggcg gggtccggcg aagccacgat gaagccgagc agcgaggaag
      181 agggagagtt ggtgcagggc gtgggcccct gggacgagtg cttcgaggtg gccgtgcagt
      241 tggcgctgcg tgcgggacaa atcatcagga aggccctgac agaggaaaaa cgcgtctcta
      301 caaaaacatc tgctgccgat cttgtgacag aaacagatca ccgagtagaa gatttaattg
      361 tttctgagtt gcgaaagcgg tttccttcac acaggttcat tgcagaagag gccacagcct
      421 ccggggccaa gtgtgtgctc acccacagcc cgacctggat catcgacccc atcgacggca
      481 cctgcaactt tgtgcacagg ttccccactg tggcagttag catcggattt gctgttcacc
      541 aggagctgga atttggagtg attcaccact gcacagagga gcggctgtac accggcagga
      601 ggggccaagg cgccttttgc aatggccagc ggcttcaggt ctccagggag acagatctcg
      661 caaaggcctt ggttctgaca gaaatcgggc ccaaacgcga ccccgatact ctgaaagtat
      721 tcctgagcaa catggagcgg ctgctgcacg ccaaggctca tggggtccga gtgattggca
      781 gctccacctt ggccctctgt tacctggcct caggtgcagc cgacgcctat tatcagtttg
      841 gccttcactg ctgggacctg gcagctgcca cagtcatcat tagagaagca ggcggcattg
      901 tgattgacac ctcaggtgga ccccttgacc tcatgtcgtg cagagtcgta gctgctggca
      961 ccagagagat ggcagtgctc atagctcagg ccctacaaac tattaactac ggccgagacg
     1021 atgagaagtg agccacacac agctcgaagg ctaaaaacgc agcagcaacc tgggaaagag
     1081 ctgtcccggt ggcttaagtt ccaggacagt ctaccatagc tctccctggg ccttgcctcg
     1141 gtgcttagct gattctctct aatctcgtgt agcccctttt caggtcggta cgtgttcttt
     1201 tcatcagagc caaacccaga tcttgtgagg ggtgtgttag tcatccatcc tgattgtttt
     1261 tccagaatgc aaatctcagg tgatacagct ttagaacggg ctctcaggcc ctcccctgac
     1321 cgtggtaaga cggaatgcaa taaatcagaa ttatagtggt ctgctttggg tcttcctcca
     1381 gcctctggtt ctcaggcaag gctgttactg ctattacccc actggtcgtc tatgctcagc
     1441 ttggatgtct ggcacccgac catggcgacg gtgaaaactt tccctaaata tcagtctcct
     1501 gatctacagg ttgtatttaa ctacacatag ataatcttta gccatttttt tatactgcct
     1561 tcagttgacc ttcagggagt acgtgtatcg tataaattaa aatgctgtat acagaaccct
     1621 ttatcgaagc ccacgtgtac tgaaagtgga aaaaaaatga gaaactgaaa aacagtgcta
     1681 aaatattttg tgacaaacat ttttgtaaac ataaagtctt tcaggagttg caacttt
//
