LOCUS       NM_018864               4185 bp    mRNA    linear   ROD 11-OCT-2023
DEFINITION  Mus musculus inositol (myo)-1(or 4)-monophosphatase 1 (Impa1),
            transcript variant 1, mRNA.
ACCESSION   NM_018864
VERSION     NM_018864.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4185)
  AUTHORS   Sade Y, Toker L, Kara NZ, Einat H, Rapoport S, Moechars D, Berry
            GT, Bersudsky Y and Agam G.
  TITLE     IP3 accumulation and/or inositol depletion: two downstream
            lithium's effects that may mediate its behavioral and cellular
            changes
  JOURNAL   Transl Psychiatry 6 (12), e968 (2016)
   PUBMED   27922641
  REMARK    GeneRIF: Lithium affects the phosphatidylinositol signaling system
            in two ways: depleting inositol, consequently decreasing
            phosphoinositides; elevating inositol monophosphate levels followed
            by phosphoinositols accumulation. Each or both may mediate
            lithium-induced behavior
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4185)
  AUTHORS   Ohnishi T, Murata T, Watanabe A, Hida A, Ohba H, Iwayama Y, Mishima
            K, Gondo Y and Yoshikawa T.
  TITLE     Defective craniofacial development and brain function in a mouse
            model for depletion of intracellular inositol synthesis
  JOURNAL   J Biol Chem 289 (15), 10785-10796 (2014)
   PUBMED   24554717
  REMARK    GeneRIF: IMPase has a role in intracellular myo-inositol synthesis
            in craniofacial development and the maintenance of proper brain
            function
REFERENCE   3  (bases 1 to 4185)
  AUTHORS   Toker L, Bersudsky Y, Plaschkes I, Chalifa-Caspi V, Berry GT,
            Buccafusca R, Moechars D, Belmaker RH and Agam G.
  TITLE     Inositol-related gene knockouts mimic lithium's effect on
            mitochondrial function
  JOURNAL   Neuropsychopharmacology 39 (2), 319-328 (2014)
   PUBMED   23924600
REFERENCE   4  (bases 1 to 4185)
  AUTHORS   Ohnishi T, Tanizawa Y, Watanabe A, Nakamura T, Ohba H, Hirata H,
            Kaneda C, Iwayama Y, Arimoto T, Watanabe K, Mori I and Yoshikawa T.
  TITLE     Human myo-inositol monophosphatase 2 rescues the nematode
            thermotaxis mutant ttx-7 more efficiently than IMPA1: functional
            and evolutionary considerations of the two mammalian myo-inositol
            monophosphatase genes
  JOURNAL   J Neurochem 124 (5), 685-694 (2013)
   PUBMED   23205734
REFERENCE   5  (bases 1 to 4185)
  AUTHORS   Singh N, Halliday AC, Knight M, Lack NA, Lowe E and Churchill GC.
  TITLE     Cloning, expression, purification, crystallization and X-ray
            analysis of inositol monophosphatase from Mus musculus and Homo
            sapiens
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 68 (Pt 10),
            1149-1152 (2012)
   PUBMED   23027737
  REMARK    GeneRIF: Comparison of MmIMPase 1 and HsIMPase 1 revealed a core
            r.m.s. deviation of 0.516 A
REFERENCE   6  (bases 1 to 4185)
  AUTHORS   Sakuraba Y, Sezutsu H, Takahasi KR, Tsuchihashi K, Ichikawa R,
            Fujimoto N, Kaneko S, Nakai Y, Uchiyama M, Goda N, Motoi R, Ikeda
            A, Karashima Y, Inoue M, Kaneda H, Masuya H, Minowa O, Noguchi H,
            Toyoda A, Sakaki Y, Wakana S, Noda T, Shiroishi T and Gondo Y.
  TITLE     Molecular characterization of ENU mouse mutagenesis and archives
  JOURNAL   Biochem Biophys Res Commun 336 (2), 609-616 (2005)
   PUBMED   16139793
REFERENCE   7  (bases 1 to 4185)
  AUTHORS   Schmidt H, Schwaller B and Eilers J.
  TITLE     Calbindin D28k targets myo-inositol monophosphatase in spines and
            dendrites of cerebellar Purkinje neurons
  JOURNAL   Proc Natl Acad Sci U S A 102 (16), 5850-5855 (2005)
   PUBMED   15809430
  REMARK    GeneRIF: Results suggest that calbindin D28k acts as an
            activity-dependent sensor that targets membrane/cytoskeleton-bound
            myo-inositol monophosphatase in central neurons.
REFERENCE   8  (bases 1 to 4185)
  AUTHORS   Chauvin TR and Griswold MD.
  TITLE     Characterization of the expression and regulation of genes
            necessary for myo-inositol biosynthesis and transport in the
            seminiferous epithelium
  JOURNAL   Biol Reprod 70 (3), 744-751 (2004)
   PUBMED   14613899
  REMARK    GeneRIF: IMPA1 was expressed in round spermatids
REFERENCE   9  (bases 1 to 4185)
  AUTHORS   Loebel DA, O'Rourke MP, Steiner KA, Banyer J and Tam PP.
  TITLE     Isolation of differentially expressed genes from wild-type and
            Twist mutant mouse limb buds
  JOURNAL   Genesis 33 (3), 103-113 (2002)
   PUBMED   12124942
REFERENCE   10 (bases 1 to 4185)
  AUTHORS   Shamir A, Sjoholt G, Ebstein RP, Agam G and Steen VM.
  TITLE     Characterization of two genes, Impa1 and Impa2 encoding mouse
            myo-inositol monophosphatases
  JOURNAL   Gene 271 (2), 285-291 (2001)
   PUBMED   11418250
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY283562.1, AK152774.1 and AK145472.1.
            
            [WARNING] On Apr 1, 2024 this sequence was replaced by NM_018864.7.
            
            On Jul 14, 2015 this sequence version replaced NM_018864.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145472.1, AK083238.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                BY283562.1         2-51
            51-2066             AK152774.1         2-2017
            2067-4185           AK145472.1         2006-4124
FEATURES             Location/Qualifiers
     source          1..4185
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 2.61 cM"
     gene            1..4185
                     /gene="Impa1"
                     /gene_synonym="2610002K09Rik; 2900059K10Rik"
                     /note="inositol (myo)-1(or 4)-monophosphatase 1"
                     /db_xref="GeneID:55980"
                     /db_xref="MGI:MGI:1933158"
     exon            1..118
                     /gene="Impa1"
                     /gene_synonym="2610002K09Rik; 2900059K10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            119..184
                     /gene="Impa1"
                     /gene_synonym="2610002K09Rik; 2900059K10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..955
                     /gene="Impa1"
                     /gene_synonym="2610002K09Rik; 2900059K10Rik"
                     /EC_number="3.1.3.25"
                     /EC_number="3.1.3.94"
                     /note="isoform 1 is encoded by transcript variant 1;
                     lithium-sensitive myo-inositol monophosphatase A1;
                     inositol monophosphatase 1; IMP 1; IMPase 1; inositol-1(or
                     4)-monophosphatase 1; D-galactose 1-phosphate phosphatase;
                     myo-inositol monophosphatase 1"
                     /codon_start=1
                     /product="inositol monophosphatase 1 isoform 1"
                     /protein_id="NP_061352.2"
                     /db_xref="CCDS:CCDS17240.1"
                     /db_xref="GeneID:55980"
                     /db_xref="MGI:MGI:1933158"
                     /translation="MADPWQECMDYAVILARQAGEMIREALKNEMDVMIKSSPADLVT
                     VTDQKVEKMLMSSIKEKYPCHSFIGEESVAAGEKTVFTEQPTWVIDPIDGTTNFVHRF
                     PFVAVSIGFLVNKEMEFGIVYSCVEDKMYTGRKGKGAFCNGQKLQVSQQEDITKSLLV
                     TELGSSRKPETLRIVLSNMEKLCSIPIHGIRSVGTAAVNMCLVATGGADAYYEMGIHC
                     WDMAGAGIIVTEAGGVLMDVTGGPFDLMSRRIIAANSITLAKRIAKEIEIIPLQRDDE
                     S"
     exon            185..318
                     /gene="Impa1"
                     /gene_synonym="2610002K09Rik; 2900059K10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            319..423
                     /gene="Impa1"
                     /gene_synonym="2610002K09Rik; 2900059K10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            424..469
                     /gene="Impa1"
                     /gene_synonym="2610002K09Rik; 2900059K10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            470..578
                     /gene="Impa1"
                     /gene_synonym="2610002K09Rik; 2900059K10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            579..687
                     /gene="Impa1"
                     /gene_synonym="2610002K09Rik; 2900059K10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            688..839
                     /gene="Impa1"
                     /gene_synonym="2610002K09Rik; 2900059K10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            840..4185
                     /gene="Impa1"
                     /gene_synonym="2610002K09Rik; 2900059K10Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggttttaa tggggcggga cttcctgtcg gagcaatccc cgttacctcc ggaagagccg
       61 aagaaccgag ccctcggacg ccggcggttg agcatcgatc gcggtgcgct cgcgcgagat
      121 aatggcagac ccttggcagg agtgcatgga ctatgcagta atcctcgcga ggcaagctgg
      181 agagatgatt cgtgaagctt taaaaaatga gatggatgtc atgattaaaa gttctccagc
      241 cgacttggta acagttactg accaaaaagt tgaaaaaatg ctcatgtctt ctataaagga
      301 aaagtatcca tgtcacagct tcattggtga agagtctgtg gcagctgggg agaagacggt
      361 cttcacagag cagcccacgt gggtcattga ccccattgat ggaacgacta acttcgtgca
      421 tcggtttccc tttgtagctg tttcaattgg cttccttgtg aataaagaga tggagtttgg
      481 aattgtgtac agctgtgtgg aagataagat gtacaccggc aggaaaggga aaggtgcctt
      541 ttgtaacggt cagaagcttc aggtgtccca gcaggaagac attaccaagt cactcttggt
      601 gaccgagttg ggctcgtcca gaaagcccga gactttacgg atcgttctct ccaacatgga
      661 aaagctgtgt tccatcccca tccatggaat ccggagtgtt ggaacagctg ctgttaatat
      721 gtgccttgtg gcaacgggag gagcagatgc ctattatgag atgggaatcc actgctggga
      781 catggcggga gctggcatca ttgtcaccga ggcaggcgga gtgctcatgg atgtcacggg
      841 tggaccgttc gatctgatgt ctcggagaat aattgccgca aatagtataa cattagccaa
      901 aagaatagcc aaagaaattg agataatacc tttgcaaaga gacgacgaaa gctagtcaca
      961 gagaacagtg tccagctcca gtgtcatcct tgctgtccct ggggtgtttc agatggatgg
     1021 tgtcactgat ttagactgaa ctttgaggtc ctgattttaa aatggaaact ttttttttac
     1081 agatgacata ttcaaaatta gatggaatat ttgattattg aaagaaaatt tgcatgtagt
     1141 aatattcttg gggaaaatat acaaaaagta tacttaatga actagccatt gaaattgtcc
     1201 ctagtcctta tgatcccctt caacttaatg tactgtttat atgcataatt ctcaattaca
     1261 aagtttcttt ttgtaagtgg ctttctctat gttccagaag ccatatttga ttaagtctaa
     1321 aggctgtaac aagctggctc tccctgtgca gagggccttt gtgttttatt aatcactgta
     1381 agatagtgcc tggcccagtg cctgtcagac agtaggcagt ctgaagtcca cacctgacaa
     1441 tgcgtgctcg aagctgcagc tgctgcctct aatgcgtcac agtaagataa ccaccctcct
     1501 gttgcgaggt agaagttact tcactgtcct ttttatattt cttattgcta tgccatttca
     1561 caggatcgtg ctgccagaga cgactgcttc tagtggacat ttctgcagtt agtacactgc
     1621 tgtatgttgt aggttctgct taaagctgcc gtgctaaaga gattttcaca gacatcttcc
     1681 aggtacctgg tctagttagt ggcagggata tgttttacaa aaggcagctt tctcattcag
     1741 atccgtaccc tggtgctgac ctgtgtactg tggtgtaatg gtgaactttt tgatttcttt
     1801 ccagacttgc tgaatttcat cactgctaac tctagatgct ctctctataa ggtcttgggc
     1861 ctctcaaact caagaaaatt taatggctcc tattcctttg ttaaagggtt aattcattgt
     1921 ctagccttgg cccttggcat atgaacagat gttttgctct tagtatgttt gaaccttgca
     1981 tttgatacaa tgaagtgttt ttgtaagttt caaggcagtt atcttgattt tggggggatt
     2041 taatatatta aagctatata atactcagat ttgggcactg taatgactat atctgtgctg
     2101 ttaattacat gtatttaaaa cgtcacgtac catgtaaatt ctattacaag acaggttgct
     2161 ttgcaattaa atttatttta gttaagactt aggaatacca ttttctttca ttgtattcat
     2221 ttgcgtatcc caggctgccc tcagaattgt tgcatacccg aggatgaact tgaacttgtg
     2281 acggctctgc ttttctctct taagttctgg gatgcagaga agatggccac aggccaccac
     2341 acacagtttc tgtggtgctg gagactgcac agggccacac gtgtacttag cgtaagcact
     2401 ctgctgccca agctgcgctc cagcccatga acacacgtgg aattaaagga gtaattaatg
     2461 atatcttatc aaagttaata gcctcagccc tttttagggg ttttgagttt agttacagat
     2521 atttgaagct aatattggtt atgaatattc actttttgca tatagatttt cccactatag
     2581 ataaacactt aatactttcc ctatctgttt gtatctttgt atgctaagtg cagttgagta
     2641 ttatctggct aaacattgcg tcggtgtgga aaaaagatga ccagaaagtc aggtaccccg
     2701 aatcactgga aactcctttc ttatgtagca gaacctctca ccctcgccct agcccagcgt
     2761 ttatctcgtg ttctcatttt cggagccttc ttcctggcag cttgaggcta tgtgtaagga
     2821 gatctataac cttatgtgca agccactggc tgtaggacta agtctataag aatcagcaga
     2881 agaactctga tgtctctgga ggtatggtgg atacccctgt gtgtgcaagc agcagtgcac
     2941 aggatagctc tgcacatgtg cggcacctgc tcagcgtaag gaggggtcgg agatcagatc
     3001 ctgctaagga ggctgtggaa gaactatgca cagagcaact ctaaagtgtt aatgagaaaa
     3061 agttatagtt gtgtatgtat ggggtcaggc gcatgtgtgc atcactgtgc ctgtggctgt
     3121 cagggcaatt gaacctgagg ggcatcaggc atggaccagg cttccctacc aagccattcc
     3181 accagctcga agatcttcta agtgccatgt ctactcatgc tttggaagtc ttggcggtgt
     3241 cacatataat gccttcctga tcaaaatcct gatggtattt agaggaggga gatgtcggct
     3301 ttctgtccca ttgacagttt ctctgagggg attaataaga aaagtattgc tttggttcag
     3361 cttggagtta taatgtcatt ggttgtccct gtggctttgt cctgtggcaa gactgtacat
     3421 catgggtgtc atagtttaca atgacctcac gtgggtcccc ctttttctct atctccccca
     3481 aactatcacc ctaaagcctt tttgattatt aagggtttgg ggtttttgtt tgtttgtttg
     3541 tttgagtcat gtttttgcta tgtagtccag gctggcctag aagtcacagt cttcctatat
     3601 ctgcctccat actgcttaca gtataggcat gtactactgc agtggctggg ccagcccttt
     3661 accacatggg cctttgggca ttagccaatt ttcaaactat gaaaagaagt aaagctagaa
     3721 attaacaact aacacagaat ggcagagagc cctaagtagc taaaaccatc agaaagcaga
     3781 aggcaaagtt agaatctgac tgttcaccag ataggagccc agtgccgtaa ttaaagcagt
     3841 ggcatttgcc caaggccacg caagcagctc tgtgaggtaa agagtcccag gctgctcttg
     3901 gctgtgagtg gccgagttgg ctgcccccca cggcaggaga catactgacc ccatcccgtc
     3961 aagttctcag atcaagttgt agaattggaa tcggacagaa aggaggaggc cacacagatg
     4021 agtcagtgag taaaggtgct cttcttcaag tctgacaacc tgaggttgat ccctggggtt
     4081 cacaaggtag aagggaaaac ctgacagctg gaagctatcc actgatctaa acttgtacca
     4141 tggtttgtgg aatttttttt tttttaaagt aaaagtttct gaaag
//
