LOCUS       NM_029673               2777 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus inner membrane protein, mitochondrial (Immt),
            transcript variant 1, mRNA.
ACCESSION   NM_029673
VERSION     NM_029673.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2777)
  AUTHORS   Rockfield,S.M., Turnis,M.E., Rodriguez-Enriquez,R., Bathina,M.,
            Ng,S.K., Kurtz,N., Becerra Mora,N., Pelletier,S., Robinson,C.G.,
            Vogel,P. and Opferman,J.T.
  TITLE     Genetic ablation of Immt induces a lethal disruption of the MICOS
            complex
  JOURNAL   Life Sci Alliance 7 (6), e202302329 (2024)
   PUBMED   38467404
  REMARK    GeneRIF: Genetic ablation of Immt induces a lethal disruption of
            the MICOS complex.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2777)
  AUTHORS   Dong,T., Zhang,Z.Q., Sun,L.H., Zhang,W., Zhu,Z., Lin,L., Yang,L.,
            Lv,A., Liu,C., Li,Q., Yang,R.F., Zhang,X., Niu,Y., Chen,H.Z.,
            Liu,D.P. and Tong,W.M.
  TITLE     Mic60 is essential to maintain mitochondrial integrity and to
            prevent encephalomyopathy
  JOURNAL   Brain Pathol 33 (4), e13157 (2023)
   PUBMED   36974636
  REMARK    GeneRIF: Mic60 is essential to maintain mitochondrial integrity and
            to prevent encephalomyopathy.
REFERENCE   3  (bases 1 to 2777)
  AUTHORS   Shimada,K., Park,S., Miyata,H., Yu,Z., Morohoshi,A., Oura,S.,
            Matzuk,M.M. and Ikawa,M.
  TITLE     ARMC12 regulates spatiotemporal mitochondrial dynamics during
            spermiogenesis and is required for male fertility
  JOURNAL   Proc Natl Acad Sci U S A 118 (6) (2021)
   PUBMED   33536340
REFERENCE   4  (bases 1 to 2777)
  AUTHORS   Lv,Y.J., Yang,Y., Sui,B.D., Hu,C.H., Zhao,P., Liao,L., Chen,J.,
            Zhang,L.Q., Yang,T.T., Zhang,S.F. and Jin,Y.
  TITLE     Resveratrol counteracts bone loss via mitofilin-mediated osteogenic
            improvement of mesenchymal stem cells in senescence-accelerated
            mice
  JOURNAL   Theranostics 8 (9), 2387-2406 (2018)
   PUBMED   29721087
  REMARK    GeneRIF: Unravel Mitofilin as a novel mechanism mediating RESV
            promotion on mitochondrial function in stem cell senescence.
            Erratum:[Theranostics. 2022 Jul 8;12(12):5334. doi:
            10.7150/thno.74941.. PMID: 35910790]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2777)
  AUTHORS   Terzenidou,M.E., Segklia,A., Kano,T., Papastefanaki,F.,
            Karakostas,A., Charalambous,M., Ioakeimidis,F., Papadaki,M.,
            Kloukina,I., Chrysanthou-Piterou,M., Samiotaki,M., Panayotou,G.,
            Matsas,R. and Douni,E.
  TITLE     Novel insights into SLC25A46-related pathologies in a genetic mouse
            model
  JOURNAL   PLoS Genet 13 (4), e1006656 (2017)
   PUBMED   28376086
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2777)
  AUTHORS   Park,Y.U., Jeong,J., Lee,H., Mun,J.Y., Kim,J.H., Lee,J.S.,
            Nguyen,M.D., Han,S.S., Suh,P.G. and Park,S.K.
  TITLE     Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in
            mitochondria in collaboration with Mitofilin
  JOURNAL   Proc Natl Acad Sci U S A 107 (41), 17785-17790 (2010)
   PUBMED   20880836
REFERENCE   7  (bases 1 to 2777)
  AUTHORS   Wang,Q., Liu,Y., Zou,X., Wang,Q., An,M., Guan,X., He,J., Tong,Y.
            and Ji,J.
  TITLE     The hippocampal proteomic analysis of senescence-accelerated mouse:
            implications of Uchl3 and mitofilin in cognitive disorder and
            mitochondria dysfunction in SAMP8
  JOURNAL   Neurochem Res 33 (9), 1776-1782 (2008)
   PUBMED   18307031
  REMARK    GeneRIF: Data show that Uchl3 and mitofilin are differentially
            expressed in the hippocampi of inbred senescence-acclerated mice
            compared to normally-aging mice.
REFERENCE   8  (bases 1 to 2777)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   9  (bases 1 to 2777)
  AUTHORS   John,G.B., Shang,Y., Li,L., Renken,C., Mannella,C.A., Selker,J.M.,
            Rangell,L., Bennett,M.J. and Zha,J.
  TITLE     The mitochondrial inner membrane protein mitofilin controls cristae
            morphology
  JOURNAL   Mol Biol Cell 16 (3), 1543-1554 (2005)
   PUBMED   15647377
  REMARK    GeneRIF: mitofilin is a critical organizer of the mitochondrial
            cristae morphology and thus indispensable for normal mitochondrial
            function
REFERENCE   10 (bases 1 to 2777)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ058627.1, AK038129.1 and BU754623.1.
            
            On Nov 30, 2011 this sequence version replaced NM_029673.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK038129.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                CJ058627.1         2-12
            12-2739             AK038129.1         2-2729
            2740-2777           BU754623.1         1-38                c
FEATURES             Location/Qualifiers
     source          1..2777
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 32.21 cM"
     gene            1..2777
                     /gene="Immt"
                     /gene_synonym="1700082C19Rik; D830041H16Rik; HMP; Micos60;
                     P87; P87/89; P89"
                     /note="inner membrane protein, mitochondrial"
                     /db_xref="GeneID:76614"
                     /db_xref="MGI:MGI:1923864"
     exon            1..196
                     /gene="Immt"
                     /gene_synonym="1700082C19Rik; D830041H16Rik; HMP; Micos60;
                     P87; P87/89; P89"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..2425
                     /gene="Immt"
                     /gene_synonym="1700082C19Rik; D830041H16Rik; HMP; Micos60;
                     P87; P87/89; P89"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mitochondrial inner membrane protein; mitofilin; MICOS
                     complex subunit Mic60"
                     /codon_start=1
                     /product="MICOS complex subunit Mic60 isoform 1"
                     /protein_id="NP_083949.2"
                     /db_xref="CCDS:CCDS39509.1"
                     /db_xref="GeneID:76614"
                     /db_xref="MGI:MGI:1923864"
                     /translation="MLRACQLSGVTVAAQSCLCGKFVLRPLRPCRRYSTSSSSGLTAG
                     KIAGAGLLFVGGGIGGTILYAKWDSHFRESVEKTIPYSDKLFGMVLGSAPYTVPLPKK
                     PVQSGPLKISSVSEVMKDSKLPVAQSQKTKGDTPASAASTGAAQIISAAGDTLSVPAP
                     AVQHEDTIKTECPNTNEGKSTSETTEEAFSSSVRERPPEEVAARLAQQEKQEQVEMES
                     LAKSLEDALNRTSSVTLQTITAQNAAVQAVKAHSNILKTAMDNSEIAGEKKSAQWRTV
                     EGALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKREIAGATPHITAAEGRLHNMI
                     VDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSITPDITPGWKGMSISDLA
                     GKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEKHKLEEKRTFDSAVAK
                     ALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEF
                     EQGLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH
                     QLWLSVEALKYSMKTSSAEMPTIPLGSAVEAIRVNCSDNEFTQALTAAIPPESLTRGV
                     YSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPKQLKPPAELYPE
                     DINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKEARMTLETKQIVEIL
                     TAYASAVGIGTTQVQQE"
     exon            197..270
                     /gene="Immt"
                     /gene_synonym="1700082C19Rik; D830041H16Rik; HMP; Micos60;
                     P87; P87/89; P89"
                     /inference="alignment:Splign:2.1.0"
     exon            271..460
                     /gene="Immt"
                     /gene_synonym="1700082C19Rik; D830041H16Rik; HMP; Micos60;
                     P87; P87/89; P89"
                     /inference="alignment:Splign:2.1.0"
     exon            461..569
                     /gene="Immt"
                     /gene_synonym="1700082C19Rik; D830041H16Rik; HMP; Micos60;
                     P87; P87/89; P89"
                     /inference="alignment:Splign:2.1.0"
     exon            570..707
                     /gene="Immt"
                     /gene_synonym="1700082C19Rik; D830041H16Rik; HMP; Micos60;
                     P87; P87/89; P89"
                     /inference="alignment:Splign:2.1.0"
     exon            708..803
                     /gene="Immt"
                     /gene_synonym="1700082C19Rik; D830041H16Rik; HMP; Micos60;
                     P87; P87/89; P89"
                     /inference="alignment:Splign:2.1.0"
     exon            804..940
                     /gene="Immt"
                     /gene_synonym="1700082C19Rik; D830041H16Rik; HMP; Micos60;
                     P87; P87/89; P89"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1044
                     /gene="Immt"
                     /gene_synonym="1700082C19Rik; D830041H16Rik; HMP; Micos60;
                     P87; P87/89; P89"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1180
                     /gene="Immt"
                     /gene_synonym="1700082C19Rik; D830041H16Rik; HMP; Micos60;
                     P87; P87/89; P89"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1310
                     /gene="Immt"
                     /gene_synonym="1700082C19Rik; D830041H16Rik; HMP; Micos60;
                     P87; P87/89; P89"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1325
                     /gene="Immt"
                     /gene_synonym="1700082C19Rik; D830041H16Rik; HMP; Micos60;
                     P87; P87/89; P89"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1549
                     /gene="Immt"
                     /gene_synonym="1700082C19Rik; D830041H16Rik; HMP; Micos60;
                     P87; P87/89; P89"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1681
                     /gene="Immt"
                     /gene_synonym="1700082C19Rik; D830041H16Rik; HMP; Micos60;
                     P87; P87/89; P89"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1811
                     /gene="Immt"
                     /gene_synonym="1700082C19Rik; D830041H16Rik; HMP; Micos60;
                     P87; P87/89; P89"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..2761
                     /gene="Immt"
                     /gene_synonym="1700082C19Rik; D830041H16Rik; HMP; Micos60;
                     P87; P87/89; P89"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2729..2734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Immt"
                     /gene_synonym="1700082C19Rik; D830041H16Rik; HMP; Micos60;
                     P87; P87/89; P89"
                     /note="hexamer: AATAAA"
     polyA_site      2744
                     /gene="Immt"
                     /gene_synonym="1700082C19Rik; D830041H16Rik; HMP; Micos60;
                     P87; P87/89; P89"
     polyA_site      2753
                     /gene="Immt"
                     /gene_synonym="1700082C19Rik; D830041H16Rik; HMP; Micos60;
                     P87; P87/89; P89"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcgtgcg cagtggtgcc ggtggccctt ccggtgcgcc ggacgcagct aggctgtaca
       61 gacgcgggca cgcacaccag cacgcacgcc ctcctctcgt gcggccgcgg tcgttcccgc
      121 gtccaccagc agcgctgtcg cttcggcaga aatgctgcgg gcctgtcagt tatccggcgt
      181 gaccgtcgcg gcccagagtt gtctgtgtgg gaagttcgtc ctccgtccac tacgaccatg
      241 ccgtagatac tccacttcaa gcagttctgg gttgactgct ggtaagattg ctggagctgg
      301 ccttttgttc gttggtggag ggattggtgg cactatcctg tatgccaaat gggattccca
      361 tttccgggaa agtgtagaga aaaccatccc ttactcagac aaactctttg ggatggttct
      421 tggttctgcg ccttatactg ttccattacc aaagaaaccg gttcagtctg gtccactaaa
      481 aatctccagt gtatcagagg tgatgaaaga ctccaaactg cctgtggcac agagccagaa
      541 aacgaaggga gacactccag cttcagcagc atctacaggg gcagctcaaa ttatttctgc
      601 agcaggtgat acactttcgg tcccggcccc tgcagttcag catgaggaca ctataaaaac
      661 cgaatgtccc aacactaatg aaggaaaatc tacgtctgaa accacagagg aagcattctc
      721 atcttctgta agggagcgac cacccgaaga agttgcagct cgtctagcgc aacaggaaaa
      781 gcaagaacaa gttgagatgg agtctctagc caagagttta gaagatgctc tgaaccggac
      841 ttcgtctgtc actctgcaga ctattacagc ccagaatgct gcagttcagg ctgtcaaggc
      901 acactccaac atactgaaaa cagccatgga caattctgag attgcaggtg agaagaagtc
      961 ggcccagtgg cgaacagtgg agggtgcatt gaaggagcga agaaaggcag ttgatgaagc
     1021 tgccgatgcc ctgctcaaag caaaagaaga gttagagaag atgaaaacta taattgaaga
     1081 tgcaaagaaa agagagattg ctggagccac ccctcatata actgctgcag aggggagact
     1141 tcacaacatg atagttgatc tggataacgt cgtcaaaaag gtccaggctg ctcagtcaga
     1201 ggcaaaggtg gtatctcagt atcatgaact tgtggtccaa gcaagagatg actttagaaa
     1261 agagctggac agtatcactc cagacatcac tcctggatgg aaagggatga gtatttctga
     1321 cctagctggc aaactctcta ctgatgacct gaactcactc attgctcatg cccatcgtcg
     1381 cattgatcag ctcaacagag agctagcaca acagaaagcc acagagaagc agcacattga
     1441 gctagccttg gaaaagcaca agctagaaga aaagcggacc tttgactctg cagtggcaaa
     1501 agcattggag caccacagaa gtgaaattca ggctgagcag gacagaaagg tagaagaagt
     1561 cagagatgcc atggagaatg aaatgcggac ccaacttcga cggcaggcag ctgcccacac
     1621 tgatcattta cgagatgtcc tcaaggtgca ggaacaggaa ctgaagtatg aatttgaaca
     1681 gggcctgtct gagaaactgt ctgagcaaga attagagttt cgtcgtcgca gtcaagaaca
     1741 aatggacagc tttactctgg acataaatac tgcctatgcc aggttgagag ggattgagca
     1801 ggctgttcag agtcatgcag ttgctgaaga agaagccaga aaagcccacc agctctggct
     1861 ttcagtggag gcattaaagt acagcatgaa gacctcatct gcagaaatgc ctaccatccc
     1921 attggggagt gcagttgagg ccatcagagt caactgttct gataatgaat ttacccaggc
     1981 tttaactgca gccattcctc cagagtccct gacccggggg gtatacagtg aagagaccct
     2041 aagagcccgt ttctatgctg ttcaaaaact agcccgaagg gtagcgatga ttgacgaaac
     2101 cagaaatagc ctgtaccaat acttcctttc ctacttacag tccctactcc tgttcccgcc
     2161 taagcaactg aagcccccgg cggagctcta ccctgaagat ataaatacat ttaaattgct
     2221 ctcatatgcc tcctattgta ttgagcatgg tgacctggag ctggcagcaa agtttgtcaa
     2281 tcagctcaaa ggggagtcca gaagagtggc acaggactgg ctgaaggagg cccgaatgac
     2341 cctagaaact aagcagatag tggagatcct gactgcatac gccagcgccg taggaatagg
     2401 aaccactcaa gtgcagcaag agtaaggcct aggaagagtt gtgtaatgtc atatttcata
     2461 tcaaagaaaa tcagcattgg tatctgcagg gtttgcaaca agggtcccag aattgtccag
     2521 aagtgagcag gttccaagtc ctgtgtgaga tgttaacacc tgttgcattt accgtcctta
     2581 cactgctatc atgccaatga actccaggag gctttatttg caacttgtgt aacacttcct
     2641 gttttttagg ttttactgat caggcttgtg agccactcaa aataatgttt gtgatcccta
     2701 ctattgattc tgcccttgga gcaaactgaa taaagcaaca caatgaaaac tgagtactct
     2761 aaaaaaaaaa aaaaaaa
//
