LOCUS       NM_053122               1147 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus IMP2 inner mitochondrial membrane peptidase-like (S.
            cerevisiae) (Immp2l), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_053122
VERSION     NM_053122.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1147)
  AUTHORS   Qu,X., Pan,P., Cao,S., Ma,Y., Yang,J., Gao,H., Pei,X. and Yang,Y.
  TITLE     Immp2l Deficiency Induced Granulosa Cell Senescence Through
            STAT1/ATF4 Mediated UPRmt and STAT1/(ATF4)/HIF1alpha/BNIP3 Mediated
            Mitophagy: Prevented by Enocyanin
  JOURNAL   Int J Mol Sci 25 (20), 11122 (2024)
   PUBMED   39456903
  REMARK    GeneRIF: Immp2l Deficiency Induced Granulosa Cell Senescence
            Through STAT1/ATF4 Mediated UPR[mt] and
            STAT1/(ATF4)/HIF1alpha/BNIP3 Mediated Mitophagy: Prevented by
            Enocyanin.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1147)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1147)
  AUTHORS   Clarke,R.A., Govindaraju,H., Beretta,M., Olzomer,E., Lawther,A.J.,
            Walker,A.K., Fang,Z., Eapen,V., Hyams,T.C., Killingsworth,M.,
            Bridge,W., Turner,N. and Siddiqui,K.S.
  TITLE     Immp2l Enhances the Structure and Function of Mitochondrial Gpd2
            Dehydrogenase
  JOURNAL   Int J Mol Sci 25 (2), 990 (2024)
   PUBMED   38256063
  REMARK    GeneRIF: Immp2l Enhances the Structure and Function of
            Mitochondrial Gpd2 Dehydrogenase.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1147)
  AUTHORS   Lawther,A.J., Zieba,J., Fang,Z., Furlong,T.M., Conn,I.,
            Govindaraju,H., Choong,L.L.Y., Turner,N., Siddiqui,K.S., Bridge,W.,
            Merlin,S., Hyams,T.C., Killingsworth,M., Eapen,V., Clarke,R.A. and
            Walker,A.K.
  TITLE     Antioxidant Behavioural Phenotype in the Immp2l Gene Knock-Out
            Mouse
  JOURNAL   Genes (Basel) 14 (9), 1717 (2023)
   PUBMED   37761857
  REMARK    GeneRIF: Antioxidant Behavioural Phenotype in the Immp2l Gene
            Knock-Out Mouse.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1147)
  AUTHORS   Leung,B.K., Merlin,S., Walker,A.K., Lawther,A.J., Paxinos,G.,
            Eapen,V., Clarke,R., Balleine,B.W. and Furlong,T.M.
  TITLE     Immp2l knockdown in male mice increases stimulus-driven
            instrumental behaviour but does not alter goal-directed learning or
            neuron density in cortico-striatal circuits in a model of Tourette
            syndrome and autism spectrum disorder
  JOURNAL   Behav Brain Res 452, 114610 (2023)
   PUBMED   37541448
  REMARK    GeneRIF: Immp2l knockdown in male mice increases stimulus-driven
            instrumental behaviour but does not alter goal-directed learning or
            neuron density in cortico-striatal circuits in a model of Tourette
            syndrome and autism spectrum disorder.
REFERENCE   6  (bases 1 to 1147)
  AUTHORS   Qian,J., Dong,Y., Pang,Y.Y., Ibrahim,R., Berzofsky,J.A.,
            Schiller,J.T. and Khleif,S.N.
  TITLE     Combined prophylactic and therapeutic cancer vaccine: enhancing CTL
            responses to HPV16 E2 using a chimeric VLP in HLA-A2 mice
  JOURNAL   Int J Cancer 118 (12), 3022-3029 (2006)
   PUBMED   16425257
REFERENCE   7  (bases 1 to 1147)
  AUTHORS   Burri,L., Strahm,Y., Hawkins,C.J., Gentle,I.E., Puryer,M.A.,
            Verhagen,A., Callus,B., Vaux,D. and Lithgow,T.
  TITLE     Mature DIABLO/Smac is produced by the IMP protease complex on the
            mitochondrial inner membrane
  JOURNAL   Mol Biol Cell 16 (6), 2926-2933 (2005)
   PUBMED   15814844
REFERENCE   8  (bases 1 to 1147)
  AUTHORS   Petek,E., Windpassinger,C., Vincent,J.B., Cheung,J., Boright,A.P.,
            Scherer,S.W., Kroisel,P.M. and Wagner,K.
  TITLE     Disruption of a novel gene (IMMP2L) by a breakpoint in 7q31
            associated with Tourette syndrome
  JOURNAL   Am J Hum Genet 68 (4), 848-858 (2001)
   PUBMED   11254443
REFERENCE   9  (bases 1 to 1147)
  AUTHORS   Colella,T.A., Bullock,T.N., Russell,L.B., Mullins,D.W.,
            Overwijk,W.W., Luckey,C.J., Pierce,R.A., Restifo,N.P. and
            Engelhard,V.H.
  TITLE     Self-tolerance to the murine homologue of a tyrosinase-derived
            melanoma antigen: implications for tumor immunotherapy
  JOURNAL   J Exp Med 191 (7), 1221-1232 (2000)
   PUBMED   10748239
REFERENCE   10 (bases 1 to 1147)
  AUTHORS   Newberg,M.H., Smith,D.H., Haertel,S.B., Vining,D.R., Lacy,E. and
            Engelhard,V.H.
  TITLE     Importance of MHC class 1 alpha2 and alpha3 domains in the
            recognition of self and non-self MHC molecules
  JOURNAL   J Immunol 156 (7), 2473-2480 (1996)
   PUBMED   8786307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153793.4, AC240395.3, AC124826.8 and AC123620.14.
            
            On Jul 30, 2020 this sequence version replaced NM_053122.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061049.1, CB596676.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AC153793.4         200170-200225       c
            57-129              AC153793.4         199682-199754       c
            130-266             AC153793.4         155869-156005       c
            267-370             AC153793.4         113372-113475       c
            371-436             AC240395.3         53324-53389
            437-539             AC124826.8         117576-117678
            540-1147            AC123620.14        63459-64066         c
FEATURES             Location/Qualifiers
     source          1..1147
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 18.69 cM"
     gene            1..1147
                     /gene="Immp2l"
                     /gene_synonym="IMP2; Tg(HLA-A/H2-D)2Enge"
                     /note="IMP2 inner mitochondrial membrane peptidase-like
                     (S. cerevisiae)"
                     /db_xref="GeneID:93757"
                     /db_xref="MGI:MGI:2135611"
     exon            1..56
                     /gene="Immp2l"
                     /gene_synonym="IMP2; Tg(HLA-A/H2-D)2Enge"
                     /inference="alignment:Splign:2.1.0"
     exon            57..129
                     /gene="Immp2l"
                     /gene_synonym="IMP2; Tg(HLA-A/H2-D)2Enge"
                     /inference="alignment:Splign:2.1.0"
     exon            130..266
                     /gene="Immp2l"
                     /gene_synonym="IMP2; Tg(HLA-A/H2-D)2Enge"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..659
                     /gene="Immp2l"
                     /gene_synonym="IMP2; Tg(HLA-A/H2-D)2Enge"
                     /note="IMP2-like protein; AAD mice"
                     /codon_start=1
                     /product="mitochondrial inner membrane protease subunit 2"
                     /protein_id="NP_444352.2"
                     /db_xref="CCDS:CCDS83961.1"
                     /db_xref="GeneID:93757"
                     /db_xref="MGI:MGI:2135611"
                     /translation="MAQSQSWARRCFKAFCKGFFVAVPVAVTFLDRVACVARVEGSSM
                     QPSLNPGGSQSSDVVLLNHWKVRNFEVQRGDIVSLVSPKNPEQKIIKRVIALEGDIVR
                     TIGHKNRLVKVPRGHMWVEGDHHGHSFDSNSFGPVSLGLLHAHATHILWPPERWQRLE
                     SVLPPERCPLQTGEK"
     exon            267..370
                     /gene="Immp2l"
                     /gene_synonym="IMP2; Tg(HLA-A/H2-D)2Enge"
                     /inference="alignment:Splign:2.1.0"
     exon            371..436
                     /gene="Immp2l"
                     /gene_synonym="IMP2; Tg(HLA-A/H2-D)2Enge"
                     /inference="alignment:Splign:2.1.0"
     exon            437..539
                     /gene="Immp2l"
                     /gene_synonym="IMP2; Tg(HLA-A/H2-D)2Enge"
                     /inference="alignment:Splign:2.1.0"
     exon            540..1147
                     /gene="Immp2l"
                     /gene_synonym="IMP2; Tg(HLA-A/H2-D)2Enge"
                     /inference="alignment:Splign:2.1.0"
     regulatory      782..787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Immp2l"
                     /gene_synonym="IMP2; Tg(HLA-A/H2-D)2Enge"
                     /note="hexamer: ATTAAA"
     polyA_site      802
                     /gene="Immp2l"
                     /gene_synonym="IMP2; Tg(HLA-A/H2-D)2Enge"
                     /note="major polyA site"
ORIGIN      
        1 gcggcggagg gcggagcgtg ccgcggggac ttcccctggg ttgagctgcg cagcgggatt
       61 ttggccaaat tgggcgaggg tacaatatta ccacttaccc cttctcaccg aggaagagcg
      121 ggagaaaggg tatggcacag tcacaaagct gggcgagaag atgcttcaag gccttttgca
      181 aaggcttctt cgtggcggtg cccgtggcag tcactttctt ggatcgcgtg gcctgcgtgg
      241 ctcgggtgga aggctcgtca atgcagcctt ctttgaatcc tggaggaagc cagtcctcag
      301 atgtggtact tttgaaccac tggaaagtga gaaattttga agtacagcgt ggtgacattg
      361 tgtcattggt gtctcctaaa aacccagaac agaaaatcat taagagagtg atcgctcttg
      421 aaggagatat tgtaagaaca attggacaca aaaaccggtt ggtcaaagtc ccccgcggtc
      481 acatgtgggt tgaaggcgat catcatggac acagttttga tagtaattct tttggaccgg
      541 tttctctggg actcctgcat gcccatgcca cacatatttt gtggcctcca gagcgctggc
      601 agagactgga atctgttctt cctccagagc gctgtccact ccagactggt gagaaataac
      661 tgcacaagag cccaccatag gaggagctga acacaccaga tgcctccttc tggagggaga
      721 tgttccagtg atgctgaaca caagacctct gtatatcttt aaggttgtct ggaatttcca
      781 tattaaacag tattaaatgg cacttgattg tgtgttgtat ttaattccat attgcttatc
      841 accaaaaaaa tccagttctt ggagaacatg aaagcatgct atctgtacat attaaagaag
      901 ataaatagag aatgctgtgc atagttatcg atgagaattt ttctgtgaag cctgctgctc
      961 aacgaatttt aaaattaatg tgcagcaaag atgatttgtc ttttactatt ttaagactga
     1021 acgaggaaaa caaagtatta tgcacataaa aatagtgatt atattgtaat tgaagatatc
     1081 cacagaatag tgactgccag ttaggaagga ccagaaaccg tgataaaata aaacaaccat
     1141 ttgtcca
//
