LOCUS       NM_001359302            2272 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus ilvB (bacterial acetolactate synthase)-like (Ilvbl),
            transcript variant 3, mRNA.
ACCESSION   NM_001359302
VERSION     NM_001359302.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2272)
  AUTHORS   Rhein,S., Costalunga,R., Inderhees,J., Gurtzgen,T., Faupel,T.C.,
            Shaheryar,Z., Arrulo Pereira,A., Othman,A., Begemann,K., Binder,S.,
            Stolting,I., Dorta,V., Nawroth,P.P., Fleming,T., Oexle,K.,
            Prevot,V., Nogueiras,R., Meyhofer,S., Meyhofer,S.M. and
            Schwaninger,M.
  TITLE     The reactive pyruvate metabolite dimethylglyoxal mediates
            neurological consequences of diabetes
  JOURNAL   Nat Commun 15 (1), 5745 (2024)
   PUBMED   38987239
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2272)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2272)
  AUTHORS   Mori,K., Naganuma,T. and Kihara,A.
  TITLE     Role of 2-hydroxy acyl-CoA lyase HACL2 in odd-chain fatty acid
            production via alpha-oxidation in vivo
  JOURNAL   Mol Biol Cell 34 (9), ar85 (2023)
   PUBMED   37285239
REFERENCE   4  (bases 1 to 2272)
  AUTHORS   Liu,S., Lu,S., Xu,R., Atzberger,A., Gunther,S., Wettschureck,N. and
            Offermanns,S.
  TITLE     Members of Bitter Taste Receptor Cluster Tas2r143/Tas2r135/Tas2r126
            Are Expressed in the Epithelium of Murine Airways and Other
            Non-gustatory Tissues
  JOURNAL   Front Physiol 8, 849 (2017)
   PUBMED   29163195
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2272)
  AUTHORS   Wiltshire,T., Pletcher,M., Cole,S.E., Villanueva,M., Birren,B.,
            Lehoczky,J., Dewar,K. and Reeves,R.H.
  TITLE     Perfect conserved linkage across the entire mouse chromosome 10
            region homologous to human chromosome 21
  JOURNAL   Genome Res 9 (12), 1214-1222 (1999)
   PUBMED   10613844
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133553.1, AK146075.1 and AI842669.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.245691.1, AK146075.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AK133553.1         1-3
            4-2236              AK146075.1         2-2234
            2237-2272           AI842669.1         1-36                c
FEATURES             Location/Qualifiers
     source          1..2272
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..2272
                     /gene="Ilvbl"
                     /gene_synonym="5830463I21"
                     /note="ilvB (bacterial acetolactate synthase)-like"
                     /db_xref="GeneID:216136"
                     /db_xref="MGI:MGI:1351911"
     exon            1..241
                     /gene="Ilvbl"
                     /gene_synonym="5830463I21"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..2005
                     /gene="Ilvbl"
                     /gene_synonym="5830463I21"
                     /EC_number="2.2.1.-"
                     /note="isoform 2 is encoded by transcript variant 3;
                     acetolactate synthase-like protein; ilvB-like protein;
                     2-hydroxyacyl-CoA lyase 2"
                     /codon_start=1
                     /product="2-hydroxyacyl-CoA lyase 2 isoform 2"
                     /protein_id="NP_001346231.1"
                     /db_xref="CCDS:CCDS23966.1"
                     /db_xref="GeneID:216136"
                     /db_xref="MGI:MGI:1351911"
                     /translation="METSAAAASAGGFFPSFLLLAFGTLVAAVLGVAHRLGLFYQLMH
                     KVDKTSIRHGGESVAAVLRAHGVRFVFTLVGGHISPLLVACEKLGIRVVDTRHEVTAV
                     FAADAVARLTGTVGVAAVTAGPGLTNTVTAVKNAQVAQSPVLLLGGAASTLLQKRGAL
                     QAIDQMSLFRPLCKFCASVRRVRDIVPTLRTAIAAAQSGTPGPVFVELPLDVLYPYFM
                     VEKEMIPTKLPNSLMGRVVVWYLQNCLANLFVGAWEPRPEGPLPLDIPQASPQQVQRC
                     VEILSRAKRPLLVLGSQALLPPTPANKLRAAVETLGVPCFLGGMSRGLLGRNHPLHIR
                     QNRSAALKKADVVVLAGAVCDFRLSYGRVLNRKSSIIIVNRNRDDLLLNSDIFWKPQE
                     AVQGDVGSFMIKLVEGLQGQMWSSDWAEELRKADQQKEQTYRDKALMPVLQHLNPVWV
                     LQQVEETLPDNALLVVDGGDFVATAAYLVQPRGPLRWLDPGAFGTLGVGAGFALGAKL
                     CQPEAEVWCLFGDGAFGYSLIEFDTFVRHKVPVIALVGNDAGWTQISREQVPRLGSDV
                     ACSLAYTDYHKAAMGLGAQGLILSRDNKDQVVKVLREGQQLCQDGHAVVVNILIGRTD
                     FRDGSISV"
     exon            242..443
                     /gene="Ilvbl"
                     /gene_synonym="5830463I21"
                     /inference="alignment:Splign:2.1.0"
     exon            444..571
                     /gene="Ilvbl"
                     /gene_synonym="5830463I21"
                     /inference="alignment:Splign:2.1.0"
     exon            572..710
                     /gene="Ilvbl"
                     /gene_synonym="5830463I21"
                     /inference="alignment:Splign:2.1.0"
     exon            711..822
                     /gene="Ilvbl"
                     /gene_synonym="5830463I21"
                     /inference="alignment:Splign:2.1.0"
     exon            823..922
                     /gene="Ilvbl"
                     /gene_synonym="5830463I21"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1020
                     /gene="Ilvbl"
                     /gene_synonym="5830463I21"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1157
                     /gene="Ilvbl"
                     /gene_synonym="5830463I21"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1292
                     /gene="Ilvbl"
                     /gene_synonym="5830463I21"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1407
                     /gene="Ilvbl"
                     /gene_synonym="5830463I21"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1577
                     /gene="Ilvbl"
                     /gene_synonym="5830463I21"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1648
                     /gene="Ilvbl"
                     /gene_synonym="5830463I21"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1720
                     /gene="Ilvbl"
                     /gene_synonym="5830463I21"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1826
                     /gene="Ilvbl"
                     /gene_synonym="5830463I21"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..2259
                     /gene="Ilvbl"
                     /gene_synonym="5830463I21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2216..2221
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ilvbl"
                     /gene_synonym="5830463I21"
                     /note="hexamer: AATAAA"
     polyA_site      2259
                     /gene="Ilvbl"
                     /gene_synonym="5830463I21"
                     /note="major polyA site"
ORIGIN      
        1 ggcaggtcgg ggaggtgtgg cccaggtccg gcggacgatc ctgcttccgg attagattat
       61 agtactaaga ttctggctct gtgctttctt acttaggttc tgcctcatgg aaacttctgc
      121 ggccgctgca tctgcgggag gcttcttccc ctccttcctg ctcctggcgt ttgggacgct
      181 ggtggctgcc gtgctgggcg tcgctcacag actggggctc ttctatcagc tgatgcacaa
      241 ggtggacaag acaagcatcc ggcatggtgg agagagtgtc gcagctgtgc tccgagccca
      301 tggtgtacgc tttgtcttca cattggtcgg tgggcacatt tccccactgc tggtggcctg
      361 tgagaagctg ggtatccgag tggtagacac acgccacgag gtcactgctg tctttgctgc
      421 tgatgctgtg gcccgcctga ctgggacagt gggtgtggca gcagtgacag ccggtcctgg
      481 cctcaccaac actgtgactg cagtgaagaa tgcacaagtg gcacagtccc cagtcctgct
      541 tttgggtgga gctgccagca ccctgctgca gaaacggggc gcacttcagg ccattgatca
      601 gatgtctctg ttcaggccac tctgcaagtt ttgtgcttct gtgcgaaggg tacgggacat
      661 tgtacctacc ctgaggactg caatagctgc tgcccagtca ggcaccccag gtccagtgtt
      721 tgtggagctg cctcttgatg tactatatcc ttacttcatg gttgagaagg agatgatacc
      781 aaccaagttg cccaatagcc tcatgggccg tgtggttgtc tggtatttac agaactgcct
      841 ggccaacctc tttgttgggg cttgggaacc tcgtcccgag ggacctctgc ccttggatat
      901 tccccaggca tctccgcagc aggtccagcg ctgtgtggag atcctgagcc gggccaagag
      961 gcctctgctg gtactgggga gccaggcctt gctgcccccg acccctgcca acaagcttag
     1021 agctgccgtg gagaccctgg gtgtcccctg ctttctaggg gggatgtctc gggggctgct
     1081 gggccgcaac caccctctcc acatccggca gaaccgcagc gctgctctga agaaagcaga
     1141 tgttgttgtc ctggcaggcg ctgtgtgtga tttccgcctg tcttatggcc gggtcctcaa
     1201 ccgcaagagc agcatcatca ttgtcaaccg gaaccgggat gatctcttgc tcaactcgga
     1261 catcttctgg aagcctcagg aggctgtgca gggagatgtg ggctccttca tgataaaact
     1321 ggtggaaggc cttcagggcc agatgtggtc ttcagattgg gctgaggagc ttcggaaagc
     1381 tgaccagcag aaggagcaga cctatcggga taaggcttta atgcctgtat tacagcacct
     1441 gaacccagta tgggtgttac agcaggtgga ggaaactctg cctgacaatg cacttcttgt
     1501 ggttgacgga ggggactttg tggccactgc tgcctactta gtccagccca gagggcctct
     1561 gcgctggctc gatcctgggg cctttgggac tctgggagtt ggcgcaggtt ttgcacttgg
     1621 ggccaagctg tgtcagccgg aggctgaggt ttggtgcctg tttggggatg gagcctttgg
     1681 ctacagcctc attgagtttg acacgttcgt cagacataag gtaccagtga tagccttggt
     1741 aggaaacgat gcaggttgga cccagatttc tcgagagcag gtgcccaggt tgggcagtga
     1801 tgtagcctgt agcctggctt acactgatta tcacaaggca gccatgggcc tgggggccca
     1861 gggattgata ctctcacggg acaataagga tcaagtggtc aaggtacttc gtgaaggcca
     1921 gcagctgtgc caggatggtc atgcagttgt ggtcaacatc ctgattggga ggacagactt
     1981 ccgagatggc tccatttctg tatagggact atccagggtt agtgtgcttg cctctttgga
     2041 ccaggacttt gtctacctgg agttttcatc cttgcctgtc ctgagcttgt ctcataaggt
     2101 ctaaccctct aagtggggaa tgtgggggtg gggaaccaaa gctcaaagag gcaccttggc
     2161 aaccctgggt agctctttcc aaaaggttca gctgtaccct ctctcttaca aaattaataa
     2221 atctcttggc tatatgagcc caaggactca gtcacagaaa aaaaaaaaaa aa
//
