LOCUS       NM_001033279            3812 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus inflammation and lipid regulator with UBA-like and
            NBR1-like domains (Ilrun), transcript variant 1, mRNA.
ACCESSION   NM_001033279 XM_128587 XM_899776 XM_899784 XM_899792 XM_899798
            XM_915193 XM_923626 XM_923628 XM_923630 XM_923632
VERSION     NM_001033279.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3812)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3812)
  AUTHORS   Tribolet,L., Brice,A.M., Fulford,T.S., Layton,D.S., Godfrey,D.I.,
            Bean,A.G.D. and Stewart,C.R.
  TITLE     Identification of a novel role for the immunomodulator ILRUN in the
            development of several T cell subsets in mice
  JOURNAL   Immunobiology 228 (3), 152380 (2023)
   PUBMED   37031606
REFERENCE   3  (bases 1 to 3812)
  AUTHORS   Bi,X., Stankov,S., Lee,P.C., Wang,Z., Wu,X., Li,L., Ko,Y.A.,
            Cheng,L., Zhang,H., Hand,N.J. and Rader,D.J.
  TITLE     ILRUN Promotes Atherosclerosis Through Lipid-Dependent and
            Lipid-Independent Factors
  JOURNAL   Arterioscler Thromb Vasc Biol 42 (9), 1139-1151 (2022)
   PUBMED   35861973
  REMARK    GeneRIF: ILRUN Promotes Atherosclerosis Through Lipid-Dependent and
            Lipid-Independent Factors.
REFERENCE   4  (bases 1 to 3812)
  AUTHORS   Bi,X., Kuwano,T., Lee,P.C., Millar,J.S., Li,L., Shen,Y.,
            Soccio,R.E., Hand,N.J. and Rader,D.J.
  TITLE     ILRUN, a Human Plasma Lipid GWAS Locus, Regulates Lipoprotein
            Metabolism in Mice
  JOURNAL   Circ Res 127 (11), 1347-1361 (2020)
   PUBMED   32912065
  REMARK    GeneRIF: ILRUN, a Human Plasma Lipid GWAS Locus, Regulates
            Lipoprotein Metabolism in Mice.
REFERENCE   5  (bases 1 to 3812)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK161603.1 and AC131799.3.
            
            On Oct 5, 2012 this sequence version replaced NM_001033279.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145403.1, AK161603.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-538               AK161603.1         2-539
            539-717             AC131799.3         33362-33540
            718-817             AK161603.1         719-818
            818-868             AC131799.3         51472-51522
            869-1219            AK161603.1         870-1220
            1220-3812           AC131799.3         65789-68381
FEATURES             Location/Qualifiers
     source          1..3812
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 14.59 cM"
     gene            1..3812
                     /gene="Ilrun"
                     /gene_synonym="C030010A15; D17Wsu92e"
                     /note="inflammation and lipid regulator with UBA-like and
                     NBR1-like domains"
                     /db_xref="GeneID:224647"
                     /db_xref="MGI:MGI:106281"
     exon            1..366
                     /gene="Ilrun"
                     /gene_synonym="C030010A15; D17Wsu92e"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..1084
                     /gene="Ilrun"
                     /gene_synonym="C030010A15; D17Wsu92e"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C6orf106 homolog; protein ILRUN"
                     /codon_start=1
                     /product="protein ILRUN isoform 1"
                     /protein_id="NP_001028451.2"
                     /db_xref="CCDS:CCDS28569.1"
                     /db_xref="GeneID:224647"
                     /db_xref="MGI:MGI:106281"
                     /translation="MEGMDVDLDPELMQKFSCLGTTDKDVLISEFQRLLGFQLNPAGC
                     AFFLDMTNWNLQAAIGAYYDFESPNISVPSMSFVEDVTIGEGESIPPDTQFIKTWRIQ
                     NSGAEAWPPGVCLKYVGGDQFGHVNMVMVRSLEPQEIADVSVQMCSPSRAGMYQGQWR
                     MCTATGLYYGDVIWVILSVEVGGLLGVTQQLSSFETEFNTQPHRKVEGNFNPFASPQK
                     NRQSDENNLTDPGGSEFDSISKNTWAPVPEQSEQDQDRLSQSSVNLSPSSPANNLSVV
                     TYSKGLHGPYPFGQS"
     exon            367..521
                     /gene="Ilrun"
                     /gene_synonym="C030010A15; D17Wsu92e"
                     /inference="alignment:Splign:2.1.0"
     exon            522..719
                     /gene="Ilrun"
                     /gene_synonym="C030010A15; D17Wsu92e"
                     /inference="alignment:Splign:2.1.0"
     exon            720..1048
                     /gene="Ilrun"
                     /gene_synonym="C030010A15; D17Wsu92e"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..3812
                     /gene="Ilrun"
                     /gene_synonym="C030010A15; D17Wsu92e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1420..1425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ilrun"
                     /gene_synonym="C030010A15; D17Wsu92e"
                     /note="hexamer: AACAAA"
     polyA_site      1441
                     /gene="Ilrun"
                     /gene_synonym="C030010A15; D17Wsu92e"
                     /note="major polyA site"
     polyA_site      1713
                     /gene="Ilrun"
                     /gene_synonym="C030010A15; D17Wsu92e"
     polyA_site      3621
                     /gene="Ilrun"
                     /gene_synonym="C030010A15; D17Wsu92e"
ORIGIN      
        1 gagagaggag cgagcggtgc ggtgcggcgc ggctcggcgc ggcgcgcgca gcccatgagg
       61 cggtgagagg cctggggcct gtctcggagc agtgcgcgcg gcgccggcca gcagcgggcc
      121 gcccttcgtg ggctcgggcc cgggcgcggc ggccgcccgt ggagaagcag gtcggggcgg
      181 tggaagctgt gcgtccgggc cccccgccat ggagggcatg gacgtggact tggatccgga
      241 gctcatgcag aagttcagct gcctgggcac cacagacaag gacgtgctca tctccgagtt
      301 ccagcggcta ctcggcttcc agctcaaccc ggccggctgc gccttcttcc tggacatgac
      361 caactggaac ttacaagcag cgattggcgc ctattatgac ttcgagagcc caaatatcag
      421 tgtgccctcc atgtcctttg ttgaagatgt caccatagga gaaggggagt caataccccc
      481 tgatacccag ttcataaaaa cttggcggat acagaattct ggagcagagg cctggcctcc
      541 aggggtttgt cttaaatatg tcgggggaga ccagtttgga catgtgaaca tggtgatggt
      601 gagatcacta gagccccaag agatcgcaga cgtcagcgtc cagatgtgca gtcccagcag
      661 agcaggcatg taccagggac agtggcggat gtgcactgct actggactct actatggaga
      721 tgtcatctgg gtgattctca gtgtggaggt gggtggactt ttaggagtaa cgcagcagct
      781 gtcatctttt gaaacggaat tcaacacaca gccacatcgc aaggtagaag gaaacttcaa
      841 cccgtttgcc tctccccaaa agaaccgaca atcagatgaa aacaacctaa cagaccctgg
      901 gggttccgag ttcgactcga tcagcaaaaa tacatgggct cctgttcctg agcaaagcga
      961 gcaagatcag gatagactgt cacagagctc tgtaaatctg tcccccagca gtcccgcaaa
     1021 caacttatca gtagtgactt acagtaaggg gctccacggg ccttacccct tcggccagtc
     1081 ttaaacgggt gtcagcaaga agaaaaacta acaaaagaca gaaggcctga ctttgggggg
     1141 agagggcaag gggttcctct ggattgcaga ccacatcgca cggacccctg gctcagaccc
     1201 ccacctaccc cccaatcaca gaagaagagg aagaaagaga ctagttttga gtgaactcag
     1261 tatgcatgtg tgaatgctga actgcaggag tggtgttgag gcgaccgaga agatccacgc
     1321 agccatcttg ggttttggtg atgacgtcag tctaatgagt tgttaggtca cttgggaagg
     1381 ggaagaaatt taaatggggg aaaataagcc atctttttaa acaaaaatta ttttacctac
     1441 agagaggttg tagttttgag cacatgttag ttcctccctc ttcccgatgt tcatcttcta
     1501 agtaagggac agcatgctac aggacagacc tgctctggaa gcctgtcata gtaaggctgg
     1561 cgtggcacgt ttggggactc tgccagtcgg agttgctggg cacatgctgt gtaccaccga
     1621 ctgcagtctg gccctgttct tagtggcatc tgccaatgag atatcacctt ccccctctcc
     1681 tctttaatct cttgttaaat tacccctttg atattggtgt ctgtcagcgt tggggcttct
     1741 tagtatcagg acctctctga ggtaaggact ttcctgtgtg gccacagaaa cctgggggca
     1801 ttccgttgca gaggtgtcct ctgtcacgtg tgtaacagct ggaacacagt ggccgtcttc
     1861 cctcggctct tgttggtgtg tgcatgtgct gcgtgcacac cgggttgtat ggcgtcagca
     1921 ggtgtgagct gtcccttgct tctcttgtca cacagtgccc cttccccacg tgtcctgtgg
     1981 ctccagccat tacagagtga aggtgcaacc ccatgtggga gccccactag tgaccactcc
     2041 ctgagaggcc gcaatcaggt gggaatgaaa aggcctcctc cagcggggca ggctgctcag
     2101 tgtgggtggc aagttgtagc ccagctggag gacaggcctt tgctccctgg gcaggtgccc
     2161 actggtgtcc catggaatcc actcgggttg aaatgtggat ctctccatgg gactctttaa
     2221 ccaggctaga acagctgtct gccaaagata caagaatatg caaagtccct cctcctaacc
     2281 ctccttccct ctaagtcggt ggcttgagag ccggggatgt ggatttggtg tggttacagg
     2341 gtcccctgcc tgcctccagc ctccgtgtgc tccagggttg tgagcagagc aggaaggtca
     2401 ggtgagagtg gctgtaggag gtcctccagc ccgggtgcgt gggtgcacag gtgcgtgggt
     2461 gtgtggaacg ggtctgctct gcctgcttct gtctctgtct gggtgtttga gttccaaaaa
     2521 gtgtgtggtg tttgttcctc ctcatcctct tctgagactg ttgattttaa acacttgatt
     2581 gtgaacgaag agcttctatg aaaaccctca cctttccatg tcccaaaaac caacacaagt
     2641 ccctggggcg ggtggagaag atggtggagc cccgtgagac ggggcttctg tgtgaccctt
     2701 acttcctctg cacactggga cccttgagcc aagggcagtc cctaccaggt gcccaagccg
     2761 caagtctcag ggggcttttg tctgaggacc ttcttggggc cagtctctga ggacgctgcc
     2821 accctagagc acatgcatgc ccagccattc ttcctgcttc tggcctcgga gctgcttgtc
     2881 tccagatgcc ctcctgaaac catgagaagc ttcagccttg cctcactggc ttccccatct
     2941 gaccccacca ggtaccacac tgtcacccag tgtccttgat ctcctcttgt tcccctttct
     3001 gcttgtagca gcctcacttg gcaaatgtaa cggctcaggt accctggctt ccttcccaga
     3061 aacaagcctt gcctgtgcat cctggagagt taggtccttc agaaggccag agctgggaca
     3121 agccttgacc cgttctgcag cccttagagc cttcacacgt gagcactagg ccatcttagc
     3181 agaaccccca tctggcagca catgccaagt ttcaggagga ttggggggag gcgggtgcag
     3241 gcttgagaag aatctgggtg tgtgggtatg tgtgcacatg tgcatgtggg tgtgtgtgtg
     3301 cacatgtgca tgtgggtgtg tgtaagtatg tgtgcacatg ggagtgtggg tgtgtgtgtg
     3361 tgcacatgtg tgggtgtgtg tgcacatgtt tggatgtgtg cacatgtgca tgcctgtttc
     3421 tttttgccag ggagacaact gaatttgggg catttttcta caaacacagc ctcctctccc
     3481 cctgtatgga ctggctataa ccataagcca ggcgctttca ccaagatggc tggtggccaa
     3541 ggtgggcagt aggcatgagc ttccagcagg aaaggacaag agagtaggca ggcttacagg
     3601 tgcagactga gtgcttctcc gcctgccctc ttccccttgt ttccttgggt gagtgtgggg
     3661 ggcagcctgc tgtccctccc acctgcacag tgatgctgtc tggtggggcc tcgtggtgcc
     3721 taggagatga agatgaggtt ttccttaccg tgtaaatgaa tatttgtatg attaaattaa
     3781 cacacacaaa aaaaaaaacc ccgcctttat cc
//
