LOCUS       NM_023343               1412 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus integrin-linked kinase-associated serine/threonine
            phosphatase 2C (Ilkap), transcript variant 1, mRNA.
ACCESSION   NM_023343 XM_129949
VERSION     NM_023343.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1412)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1412)
  AUTHORS   Li,Q., Hao,Q., Cao,W., Li,J., Wu,K., Elshimali,Y., Zhu,D.,
            Chen,Q.H., Chen,G., Pollack,J.R., Vadgama,J. and Wu,Y.
  TITLE     PP2Cdelta inhibits p300-mediated p53 acetylation via ATM/BRCA1
            pathway to impede DNA damage response in breast cancer
  JOURNAL   Sci Adv 5 (10), eaaw8417 (2019)
   PUBMED   31663018
  REMARK    GeneRIF: PP2Cdelta, via dephosphorylation of ATM, suppresses DNA
            damage-induced BRCA1 phosphorylation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1412)
  AUTHORS   Tan,J., Chen,X.J., Shen,C.L., Zhang,H.X., Tang,L.Y., Lu,S.Y.,
            Wu,W.T., Kuang,Y., Fei,J. and Wang,Z.G.
  TITLE     Lacking of palladin leads to multiple cellular events changes which
            contribute to NTD
  JOURNAL   Neural Dev 12 (1), 4 (2017)
   PUBMED   28340616
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1412)
  AUTHORS   Chida,T., Ando,M., Matsuki,T., Masu,Y., Nagaura,Y.,
            Takano-Yamamoto,T., Tamura,S. and Kobayashi,T.
  TITLE     N-Myristoylation is essential for protein phosphatases PPM1A and
            PPM1B to dephosphorylate their physiological substrates in cells
  JOURNAL   Biochem J 449 (3), 741-749 (2013)
   PUBMED   23088624
REFERENCE   5  (bases 1 to 1412)
  AUTHORS   Nakrieko,K.A., Vespa,A., Mason,D., Irvine,T.S., D'Souza,S.J. and
            Dagnino,L.
  TITLE     Modulation of integrin-linked kinase nucleo-cytoplasmic shuttling
            by ILKAP and CRM1
  JOURNAL   Cell Cycle 7 (14), 2157-2166 (2008)
   PUBMED   18635968
  REMARK    GeneRIF: These studies demonstrate the importance for keratinocyte
            proliferation of ILK regulation through changes in its subcellular
            localization, and establish ILKAP and CRM1 as pivotal modulators of
            ILK subcellular distribution and activity in these cells.
REFERENCE   6  (bases 1 to 1412)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 1412)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110510.6.
            
            On Sep 9, 2017 this sequence version replaced NM_023343.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026953.1, SRR5189676.104821.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               AC110510.6         163684-163856       c
            174-239             AC110510.6         156165-156230       c
            240-296             AC110510.6         155640-155696       c
            297-416             AC110510.6         153378-153497       c
            417-543             AC110510.6         152248-152374       c
            544-650             AC110510.6         150273-150379       c
            651-744             AC110510.6         149598-149691       c
            745-832             AC110510.6         148337-148424       c
            833-954             AC110510.6         146884-147005       c
            955-1074            AC110510.6         143499-143618       c
            1075-1156           AC110510.6         141351-141432       c
            1157-1412           AC110510.6         140860-141115       c
FEATURES             Location/Qualifiers
     source          1..1412
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 46.11 cM"
     gene            1..1412
                     /gene="Ilkap"
                     /gene_synonym="0710007A14Rik; 1600009O09Rik; PP2C-DELTA"
                     /note="integrin-linked kinase-associated serine/threonine
                     phosphatase 2C"
                     /db_xref="GeneID:67444"
                     /db_xref="MGI:MGI:1914694"
     exon            1..173
                     /gene="Ilkap"
                     /gene_synonym="0710007A14Rik; 1600009O09Rik; PP2C-DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            174..239
                     /gene="Ilkap"
                     /gene_synonym="0710007A14Rik; 1600009O09Rik; PP2C-DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            240..296
                     /gene="Ilkap"
                     /gene_synonym="0710007A14Rik; 1600009O09Rik; PP2C-DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            297..416
                     /gene="Ilkap"
                     /gene_synonym="0710007A14Rik; 1600009O09Rik; PP2C-DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            417..543
                     /gene="Ilkap"
                     /gene_synonym="0710007A14Rik; 1600009O09Rik; PP2C-DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            544..650
                     /gene="Ilkap"
                     /gene_synonym="0710007A14Rik; 1600009O09Rik; PP2C-DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            651..744
                     /gene="Ilkap"
                     /gene_synonym="0710007A14Rik; 1600009O09Rik; PP2C-DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            745..832
                     /gene="Ilkap"
                     /gene_synonym="0710007A14Rik; 1600009O09Rik; PP2C-DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            833..954
                     /gene="Ilkap"
                     /gene_synonym="0710007A14Rik; 1600009O09Rik; PP2C-DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1074
                     /gene="Ilkap"
                     /gene_synonym="0710007A14Rik; 1600009O09Rik; PP2C-DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1156
                     /gene="Ilkap"
                     /gene_synonym="0710007A14Rik; 1600009O09Rik; PP2C-DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1412
                     /gene="Ilkap"
                     /gene_synonym="0710007A14Rik; 1600009O09Rik; PP2C-DELTA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1386..1391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ilkap"
                     /gene_synonym="0710007A14Rik; 1600009O09Rik; PP2C-DELTA"
                     /note="hexamer: AATAAA"
     polyA_site      1408
                     /gene="Ilkap"
                     /gene_synonym="0710007A14Rik; 1600009O09Rik; PP2C-DELTA"
                     /note="major polyA site"
ORIGIN      
        1 tctggggcgg cggctgggcg gcgcgcgatt ggcagggtct cccgcggtga gtgacggcgc
       61 cgccgccgcc gccgccgccc agggtagcgc ggagcctccg ctccactgcc ccgccgccat
      121 ggacctcttc ggggacctgc cggagcccga gcgcgcgccg cggccatctg ccgggaagga
      181 agcacaggga cgacccgtgc tctttgagga cctgcccccg gccagcagta ctgactcagg
      241 ctctggggga cctttactct ttgatgatct tccgcctgct gccagtggca attcaggttc
      301 tcttgccaca tcaggttccc aggtggtgaa gactgaaggg aaaggagcaa agaggaaagc
      361 ccctgaggag gagaagaatg gcggtgaaga gcttgtggaa aagaaagttt gtaaagcctc
      421 ttcggtgatc tttggtctga aaggctatgt ggcagagcgg aagggtgaga gggaggagat
      481 gcaggatgcc catgtcatcc tgaacgatat cactcaggag tgtaatcctc catcatctct
      541 cattactcgg gtttcatact ttgctgtgtt tgatggacat ggaggaatac gagcctcgaa
      601 atttgctgca cagaatttgc accagaactt aatcaggaaa tttcctaaag gagatataat
      661 cagtgtggag aagactgtaa agaggtgtct gctagatact tttaagcaca ccgatgaaga
      721 gttcctgaaa caggcttcaa gccagaagcc tgcctggaaa gacgggtcca ctgccacgtg
      781 tgtcctggct gtggacaaca tcctgtatat cgccaacctt ggagatagtc gggcaatcct
      841 gtgtcgatat aatgaggaaa gtcagaagca cgcagcctta agcctcagca aagagcacaa
      901 cccaactcag tatgaagagc gcatgaggat acagaaagct ggagggaatg tcagagatgg
      961 gcgtgtcttg ggcgtgctgg aggtatcgcg ttccattgga gatgggcagt acaagcgctg
     1021 tggggtcaca tctgtgcctg atatcagacg ctgccagctg acccccaatg acaggttcat
     1081 tttgctggct tgcgacgggc ttttcaaggt ctttacccca gaagaagctg tgaacttcat
     1141 cttgtcctgc cttgaggatg acaagatcca gacccgggaa gggaagcctg ctgttgatgc
     1201 ccgctatgaa gctgcatgca acaggctggc caacaaggca gtgcagcggg gctcagcaga
     1261 caacgtgacg gtgatggtgg tgaggatagg acactgaggc cagcacactg gcgtgtgctc
     1321 ttgacttgca ggttcatttt gtttgtgcac gctgtgtgta ctcctgtggg acttccatgg
     1381 ttgtaaataa aggtttcttt ttttcctagt ta
//
