LOCUS       NM_001161724            1797 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Mus musculus integrin linked kinase (Ilk), transcript variant 1,
            mRNA.
ACCESSION   NM_001161724
VERSION     NM_001161724.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1797)
  AUTHORS   Li,B., He,J., Zhang,R., Liu,S., Zhang,X., Li,Z., Ma,C., Wang,W.,
            Cui,Y. and Zhang,Y.
  TITLE     Integrin-Linked Kinase in the Development of Gastric Tumors Induced
            by Helicobacter pylori: Regulation and Prevention Potential
  JOURNAL   Helicobacter 29 (4), e13109 (2024)
   PUBMED   38951739
  REMARK    GeneRIF: Integrin-Linked Kinase in the Development of Gastric
            Tumors Induced by Helicobacter pylori: Regulation and Prevention
            Potential.
REFERENCE   2  (bases 1 to 1797)
  AUTHORS   Campillo,S., Gutierrez-Calabres,E., Garcia-Miranda,S., Griera,M.,
            Fernandez Rodriguez,L., de Frutos,S., Rodriguez-Puyol,D. and
            Calleros,L.
  TITLE     Integrin-linked kinase mRNA expression in circulating mononuclear
            cells as a biomarker of kidney and vascular damage in experimental
            chronic kidney disease
  JOURNAL   Cell Commun Signal 22 (1), 264 (2024)
   PUBMED   38734696
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1797)
  AUTHORS   Huang,Z., Huang,L., Ding,J., Huang,Y., Huang,X. and Li,T.
  TITLE     ILK inhibition reduces osteophyte formation through suppression of
            osteogenesis in BMSCs via Akt/GSK-3beta/beta-catenin pathway
  JOURNAL   Mol Biol Rep 51 (1), 421 (2024)
   PUBMED   38483756
  REMARK    GeneRIF: ILK inhibition reduces osteophyte formation through
            suppression of osteogenesis in BMSCs via Akt/GSK-3beta/beta-catenin
            pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1797)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 1797)
  AUTHORS   Ahmed,A.U., Almasabi,S., Firestein,R. and Williams,B.R.G.
  TITLE     Integrin-linked kinase expression in myeloid cells promotes colon
            tumorigenesis
  JOURNAL   Front Immunol 14, 1270194 (2023)
   PUBMED   38077324
  REMARK    GeneRIF: Integrin-linked kinase expression in myeloid cells
            promotes colon tumorigenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1797)
  AUTHORS   White,D.E., Cardiff,R.D., Dedhar,S. and Muller,W.J.
  TITLE     Mammary epithelial-specific expression of the integrin-linked
            kinase (ILK) results in the induction of mammary gland hyperplasias
            and tumors in transgenic mice
  JOURNAL   Oncogene 20 (48), 7064-7072 (2001)
   PUBMED   11704830
REFERENCE   7  (bases 1 to 1797)
  AUTHORS   Nikolopoulos,S.N. and Turner,C.E.
  TITLE     Integrin-linked kinase (ILK) binding to paxillin LD1 motif
            regulates ILK localization to focal adhesions
  JOURNAL   J Biol Chem 276 (26), 23499-23505 (2001)
   PUBMED   11304546
REFERENCE   8  (bases 1 to 1797)
  AUTHORS   Tu,Y., Huang,Y., Zhang,Y., Hua,Y. and Wu,C.
  TITLE     A new focal adhesion protein that interacts with integrin-linked
            kinase and regulates cell adhesion and spreading
  JOURNAL   J Cell Biol 153 (3), 585-598 (2001)
   PUBMED   11331308
REFERENCE   9  (bases 1 to 1797)
  AUTHORS   Li,F., Zhang,Y. and Wu,C.
  TITLE     Integrin-linked kinase is localized to cell-matrix focal adhesions
            but not cell-cell adhesion sites and the focal adhesion
            localization of integrin-linked kinase is regulated by the
            PINCH-binding ANK repeats
  JOURNAL   J Cell Sci 112 (Pt 24), 4589-4599 (1999)
   PUBMED   10574708
REFERENCE   10 (bases 1 to 1797)
  AUTHORS   Li,F., Liu,J., Mayne,R. and Wu,C.
  TITLE     Identification and characterization of a mouse protein kinase that
            is highly homologous to human integrin-linked kinase
  JOURNAL   Biochim Biophys Acta 1358 (3), 215-220 (1997)
   PUBMED   9366252
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121823.3, CA752166.1, AK002344.1, AK011766.1 and CK625497.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011766.1, AK002344.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC121823.3         129965-129978       c
            15-85               CA752166.1         15-85
            86-992              AK002344.1         4-910
            993-1789            AK011766.1         931-1727
            1790-1797           CK625497.1         431-438
FEATURES             Location/Qualifiers
     source          1..1797
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 55.97 cM"
     gene            1..1797
                     /gene="Ilk"
                     /gene_synonym="ESTM24; ILK-1; ILK-2; p59ILK"
                     /note="integrin linked kinase"
                     /db_xref="GeneID:16202"
                     /db_xref="MGI:MGI:1195267"
     exon            1..127
                     /gene="Ilk"
                     /gene_synonym="ESTM24; ILK-1; ILK-2; p59ILK"
                     /inference="alignment:Splign:2.1.0"
     exon            128..264
                     /gene="Ilk"
                     /gene_synonym="ESTM24; ILK-1; ILK-2; p59ILK"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1534
                     /gene="Ilk"
                     /gene_synonym="ESTM24; ILK-1; ILK-2; p59ILK"
                     /EC_number="2.7.11.1"
                     /note="integrin binding protein kinase; integrin-linked
                     protein kinase; beta-integrin-linked kinase; inactive
                     integrin-linked kinase; 59 kDa serine/threonine-protein
                     kinase"
                     /codon_start=1
                     /product="scaffold protein ILK"
                     /protein_id="NP_001155196.1"
                     /db_xref="CCDS:CCDS21659.1"
                     /db_xref="GeneID:16202"
                     /db_xref="MGI:MGI:1195267"
                     /translation="MDDIFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACRE
                     GRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNV
                     PLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKAPLRELLRERAEKMGQNLN
                     RIPYKDTFWKGTTRTRPRNGTLNKHSGIDFKQLNFLAKLNENHSGELWKGRWQGNDIV
                     VKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQAPPAPHPTLITHWMPYGS
                     LYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSVMIDEDMTAR
                     ISMADVKFSFQCPGRMYAPAWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPF
                     ADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKICMNEDPAKRPKFDMIVPILEKMQ
                     DK"
     exon            265..430
                     /gene="Ilk"
                     /gene_synonym="ESTM24; ILK-1; ILK-2; p59ILK"
                     /inference="alignment:Splign:2.1.0"
     exon            431..526
                     /gene="Ilk"
                     /gene_synonym="ESTM24; ILK-1; ILK-2; p59ILK"
                     /inference="alignment:Splign:2.1.0"
     exon            527..623
                     /gene="Ilk"
                     /gene_synonym="ESTM24; ILK-1; ILK-2; p59ILK"
                     /inference="alignment:Splign:2.1.0"
     exon            624..707
                     /gene="Ilk"
                     /gene_synonym="ESTM24; ILK-1; ILK-2; p59ILK"
                     /inference="alignment:Splign:2.1.0"
     exon            708..793
                     /gene="Ilk"
                     /gene_synonym="ESTM24; ILK-1; ILK-2; p59ILK"
                     /inference="alignment:Splign:2.1.0"
     exon            794..903
                     /gene="Ilk"
                     /gene_synonym="ESTM24; ILK-1; ILK-2; p59ILK"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1031
                     /gene="Ilk"
                     /gene_synonym="ESTM24; ILK-1; ILK-2; p59ILK"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1153
                     /gene="Ilk"
                     /gene_synonym="ESTM24; ILK-1; ILK-2; p59ILK"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1253
                     /gene="Ilk"
                     /gene_synonym="ESTM24; ILK-1; ILK-2; p59ILK"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1384
                     /gene="Ilk"
                     /gene_synonym="ESTM24; ILK-1; ILK-2; p59ILK"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1797
                     /gene="Ilk"
                     /gene_synonym="ESTM24; ILK-1; ILK-2; p59ILK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1775..1780
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ilk"
                     /gene_synonym="ESTM24; ILK-1; ILK-2; p59ILK"
                     /note="hexamer: AATAAA"
     polyA_site      1794
                     /gene="Ilk"
                     /gene_synonym="ESTM24; ILK-1; ILK-2; p59ILK"
                     /note="major polyA site"
ORIGIN      
        1 aggtcggaag ggagggaccg cggcccgcgc tggcccgagc tggccggggc gggccggggc
       61 ggggccgggc ggcgggcgcg gccggacggg agttcccccg gagaaggcgc ctgcggcccg
      121 agtcccgtcc cccgaggctt ccccagtccc ggggtctctg tgccgggacg ctgctatgga
      181 cgacattttc actcagtgcc gggagggcaa cgcggtggcg gtgcgcttgt ggctggacaa
      241 cacagagaac gacctcaatc agggggatga tcatggcttc tcccccttgc actgggcctg
      301 ccgagaaggc cgctctgcgg tggttgaaat gctgatcatg cgtggagcac ggattaatgt
      361 gatgaatcgt ggggatgata cccccctgca cctggcagct agtcatggac accgtgacat
      421 tgtacagaag ctgttgcaat acaaggctga catcaatgca gtgaatgagc acggcaatgt
      481 gccacttcac tatgcatgtt tctggggcca agaccaggtg gcagaggacc tggtggctaa
      541 cggggctctt gtgagcatct gtaacaagta tggagagatg cctgtggaca aagccaaggc
      601 accccttaga gagcttctcc gagaacgggc agagaaaatg ggccagaatc tcaaccgtat
      661 tccatacaag gacacattct ggaaggggac cactcgcaca aggccccgaa atgggaccct
      721 gaacaaacac tccggtattg acttcaaaca gctcaacttt ctggcaaagc tcaatgagaa
      781 tcattctgga gagctttgga aaggccgctg gcagggcaat gatattgttg tgaaggtgct
      841 gaaggttcga gactggagta caaggaaaag cagggacttc aatgaggaat gtccccggct
      901 caggattttc tcacacccta acgtgctccc agtgctaggt gcttgccagg ctcccccagc
      961 cccccaccca accctcatca cacactggat gccatatgga tctctctaca atgttctaca
     1021 tgaaggcacc aatttcgttg tggaccagag ccaagctgta aagtttgctt tggacatggc
     1081 aagaggcatg gcttttcttc acacactaga gcctctcata ccccggcatg cactcaatag
     1141 ccgcagtgta atgatcgatg aagatatgac tgcccgaatc agcatggctg atgttaagtt
     1201 ttctttccag tgccctgggc gcatgtatgc gcctgcctgg gtggcccctg aagccctgca
     1261 gaagaagcct gaagacacaa acagacgctc agcagacatg tggagtttcg cggtgcttct
     1321 gtgggaactg gtgacacgag aggtgccctt tgctgacctc tctaatatgg agattgggat
     1381 gaaggtggca ctggaaggcc ttcggcctac catcccacca ggtatttccc cccatgtgtg
     1441 taagctcatg aagatttgca tgaatgaaga ccctgcaaag cgacccaagt ttgacatgat
     1501 tgtgcctatc ttggagaaga tgcaggacaa gtaggacctt caggtccttg cccaaactcc
     1561 agaagtgtca aaacatggct gggggagtac acttctccaa agttaaagac ctctggttgc
     1621 ctcccctgtc tctaatcatg gtactacccc agttatggga cttgttccct gctcccatcc
     1681 ctaccactgt agccccaaaa ggggctgggc tcagagcttt gtcacttgcc acatgatgtc
     1741 tcccaacatg ggagggatca gccccgcctg tcacaataaa gtttattatg aaaacag
//
