LOCUS       NM_001042707            3564 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus interleukin enhancer binding factor 3 (Ilf3),
            transcript variant 2, mRNA.
ACCESSION   NM_001042707
VERSION     NM_001042707.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3564)
  AUTHORS   Wang,Z.Y., Cheng,J., Wang,Y., Yuan,H.T., Bi,S.J., Wang,S.X.,
            Hou,Y.M., Zhang,X., Xu,B.H., Wang,Z.Y., Zhang,Y., Jiang,W.J.,
            Chen,Y.G. and Zhang,M.X.
  TITLE     Macrophage ILF3 promotes abdominal aortic aneurysm by inducing
            inflammatory imbalance in male mice
  JOURNAL   Nat Commun 15 (1), 7249 (2024)
   PUBMED   39179537
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3564)
  AUTHORS   Xie,F., Liu,B., Qiao,W., He,J.Z., Cheng,J., Wang,Z.Y., Hou,Y.M.,
            Zhang,X., Xu,B.H., Zhang,Y., Chen,Y.G. and Zhang,M.X.
  TITLE     Smooth muscle NF90 deficiency ameliorates diabetic atherosclerotic
            calcification in male mice via FBXW7-AGER1-AGEs axis
  JOURNAL   Nat Commun 15 (1), 4985 (2024)
   PUBMED   38862515
  REMARK    GeneRIF: Smooth muscle NF90 deficiency ameliorates diabetic
            atherosclerotic calcification in male mice via FBXW7-AGER1-AGEs
            axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3564)
  AUTHORS   Hou,Y.M., Xu,B.H., Zhang,Q.T., Cheng,J., Zhang,X., Yang,H.R.,
            Wang,Z.Y., Wang,P. and Zhang,M.X.
  TITLE     Deficiency of smooth muscle cell ILF3 alleviates intimal
            hyperplasia via HMGB1 mRNA degradation-mediated regulation of the
            STAT3/DUSP16 axis
  JOURNAL   J Mol Cell Cardiol 190, 62-75 (2024)
   PUBMED   38583797
  REMARK    GeneRIF: Deficiency of smooth muscle cell ILF3 alleviates intimal
            hyperplasia via HMGB1 mRNA degradation-mediated regulation of the
            STAT3/DUSP16 axis.
REFERENCE   4  (bases 1 to 3564)
  AUTHORS   Wang,W., Xu,R., He,P., Xiong,Y., Zhao,H., Fu,X., Lin,J. and Ye,L.
  TITLE     Role of ATF3 triggering M2 macrophage polarization to protect
            against the inflammatory injury of sepsis through ILF3/NEAT1 axis
  JOURNAL   Mol Med 30 (1), 30 (2024)
   PUBMED   38395749
  REMARK    GeneRIF: Role of ATF3 triggering M2 macrophage polarization to
            protect against the inflammatory injury of sepsis through
            ILF3/NEAT1 axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3564)
  AUTHORS   Barber,G.N.
  TITLE     The NFAR's (nuclear factors associated with dsRNA): evolutionarily
            conserved members of the dsRNA binding protein family
  JOURNAL   RNA Biol 6 (1), 35-39 (2009)
   PUBMED   19106622
  REMARK    Review article
REFERENCE   6  (bases 1 to 3564)
  AUTHORS   Viranaicken,W., Gasmi,L., Chauvin,C., Denoulet,P. and Larcher,J.C.
  TITLE     Identification of a newly spliced exon in the mouse Ilf3 gene
            generating two long and short isoforms of Ilf3 and NF90
  JOURNAL   Genomics 88 (5), 622-632 (2006)
   PUBMED   16952437
REFERENCE   7  (bases 1 to 3564)
  AUTHORS   Saunders,L.R., Perkins,D.J., Balachandran,S., Michaels,R., Ford,R.,
            Mayeda,A. and Barber,G.N.
  TITLE     Characterization of two evolutionarily conserved, alternatively
            spliced nuclear phosphoproteins, NFAR-1 and -2, that function in
            mRNA processing and interact with the double-stranded RNA-dependent
            protein kinase, PKR
  JOURNAL   J Biol Chem 276 (34), 32300-32312 (2001)
   PUBMED   11438536
  REMARK    GeneRIF: characterization of NFAR-1 and NFAR-2 splice forms in
            human sample
REFERENCE   8  (bases 1 to 3564)
  AUTHORS   Tang,J., Kao,P.N. and Herschman,H.R.
  TITLE     Protein-arginine methyltransferase I, the predominant
            protein-arginine methyltransferase in cells, interacts with and is
            regulated by interleukin enhancer-binding factor 3
  JOURNAL   J Biol Chem 275 (26), 19866-19876 (2000)
   PUBMED   10749851
REFERENCE   9  (bases 1 to 3564)
  AUTHORS   Buaas,F.W., Lee,K., Edelhoff,S., Disteche,C. and Braun,R.E.
  TITLE     Cloning and characterization of the mouse interleukin enhancer
            binding factor 3 (Ilf3) homolog in a screen for RNA binding
            proteins
  JOURNAL   Mamm Genome 10 (5), 451-456 (1999)
   PUBMED   10337617
REFERENCE   10 (bases 1 to 3564)
  AUTHORS   Kao,P.N., Chen,L., Brock,G., Ng,J., Kenny,J., Smith,A.J. and
            Corthesy,B.
  TITLE     Cloning and expression of cyclosporin A- and FK506-sensitive
            nuclear factor of activated T-cells: NF45 and NF90
  JOURNAL   J Biol Chem 269 (32), 20691-20699 (1994)
   PUBMED   7519613
  REMARK    GeneRIF: cloning of human NF90
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BB851524.1, AF497752.2 and
            AI415652.1.
            
            On Mar 30, 2013 this sequence version replaced NM_001042707.1.
            
            Summary: The protein encoded by this gene contains two
            double-stranded RNA binding domains and functions in the
            post-transcriptional regulation of gene expression. It is a
            component of an RNA-protein complex that may be involved in
            mediating the export of messenger RNAs. Alternative splicing
            results in multiple transcript variants encoding distinct isoforms.
            These isoforms are grouped into two categories, NFAR-1 or NFAR-2,
            based on variation at the C-terminus. [provided by RefSeq, Mar
            2013].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1. The encoded
            isoform (2) is shorter and has a distinct N-terminus, compared to
            isoform 1. This variant encodes an NFAR-2 isoform that is also
            known as Ilf3 S.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK048096.1, AF497752.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               BB851524.1         2-133
            133-3550            AF497752.2         1-3418
            3551-3564           AI415652.1         1-14                c
FEATURES             Location/Qualifiers
     source          1..3564
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.78 cM"
     gene            1..3564
                     /gene="Ilf3"
                     /gene_synonym="MBII-26; MPHOSPH4; NF90; NFAR"
                     /note="interleukin enhancer binding factor 3"
                     /db_xref="GeneID:16201"
                     /db_xref="MGI:MGI:1339973"
     exon            1..229
                     /gene="Ilf3"
                     /gene_synonym="MBII-26; MPHOSPH4; NF90; NFAR"
                     /inference="alignment:Splign:2.1.0"
     exon            230..327
                     /gene="Ilf3"
                     /gene_synonym="MBII-26; MPHOSPH4; NF90; NFAR"
                     /inference="alignment:Splign:2.1.0"
     CDS             325..3021
                     /gene="Ilf3"
                     /gene_synonym="MBII-26; MPHOSPH4; NF90; NFAR"
                     /note="isoform 2 is encoded by transcript variant 2;
                     nuclear factor 90; M phase phosphoprotein 4; nuclear
                     factor associated with dsRNA"
                     /codon_start=1
                     /product="interleukin enhancer-binding factor 3 isoform 2"
                     /protein_id="NP_001036172.1"
                     /db_xref="CCDS:CCDS40552.1"
                     /db_xref="GeneID:16201"
                     /db_xref="MGI:MGI:1339973"
                     /translation="MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKA
                     VSDWIDEQEKGNSELSEAENMDTPPDDESKEGAGEQKAEHMTRTLRGVMRVGLVAKGL
                     LLKGDLDLELVLLCKEKPTTALLDKVADNLAIQLTTVTEDKYEILQSVDDAAIVIKNT
                     KEPPLSLTIHLTSPVVREEMEKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQA
                     RANGLKSCVIVIRVLRDLCTRVPTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVL
                     ECLASGIVMPDGSGIYDPCEKEATDAIGHLDRQQREDITQSAQHALRLAAFGQLHKVL
                     GMDPLPSKMPKKPKNENPVDYTVQIPPSTTYAITPMKRPMEEDGEEKSPSKKKKKIQK
                     KEEKADPPQAMNALMRLNQLKPGLQYKLISQTGPVHAPIFTMSVEVDGSNFEASGPSK
                     KTAKLHVAVKVLQDMGLPTGAEGRDSSKGEDSAEESDGKPAIVAPPPVVEAVSNPSSV
                     FPSDATTEQGPILTKHGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKF
                     QGAGSNKKVAKAYAALAALEKLFPDTPLALEANKKKRTPVPVRGGPKFAAKPHNPGFG
                     MGGPMHNEVPPPPNIRGRGRGGNIRGRGRGRGFGGANHGGGYMNAGAGYGSYGYSSNS
                     ATAGYSQFYSNGGHSGNAGGGGSGGGGGSSSYSSYYQGDSYNSPVPPKHAGKKPLHGG
                     QQKASYSSGYQSHQGQQQPYNQSQYSSYGTPQGKQKGYGHGQGSYSSYSNSYNSPGGG
                     GGSDYSYDSKFNYSGSGGRSGGNSYGSSGSSSYNTGSHGGYGTGSGGSSSYQGKQGGY
                     SSQSNYSSPGSSQSYSGPASSYQSSQGGYSRNTEHSMNYQYR"
     exon            328..557
                     /gene="Ilf3"
                     /gene_synonym="MBII-26; MPHOSPH4; NF90; NFAR"
                     /inference="alignment:Splign:2.1.0"
     exon            558..735
                     /gene="Ilf3"
                     /gene_synonym="MBII-26; MPHOSPH4; NF90; NFAR"
                     /inference="alignment:Splign:2.1.0"
     exon            736..883
                     /gene="Ilf3"
                     /gene_synonym="MBII-26; MPHOSPH4; NF90; NFAR"
                     /inference="alignment:Splign:2.1.0"
     exon            884..975
                     /gene="Ilf3"
                     /gene_synonym="MBII-26; MPHOSPH4; NF90; NFAR"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1071
                     /gene="Ilf3"
                     /gene_synonym="MBII-26; MPHOSPH4; NF90; NFAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1183
                     /gene="Ilf3"
                     /gene_synonym="MBII-26; MPHOSPH4; NF90; NFAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1281
                     /gene="Ilf3"
                     /gene_synonym="MBII-26; MPHOSPH4; NF90; NFAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1393
                     /gene="Ilf3"
                     /gene_synonym="MBII-26; MPHOSPH4; NF90; NFAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1504
                     /gene="Ilf3"
                     /gene_synonym="MBII-26; MPHOSPH4; NF90; NFAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1704
                     /gene="Ilf3"
                     /gene_synonym="MBII-26; MPHOSPH4; NF90; NFAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1872
                     /gene="Ilf3"
                     /gene_synonym="MBII-26; MPHOSPH4; NF90; NFAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..1998
                     /gene="Ilf3"
                     /gene_synonym="MBII-26; MPHOSPH4; NF90; NFAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2175
                     /gene="Ilf3"
                     /gene_synonym="MBII-26; MPHOSPH4; NF90; NFAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2332
                     /gene="Ilf3"
                     /gene_synonym="MBII-26; MPHOSPH4; NF90; NFAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2386
                     /gene="Ilf3"
                     /gene_synonym="MBII-26; MPHOSPH4; NF90; NFAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2752
                     /gene="Ilf3"
                     /gene_synonym="MBII-26; MPHOSPH4; NF90; NFAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2884
                     /gene="Ilf3"
                     /gene_synonym="MBII-26; MPHOSPH4; NF90; NFAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2885..3552
                     /gene="Ilf3"
                     /gene_synonym="MBII-26; MPHOSPH4; NF90; NFAR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3532..3537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ilf3"
                     /gene_synonym="MBII-26; MPHOSPH4; NF90; NFAR"
                     /note="hexamer: AATAAA"
     polyA_site      3552
                     /gene="Ilf3"
                     /gene_synonym="MBII-26; MPHOSPH4; NF90; NFAR"
                     /note="major polyA site"
ORIGIN      
        1 agtcacgtgg ccctgcacct ccccggcgcg cgcccgcccg cccgctcgct cgcccccggt
       61 ccccggctcc tcctcctcct tttctcgcca ttgcagttgg gactgaagca gccccggcga
      121 aaaccgcgtg gctttttttt ttttttttga ggggggttgt gaagactccg gaaggctcgt
      181 ggcaggaggg cggcggcgcc tgaaggcgaa ggacgggaac accggcaaga tagttgaagt
      241 attggtaaca ccaaggaact gtcacaattt gaaaagataa gccaagactg atttccagac
      301 actacaagaa aaaaggaggg gaaaatgcgt cccatgagaa tttttgtgaa tgatgatcgc
      361 cacgtgatgg caaagcattc ttcagtgtac ccaacacaag aggagctgga ggctgtacag
      421 aacatggtgt cccatactga gcgggccctg aaggctgtct ctgactggat tgatgagcag
      481 gagaaaggca acagcgagct ctctgaggca gaaaatatgg acacaccccc agacgatgag
      541 agcaaagaag gggctgggga acagaaggcg gaacacatga ctaggaccct gaggggcgtg
      601 atgcgggtcg gcctggtagc caagggtctt ctgctcaagg gggacttgga tctggagctg
      661 gttctgctct gtaaggagaa gcccacaacc gcccttctgg acaaggtggc tgacaacctg
      721 gccatccagc tcactactgt aacagaagac aagtatgaaa tactccagtc tgtggatgat
      781 gctgcgattg tgataaaaaa cacaaaagag ccccccttgt ccttgaccat ccatctgacc
      841 tcccctgttg tcagagaaga aatggagaaa gtattagctg gagaaacgct atcagtcaac
      901 gatcccccgg acgttctgga caggcagaaa tgccttgctg ccttggcgtc cctccgacac
      961 gccaagtggt tccaggccag agccaatgga ctgaagtcat gtgtcattgt catccgtgtc
     1021 ctaagggact tgtgtacccg agtgcccacc tggggtcccc tcagaggatg gcctctggag
     1081 ctgctgtgtg agaagtccat cggcactgcc aataggccaa tgggtgctgg tgaagccctg
     1141 cggagagtgc tggagtgcct ggcatccggc atcgtaatgc cagatggttc tggcatttat
     1201 gacccttgtg aaaaagaagc cactgatgct attgggcatc tagacagaca gcaacgggaa
     1261 gatatcacac agagtgcgca gcatgctctg cggcttgctg cctttggtca actccataaa
     1321 gtactgggaa tggaccccct gccttccaaa atgcccaaga aaccaaagaa cgagaacccg
     1381 gtggactaca ctgttcaaat tcctcccagc accacctatg ctatcacacc catgaaacgc
     1441 cctatggaag aggatgggga ggagaagtct cccagcaaga agaaaaagaa gatccagaag
     1501 aaagaggaga aggctgatcc tcctcaagct atgaatgccc tgatgaggtt aaatcagctg
     1561 aagccagggc tgcagtacaa gctgatctcc cagacaggcc ctgttcatgc tcccatcttc
     1621 accatgtctg tggaggtaga cggcagtaac ttcgaggcct cggggccatc taaaaagact
     1681 gccaagcttc atgtagctgt gaaggtgtta caggacatgg gcttgccaac aggcgctgaa
     1741 ggcagagact ccagcaaggg ggaagactcc gctgaggagt cagatgggaa gccagcaata
     1801 gtggccccac cccctgtggt ggaagctgtc tccaacccca gttctgtctt cccttcagat
     1861 gccactactg agcagggacc gattttgact aagcatggca agaaccctgt tatggagctt
     1921 aatgagaaga gacgtggcct caaatatgag ctcatttctg agacgggggg cagccacgac
     1981 aaaaggtttg ttatggaggt tgaggtggac ggacagaagt ttcaaggtgc tggttcaaac
     2041 aaaaaggtgg caaaggctta tgctgcactt gccgcattag aaaaactttt ccctgatacc
     2101 cctcttgctc ttgaagccaa caaaaagaaa aggaccccag tacctgtccg aggtggaccc
     2161 aaatttgctg ccaagccaca caaccctggt tttggcatgg gaggccccat gcataatgaa
     2221 gtgccgccac ctcctaacat ccgaggtcgg ggccgaggag gtaacatccg agggcgagga
     2281 cgggggcgag gatttggtgg cgccaaccat ggaggaggct acatgaatgc tggtgctgga
     2341 tatggaagct atgggtacag cagcaattcg gccacagcag gctacagtca gttctacagc
     2401 aatggagggc attctgggaa tgccggtggt ggaggcagcg ggggaggtgg tggctcatcc
     2461 agctacagct cctactacca aggagacagc tacaactcac cagtaccccc gaagcatgct
     2521 gggaagaagc cgctgcatgg gggccagcag aaagcctcct acagctcggg ctaccagtcc
     2581 caccagggcc agcagcaacc ttacaaccag agccagtaca gcagctacgg cacgccacag
     2641 ggcaagcaga aaggctatgg ccatgggcag ggcagctact cctcctactc caactcttac
     2701 aactccccag gtggtggtgg gggctctgac tacagctacg acagcaaatt caactacagt
     2761 gggagtggag gccggagtgg aggcaacagc tatggctcca gcgggtcatc gtcctacaac
     2821 acaggctcac atggaggcta tggcacaggc tccggaggca gctcttcata ccaaggcaaa
     2881 caaggaggct actcatcaca gtcaaactac agctcacctg ggtccagcca gagctacagt
     2941 ggtcctgcca gctcctacca gtcctcacag ggtggctaca gtcggaacac agagcacagc
     3001 atgaactacc agtacagata aaggcccagg ctgcctgccc ctctcaacct tctgcacctc
     3061 tgcctccaac ttgtctcggg agattgagtc tgcacatcac cagttgccat gttcactggg
     3121 ccagtgccca cccgtccacg ttgctgacat tgccacgctt tgaggtgtgg tggtcgctgg
     3181 gacccgtgcc gtgaccccta tttagctgtg ttttggactc cgtgtcttca gtggtttgtt
     3241 agttaccatt acgtaaacct tgtctgagta gtgttccgag gtcttgccgt tccggatccc
     3301 tctgtctgtt tatgcctggt gtgagttcca tcgggtgtct ttaaatagtt gcagaaggga
     3361 tacgtcatct gttaatgctt tttgtgaagt gagttaatga gccttcatta ttttaatgct
     3421 tagtgtttca gttttataag tgaaaatttt attttaaaaa acagtggttt ttttttttgg
     3481 gtatgtctgg atcattcaga cagtacattt gaattccgct gaatgtagat aaataaaaga
     3541 aaaacaaaag aaaaaaaaaa aaaa
//
