LOCUS       NP_001036172             898 aa            linear   ROD 17-DEC-2024
DEFINITION  interleukin enhancer-binding factor 3 isoform 2 [Mus musculus].
ACCESSION   NP_001036172
VERSION     NP_001036172.1
DBSOURCE    REFSEQ: accession NM_001042707.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 898)
  AUTHORS   Wang,Z.Y., Cheng,J., Wang,Y., Yuan,H.T., Bi,S.J., Wang,S.X.,
            Hou,Y.M., Zhang,X., Xu,B.H., Wang,Z.Y., Zhang,Y., Jiang,W.J.,
            Chen,Y.G. and Zhang,M.X.
  TITLE     Macrophage ILF3 promotes abdominal aortic aneurysm by inducing
            inflammatory imbalance in male mice
  JOURNAL   Nat Commun 15 (1), 7249 (2024)
   PUBMED   39179537
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 898)
  AUTHORS   Xie,F., Liu,B., Qiao,W., He,J.Z., Cheng,J., Wang,Z.Y., Hou,Y.M.,
            Zhang,X., Xu,B.H., Zhang,Y., Chen,Y.G. and Zhang,M.X.
  TITLE     Smooth muscle NF90 deficiency ameliorates diabetic atherosclerotic
            calcification in male mice via FBXW7-AGER1-AGEs axis
  JOURNAL   Nat Commun 15 (1), 4985 (2024)
   PUBMED   38862515
  REMARK    GeneRIF: Smooth muscle NF90 deficiency ameliorates diabetic
            atherosclerotic calcification in male mice via FBXW7-AGER1-AGEs
            axis.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 898)
  AUTHORS   Hou,Y.M., Xu,B.H., Zhang,Q.T., Cheng,J., Zhang,X., Yang,H.R.,
            Wang,Z.Y., Wang,P. and Zhang,M.X.
  TITLE     Deficiency of smooth muscle cell ILF3 alleviates intimal
            hyperplasia via HMGB1 mRNA degradation-mediated regulation of the
            STAT3/DUSP16 axis
  JOURNAL   J Mol Cell Cardiol 190, 62-75 (2024)
   PUBMED   38583797
  REMARK    GeneRIF: Deficiency of smooth muscle cell ILF3 alleviates intimal
            hyperplasia via HMGB1 mRNA degradation-mediated regulation of the
            STAT3/DUSP16 axis.
REFERENCE   4  (residues 1 to 898)
  AUTHORS   Wang,W., Xu,R., He,P., Xiong,Y., Zhao,H., Fu,X., Lin,J. and Ye,L.
  TITLE     Role of ATF3 triggering M2 macrophage polarization to protect
            against the inflammatory injury of sepsis through ILF3/NEAT1 axis
  JOURNAL   Mol Med 30 (1), 30 (2024)
   PUBMED   38395749
  REMARK    GeneRIF: Role of ATF3 triggering M2 macrophage polarization to
            protect against the inflammatory injury of sepsis through
            ILF3/NEAT1 axis.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 898)
  AUTHORS   Barber,G.N.
  TITLE     The NFAR's (nuclear factors associated with dsRNA): evolutionarily
            conserved members of the dsRNA binding protein family
  JOURNAL   RNA Biol 6 (1), 35-39 (2009)
   PUBMED   19106622
  REMARK    Review article
REFERENCE   6  (residues 1 to 898)
  AUTHORS   Viranaicken,W., Gasmi,L., Chauvin,C., Denoulet,P. and Larcher,J.C.
  TITLE     Identification of a newly spliced exon in the mouse Ilf3 gene
            generating two long and short isoforms of Ilf3 and NF90
  JOURNAL   Genomics 88 (5), 622-632 (2006)
   PUBMED   16952437
REFERENCE   7  (residues 1 to 898)
  AUTHORS   Saunders,L.R., Perkins,D.J., Balachandran,S., Michaels,R., Ford,R.,
            Mayeda,A. and Barber,G.N.
  TITLE     Characterization of two evolutionarily conserved, alternatively
            spliced nuclear phosphoproteins, NFAR-1 and -2, that function in
            mRNA processing and interact with the double-stranded RNA-dependent
            protein kinase, PKR
  JOURNAL   J Biol Chem 276 (34), 32300-32312 (2001)
   PUBMED   11438536
  REMARK    GeneRIF: characterization of NFAR-1 and NFAR-2 splice forms in
            human sample
REFERENCE   8  (residues 1 to 898)
  AUTHORS   Tang,J., Kao,P.N. and Herschman,H.R.
  TITLE     Protein-arginine methyltransferase I, the predominant
            protein-arginine methyltransferase in cells, interacts with and is
            regulated by interleukin enhancer-binding factor 3
  JOURNAL   J Biol Chem 275 (26), 19866-19876 (2000)
   PUBMED   10749851
REFERENCE   9  (residues 1 to 898)
  AUTHORS   Buaas,F.W., Lee,K., Edelhoff,S., Disteche,C. and Braun,R.E.
  TITLE     Cloning and characterization of the mouse interleukin enhancer
            binding factor 3 (Ilf3) homolog in a screen for RNA binding
            proteins
  JOURNAL   Mamm Genome 10 (5), 451-456 (1999)
   PUBMED   10337617
REFERENCE   10 (residues 1 to 898)
  AUTHORS   Kao,P.N., Chen,L., Brock,G., Ng,J., Kenny,J., Smith,A.J. and
            Corthesy,B.
  TITLE     Cloning and expression of cyclosporin A- and FK506-sensitive
            nuclear factor of activated T-cells: NF45 and NF90
  JOURNAL   J Biol Chem 269 (32), 20691-20699 (1994)
   PUBMED   7519613
  REMARK    GeneRIF: cloning of human NF90
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BB851524.1, AF497752.2 and
            AI415652.1.
            
            Summary: The protein encoded by this gene contains two
            double-stranded RNA binding domains and functions in the
            post-transcriptional regulation of gene expression. It is a
            component of an RNA-protein complex that may be involved in
            mediating the export of messenger RNAs. Alternative splicing
            results in multiple transcript variants encoding distinct isoforms.
            These isoforms are grouped into two categories, NFAR-1 or NFAR-2,
            based on variation at the C-terminus. [provided by RefSeq, Mar
            2013].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1. The encoded
            isoform (2) is shorter and has a distinct N-terminus, compared to
            isoform 1. This variant encodes an NFAR-2 isoform that is also
            known as Ilf3 S.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK048096.1, AF497752.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..898
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.78 cM"
     Protein         1..898
                     /product="interleukin enhancer-binding factor 3 isoform 2"
                     /note="nuclear factor 90; M phase phosphoprotein 4;
                     nuclear factor associated with dsRNA"
                     /calculated_mol_wt=95890
     Region          52..85
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1X4.2)"
     Site            67
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1X4.2)"
     Region          88..342
                     /region_name="DZF"
                     /note="domain in DSRM or ZnF_C2H2 domain containing
                     proteins; smart00572"
                     /db_xref="CDD:128842"
     Site            100
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1X4.2)"
     Site            188
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by PKR.
                     /evidence=ECO:0000269|PubMed:21123651; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1X4.2)"
     Site            190
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1X4.2)"
     Site            315
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by PKR.
                     /evidence=ECO:0000269|PubMed:21123651; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1X4.2)"
     Region          363..402
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1X4.2)"
     Region          371..389
                     /region_name="Bipartite nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1X4.2)"
     Site            382
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1X4.2)"
     Site            384
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1X4.2)"
     Region          398..470
                     /region_name="DSRM_ILF3_rpt1"
                     /note="first double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; cd19910"
                     /db_xref="CDD:380739"
     Site            order(403,406..407,410..411,413,427..428,430,432,449..451,
                     454)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:380739"
     Site            460
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1X4.2)"
     Region          466..495
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1X4.2)"
     Site            476
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1X4.2)"
     Site            477
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1X4.2)"
     Site            482
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1X4.2)"
     Site            486
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1X4.2)"
     Region          505..524
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1X4.2)"
     Region          520..591
                     /region_name="DSRM_ILF3_rpt2"
                     /note="second double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; cd19912"
                     /db_xref="CDD:380741"
     Site            order(527,529..530,533,546,549..551,555,571..574)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:380741"
     Site            592
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1X4.2)"
     Region          609..898
                     /region_name="Interaction with PRMT1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1X4.2)"
     Region          631..661
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1X4.2)"
     Region          719..898
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1X4.2)"
     Site            794
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1X4.2)"
     Site            812
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1X4.2)"
     Site            814
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1X4.2)"
     Site            818
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1X4.2)"
     CDS             1..898
                     /gene="Ilf3"
                     /gene_synonym="MBII-26; MPHOSPH4; NF90; NFAR"
                     /coded_by="NM_001042707.2:325..3021"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS40552.1"
                     /db_xref="GeneID:16201"
                     /db_xref="MGI:MGI:1339973"
ORIGIN      
        1 mrpmrifvnd drhvmakhss vyptqeelea vqnmvshter alkavsdwid eqekgnsels
       61 eaenmdtppd deskegageq kaehmtrtlr gvmrvglvak glllkgdldl elvllckekp
      121 ttalldkvad nlaiqlttvt edkyeilqsv ddaaiviknt kepplsltih ltspvvreem
      181 ekvlagetls vndppdvldr qkclaalasl rhakwfqara nglkscvivi rvlrdlctrv
      241 ptwgplrgwp lellceksig tanrpmgage alrrvlecla sgivmpdgsg iydpcekeat
      301 daighldrqq reditqsaqh alrlaafgql hkvlgmdplp skmpkkpkne npvdytvqip
      361 psttyaitpm krpmeedgee kspskkkkki qkkeekadpp qamnalmrln qlkpglqykl
      421 isqtgpvhap iftmsvevdg snfeasgpsk ktaklhvavk vlqdmglptg aegrdsskge
      481 dsaeesdgkp aivapppvve avsnpssvfp sdatteqgpi ltkhgknpvm elnekrrglk
      541 yelisetggs hdkrfvmeve vdgqkfqgag snkkvakaya alaaleklfp dtplaleank
      601 kkrtpvpvrg gpkfaakphn pgfgmggpmh nevppppnir grgrggnirg rgrgrgfgga
      661 nhgggymnag agygsygyss nsatagysqf ysngghsgna ggggsggggg sssyssyyqg
      721 dsynspvppk hagkkplhgg qqkasyssgy qshqgqqqpy nqsqyssygt pqgkqkgygh
      781 gqgsyssysn synspggggg sdysydskfn ysgsggrsgg nsygssgsss yntgshggyg
      841 tgsggsssyq gkqggyssqs nysspgssqs ysgpassyqs sqggysrnte hsmnyqyr
//
