LOCUS       NM_001164528            8260 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus immunoglobulin-like domain containing receptor 2
            (Ildr2), transcript variant 1, mRNA.
ACCESSION   NM_001164528 XM_001473525 XM_001479680
VERSION     NM_001164528.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8260)
  AUTHORS   Siegerist,F., Kliewe,F., Hammer,E., Schakau,P., Chi Soh,J.E.,
            Weber,C., Lindenmeyer,M., Reichelt-Wurm,S., Drenic,V.,
            Chatziantoniou,C., Chadjichristos,C.E., Zhang,Y., Simm,S.,
            Banas,M.C., Nauck,M., Volker,U. and Endlich,N.
  TITLE     The role of the tricellular junction protein ILDR2 in
            glomerulopathies: Expression patterns and functional insights
  JOURNAL   iScience 27 (12), 111329 (2024)
   PUBMED   39640577
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8260)
  AUTHORS   Higashi,A.Y., Saito,A.C., Higashi,T., Furuse,K., Furuse,M.,
            Chiba,H. and Kazama,J.J.
  TITLE     Bicellular Localization of Tricellular Junctional Protein
            Angulin-3/ILDR2 Allows Detection of Podocyte Injury
  JOURNAL   Am J Pathol 194 (5), 673-683 (2024)
   PUBMED   38311119
REFERENCE   3  (bases 1 to 8260)
  AUTHORS   Higashi,A.Y., Higashi,T., Furuse,K., Ozeki,K., Furuse,M. and
            Chiba,H.
  TITLE     Claudin-9 constitutes tight junctions of folliculo-stellate cells
            in the anterior pituitary gland
  JOURNAL   Sci Rep 11 (1), 21642 (2021)
   PUBMED   34737342
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8260)
  AUTHORS   Watanabe,K., Nakayama,K., Ohta,S., Matsumoto,A., Tsuda,H. and
            Iwamoto,S.
  TITLE     ILDR2 stabilization is regulated by its interaction with GRP78
  JOURNAL   Sci Rep 11 (1), 8414 (2021)
   PUBMED   33863978
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8260)
  AUTHORS   Huetter,J., Gritzan,U., Gutcher,I., Doecke,W.D.,
            Luetke-Eversloh,M.V., Golfier,S., Roider,H.G., Frisk,A.L.,
            Hunter,J., Pow,A., Drake,A., Levine,Z., Levy,O., Azulay,M.,
            Barbiro,I., Cojocaru,G., Vaknin,I., Kreft,B. and Roese,L.
  TITLE     Characterization of BAY 1905254, an Immune Checkpoint Inhibitor
            Targeting the Immunoglobulin-Like Domain Containing Receptor 2
            (ILDR2)
  JOURNAL   Cancer Immunol Res 8 (7), 895-911 (2020)
   PUBMED   32312711
  REMARK    GeneRIF: Characterization of BAY 1905254, an Immune Checkpoint
            Inhibitor Targeting the Immunoglobulin-Like Domain Containing
            Receptor 2 (ILDR2).
REFERENCE   6  (bases 1 to 8260)
  AUTHORS   Watanabe,K., Watson,E., Cremona,M.L., Millings,E.J.,
            Lefkowitch,J.H., Fischer,S.G., LeDuc,C.A. and Leibel,R.L.
  TITLE     ILDR2: an endoplasmic reticulum resident molecule mediating hepatic
            lipid homeostasis
  JOURNAL   PLoS One 8 (6), e67234 (2013)
   PUBMED   23826244
  REMARK    GeneRIF: manipulation of Ildr2 expression in liver affects both
            lipid homeostasis and ER stress pathways.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 8260)
  AUTHORS   Higashi,T., Tokuda,S., Kitajiri,S., Masuda,S., Nakamura,H., Oda,Y.
            and Furuse,M.
  TITLE     Analysis of the 'angulin' proteins LSR, ILDR1 and
            ILDR2--tricellulin recruitment, epithelial barrier function and
            implication in deafness pathogenesis
  JOURNAL   J Cell Sci 126 (Pt 4), 966-977 (2013)
   PUBMED   23239027
  REMARK    Erratum:[J Cell Sci. 2013 Aug 15;126(Pt 16):3797]
REFERENCE   8  (bases 1 to 8260)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   9  (bases 1 to 8260)
  AUTHORS   Kumada,T., Yamanaka,Y., Kitano,A., Shibata,M., Awaya,T., Kato,T.,
            Okawa,K., Abe,T., Oshima,N., Nakahata,T. and Heike,T.
  TITLE     Ttyh1, a Ca(2+)-binding protein localized to the endoplasmic
            reticulum, is required for early embryonic development
  JOURNAL   Dev Dyn 239 (8), 2233-2245 (2010)
   PUBMED   20568244
REFERENCE   10 (bases 1 to 8260)
  AUTHORS   Dokmanovic-Chouinard,M., Chung,W.K., Chevre,J.C., Watson,E.,
            Yonan,J., Wiegand,B., Bromberg,Y., Wakae,N., Wright,C.V.,
            Overton,J., Ghosh,S., Sathe,G.M., Ammala,C.E., Brown,K.K., Ito,R.,
            LeDuc,C., Solomon,K., Fischer,S.G. and Leibel,R.L.
  TITLE     Positional cloning of 'Lisch-Like', a candidate modifier of
            susceptibility to type 2 diabetes in mice
  JOURNAL   PLoS Genet 4 (7), e1000137 (2008)
   PUBMED   18654634
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC034122.12.
            
            On or before Sep 9, 2009 this sequence version replaced
            XM_001479680.1, XM_001473525.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FJ024495.1, SRR7974084.11987.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-328               AC034122.12        100073-100400
            329-661             AC034122.12        115239-115571
            662-781             AC034122.12        116433-116552
            782-838             AC034122.12        137350-137406
            839-985             AC034122.12        140525-140671
            986-1162            AC034122.12        141686-141862
            1163-1276           AC034122.12        149436-149549
            1277-1490           AC034122.12        153654-153867
            1491-2187           AC034122.12        154781-155477
            2188-8260           AC034122.12        156694-162766
FEATURES             Location/Qualifiers
     source          1..8260
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 73.61 cM"
     gene            1..8260
                     /gene="Ildr2"
                     /gene_synonym="2810478N18Rik; 3110063L10Rik; D1Ertd471e;
                     Dbsm1; Ll"
                     /note="immunoglobulin-like domain containing receptor 2"
                     /db_xref="GeneID:100039795"
                     /db_xref="MGI:MGI:1196370"
     exon            1..328
                     /gene="Ildr2"
                     /gene_synonym="2810478N18Rik; 3110063L10Rik; D1Ertd471e;
                     Dbsm1; Ll"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..2223
                     /gene="Ildr2"
                     /gene_synonym="2810478N18Rik; 3110063L10Rik; D1Ertd471e;
                     Dbsm1; Ll"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; angulin-3; lisch-like protein"
                     /codon_start=1
                     /product="immunoglobulin-like domain-containing receptor 2
                     isoform 1 precursor"
                     /protein_id="NP_001158000.1"
                     /db_xref="CCDS:CCDS48431.1"
                     /db_xref="GeneID:100039795"
                     /db_xref="MGI:MGI:1196370"
                     /translation="MPAFPTLDLDGKLGKMDRVVLGWTAVFWLTAMVEGLQVTVPDKK
                     KVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSPRAQALSKRNLEW
                     DPYLDCLDSRRTVRVVASKQGSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYC
                     IITTPDDLEGKNEDSVELLVLGRTGLLADLLPSFAVEIMPEWVFVGLVILGIFLFFVL
                     VGICWCQCCPHSCCCYVRCPCCPDSCCCPQALYEAGKAAKAGYPPSVSGVPGPYSIPS
                     VPLGGAPSSGMLMDKPHPPPLAPSDSTGGSHSVRKGYRIQADKERDSMKVLYYVEKEL
                     AQFDPARRMRGRYNNTISELSSLHDDDSNFRQSYHQMRNKQFPMSGDLESNPDYWSGV
                     MGGNSGTNRGPALEYNKEDRESFRHSQQRSKSEMLSRKNFATGVPAVSMDELAAFADS
                     YGQRSRRANGNSHEARAGSRFERSESRAHGAFYQDGSLDEYYGRGRSREPPGDGERGW
                     TYSPAPARRRPPEDAPLPRLVSRTPGTAPKYDHSYLSSVLERQARPESSSRGGSLETP
                     SKLGAQLGPRSASYYAWSPPTTYKAGASEGEDEDDAADEDALPPYSELELSRGELSRG
                     PSYRGRDLSFHSNSEKRRKKEPAKKPGDFPTRMSLVV"
     exon            329..661
                     /gene="Ildr2"
                     /gene_synonym="2810478N18Rik; 3110063L10Rik; D1Ertd471e;
                     Dbsm1; Ll"
                     /inference="alignment:Splign:2.1.0"
     exon            662..781
                     /gene="Ildr2"
                     /gene_synonym="2810478N18Rik; 3110063L10Rik; D1Ertd471e;
                     Dbsm1; Ll"
                     /inference="alignment:Splign:2.1.0"
     exon            782..838
                     /gene="Ildr2"
                     /gene_synonym="2810478N18Rik; 3110063L10Rik; D1Ertd471e;
                     Dbsm1; Ll"
                     /inference="alignment:Splign:2.1.0"
     exon            839..985
                     /gene="Ildr2"
                     /gene_synonym="2810478N18Rik; 3110063L10Rik; D1Ertd471e;
                     Dbsm1; Ll"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1162
                     /gene="Ildr2"
                     /gene_synonym="2810478N18Rik; 3110063L10Rik; D1Ertd471e;
                     Dbsm1; Ll"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1276
                     /gene="Ildr2"
                     /gene_synonym="2810478N18Rik; 3110063L10Rik; D1Ertd471e;
                     Dbsm1; Ll"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1490
                     /gene="Ildr2"
                     /gene_synonym="2810478N18Rik; 3110063L10Rik; D1Ertd471e;
                     Dbsm1; Ll"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..2187
                     /gene="Ildr2"
                     /gene_synonym="2810478N18Rik; 3110063L10Rik; D1Ertd471e;
                     Dbsm1; Ll"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..8260
                     /gene="Ildr2"
                     /gene_synonym="2810478N18Rik; 3110063L10Rik; D1Ertd471e;
                     Dbsm1; Ll"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8234..8239
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ildr2"
                     /gene_synonym="2810478N18Rik; 3110063L10Rik; D1Ertd471e;
                     Dbsm1; Ll"
                     /note="hexamer: AATAAA"
     polyA_site      8251
                     /gene="Ildr2"
                     /gene_synonym="2810478N18Rik; 3110063L10Rik; D1Ertd471e;
                     Dbsm1; Ll"
                     /note="major polyA site"
ORIGIN      
        1 tgcggggagg cgctcgccgg tgccgcgcag cctgtgcgtg cgggaacggc ccccgcagcc
       61 caatcggact ctagagccag cggcagcgcg cctctcgcag gcggcggcgt ccagcgcccg
      121 gggccgggct gcgcggccag ccccgagggc tgcggcgcca gggacgcgcg gggcccgcgc
      181 tccgccgccg ccgccgcctg ctgctgcgag gtcatccgga tcttatcgtg ccagctgatg
      241 cccgcttttc ccactctgga tctggatggg aagttgggga agatggatag ggtcgtgttg
      301 gggtggaccg ctgtcttctg gttaacagcc atggttgaag gccttcaggt cacagtgcct
      361 gacaagaaga aggtggccat gctcttccag cccactgtgc ttcgatgcca cttttccacg
      421 tcctcccatc agcctgcggt ggttcagtgg aagttcaaat cctactgcca ggatcgcatg
      481 ggagaatcct tgggcatgtc ttctccccga gcccaagcgc tcagcaagag gaacctggaa
      541 tgggacccct acttggattg tttagacagc agaaggaccg tccgagtggt agcttccaaa
      601 cagggctcga cggttaccct gggagatttc tacaggggca gagagatcac aatagttcac
      661 gatgcagatc ttcaaattgg aaagctcatg tggggagaca gcggactcta ctactgtatc
      721 atcaccaccc cggatgacct ggaaggcaaa aacgaagact cagtggaact gctggtgttg
      781 ggcaggacag ggctgcttgc tgatctcttg cccagttttg ctgtggagat tatgccagag
      841 tgggtgtttg tcggcctggt gatcctgggg attttcctct tcttcgtgct ggtggggatc
      901 tgctggtgcc aatgctgccc tcacagttgc tgctgctatg tccgctgccc atgctgccca
      961 gattcctgct gctgccctca ggccttgtat gaagcaggga aagcagccaa ggccgggtac
     1021 cctccctctg tctccggtgt ccccggcccc tactccatcc cctctgtccc tttgggagga
     1081 gccccctctt ctggcatgct gatggacaag ccgcatccac ctcccctggc accaagtgat
     1141 tccactggag gaagccacag tgttcgcaaa ggttaccgga tccaggctga caaagagaga
     1201 gactccatga aggtcctgta ctatgtcgag aaggagctgg ctcagtttga tccagccagg
     1261 aggatgagag gcagatataa caacaccatc tcggaactca gctccctgca tgatgatgac
     1321 agcaatttcc gccagtctta ccaccagatg cggaataagc agttccctat gtctggagac
     1381 ctggaaagca atcctgacta ctggtcaggt gtcatgggag gcaacagtgg gaccaacagg
     1441 gggccagcct tggagtataa caaagaggac cgtgagagct tcaggcacag ccagcagcgc
     1501 tccaaatctg agatgctgtc gcggaagaac tttgccacgg gcgtgccggc cgtgtcgatg
     1561 gacgagctgg cagccttcgc agactcgtac ggccagcggt cgcggcgcgc caatggcaac
     1621 agccacgagg cgcgggcggg gagccgcttc gagcgctcgg agtcgcgggc ccacggtgcc
     1681 ttctaccagg acggctcgct ggatgagtac tacgggcgcg gacgcagtcg cgagccgccg
     1741 ggagacgggg agcgtggctg gacctacagc cccgcacccg cacgccgccg gccgccagag
     1801 gatgcgcctc tgccgcgcct ggtgagccgg accccgggca ccgcgcccaa gtacgatcac
     1861 tcgtacctga gcagcgtgct ggagcgccag gcgcggccgg agagcagcag ccgcgggggc
     1921 agcctggaga cgccgtccaa gctgggcgcg cagctgggcc cgcgcagcgc atcctactac
     1981 gcctggtcgc cgccaaccac atacaaagct ggggccagcg agggcgaaga cgaggacgac
     2041 gcggcggatg aggacgcgct gccaccctac agcgagctgg agctgagccg cggagagctg
     2101 agccggggcc cgtcctaccg tgggcgtgac ctgtccttcc acagcaactc ggagaagagg
     2161 aggaaaaagg agcccgccaa gaaacccggc gactttccaa ccaggatgtc ccttgtagtc
     2221 tgatacttat aagacacctc tctggatgac tggaaatcag atgcagacta tggagacaag
     2281 acccaaatct gagagccggc aagcctagga tcttctctgg ccagcaacca ccttggaagc
     2341 tttgctgatc tctgctttgg caagggatcc tcctttaaga aggctgattt caaatcttag
     2401 tgcccatcta tctcgagcaa cttaccaaga aaacgctctg tgagaacata tcacgtaata
     2461 accgaccaag tttatcttac acccccaccc ccacccccat ttccttagca gaaacaagac
     2521 tctgcgtcca gttctgaagc tggaagcttt gaacccctga tctctagaaa ttacctatgc
     2581 ctgcagtatg tttttctacg agtgctattc tgtgcttaga cagaggaatt tactactaca
     2641 gttagaagac cgtctgctca caagagagat aaatggtaaa atggaccttg tatccccttg
     2701 cttccagtca ctggtcaatg agtcttgtta tgctaaaacc agaaggcctt tagtgagcgt
     2761 actggccgtg acctcctggg caatcacaga aatggcttca atttgctgct ctgactcaca
     2821 attctaagtg gctgggacaa acagaggaga gcattttgaa aaaccatctt aagtggtctt
     2881 tctttttcca ttcagaggac acaaactgct tttcatcttt ctgtcgaaca gagtgacaat
     2941 cctaaggttc tccctgccca gcccacactg gtccctctct tccctccctc tcctggtctt
     3001 ttcagggctg gtgcctctga gggtgttcca ctccatgctt cagtgtgaat agcttgtcat
     3061 caggtgcctt tgacagatgc ttcaaacaaa catttgagag agaagaaaag cagaagtcgg
     3121 tgatacaaaa tgaacaggaa atgatatgta ggctcattat attttgaatg tgggttgttt
     3181 ccccacaaac acactcagat ttgtttttgt ttttattttt ggatttgtac ttcacttaag
     3241 aattatttct accatcctga ttctgcagct gttgggcacc agggaatgtg gtgtccacat
     3301 cttttggcct cactggccca ccactattga tgctttgggg aaaagaagga cagcacttcc
     3361 tcttcctgcc attgcaaaaa aaaaaattga tttttgcctg aatcccaaat tgaacttttg
     3421 taggtaaact gcaaaagtgg ccacaaactc ttcccctctc atgttcctgt gaagggattt
     3481 gtcctcttgc tgccacaggc cctgccaaat gcacctcagc tatcctacat gatgagagaa
     3541 gagcctggtc accaccgtca ttatctgtgc ccatcttatc aactttaagc agacttggaa
     3601 gaacatctag ccacgaccaa caaaagaact gcctagctga gccgagccca aactggagat
     3661 tcccgcttga gaggagacat tcagcattcc tgtgttcatt tatcattgac gataaacctc
     3721 ccgtcagaat atttgtctct ggtcggttac tcacccaacc ttgggtgtca cacaaccttc
     3781 acttttgtta gcagactttt caatctgcat tattgtggtg agacacgtga ctggatgaag
     3841 tgactggagc aaggggatgc ttgctatccc ctaatccagt ggtggtctac ttctacttat
     3901 tgatctacat gtagtctctg attcactggt cagtatttcc atggccacgt gactggaatt
     3961 ccagagtcca ttctgttagc atccattata cttcatgaga tttccagaaa aggtcctctg
     4021 tgagtggtgt aagagctgct gggttagggt gggtgttggg gggtggaatc attacttgga
     4081 ggagaactgg cctgccaaag gacttcacgg ttgctttggc ctgccctaga tggatcagga
     4141 ggatacttca gcccaatgct ggcacttcca agggctggaa gacaaaagcc ataacccttg
     4201 tgctgagttt taggtttgtt agtgtccctg gcctcagaac acctaggtct gatctgtctg
     4261 tttgggctct aaatcaatat ggcaaaaaca tcatttctta gtcaccagct tttgatttca
     4321 acttgctcag gcacttttga agaatattgg atagccgcag tagctattgt tatactgagc
     4381 actgtgtcag gcttcttagc accaaagagc cccatagcac aggctacaga gaccaaatat
     4441 attgctttat agagccaggg gcgtgtatga gcttggggaa agctgaggga tcgatgagtg
     4501 aaagaaaaaa gttaaaattg gaaacataag gttctaaaga caacaagtct ataggctgac
     4561 aaattaaaaa aaatttcaat gtagagaaga taacaggctt tcaatataac gggggaaagt
     4621 ggggcacaga ttgttcttta tagggcatga gtcacgtggg cttccagacc ttcagtacag
     4681 aggaaattca gttgcttctg ggtccgtgga taggagatga tctgaatgga caaggctaag
     4741 ctggccgtcc ttgatgccct cgacatttct ttacacaccc ctttgtttct tctccaaata
     4801 ctgtgtcctg tacaggaagt gcctatgcgt attagttcct ttcctgtttt tctagggcat
     4861 aagcaaagtg taagaggtga tctccatcca ctgatcccct acaatttaag aaggaagata
     4921 agtcatgccc aagaaaggat gagtatattt tatgcatatg ataagaaata gtgctatgga
     4981 taaattataa taaacccaga gatttaaagt tttctttaaa aacaaaaacc ttaaatggga
     5041 atattttgat atttaagtgt tgtgtgtttg tccatccatc ccatttttag gacatgctca
     5101 gtgatctgca aagccaggct gtagaagtct gagctgaaag gaggtgaagg agaagagaga
     5161 gggatgagtg gcctcaggga ggagggaaga gagtagaggc ccgcttacag gagcttctgt
     5221 ctctgtctgt gactcacagc tgagtcaggg acaagctgga ggagggagta tggaagcagg
     5281 tggcaggaga ggtcccctgg tgctcagagc tcttctctag gctatgtata gactcattag
     5341 gagactcagg actgtattca gttcttccat ccaagcaagc ccaggggagc ttgggattta
     5401 gtcctcctgg cacttgtatc tacagcttgg ggtgcagtag cacctcacat gggttgggga
     5461 cctcacctcc cttctcatga tcctcactct gcatgtggtg taggggtggg caccccaggg
     5521 tgagaggggg ctggcgctac atataaaaat ctggttagat ccgaagcagt ctttgagagg
     5581 agtggagtaa ctaacagaca ccgctttggc tcatctgctc tccatccatt tctaaataga
     5641 tggataagcc atcatccaca tttatggagt cacaaaccag tcagatcttt agattcccaa
     5701 tctataggcc tttcctgctg gatctgtgtt tttgcaaaat tgcctagtca taagaattac
     5761 ttgcctaggg actggagaga gatggcttaa cagtcaaaaa cactgcttta gccgaggacc
     5821 cgagtttggt tcccagcact ctactaatgc tcacagctgt ctgtaacttc aattccaggg
     5881 acccactgat ctcatagagc atctgggagc actaaactca catggtacgc atatatacca
     5941 tcaaaaaact ctcaggcaca caaaataaaa ataaatacat tgttaaaaac tgaaaaagaa
     6001 aggggctgga gagatggctc tgtgattacg tgtgctggct actcttccag aggacccaca
     6061 ttcatttttc agcacatgga gactcccagc accagttcag acacacacac acacacacac
     6121 acacacacac acacacacga aggcaaaata cacacctaac aaagaaataa agcatttaaa
     6181 aatacttggt aaaacaatta cttgcctggg ggactgggat gtggctcagt tggtagagcg
     6241 cttgattagc atgcacaaag ccctggttca atccctagca caataaacta ggggtagtgg
     6301 cacatgcctg tgatcccaac atctgggaga gtttcaagtt caaggtcatc cttggctaca
     6361 tagtgagttc aaggtcaccc tgggctgtat gatactctgc cttaaagaac caaacactga
     6421 aaataacaat gaaaaaacac aaggattact gactgccact gtcacaaatg ctgttggact
     6481 gtaccttgga gaatggatgg gtggatctgg agtaaggatt tgtattctga acatatcctt
     6541 ttagaatgcc ttgtggtaga tgcatttggg tggtgctata ctggatcata cctctggtgc
     6601 acccctatct gctggccagg aatattgttt gtgctgtgga ttatttcatt ccaatatcac
     6661 tgtgaggtcc ctctaacttc cttaggtctg gcactggtgt ggcatccagc agtcccagct
     6721 atgacactgg agaatggctc accagagtca ggctgaaagg aaacatttaa agggaggggg
     6781 ttggaggacc tccccccggg aggcttcttg acatgttcca actcccagaa tagtgatatg
     6841 ttgtgacagg ctgagatcag acaacaggaa ttacagacaa ttttcttatt cccttaccat
     6901 cctgaataaa acttagctca tgaatagaaa aaaaaaaaag ccatcagaga aaatggcaaa
     6961 cgtaaatcat ttttaaaggg taaaaattaa aagctttgct aataacataa ctttcatgct
     7021 aggaccaaaa gtgggtggag aaaaaaatag taaaatatat attacctatt ccaaaactga
     7081 tttaattgca gccagaatct tatggaagtt tagaagtgat gtatagagta caggaatcac
     7141 ccatggaaat tctaaggtct tagaaagcaa aaggttccct accaggacct accccctagt
     7201 cacttgggat tacctgtgaa gctcaaaggc cctagtggca tcaaaggtga gtaagaagaa
     7261 gccgagatgc tttaagcaac agcgtgaggt tggcatcaac ggggcacatt tgttcttcac
     7321 agcaagccca gtgttttccc atcttaccca atgtggagct gggtctgaaa gtgtgccaag
     7381 tgatcaccta ttgccaaata gcttttagtc tttagatggc cttctgactg tccaggtcct
     7441 aagcctacag taatcacggg cccagcctct agtgtgttct cttcccaagc aggtggatag
     7501 tggagagagc cctgactcaa tattcactca cacatcattg gtgaggagaa gctaggaagg
     7561 caggcatttg ccacttcatc tatccacagg aggttccttg aagtctgccc tgagaaggag
     7621 gtgtctttgc tggggaggat cttcatcatc agcatcaagc tgtgagggga aaggctttga
     7681 caaaagggtt gccactttct gaattcttct caaagaggaa tttctaagcc aagctacaga
     7741 ttcatccagg ctcagaattc catggctgtg ggcaggagct gtcatcttca ctatattttg
     7801 agatacattt ttttttaggt agaactcgag gtccagatct agagggggat aaggacgatg
     7861 agaaggataa agttgtggca gttgagctaa aagtcatgtt cgagtttttt ggtgggtctg
     7921 actggacagg ggaaaatgtg gtccgacttc ttttatctaa aagtttggga aagataccca
     7981 tagcttctct cttgccatgt ttattaacaa agatgttaga cactactcca tgagaaatgt
     8041 ccttgtgaaa ataaaaacca tgccatcaaa agagtcgggt gcaaagatgc ctacttcatg
     8101 agaatcacct gcccagttgt ttttgtgcct tgtctgtgac atcaaaactg aaacacttat
     8161 atcactgtca ctcatggttt tcttttcctg tgtcatacat acaaagtgca tttgattgta
     8221 atgatttaaa gtaaataaag catttcatct acttttgtta
//
