LOCUS       NM_001285788            3042 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus immunoglobulin-like domain containing receptor 1
            (Ildr1), transcript variant 1, mRNA.
ACCESSION   NM_001285788
VERSION     NM_001285788.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3042)
  AUTHORS   Siegerist,F., Kliewe,F., Hammer,E., Schakau,P., Chi Soh,J.E.,
            Weber,C., Lindenmeyer,M., Reichelt-Wurm,S., Drenic,V.,
            Chatziantoniou,C., Chadjichristos,C.E., Zhang,Y., Simm,S.,
            Banas,M.C., Nauck,M., Volker,U. and Endlich,N.
  TITLE     The role of the tricellular junction protein ILDR2 in
            glomerulopathies: Expression patterns and functional insights
  JOURNAL   iScience 27 (12), 111329 (2024)
   PUBMED   39640577
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3042)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3042)
  AUTHORS   Chandra,R., Aryal,D.K., Douros,J.D., Shahid,R., Davis,S.J.,
            Campbell,J.E., Ilkayeya,O., White,P.J., Rodriguez,R., Newgard,C.B.,
            Wetsel,W.C. and Liddle,R.A.
  TITLE     Ildr1 gene deletion protects against diet-induced obesity and
            hyperglycemia
  JOURNAL   PLoS One 17 (6), e0270329 (2022)
   PUBMED   35749484
  REMARK    GeneRIF: Ildr1 gene deletion protects against diet-induced obesity
            and hyperglycemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3042)
  AUTHORS   Higashi,A.Y., Higashi,T., Furuse,K., Ozeki,K., Furuse,M. and
            Chiba,H.
  TITLE     Claudin-9 constitutes tight junctions of folliculo-stellate cells
            in the anterior pituitary gland
  JOURNAL   Sci Rep 11 (1), 21642 (2021)
   PUBMED   34737342
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3042)
  AUTHORS   Hempstock,W., Sugioka,S., Ishizuka,N., Sugawara,T., Furuse,M. and
            Hayashi,H.
  TITLE     Angulin-2/ILDR1, a tricellular tight junction protein, does not
            affect water transport in the mouse large intestine
  JOURNAL   Sci Rep 10 (1), 10374 (2020)
   PUBMED   32587380
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3042)
  AUTHORS   Morozko,E.L., Nishio,A., Ingham,N.J., Chandra,R., Fitzgerald,T.,
            Martelletti,E., Borck,G., Wilson,E., Riordan,G.P., Wangemann,P.,
            Forge,A., Steel,K.P., Liddle,R.A., Friedman,T.B. and
            Belyantseva,I.A.
  TITLE     ILDR1 null mice, a model of human deafness DFNB42, show structural
            aberrations of tricellular tight junctions and degeneration of
            auditory hair cells
  JOURNAL   Hum Mol Genet 24 (3), 609-624 (2015)
   PUBMED   25217574
  REMARK    GeneRIF: Study consolidate the importance of ILDR1 as a tight
            junction protein necessary for cochlear hair cells survival, and
            the integrity of the auditory system.
REFERENCE   7  (bases 1 to 3042)
  AUTHORS   Chandra,R., Wang,Y., Shahid,R.A., Vigna,S.R., Freedman,N.J. and
            Liddle,R.A.
  TITLE     Immunoglobulin-like domain containing receptor 1 mediates
            fat-stimulated cholecystokinin secretion
  JOURNAL   J Clin Invest 123 (8), 3343-3352 (2013)
   PUBMED   23863714
  REMARK    GeneRIF: ILDR1 regulates CCK release through a mechanism dependent
            on fatty acids and lipoproteins.
REFERENCE   8  (bases 1 to 3042)
  AUTHORS   Higashi,T., Tokuda,S., Kitajiri,S., Masuda,S., Nakamura,H., Oda,Y.
            and Furuse,M.
  TITLE     Analysis of the 'angulin' proteins LSR, ILDR1 and
            ILDR2--tricellulin recruitment, epithelial barrier function and
            implication in deafness pathogenesis
  JOURNAL   J Cell Sci 126 (Pt 4), 966-977 (2013)
   PUBMED   23239027
  REMARK    GeneRIF: The findings show the heterogeneity of the molecular
            organization of tTJs in terms of the content of LSR, ILDR1 or
            ILDR2, and suggest that ILDR1-mediated recruitment of tricellulin
            to TCs is required for hearing.
            Erratum:[J Cell Sci. 2013 Aug 15;126(Pt 16):3797]
REFERENCE   9  (bases 1 to 3042)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   10 (bases 1 to 3042)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK136284.1 and AC117662.13.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136284.1, AK035504.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1034              AK136284.1         1-1034
            1035-1035           AC117662.13        201769-201769
            1036-3042           AK136284.1         1036-3042
FEATURES             Location/Qualifiers
     source          1..3042
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 25.88 cM"
     gene            1..3042
                     /gene="Ildr1"
                     /note="immunoglobulin-like domain containing receptor 1"
                     /db_xref="GeneID:106347"
                     /db_xref="MGI:MGI:2146574"
     exon            1..237
                     /gene="Ildr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..1796
                     /gene="Ildr1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; angulin-2"
                     /codon_start=1
                     /product="immunoglobulin-like domain-containing receptor 1
                     isoform 1 precursor"
                     /protein_id="NP_001272717.1"
                     /db_xref="CCDS:CCDS70718.1"
                     /db_xref="GeneID:106347"
                     /db_xref="MGI:MGI:2146574"
                     /translation="MGCGLLAAGLLLFTWLPAGCLSLLVTVQHTERYVTLFASVTLKC
                     DYTTSAQLQDVVVTWRFKSFCKDPIFDYFSASYQAALSLGQDPSNDCSDNQREVRIVA
                     QRRGQSEPVLGVDYRQRKITIQNRADLVINEVMWWDHGVYYCTIEAPGDTSGDPDKEV
                     KLIVLHWLTVIFIILGALLLLLLIGVCWCQCCPQYCCCYIRCPCCPTRCCCPEEALAR
                     HRYMKQVQALGPQMMEKPLYWGADRSSQVSSYAMNPLLQRDLSLQSSLPQMPMTQMAA
                     HPPVANGVLEYLEKELRNLNPAQPLPADLRAKSGHPCSMLSSLGSAEVVERRVIHLPP
                     LIRDPPSSRTSNPSHQQRLNAVSSRHCDLSERPRQRHHSDFLRELQDQGMRPWAPGRG
                     ELDPHWSGRHHRSRPSESSMPWSDWDSLSECPSSSEAPWPPRRPEPREGAQRRERRRH
                     RSYSPPLPSGPSSWSSEEEKESLPRNWGAQRRHHHRRRRSQSPNWPEEKPPSYRSLDV
                     TPGKNNRKKGNVERRLERESSHSGRSVVI"
     exon            238..408
                     /gene="Ildr1"
                     /inference="alignment:Splign:2.1.0"
     exon            409..558
                     /gene="Ildr1"
                     /inference="alignment:Splign:2.1.0"
     exon            559..678
                     /gene="Ildr1"
                     /inference="alignment:Splign:2.1.0"
     exon            679..825
                     /gene="Ildr1"
                     /inference="alignment:Splign:2.1.0"
     exon            826..957
                     /gene="Ildr1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1754
                     /gene="Ildr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..3042
                     /gene="Ildr1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2533..2538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ildr1"
                     /note="hexamer: AATAAA"
     polyA_site      2559
                     /gene="Ildr1"
                     /note="major polyA site"
ORIGIN      
        1 ggagctcaga gagcctcagg taccggtggg ctgggccgta cctgtggggg ccagagggga
       61 cgctcccgtc gcatagttcg acctacgggc tcctcggaga tgcgtgtcct ggccggcggc
      121 tgatgaagaa agactcgcct ctccggggcc cttgagcctc tgtagccagc gagggggcca
      181 gcatgggctg cggattgctc gctgctggcc tgctcctctt cacctggctc ccagcagggt
      241 gtctgtcctt gctagtcaca gtccagcaca cagaacgcta tgttactctg tttgcctccg
      301 ttaccctcaa gtgtgactac accacctctg cccagctcca ggacgtggtt gtgacatggc
      361 gcttcaagtc cttctgcaag gatcccatct ttgactactt ctctgcctca taccaggcag
      421 ctttgtccct gggccaggac ccctccaatg actgtagtga caatcagagg gaagttcgca
      481 tcgtggcgca gcggcgtggg cagagtgagc ccgtgctggg ggtggattac cggcaacgca
      541 agatcaccat ccagaaccga gcagatcttg tgattaatga agtgatgtgg tgggatcatg
      601 gagtatacta ttgtaccatc gaggctccag gagacacgtc aggagaccca gataaggagg
      661 tgaagctcat tgtcctgcat tggctgacag tgattttcat cattcttgga gccctcctac
      721 tcctgctgct gattggtgta tgctggtgcc agtgttgtcc gcagtattgc tgctgctata
      781 tccgctgccc ctgctgtcct acccgctgtt gctgccctga ggaagccctg gcccgccacc
      841 gctacatgaa gcaggttcag gccctaggtc ctcagatgat ggaaaaaccc ctgtactggg
      901 gggcggacag gagctcccaa gtttcatctt atgcaatgaa cccgctgctg cagcgagatc
      961 tgtccttaca gtccagcctt ccacagatgc caatgaccca gatggctgct caccctccgg
     1021 tggctaatgg tgtcctggaa tatttggaga aagaattgcg gaacctcaac ccagcccaac
     1081 ctctgcctgc ggatctcaga gccaaatctg gccacccttg cagcatgctc tcctccctgg
     1141 gctccgcaga ggttgtggaa cgcagagtca tccacctgcc cccactaatc agagacccac
     1201 cgtcctccag gaccagcaac ccctcacacc agcagcggct caatgctgtt tcttccagac
     1261 actgcgatct gagtgagcgc ccgaggcagc gccatcactc cgatttcctc cgagagctcc
     1321 aggaccaggg gatgagaccc tgggccccgg ggagagggga gctggacccc cattggagtg
     1381 ggagacacca ccgctctagg cccagcgagt catccatgcc ttggtcagac tgggacagcc
     1441 tgagcgaatg tccctcatcc agtgaggctc cttggccccc cagacgacca gagcccaggg
     1501 aaggcgccca gagacgtgag agacgcaggc atcgcagcta ctcgcctcct ctaccctcgg
     1561 gccccagctc ttggagctct gaagaggaga aagagtcgct gcccaggaac tggggtgccc
     1621 agcgacgtca ccatcaccgc cgccgccgct cacagtctcc aaactggcct gaggagaagc
     1681 cgcccagcta ccgctcactg gatgtgactc caggcaagaa caacaggaaa aaagggaatg
     1741 tggagaggcg cttggagaga gagagctccc atagtggacg gagtgtggtc atttagtctc
     1801 caggcaccat actgcttctt ggatcataca tgtcctcagc attatcaaga gttccagctg
     1861 ccttgggagg gacactatac atctgtgtct cacagttttg ggtttagatt ctaagaatca
     1921 aatagaagag ttttcaaaac aggtgtttgt ggaattaata gcaagctttc ccccttgttc
     1981 atgccctctg tctattacat gatctctgac ttgtaagggc tcctagctag gataggatcc
     2041 ctcagggaca cagtagccca aagtggtcca gtaggtcatg gtgctcggga ccaaggcagt
     2101 ctcataatga caactcagga atctttaaga agaaagcaaa caggttccag gaacaggaaa
     2161 cctatggaat attatgggca aattcccacg ggaactccct gtcctttctt gaatttcctg
     2221 agggtttttc cacgttaagc atccccacct gtggtcctga gcattcctga gtttccagtc
     2281 caagcaagca agcaagaaag ggcaaaaatt ctatagctct gtgcctttca caggctgtgc
     2341 aatgcaattc tgcaaaacca cagggaagca gttgttcacc aaccatattc ttgcttcttt
     2401 tttctttctt ctggagcctt tcccctacat ttaatttatt ttcttataca taataacata
     2461 gcaatgctaa aatcacttta aatactttca agcgccatcc agtataaaca agaaaattaa
     2521 tgtaacattc caaataaata atctgttttt ctaccctgag tttctacttc tattcattga
     2581 tttacttatc ttccagtaaa gctcagagaa gaatcaggcc acactgggta gttccaaaga
     2641 ctaccttctc caggactgct gaacatttcg gggtttcaat gtcccaagca ttaggatcta
     2701 ggtgggtttt gccacataca gagttccagg aggaaagagc tgaacctttc ctgtgtgtaa
     2761 tacagatatc actgtttccg attttccata tagctccttc acagatacat ttatgattga
     2821 tgtgtaggct ttctctgagt agactggaag gagatggttc caacaatatt gatattgtac
     2881 aagatcagca atatctctgt atggtcatga cttcaattta gagttaattg tatcaacaca
     2941 tccatttttc tccataatta aaagtgaaaa aaaaaactgg ctaaattcct gtgtttggca
     3001 gaggttattt tcagggtttt tgaaatctga acttaaatta gg
//
