LOCUS       NM_001134458            3086 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus interleukin 9 receptor (Il9r), transcript variant 1,
            mRNA.
ACCESSION   NM_001134458
VERSION     NM_001134458.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3086)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3086)
  AUTHORS   Pajulas,A., Fu,Y., Cheung,C.C.L., Chu,M., Cannon,A., Alakhras,N.,
            Zhang,J., Ulrich,B.J., Nelson,A.S., Zhou,B. and Kaplan,M.H.
  TITLE     Interleukin-9 promotes mast cell progenitor proliferation and
            CCR2-dependent mast cell migration in allergic airway inflammation
  JOURNAL   Mucosal Immunol 16 (4), 432-445 (2023)
   PUBMED   37172907
REFERENCE   3  (bases 1 to 3086)
  AUTHORS   Gokhale,S., Victor,E., Tsai,J., Spirollari,E., Matracz,B.,
            Takatsuka,S., Jung,J., Kitamura,D. and Xie,P.
  TITLE     Upregulated Expression of the IL-9 Receptor on TRAF3-Deficient B
            Lymphocytes Confers Ig Isotype Switching Responsiveness to IL-9 in
            the Presence of Antigen Receptor Engagement and IL-4
  JOURNAL   J Immunol 210 (8), 1059-1073 (2023)
   PUBMED   36883978
  REMARK    GeneRIF: Upregulated Expression of the IL-9 Receptor on
            TRAF3-Deficient B Lymphocytes Confers Ig Isotype Switching
            Responsiveness to IL-9 in the Presence of Antigen Receptor
            Engagement and IL-4.
REFERENCE   4  (bases 1 to 3086)
  AUTHORS   Feng,Y., Yan,S., Lam,S.K., Ko,F.C.F., Chen,C., Khan,M. and Ho,J.C.
  TITLE     IL-9 stimulates an anti-tumor immune response and facilitates
            immune checkpoint blockade in the CMT167 mouse model
  JOURNAL   Lung Cancer 174, 14-26 (2022)
   PUBMED   36272280
  REMARK    GeneRIF: IL-9 stimulates an anti-tumor immune response and
            facilitates immune checkpoint blockade in the CMT167 mouse model.
REFERENCE   5  (bases 1 to 3086)
  AUTHORS   Kamiya,S., Ikegami,I., Yanagi,M., Takaki,H., Kamekura,R., Sato,T.,
            Kobayashi,K., Kamiya,T., Kamada,Y., Abe,T., Inoue,K.I., Hida,T.,
            Uhara,H. and Ichimiya,S.
  TITLE     Functional Interplay between IL-9 and Peptide YY Contributes to
            Chronic Skin Inflammation
  JOURNAL   J Invest Dermatol 142 (12), 3222-3231 (2022)
   PUBMED   35850207
REFERENCE   6  (bases 1 to 3086)
  AUTHORS   Flint,J., Tufarelli,C., Peden,J., Clark,K., Daniels,R.J.,
            Hardison,R., Miller,W., Philipsen,S., Tan-Un,K.C., McMorrow,T.,
            Frampton,J., Alter,B.P., Frischauf,A.M. and Higgs,D.R.
  TITLE     Comparative genome analysis delimits a chromosomal domain and
            identifies key regulatory elements in the alpha globin cluster
  JOURNAL   Hum Mol Genet 10 (4), 371-382 (2001)
   PUBMED   11157800
REFERENCE   7  (bases 1 to 3086)
  AUTHORS   Malek,T.R., Porter,B.O. and He,Y.W.
  TITLE     Multiple gamma c-dependent cytokines regulate T-cell development
  JOURNAL   Immunol Today 20 (2), 71-76 (1999)
   PUBMED   10098325
  REMARK    Review article
REFERENCE   8  (bases 1 to 3086)
  AUTHORS   Vermeesch,J.R., Petit,P., Kermouni,A., Renauld,J.C., Van Den
            Berghe,H. and Marynen,P.
  TITLE     The IL-9 receptor gene, located in the Xq/Yq pseudoautosomal
            region, has an autosomal origin, escapes X inactivation and is
            expressed from the Y
  JOURNAL   Hum Mol Genet 6 (1), 1-8 (1997)
   PUBMED   9002663
REFERENCE   9  (bases 1 to 3086)
  AUTHORS   Jia,G.Q. and Gutierrez-Ramos,J.C.
  TITLE     Analysis of interleukin receptor gene expression in mouse fetal
            liver by quantitative polymerase chain reaction
  JOURNAL   Eur J Immunol 25 (7), 2096-2100 (1995)
   PUBMED   7621883
REFERENCE   10 (bases 1 to 3086)
  AUTHORS   Renauld,J.C., Druez,C., Kermouni,A., Houssiau,F., Uyttenhove,C.,
            Van Roost,E. and Van Snick,J.
  TITLE     Expression cloning of the murine and human interleukin 9 receptor
            cDNAs
  JOURNAL   Proc Natl Acad Sci U S A 89 (12), 5690-5694 (1992)
   PUBMED   1376929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929446.5.
            
            Transcript Variant: This variant (1) encodes a protein isoform (1)
            that is shorter by 1 amino acid due to use of an alternate splice
            acceptor site.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088694.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                AL929446.5         60763-60851         c
            90-200              AL929446.5         55645-55755         c
            201-312             AL929446.5         55198-55309         c
            313-491             AL929446.5         54931-55109         c
            492-637             AL929446.5         54306-54451         c
            638-845             AL929446.5         53746-53953         c
            846-951             AL929446.5         53219-53324         c
            952-1036            AL929446.5         52337-52421         c
            1037-3086           AL929446.5         49569-51618         c
FEATURES             Location/Qualifiers
     source          1..3086
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 18.82 cM"
     gene            1..3086
                     /gene="Il9r"
                     /note="interleukin 9 receptor"
                     /db_xref="GeneID:16199"
                     /db_xref="MGI:MGI:96564"
     exon            1..89
                     /gene="Il9r"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1471
                     /gene="Il9r"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; IL-9R; IL-9 receptor"
                     /codon_start=1
                     /product="interleukin-9 receptor isoform 1 precursor"
                     /protein_id="NP_001127930.1"
                     /db_xref="CCDS:CCDS48765.1"
                     /db_xref="GeneID:16199"
                     /db_xref="MGI:MGI:96564"
                     /translation="MALGRCIAEGWTLERVAVKQVSWFLIYSWVCSGVCRGVSVPEQG
                     GGGQKAGAFTCLSNSIYRIDCHWSAPELGQESRAWLLFTSNQVTEIKHKCTFWDSMCT
                     LVLPKEEVFLPFDNFTITLHRCIMGQEQVSLVDSQYLPRRHIKLDPPSDLQSNVSSGR
                     CVLTWGINLALEPLITSLSYELAFKRQEEAWEQARHKDRIVGVTWLILEAVELNPGSI
                     YEARLRVQMTLESYEDKTEGEYYKSHWSEWSQPVSFPSPQRRQGLLVPRWQWSASILV
                     VVPIFLLLTGFVHLLFKLSPRLKRIFYQNIPSPEAFFHPLYSVYHGDFQSWTGARRAG
                     PQARQNGVSTSSAGSESSIWEAVATLTYSPACPVQFACLKWEATAPGFPGLPGSEHVL
                     PAGCLELEGQPSAYLPQEDWAPLGSARPPPPDSDSGSSDYCMLDCCEECHLSAFPGHT
                     ESPELTLAQPVALPVSSRA"
     exon            90..200
                     /gene="Il9r"
                     /inference="alignment:Splign:2.1.0"
     exon            201..312
                     /gene="Il9r"
                     /inference="alignment:Splign:2.1.0"
     exon            313..491
                     /gene="Il9r"
                     /inference="alignment:Splign:2.1.0"
     exon            492..637
                     /gene="Il9r"
                     /inference="alignment:Splign:2.1.0"
     exon            638..845
                     /gene="Il9r"
                     /inference="alignment:Splign:2.1.0"
     exon            846..951
                     /gene="Il9r"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1036
                     /gene="Il9r"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..3086
                     /gene="Il9r"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1801
                     /gene="Il9r"
                     /note="major polyA site"
ORIGIN      
        1 agtgcaccca aggacagttg gcagtaagtc acctcctggc tggggctgcc tgagactctc
       61 catggccctg ggaagatgca ttgcggaagg ttggaccttg gagagagtgg cggtgaaaca
      121 ggtctcctgg ttcctgatct acagctgggt ctgctctgga gtctgccggg gagtctcggt
      181 cccagagcaa ggaggaggag ggcagaaggc tggagcattc acctgtctca gcaacagtat
      241 ttacaggatc gactgccact ggtcggctcc agagctgggc caggaatcca gggcctggct
      301 cctctttacc agtaaccagg tgactgaaat caaacacaaa tgcaccttct gggacagtat
      361 gtgtaccctg gtgctgccta aagaggaggt gttcttacct tttgacaact tcaccatcac
      421 acttcaccgc tgcatcatgg gacaggaaca ggtcagcctg gtggactcac agtacctgcc
      481 caggagacac atcaagttgg acccaccctc tgatctgcag agcaatgtca gctctgggcg
      541 ttgtgtcctg acctggggta tcaatcttgc cctggagcca ttgatcacat ccctcagcta
      601 cgagctggcc ttcaagaggc aggaagaggc ctgggagcag gcccggcaca aggaccgtat
      661 cgttggagtg acctggctca tccttgaagc cgtcgaactg aatcctggtt ccatctacga
      721 ggccaggctg cgtgtccaga tgactttgga gagttatgag gacaagacag agggggaata
      781 ttataagagc cattggagtg agtggagcca gcccgtgtcc tttccttctc cccagaggag
      841 acagggcctc ctggtcccac gctggcaatg gtcagccagc atccttgtag ttgtgcccat
      901 ctttcttctg ctgactggct ttgtccacct tctgttcaag ctgtcaccca ggctgaagag
      961 aatcttttac cagaacattc catctcccga ggcgttcttc catcctctct acagtgtgta
     1021 ccatggggac ttccagagtt ggacaggggc ccgcagagcc ggaccacaag caagacagaa
     1081 tggtgtcagt acttcatcag caggctcaga gtccagcatc tgggaggccg tcgccacact
     1141 cacctatagc ccggcatgcc ctgtgcagtt tgcctgcctg aagtgggagg ccacagcccc
     1201 gggcttccca gggctcccag gctcagagca tgtgctgccg gcagggtgtc tggagttgga
     1261 aggacagcca tctgcctacc tgccccagga ggactgggcc ccactgggct ctgccaggcc
     1321 ccctcctcca gactcagaca gcggcagcag cgactattgc atgttggact gctgtgagga
     1381 atgccacctc tcagccttcc caggacacac cgagagtcct gagctcacgc tagctcagcc
     1441 tgtggccctt cctgtgtcca gcagggcctg acacctacca agggatgtgg gcattctctt
     1501 ccctcctatc ctcggatggc accagacaca gtctctgcgt gtctctgcta ggtgcaccat
     1561 gtctgttttg gggagatgaa cgaaaggccc caggctgacc ctggggtgcg tgtggaactc
     1621 cggagaggag gcagctgtgc acggatcaga ggcaatgcgg atggaagcag tagactgtgc
     1681 cttacccccc tgctctgcct ttgtggtggg gatgcctcca gggtcagcat cttaacatcc
     1741 gccttcgctt ctcttgtctt tctggctctg tcccaggcct gaaaaaagaa tgtgacaagc
     1801 agcctggtct gttcttccac ccctaaaggg ctggcctggg cccagggaca ctgatgagac
     1861 aacattggtg aagtgtccct tttcagtgcc tttcccatta agaccagaag ggacgctttt
     1921 gactgcaggc tgtgggtggc tgggtacgga gggaatgatg gagctttgag caggtggggt
     1981 tgtccatctt tgagcttttg gggttccaag atcagctgga aggagtctca ccgactgatt
     2041 caaagaagtc ttacccatct gtgatatttt ctttcctggt gccgtgataa aacaccgtga
     2101 ccaaaaatga cttacaaaag gaagagttgg cttggtttaa ggttccagag gtgtggagac
     2161 atggcagcca gcggcacaca tggcagtgag gacaggaagc tgagagctca catctcaacc
     2221 aaaagttgag tgaactgaaa gtactatccc ctcccccacc ccaactccag caaggctcca
     2281 cccccctgaa ggttccatgc ctccctaaac agctcggcca aatagagacc aagtgttcaa
     2341 atatctgagt ctgtggggga catttctcat tcaaaccact tcactgcccc cactgttcct
     2401 aggaaaaagc tgaagccagg gctactggac agggttggga atggctattt ctcagcagcc
     2461 ggcctgtgaa gaatgacgat gcccctaact gccttctgag gtagcctgga gagagctgtg
     2521 ggtgggctag aatgtggctg ttattttcct aggcttgccc taacagaata ccagaaaccg
     2581 ggtggctaat accgtagatt tgttttctct ctgctctgag gtccatgggt ctggaatgga
     2641 gacaccagga aggccatgct cctggaggga agggtttgtt tccagccctg cttcacattc
     2701 ccctctgagt gtcctcttgc gtactgagac tagatgctac ccaatgacgg ggacaggttg
     2761 tgtctcatac tcttgcatgt gagcagagat tgtgacctag aaggccaaaa caggctgagc
     2821 agttggccac gtttgtgcag atttggagcc ataaagcact ggcctaacag aagtcctctt
     2881 gctccttgaa gggctcttaa agggcaagcg tgggaacaat gctagtgtga ggactatttc
     2941 caagcctgtg acaccgtgca agagacggtc gaactactgc gcagggtcca tggagcgcag
     3001 agtccatgga gcgcagagag gaactgcatg cagcattgtg agctcagagc tggtgtcctg
     3061 ggaaggctca caatgctgac cccagg
//
