LOCUS       NM_008373                547 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus interleukin 9 (Il9), mRNA.
ACCESSION   NM_008373
VERSION     NM_008373.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 547)
  AUTHORS   Schmitt,P., Duval,A., Camus,M., Lefrancais,E., Roga,S., Dedieu,C.,
            Ortega,N., Bellard,E., Mirey,E., Mouton-Barbosa,E.,
            Burlet-Schiltz,O., Gonzalez-de-Peredo,A., Cayrol,C. and Girard,J.P.
  TITLE     TL1A is an epithelial alarmin that cooperates with IL-33 for
            initiation of allergic airway inflammation
  JOURNAL   J Exp Med 221 (6) (2024)
   PUBMED   38597952
REFERENCE   2  (bases 1 to 547)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 547)
  AUTHORS   Tsuda,H., Keslar,K.S., Baldwin,W.M. 3rd, Heeger,P.S., Valujskikh,A.
            and Fairchild,R.L.
  TITLE     p40 homodimers bridge ischemic tissue inflammation and heterologous
            alloimmunity in mice via IL-15 transpresentation
  JOURNAL   J Clin Invest 134 (6), e172760 (2024)
   PUBMED   38271093
  REMARK    GeneRIF: p40 homodimers bridge ischemic tissue inflammation and
            heterologous alloimmunity in mice via IL-15 transpresentation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 547)
  AUTHORS   Yuan,C., Rayasam,A., Moe,A., Hayward,M., Wells,C., Szabo,A.,
            Mackenzie,A., Salzman,N. and Drobyski,W.R.
  TITLE     Interleukin-9 production by type 2 innate lymphoid cells induces
            Paneth cell metaplasia and small intestinal remodeling
  JOURNAL   Nat Commun 14 (1), 7963 (2023)
   PUBMED   38042840
  REMARK    GeneRIF: Interleukin-9 production by type 2 innate lymphoid cells
            induces Paneth cell metaplasia and small intestinal remodeling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 547)
  AUTHORS   Chuang,H.C., Hsueh,C.H., Hsu,P.M., Tsai,C.Y., Shih,Y.C., Chiu,H.Y.,
            Chen,Y.M., Yu,W.K., Chen,M.H. and Tan,T.H.
  TITLE     DUSP8 induces TGF-beta-stimulated IL-9 transcription and
            Th9-mediated allergic inflammation by promoting nuclear export of
            Pur-alpha
  JOURNAL   J Clin Invest 133 (21), e166269 (2023)
   PUBMED   37909329
  REMARK    GeneRIF: DUSP8 induces TGF-beta-stimulated IL-9 transcription and
            Th9-mediated allergic inflammation by promoting nuclear export of
            Pur-alpha.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 547)
  AUTHORS   Quesniaux,V.F.
  TITLE     Interleukins 9, 10, 11 and 12 and kit ligand: a brief overview
  JOURNAL   Res Immunol 143 (4), 385-400 (1992)
   PUBMED   1381512
  REMARK    Review article
REFERENCE   7  (bases 1 to 547)
  AUTHORS   King,T.R., Lee,B.K., Behringer,R.R. and Eicher,E.M.
  TITLE     Mapping anti-mullerian hormone (Amh) and related sequences in the
            mouse: identification of a new region of homology between MMU10 and
            HSA19p
  JOURNAL   Genomics 11 (2), 273-283 (1991)
   PUBMED   1685136
REFERENCE   8  (bases 1 to 547)
  AUTHORS   Renauld,J.C., Goethals,A., Houssiau,F., Merz,H., Van Roost,E. and
            Van Snick,J.
  TITLE     Human P40/IL-9. Expression in activated CD4+ T cells, genomic
            organization, and comparison with the mouse gene
  JOURNAL   J Immunol 144 (11), 4235-4241 (1990)
   PUBMED   1971295
REFERENCE   9  (bases 1 to 547)
  AUTHORS   Mock,B.A., Krall,M., Kozak,C.A., Nesbitt,M.N., McBride,O.W.,
            Renauld,J.C. and Van Snick,J.
  TITLE     IL9 maps to mouse chromosome 13 and human chromosome 5
  JOURNAL   Immunogenetics 31 (4), 265-270 (1990)
   PUBMED   1970335
REFERENCE   10 (bases 1 to 547)
  AUTHORS   Van Snick,J., Goethals,A., Renauld,J.C., Van Roost,E.,
            Uyttenhove,C., Rubira,M.R., Moritz,R.L. and Simpson,R.J.
  TITLE     Cloning and characterization of a cDNA for a new mouse T cell
            growth factor (P40)
  JOURNAL   J Exp Med 169 (1), 363-368 (1989)
   PUBMED   2521242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132901.11 and X14045.1.
            
            On Feb 5, 2019 this sequence version replaced NM_008373.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X14045.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC132901.11        48843-48853         c
            12-547              X14045.1           1-536
FEATURES             Location/Qualifiers
     source          1..547
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 30.06 cM"
     gene            1..547
                     /gene="Il9"
                     /gene_synonym="Il-9; P40"
                     /note="interleukin 9"
                     /db_xref="GeneID:16198"
                     /db_xref="MGI:MGI:96563"
     exon            1..140
                     /gene="Il9"
                     /gene_synonym="Il-9; P40"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..461
                     /gene="Il9"
                     /gene_synonym="Il-9; P40"
                     /note="cytokine P40; T-cell growth factor P40"
                     /codon_start=1
                     /product="interleukin-9 precursor"
                     /protein_id="NP_032399.1"
                     /db_xref="CCDS:CCDS26562.1"
                     /db_xref="GeneID:16198"
                     /db_xref="MGI:MGI:96563"
                     /translation="MLVTYILASVLLFSSVLGQRCSTTWGIRDTNYLIENLKDDPPSK
                     CSCSGNVTSCLCLSVPTDDCTTPCYREGLLQLTNATQKSRLLPVFHRVKRIVEVLKNI
                     TCPSFSCEKPCNQTMAGNTLSFLKSLLGTFQKTEMQRQKSRP"
     exon            141..176
                     /gene="Il9"
                     /gene_synonym="Il-9; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            177..209
                     /gene="Il9"
                     /gene_synonym="Il-9; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            210..341
                     /gene="Il9"
                     /gene_synonym="Il-9; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            342..547
                     /gene="Il9"
                     /gene_synonym="Il-9; P40"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agactgagtt ccagactccc gtcaacatgt tggtgacata catccttgcc tctgttttgc
       61 tcttcagttc tgtgctgggc cagagatgca gcaccacatg gggcatcaga gacaccaatt
      121 accttattga aaatctgaag gatgatccac cgtcaaaatg cagctgcagc ggcaacgtga
      181 ccagctgctt gtgtctctcc gtcccaactg atgattgtac cacaccgtgc tacagggagg
      241 gactgttaca gctgaccaat gccacacaga aatcaagact cttgcctgtt ttccatcggg
      301 tgaaaaggat agttgaagtc ctaaagaaca tcacgtgtcc gtccttttcc tgcgaaaagc
      361 catgcaacca gaccatggca ggcaacacac tgtcatttct gaagagtctc ctggggacgt
      421 tccagaagac agagatgcaa aggcagaaaa gccgaccatg aagacagatg ctatttattc
      481 tatttattga atttacaaaa cctcccctcc ttaactgtta cagtgaagaa ataaactaag
      541 ctattct
//
