LOCUS       NM_008372               3227 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus interleukin 7 receptor (Il7r), transcript variant 2,
            mRNA.
ACCESSION   NM_008372
VERSION     NM_008372.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3227)
  AUTHORS   Osum,K.C., Becker,S.H., Krueger,P.D., Mitchell,J.S., Hong,S.W.,
            Magill,I.R. and Jenkins,M.K.
  TITLE     A minority of Th1 and Tfh effector cells express survival genes
            shared by memory cell progeny that require IL-7 or TCR signaling to
            persist
  JOURNAL   Cell Rep 44 (1), 115111 (2025)
   PUBMED   39723889
REFERENCE   2  (bases 1 to 3227)
  AUTHORS   Mao,Y., Meng,Y., Zou,K., Qin,N., Wang,Y., Yan,J., Chen,P.,
            Cheng,Y., Shi,W., Zhou,C., Chen,H., Sheng,J., Liu,X., Pan,J. and
            Huang,H.
  TITLE     Advanced paternal age exacerbates neuroinflammation in offspring
            via m6A modification-mediated intergenerational inheritance
  JOURNAL   J Neuroinflammation 21 (1), 249 (2024)
   PUBMED   39367406
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3227)
  AUTHORS   Yazdani,R., Askari,M., Ahmadi,A.M., Azizi,G., Ciric,B., Boehm,A.,
            Zhang,G.X. and Rostami,A.
  TITLE     Mouse monocytes express CD127 by immune cells, not LPS
  JOURNAL   Front Immunol 15, 1356004 (2024)
   PUBMED   39328413
  REMARK    GeneRIF: Mouse monocytes express CD127 by immune cells, not LPS.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3227)
  AUTHORS   Rodrigues,P.F., Trsan,T., Cvijetic,G., Khantakova,D., Panda,S.K.,
            Liu,Z., Ginhoux,F., Cella,M. and Colonna,M.
  TITLE     Progenitors of distinct lineages shape the diversity of mature type
            2 conventional dendritic cells
  JOURNAL   Immunity 57 (7), 1567-1585 (2024)
   PUBMED   38821051
REFERENCE   5  (bases 1 to 3227)
  AUTHORS   Das,A., Martinez-Ruiz,G.U., Bouladoux,N., Stacy,A., Moraly,J.,
            Vega-Sendino,M., Zhao,Y., Lavaert,M., Ding,Y., Morales-Sanchez,A.,
            Harly,C., Seedhom,M.O., Chari,R., Awasthi,P., Ikeuchi,T., Wang,Y.,
            Zhu,J., Moutsopoulos,N.M., Chen,W., Yewdell,J.W., Shapiro,V.S.,
            Ruiz,S., Taylor,N., Belkaid,Y. and Bhandoola,A.
  TITLE     Transcription factor Tox2 is required for metabolic adaptation and
            tissue residency of ILC3 in the gut
  JOURNAL   Immunity 57 (5), 1019-1036 (2024)
   PUBMED   38677292
REFERENCE   6  (bases 1 to 3227)
  AUTHORS   He,Y.W., Adkins,B., Furse,R.K. and Malek,T.R.
  TITLE     Expression and function of the gamma c subunit of the IL-2, IL-4,
            and IL-7 receptors. Distinct interaction of gamma c in the IL-4
            receptor
  JOURNAL   J Immunol 154 (4), 1596-1605 (1995)
   PUBMED   7530740
REFERENCE   7  (bases 1 to 3227)
  AUTHORS   Venkitaraman,A.R. and Cowling,R.J.
  TITLE     Interleukin-7 induces the association of phosphatidylinositol
            3-kinase with the alpha chain of the interleukin-7 receptor
  JOURNAL   Eur J Immunol 24 (9), 2168-2174 (1994)
   PUBMED   7522165
REFERENCE   8  (bases 1 to 3227)
  AUTHORS   Brannan,C.I., Gilbert,D.J., Ceci,J.D., Matsuda,Y., Chapman,V.M.,
            Mercer,J.A., Eisen,H., Johnston,L.A., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     An interspecific linkage map of mouse chromosome 15 positioned with
            respect to the centromere
  JOURNAL   Genomics 13 (4), 1075-1081 (1992)
   PUBMED   1354638
REFERENCE   9  (bases 1 to 3227)
  AUTHORS   Pleiman,C.M., Gimpel,S.D., Park,L.S., Harada,H., Taniguchi,T. and
            Ziegler,S.F.
  TITLE     Organization of the murine and human interleukin-7 receptor genes:
            two mRNAs generated by differential splicing and presence of a type
            I-interferon-inducible promoter
  JOURNAL   Mol Cell Biol 11 (6), 3052-3059 (1991)
   PUBMED   2038316
REFERENCE   10 (bases 1 to 3227)
  AUTHORS   Goodwin,R.G., Friend,D., Ziegler,S.F., Jerzy,R., Falk,B.A.,
            Gimpel,S., Cosman,D., Dower,S.K., March,C.J., Namen,A.E. et al.
  TITLE     Cloning of the human and murine interleukin-7 receptors:
            demonstration of a soluble form and homology to a new receptor
            superfamily
  JOURNAL   Cell 60 (6), 941-951 (1990)
   PUBMED   2317865
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY776757.1, AK040364.1, AK042264.1 and BC089571.1.
            
            On Feb 22, 2008 this sequence version replaced NM_008372.3.
            
            Summary: Interleukin-7 is a glycoptorein involved in the regulation
            of lymphopoiesis. Response of cells to IL7 is dependent on the
            presence of the interleukin 7 receptor (IL7R); the active receptor
            is a alpha/gamma chain heterodimer. The gamma(c) chain, which also
            associates with the interleukin-2 receptor, serves primarily to
            activate signal transduction by the IL7R complex, while the alpha
            chain of IL7R determines specific signaling events through its
            association with cytoplasmic signaling molecules. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M29697.1, AK042264.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BY776757.1         2-19
            19-1503             AK040364.1         2-1486
            1504-1765           AK042264.1         1449-1710
            1766-3227           BC089571.1         1701-3162
FEATURES             Location/Qualifiers
     source          1..3227
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 4.16 cM"
     gene            1..3227
                     /gene="Il7r"
                     /gene_synonym="CD127; IL-7Ralpha"
                     /note="interleukin 7 receptor"
                     /db_xref="GeneID:16197"
                     /db_xref="MGI:MGI:96562"
     exon            1..216
                     /gene="Il7r"
                     /gene_synonym="CD127; IL-7Ralpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1514
                     /gene="Il7r"
                     /gene_synonym="CD127; IL-7Ralpha"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; IL-7 receptor alpha chain; interleukin-7
                     receptor subunit alpha; IL-7RA; IL-7R-alpha; IL-7R subunit
                     alpha; IL-7 receptor subunit alpha; interleukin 7 receptor
                     alpha chain"
                     /codon_start=1
                     /product="interleukin-7 receptor subunit alpha isoform 1
                     precursor"
                     /protein_id="NP_032398.3"
                     /db_xref="CCDS:CCDS27376.1"
                     /db_xref="GeneID:16197"
                     /db_xref="MGI:MGI:96562"
                     /translation="MMALGRAFAIVFCLIQAVSGESGNAQDGDLEDADADDHSFWCHS
                     QLEVDGSQHLLTCAFNDSDINTANLEFQICGALLRVKCLTLNKLQDIYFIKTSEFLLI
                     GSSNICVKLGQKNLTCKNMAINTIVKAEAPSDLKVVYRKEANDFLVTFNAPHLKKKYL
                     KKVKHDVAYRPARGESNWTHVSLFHTRTTIPQRKLRPKAMYEIKVRSIPHNDYFKGFW
                     SEWSPSSTFETPEPKNQGGWDPVLPSVTILSLFSVFLLVILAHVLWKKRIKPVVWPSL
                     PDHKKTLEQLCKKPKTSLNVSFNPESFLDCQIHEVKGVEARDEVESFLPNDLPAQPEE
                     LETQGHRAAVHSANRSPETSVSPPETVRRESPLRCLARNLSTCNAPPLLSSRSPDYRD
                     GDRNRPPVYQDLLPNSGNTNVPVPVPQPLPFQSGILIPVSQRQPISTSSVLNQEEAYV
                     TMSSFYQNK"
     exon            217..355
                     /gene="Il7r"
                     /gene_synonym="CD127; IL-7Ralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            356..513
                     /gene="Il7r"
                     /gene_synonym="CD127; IL-7Ralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            514..671
                     /gene="Il7r"
                     /gene_synonym="CD127; IL-7Ralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            672..840
                     /gene="Il7r"
                     /gene_synonym="CD127; IL-7Ralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            841..934
                     /gene="Il7r"
                     /gene_synonym="CD127; IL-7Ralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1010
                     /gene="Il7r"
                     /gene_synonym="CD127; IL-7Ralpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..3210
                     /gene="Il7r"
                     /gene_synonym="CD127; IL-7Ralpha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3184..3189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il7r"
                     /gene_synonym="CD127; IL-7Ralpha"
                     /note="hexamer: AATACA"
     polyA_site      3210
                     /gene="Il7r"
                     /gene_synonym="CD127; IL-7Ralpha"
                     /note="major polyA site"
ORIGIN      
        1 gtctgtggtt tagcaggcac agagctggtt tgggtctccc tctctctcat tcacttgcac
       61 atacaagcgt gcttcttctc tattctttct ctctctctct ctctctctct ctctctctct
      121 ctctctctct cagaatgatg gctctgggta gagctttcgc tatagttttc tgcttaattc
      181 aagctgtttc tggagaaagt ggaaatgccc aggatggaga cctagaagat gcagacgcgg
      241 acgatcactc cttctggtgc cacagccagt tggaagtgga tggaagtcaa catttattga
      301 cttgtgcttt taatgactca gacatcaaca cagctaatct ggaatttcaa atatgtgggg
      361 ctcttttacg agtgaaatgc ctaactctta acaagctgca agatatatat tttataaaga
      421 catcagaatt cttactgatt ggtagcagca atatatgtgt gaagcttgga caaaagaatt
      481 taacttgcaa aaatatggct ataaacacaa tagttaaagc cgaggctccc tctgacctga
      541 aagtcgttta tcgcaaagaa gcaaatgatt ttttggtgac atttaatgca cctcacttga
      601 aaaagaaata tttaaaaaaa gtaaagcatg atgtggccta ccgcccagca aggggtgaaa
      661 gcaactggac gcatgtatct ttattccaca caagaacaac aatcccacag agaaaactac
      721 gaccaaaagc aatgtatgaa atcaaagtcc gatccattcc ccataacgat tacttcaaag
      781 gcttctggag cgagtggagt ccaagttcta ccttcgaaac tccagaaccc aagaatcaag
      841 gaggatggga tcctgtcttg ccaagtgtca ccattctgag tttgttctct gtgtttttgt
      901 tggtcatctt agcccatgtg ctatggaaaa aaaggattaa acctgtcgta tggcctagtc
      961 tccccgatca taagaaaact ctggaacaac tatgtaagaa gccaaaaacg agtctgaatg
     1021 tgagtttcaa tcccgaaagt ttcctggact gccagattca tgaggtgaaa ggcgttgaag
     1081 ccagggacga ggtggaaagt tttctgccca atgatcttcc tgcacagcca gaggagttgg
     1141 agacacaggg acacagagcc gctgtacaca gtgcaaaccg ctcgcctgag acttcagtca
     1201 gcccaccaga aacagttaga agagagtcac ccttaagatg cctggctaga aatctgagta
     1261 cctgcaatgc ccctccactc ctttcctcta ggtcccctga ctacagagat ggtgacagaa
     1321 ataggcctcc tgtgtatcaa gacttgctgc caaactctgg aaacacaaat gtccctgtcc
     1381 ctgtccctca accattgcct ttccagtcgg gaatcctgat accagtttct cagagacagc
     1441 ccatctccac ttcctcagta ctgaatcaag aagaagcgta tgtcaccatg tctagttttt
     1501 accaaaacaa atgaattata agaaaaccct tccatcgaca accaaatgat cactgagatg
     1561 gaaagtctgg aatgcttgct ctcccccgta gctcacagaa gagaaagtca acgtgacctt
     1621 gctacacatc ttcagcattc taagaaatca ttttgctctt ctagctcaga agcatttgca
     1681 caaagcagga agaatctgtt ttccctgttg ttggattagt cataagagtc catatgaccc
     1741 aattaaaatt gcaaaactca gttaagtgaa gaaagaaaga tagacaaaag aagatagaag
     1801 gatgtggtga atgcaggaag aagaaaatga aagatgtgag tggtgggtct atcattcaaa
     1861 ttgactattt atccagcact ataccactct tctcatttct tcctcacaat aatattacaa
     1921 tgtgggctta tccattataa cttttatttt ctttgtcata gatgctgaag ttgaaagtag
     1981 agattttaag tgatatccaa atttttcttt cagctacaga tgaggcacac attccaactt
     2041 caaccctctc ttgccatgaa cctgtcctat tgttgagtgt caaacatcac cactaagtgg
     2101 atggttatgt agtccattat ccaaactgag tcgttttgga aagaaaaagt tagacataat
     2161 taacagtaag cataaactgt atatgtctaa gagagatgtg gatggatggt cattttactt
     2221 aaagtggcta tagggatgaa catgaaggac aaagtacatt tatgggtgtg gcataccatg
     2281 accatgtgtc aaaggaagtg ggaaaaagaa aaaaaaagca ccaagatcat ttgattttgt
     2341 tttgttgttt tgtttgaaaa caaactcaag aagcaatgag ttagaagccg agaagttcca
     2401 gagtcagtta tcaagaccat gattttcctg ctgctattat ccattggctt ctctgtgaca
     2461 ttgtaggagg aactatggcc aatctacagg agttcaacat ttaacagtga atggagtcct
     2521 cctatgtgag tcctcctatg tgtggagaca ccattaagaa ctaccccaag ttctacatct
     2581 ctggatattg cctgaactac agaaaaaggg ggctgcgcac accacaatga gtgccctacc
     2641 tgaaactatg ctcacagaaa cacaaagaag atgggtaagt tattcaaatt caaatgttga
     2701 tttatgactg caagtcacaa ttttgaatcc ctgctgtgta taaccaatct cctgaagaaa
     2761 acaacaaata actgaaagat actgtggttg ggtgccttag cattaaaatt ctgtttaagt
     2821 gttgacattg tttatttgga ttggagtgtc tgtccggtca tgtattgtat ccatgcatta
     2881 tattcagata accacaacag ctgctaatgc ttgattatat tctcagggac tgcatgcaat
     2941 gtaacattac tggttggttc tgccaatttt cctcttggta tttataaagg aaaaccaaaa
     3001 ctcttggtca gagacaatat gcaaaacaga gatgtcaagt actatgtcca aatactgtga
     3061 aatataatga gaaataggta acaaatttat caatcaacta tgtttggatc cagggaatct
     3121 caagttattc aattcattct ctgtaagcct ttgtctctct cttcatccag acttttgcct
     3181 tcaaatacaa gcatgcgcta ttttctggaa aaaaaaaaaa aaaaaaa
//
