LOCUS       NM_008371               2857 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus interleukin 7 (Il7), transcript variant 1, mRNA.
ACCESSION   NM_008371
VERSION     NM_008371.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2857)
  AUTHORS   Kour,R., Kim,J., Roy,A., Richardson,B., Cameron,M.J., Knott,J.G.
            and Mazumder,B.
  TITLE     Loss of function of ribosomal protein L13a blocks blastocyst
            formation and reveals a potential nuclear role in gene expression
  JOURNAL   FASEB J 37 (12), e23275 (2023)
   PUBMED   37902531
REFERENCE   2  (bases 1 to 2857)
  AUTHORS   Park,H.J., Lee,S.W., Van Kaer,L., Lee,M.S. and Hong,S.
  TITLE     IL-7 Deficiency Exacerbates Atopic Dermatitis in NC/Nga Mice
  JOURNAL   Int J Mol Sci 24 (12), 9956 (2023)
   PUBMED   37373104
  REMARK    GeneRIF: IL-7 Deficiency Exacerbates Atopic Dermatitis in NC/Nga
            Mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2857)
  AUTHORS   Lim,V.Y., Feng,X., Miao,R., Zehentmeier,S., Ewing-Crystal,N.,
            Lee,M., Tumanov,A.V., Oh,J.E., Iwasaki,A., Wang,A., Choi,J. and
            Pereira,J.P.
  TITLE     Mature B cells and mesenchymal stem cells control emergency
            myelopoiesis
  JOURNAL   Life Sci Alliance 6 (4), e202301924 (2023)
   PUBMED   36717247
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2857)
  AUTHORS   Zehentmeier,S., Lim,V.Y., Ma,Y., Fossati,J., Ito,T., Jiang,Y.,
            Tumanov,A.V., Lee,H.J., Dillinger,L., Kim,J., Csomos,K.,
            Walter,J.E., Choi,J. and Pereira,J.P.
  TITLE     Dysregulated stem cell niches and altered lymphocyte recirculation
            cause B and T cell lymphopenia in WHIM syndrome
  JOURNAL   Sci Immunol 7 (75), eabo3170 (2022)
   PUBMED   36149943
REFERENCE   5  (bases 1 to 2857)
  AUTHORS   Nagakubo,D., Hirakawa,M., Iwanami,N. and Boehm,T.
  TITLE     Limits to in vivo fate changes of epithelia in thymus and
            parathyroid by ectopic expression of transcription factors Gcm2 and
            Foxn1
  JOURNAL   Sci Rep 12 (1), 13554 (2022)
   PUBMED   35941210
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2857)
  AUTHORS   Appasamy,P.M.
  TITLE     IL 7-induced T cell receptor-gamma gene expression by pre-T cells
            in murine fetal liver cultures
  JOURNAL   J Immunol 149 (5), 1649-1656 (1992)
   PUBMED   1387147
REFERENCE   7  (bases 1 to 2857)
  AUTHORS   Aoki,T., Tashiro,K., Miyatake,S., Kinashi,T., Nakano,T., Oda,Y.,
            Kikuchi,H. and Honjo,T.
  TITLE     Expression of murine interleukin 7 in a murine glioma cell line
            results in reduced tumorigenicity in vivo
  JOURNAL   Proc Natl Acad Sci U S A 89 (9), 3850-3854 (1992)
   PUBMED   1570303
REFERENCE   8  (bases 1 to 2857)
  AUTHORS   Hogan,A., Heyner,S., Charron,M.J., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Thorens,B. and Schultz,G.A.
  TITLE     Glucose transporter gene expression in early mouse embryos
  JOURNAL   Development 113 (1), 363-372 (1991)
   PUBMED   1765007
REFERENCE   9  (bases 1 to 2857)
  AUTHORS   Montgomery,R.A. and Dallman,M.J.
  TITLE     Analysis of cytokine gene expression during fetal thymic ontogeny
            using the polymerase chain reaction
  JOURNAL   J Immunol 147 (2), 554-560 (1991)
   PUBMED   1649220
REFERENCE   10 (bases 1 to 2857)
  AUTHORS   Siracusa,L.D., Rosner,M.H., Vigano,M.A., Gilbert,D.J., Staudt,L.M.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     Chromosomal location of the octamer transcription factors, Otf-1,
            Otf-2, and Otf-3, defines multiple Otf-3-related sequences
            dispersed in the mouse genome
  JOURNAL   Genomics 10 (2), 313-326 (1991)
   PUBMED   1676977
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK052452.1, AK041307.1 and
            AK040399.1.
            
            On Sep 5, 2015 this sequence version replaced NM_008371.4.
            
            Summary: The protein encoded by this gene is a hematopoietic growth
            factor important for B and T cell development. Alternative splicing
            results in several transcript variants encoding different isoforms.
            [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK041307.1, AK145184.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-333               AK052452.1         2-334
            334-1919            AK041307.1         2-1587
            1920-2857           AK040399.1         1371-2308
FEATURES             Location/Qualifiers
     source          1..2857
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 2.02 cM"
     gene            1..2857
                     /gene="Il7"
                     /gene_synonym="A630026I06Rik; hlb368; Il-7"
                     /note="interleukin 7"
                     /db_xref="GeneID:16196"
                     /db_xref="MGI:MGI:96561"
     exon            1..590
                     /gene="Il7"
                     /gene_synonym="A630026I06Rik; hlb368; Il-7"
                     /inference="alignment:Splign:2.1.0"
     CDS             581..1045
                     /gene="Il7"
                     /gene_synonym="A630026I06Rik; hlb368; Il-7"
                     /note="isoform a precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="interleukin-7 isoform a precursor"
                     /protein_id="NP_032397.1"
                     /db_xref="CCDS:CCDS50859.1"
                     /db_xref="GeneID:16196"
                     /db_xref="MGI:MGI:96561"
                     /translation="MFHVSFRYIFGIPPLILVLLPVTSSECHIKDKEGKAYESVLMIS
                     IDELDKMTGTDSNCPNNEPNFFRKHVCDDTKEAAFLNRAARKLKQFLKMNISEEFNVH
                     LLTVSQGTQTLVNCTSKEEKNVKEQKKNDACFLKRLLREIKTCWNKILKGSI"
     exon            591..724
                     /gene="Il7"
                     /gene_synonym="A630026I06Rik; hlb368; Il-7"
                     /inference="alignment:Splign:2.1.0"
     exon            725..805
                     /gene="Il7"
                     /gene_synonym="A630026I06Rik; hlb368; Il-7"
                     /inference="alignment:Splign:2.1.0"
     exon            806..937
                     /gene="Il7"
                     /gene_synonym="A630026I06Rik; hlb368; Il-7"
                     /inference="alignment:Splign:2.1.0"
     exon            938..2857
                     /gene="Il7"
                     /gene_synonym="A630026I06Rik; hlb368; Il-7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1687..1692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il7"
                     /gene_synonym="A630026I06Rik; hlb368; Il-7"
                     /note="hexamer: AATAAA"
     polyA_site      1707
                     /gene="Il7"
                     /gene_synonym="A630026I06Rik; hlb368; Il-7"
                     /note="major polyA site"
     regulatory      2811..2816
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il7"
                     /gene_synonym="A630026I06Rik; hlb368; Il-7"
                     /note="hexamer: AATAAA"
     polyA_site      2836
                     /gene="Il7"
                     /gene_synonym="A630026I06Rik; hlb368; Il-7"
     regulatory      2838..2843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il7"
                     /gene_synonym="A630026I06Rik; hlb368; Il-7"
                     /note="hexamer: ATTAAA"
     polyA_site      2857
                     /gene="Il7"
                     /gene_synonym="A630026I06Rik; hlb368; Il-7"
                     /note="major polyA site"
ORIGIN      
        1 gcagaagcag cgacgcctcc tcagtggaac tgacttgcaa tagcgagctt tctctgctgc
       61 acatttgtgg cttctgtgga catattagta accagcggtt ttagctccca gtctcacaga
      121 gttgccagag aggttagaag tcatttgaaa agcctattag ccgaatcttt ctgatccaga
      181 aggccagctg gcttctcctg agctactttc aattcgcagc aaccactgat cctggtccag
      241 gtgactgggg aagacgctga gggtataaac ccaaacattg aacctgaaga cccagcgcaa
      301 agtagaaact gaaagtaccc tgcttagtct gccggcagat cctacggaag ttatggcaaa
      361 gccagagcgc ctgggtggcc ggtgatgcat gcggcccctc ttgggatgga tggaccaggc
      421 gtggcgtggg tgagaggagt cagctgcctg aactgccctg cccagcaccg gtttgcggcc
      481 acccggtgga tgaccggggt cctgggagtg attatgggtg gtgagagccg gctcctgctg
      541 cagtcccagt catcatgact acacccacct cccgcagacc atgttccatg tttcttttag
      601 atatatcttt ggaattcctc cactgatcct tgttctgctg cctgtcacat catctgagtg
      661 ccacattaaa gacaaagaag gtaaagcata tgagagtgta ctgatgatca gcatcgatga
      721 attggacaaa atgacaggaa ctgatagtaa ttgcccgaat aatgaaccaa acttttttag
      781 aaaacatgta tgtgatgata caaaggaagc tgcttttcta aatcgtgctg ctcgcaagtt
      841 gaagcaattt cttaaaatga atatcagtga agaattcaat gtccacttac taacagtatc
      901 acaaggcaca caaacactgg tgaactgcac aagtaaggaa gaaaaaaacg taaaggaaca
      961 gaaaaagaat gatgcatgtt tcctaaagag actactgaga gaaataaaaa cttgttggaa
     1021 taaaattttg aagggcagta tataaacagg acatgtagta acaacctcca agaatctact
     1081 ggttcatata cttggagagg ttgaaaccct tccagaagtt cctggatgcc tcctgctcaa
     1141 ataagccaag cagctgagaa atctacagtg aggtatgaga tgatggacac agaaatgcag
     1201 ctgactgctg ccgtcagcat atacatataa agatatatca actatacaga tttttgtaat
     1261 gcaatcatgt caactgcaat gcttttaaaa ccgttccaaa tgtttctaac actacaaagt
     1321 ctacaaaaag caaggctatg aagattcaga gtcaccactg ttttcttagc aaaatgatgg
     1381 tatggttaaa cattcattgg tgaaccactg ggggagtgga actgtcctgt tttagactgg
     1441 agatactgga gggctcacgg tgatggataa tgctcttgaa aacaagagtc tatcttaaag
     1501 cagcagcaaa aagaagctta aggcacttaa ggcatcaaca aatgtagtta aatatgaatg
     1561 tataacacat aacttcagta aagagcatag cagatatttt taaataaaag tatttttaaa
     1621 gatagaaatg cacttattcc aaagatactg aaccttagta ttcagtcgct tttgacactt
     1681 gtgtataata aagcttatat aactgaattt tcaatttgaa aagtatattt ttaaaagaat
     1741 aatatatgct agacttttaa ttaatgtata tgtttaattt tggcattctg tctgtctctc
     1801 tgtctctctc tctctctctc tctctctcta cctatctatc tatatatata attttcatat
     1861 actaccaatt gcgtactttg gatagtgtct ctttttaacc taaatgacct ttattaacac
     1921 tgtcaggttc ccttactctc gagagtgttc attgctgcac tgtcatttga tcccagtttt
     1981 attgaacaca tatcctttaa cacactcacg tccagattta gcaggagact aggaccctat
     2041 aactttgtta agagagaaaa cactaatttc ttgttttata gtagggtctt attcgtatct
     2101 aaggcaggct aggattgcag acatgagcca atatgcttaa ttagaaacat tctttttatg
     2161 ttaaactcat gtcttttaca agatgcctac atatatccta tgtatatgcc tgtttaaatc
     2221 cttttttgta aggtctgctg tcttccttca gttgtaatgg aaagaaacac tatgttgtag
     2281 aggccaaatt tctgaaagtg ataagggttt gcttgtactg aattctcatt ctccttgctt
     2341 tttccagcca cgtgagcatc tagctatcta tacgctggat gtatttgacc gatgcctgct
     2401 ccactggcac attgcatgtg tggtagccat gccttcttgc ttctcctttt ccccaacccc
     2461 tataatgctc tactcagtgg tacagatagc tgggattatc acaattttga gagaaacacc
     2521 aattgtttaa agtttgtttc ataatcacca tttgcccaga aaacagttct ctcaacttgt
     2581 ttgcaacatg taataattta agaaactcaa ttttgttaat ggactttcga taacttcctt
     2641 agatatccca catctcctac gtgtcagtcc tttgtcctga ggaactggta aaatgggtaa
     2701 gcccttagct agcgaactga aggcattcgc atgtgtaaga taatctctat acctgcaagg
     2761 ctgtctggat ggctccctac caatattgaa caatattctg attttggcaa aataaaggat
     2821 aatattttaa aatgcttatt aaaagtttta aaaattt
//
