LOCUS       NM_010560               5452 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus interleukin 6 signal transducer (Il6st), mRNA.
ACCESSION   NM_010560
VERSION     NM_010560.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5452)
  AUTHORS   Ishibashi,T., Inagaki,T., Okazawa,M., Yamagishi,A., Ohta-Ogo,K.,
            Asano,R., Masaki,T., Kotani,Y., Ding,X., Chikaishi-Kirino,T.,
            Maedera,N., Shirai,M., Hatakeyama,K., Kubota,Y., Kishimoto,T. and
            Nakaoka,Y.
  TITLE     IL-6/gp130 signaling in CD4+ T cells drives the pathogenesis of
            pulmonary hypertension
  JOURNAL   Proc Natl Acad Sci U S A 121 (16), e2315123121 (2024)
   PUBMED   38602915
  REMARK    GeneRIF: IL-6/gp130 signaling in CD4[+] T cells drives the
            pathogenesis of pulmonary hypertension.
REFERENCE   2  (bases 1 to 5452)
  AUTHORS   Chang,Y., Bach,L., Hasiuk,M., Wen,L., Elmzzahi,T., Tsui,C.,
            Gutierrez-Melo,N., Steffen,T., Utzschneider,D.T., Raj,T.,
            Jost,P.J., Heink,S., Cheng,J., Burton,O.T., Zeitrag,J.,
            Alterauge,D., Dahlstrom,F., Becker,J.C., Kastl,M., Symeonidis,K.,
            van Uelft,M., Becker,M., Reschke,S., Krebs,S., Blum,H.,
            Abdullah,Z., Paeschke,K., Ohnmacht,C., Neumann,C., Liston,A.,
            Meissner,F., Korn,T., Hasenauer,J., Heissmeyer,V., Beyer,M.,
            Kallies,A., Jeker,L.T. and Baumjohann,D.
  TITLE     TGF-beta specifies TFH versus TH17 cell fates in murine CD4+ T
            cells through c-Maf
  JOURNAL   Sci Immunol 9 (93), eadd4818 (2024)
   PUBMED   38427718
  REMARK    Erratum:[Sci Immunol. 2024 May 31;9(95):eadp3365. doi:
            10.1126/sciimmunol.adq3365.. PMID: 38820142]
REFERENCE   3  (bases 1 to 5452)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 5452)
  AUTHORS   Kang,S., Onishi,S., Ling,Z., Inoue,H., Zhang,Y., Chang,H., Zhao,H.,
            Wang,T., Okuzaki,D., Matsuura,H., Takamatsu,H., Oda,J. and
            Kishimoto,T.
  TITLE     Gp130-HIF1alpha axis-induced vascular damage is prevented by the
            short-term inhibition of IL-6 receptor signaling
  JOURNAL   Proc Natl Acad Sci U S A 121 (2), e2315898120 (2024)
   PUBMED   38165930
  REMARK    GeneRIF: Gp130-HIF1alpha axis-induced vascular damage is prevented
            by the short-term inhibition of IL-6 receptor signaling.
REFERENCE   5  (bases 1 to 5452)
  AUTHORS   Thilakasiri,P., O'Keefe,R.N., To,S.Q., Chisanga,D., Eissmann,M.F.,
            Carli,A.L., Duscio,B., Baloyan,D., Dmello,R.S., Williams,D.,
            Mariadason,J., Poh,A.R., Pal,B., Kile,B.T., Vissers,J.H.,
            Harvey,K.F., Buchert,M., Shi,W., Ernst,M. and Chand,A.L.
  TITLE     Mechanisms of cellular crosstalk in the gastric tumor
            microenvironment are mediated by YAP1 and STAT3
  JOURNAL   Life Sci Alliance 7 (2), e202302411 (2023)
   PUBMED   37957015
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5452)
  AUTHORS   Jia,G.Q. and Gutierrez-Ramos,J.C.
  TITLE     Analysis of interleukin receptor gene expression in mouse fetal
            liver by quantitative polymerase chain reaction
  JOURNAL   Eur J Immunol 25 (7), 2096-2100 (1995)
   PUBMED   7621883
REFERENCE   7  (bases 1 to 5452)
  AUTHORS   Hilton,D.J., Hilton,A.A., Raicevic,A., Rakar,S., Harrison-Smith,M.,
            Gough,N.M., Begley,C.G., Metcalf,D., Nicola,N.A. and Willson,T.A.
  TITLE     Cloning of a murine IL-11 receptor alpha-chain; requirement for
            gp130 for high affinity binding and signal transduction
  JOURNAL   EMBO J 13 (20), 4765-4775 (1994)
   PUBMED   7957045
REFERENCE   8  (bases 1 to 5452)
  AUTHORS   Saito,M., Yoshida,K., Hibi,M., Taga,T. and Kishimoto,T.
  TITLE     Molecular cloning of a murine IL-6 receptor-associated signal
            transducer, gp130, and its regulated expression in vivo
  JOURNAL   J Immunol 148 (12), 4066-4071 (1992)
   PUBMED   1602143
REFERENCE   9  (bases 1 to 5452)
  AUTHORS   Gearing,D.P., Comeau,M.R., Friend,D.J., Gimpel,S.D., Thut,C.J.,
            McGourty,J., Brasher,K.K., King,J.A., Gillis,S., Mosley,B. et al.
  TITLE     The IL-6 signal transducer, gp130: an oncostatin M receptor and
            affinity converter for the LIF receptor
  JOURNAL   Science 255 (5050), 1434-1437 (1992)
   PUBMED   1542794
REFERENCE   10 (bases 1 to 5452)
  AUTHORS   Gearing,D.P., Thut,C.J., VandeBos,T., Gimpel,S.D., Delaney,P.B.,
            King,J., Price,V., Cosman,D. and Beckmann,M.P.
  TITLE     Leukemia inhibitory factor receptor is structurally related to the
            IL-6 signal transducer, gp130
  JOURNAL   EMBO J 10 (10), 2839-2848 (1991)
   PUBMED   1915266
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ177012.1, BC058679.1, BU709006.1 and CV556562.1.
            
            On Mar 17, 2009 this sequence version replaced NM_010560.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058679.1, SRR1660813.169299.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                CJ177012.1         3-41
            40-2211             BC058679.1         1-2172
            2212-2779           BU709006.1         128-695
            2780-5433           BC058679.1         2741-5394
            5434-5452           CV556562.1         710-728
FEATURES             Location/Qualifiers
     source          1..5452
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 63.73 cM"
     gene            1..5452
                     /gene="Il6st"
                     /gene_synonym="5133400A03Rik; CD130; D13Ertd699e; gp130"
                     /note="interleukin 6 signal transducer"
                     /db_xref="GeneID:16195"
                     /db_xref="MGI:MGI:96560"
     exon            1..181
                     /gene="Il6st"
                     /gene_synonym="5133400A03Rik; CD130; D13Ertd699e; gp130"
                     /inference="alignment:Splign:2.1.0"
     exon            182..268
                     /gene="Il6st"
                     /gene_synonym="5133400A03Rik; CD130; D13Ertd699e; gp130"
                     /inference="alignment:Splign:2.1.0"
     exon            269..347
                     /gene="Il6st"
                     /gene_synonym="5133400A03Rik; CD130; D13Ertd699e; gp130"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..3037
                     /gene="Il6st"
                     /gene_synonym="5133400A03Rik; CD130; D13Ertd699e; gp130"
                     /note="interleukin-6 receptor subunit beta; IL-6RB;
                     IL-6R-beta; IL-6R subunit beta; membrane glycoprotein 130;
                     IL-6 receptor subunit beta; oncostatin-M receptor subunit
                     alpha"
                     /codon_start=1
                     /product="interleukin-6 receptor subunit beta precursor"
                     /protein_id="NP_034690.3"
                     /db_xref="CCDS:CCDS26773.1"
                     /db_xref="GeneID:16195"
                     /db_xref="MGI:MGI:96560"
                     /translation="MSAPRIWLAQALLFFLTTESIGQLLEPCGYIYPEFPVVQRGSNF
                     TAICVLKEACLQHYYVNASYIVWKTNHAAVPREQVTVINRTTSSVTFTDVVLPSVQLT
                     CNILSFGQIEQNVYGVTMLSGFPPDKPTNLTCIVNEGKNMLCQWDPGRETYLETNYTL
                     KSEWATEKFPDCQSKHGTSCMVSYMPTYYVNIEVWVEAENALGKVSSESINFDPVDKV
                     KPTPPYNLSVTNSEELSSILKLSWVSSGLGGLLDLKSDIQYRTKDASTWIQVPLEDTM
                     SPRTSFTVQDLKPFTEYVFRIRSIKDSGKGYWSDWSEEASGTTYEDRPSRPPSFWYKT
                     NPSHGQEYRSVRLIWKALPLSEANGKILDYEVILTQSKSVSQTYTVTGTELTVNLTND
                     RYVASLAARNKVGKSAAAVLTIPSPHVTAAYSVVNLKAFPKDNLLWVEWTPPPKPVSK
                     YILEWCVLSENAPCVEDWQQEDATVNRTHLRGRLLESKCYQITVTPVFATGPGGSESL
                     KAYLKQAAPARGPTVRTKKVGKNEAVLAWDQIPVDDQNGFIRNYSISYRTSVGKEMVV
                     HVDSSHTEYTLSSLSSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVPVC
                     LAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSKSHIAQWSPHTPPRHNFNSKDQMYS
                     DGNFTDVSVVEIEANNKKPCPDDLKSVDLFKKEKVSTEGHSSGIGGSSCMSSSRPSIS
                     SNEENESAQSTASTVQYSTVVHSGYRHQVPSVQVFSRSESTQPLLDSEERPEDLQLVD
                     SVDGGDEILPRQPYFKQNCSQPEACPEISHFERSNQVLSGNEEDFVRLKQQQVSDHIS
                     QPYGSEQRRLFQEGSTADALGTGADGQMERFESVGMETTIDEEIPKSYLPQTVRQGGY
                     MPQ"
     exon            348..653
                     /gene="Il6st"
                     /gene_synonym="5133400A03Rik; CD130; D13Ertd699e; gp130"
                     /inference="alignment:Splign:2.1.0"
     exon            654..774
                     /gene="Il6st"
                     /gene_synonym="5133400A03Rik; CD130; D13Ertd699e; gp130"
                     /inference="alignment:Splign:2.1.0"
     exon            775..935
                     /gene="Il6st"
                     /gene_synonym="5133400A03Rik; CD130; D13Ertd699e; gp130"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1090
                     /gene="Il6st"
                     /gene_synonym="5133400A03Rik; CD130; D13Ertd699e; gp130"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1250
                     /gene="Il6st"
                     /gene_synonym="5133400A03Rik; CD130; D13Ertd699e; gp130"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1333
                     /gene="Il6st"
                     /gene_synonym="5133400A03Rik; CD130; D13Ertd699e; gp130"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1544
                     /gene="Il6st"
                     /gene_synonym="5133400A03Rik; CD130; D13Ertd699e; gp130"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1727
                     /gene="Il6st"
                     /gene_synonym="5133400A03Rik; CD130; D13Ertd699e; gp130"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1829
                     /gene="Il6st"
                     /gene_synonym="5133400A03Rik; CD130; D13Ertd699e; gp130"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1976
                     /gene="Il6st"
                     /gene_synonym="5133400A03Rik; CD130; D13Ertd699e; gp130"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2117
                     /gene="Il6st"
                     /gene_synonym="5133400A03Rik; CD130; D13Ertd699e; gp130"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2214
                     /gene="Il6st"
                     /gene_synonym="5133400A03Rik; CD130; D13Ertd699e; gp130"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2296
                     /gene="Il6st"
                     /gene_synonym="5133400A03Rik; CD130; D13Ertd699e; gp130"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..5452
                     /gene="Il6st"
                     /gene_synonym="5133400A03Rik; CD130; D13Ertd699e; gp130"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5412..5417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il6st"
                     /gene_synonym="5133400A03Rik; CD130; D13Ertd699e; gp130"
                     /note="hexamer: AATAAA"
     polyA_site      5434
                     /gene="Il6st"
                     /gene_synonym="5133400A03Rik; CD130; D13Ertd699e; gp130"
                     /note="major polyA site"
ORIGIN      
        1 ggggccgtgg ggggcggagc taggagagcc cgggtcagcg gcggacggag ggtggcgtgt
       61 gcggtcggga ggccagagct tcgagccatc cgggctgcgg ctccgctgag ggaccggtgg
      121 tgtgggccgg gatccgcggg gctgagggac gctcaggagc ggcgaggctc gcgtccggaa
      181 ggaagacccg atagaaggaa catgacatct agaggcagcg aacttgtttc cgattcatgc
      241 tttatcattt cttaatttcg tatgttggga acatccctgc aagatgtcag caccaaggat
      301 ttggctagcg caagctttgc tttttttcct caccactgaa tctataggtc aacttttgga
      361 accgtgtggt tacatctacc ctgaatttcc agttgtccag cgcggctcga acttcactgc
      421 catttgtgtg ctgaaggagg cgtgtctgca gcattactac gtgaatgcca gctacatcgt
      481 gtggaagacc aaccatgctg ctgttcccag ggagcaggtc actgtcatca acagaaccac
      541 gtccagtgtc acgttcacag acgtggtcct cccgagcgtg cagctcacct gcaacatcct
      601 gtcctttggg cagatcgagc agaatgtgta tggagtcacc atgctttcag gctttcctcc
      661 agataaacct acaaatttga cttgcattgt gaatgagggg aagaatatgc tgtgccagtg
      721 ggaccccgga agggagactt accttgaaac aaactacact ttgaaatcag agtgggcaac
      781 agagaagttt cctgattgcc agtcaaagca tggcacttca tgtatggtca gctacatgcc
      841 cacctattat gtcaacattg aagtctgggt ggaagcagag aatgcccttg ggaaggtctc
      901 ctcagagtct atcaattttg accccgtgga taaagtgaaa cccaccccac catataattt
      961 atcagtgacc aactcagaag aattatccag tatattaaag ctatcatggg tcagttcagg
     1021 gctgggcggt cttttagatc taaagtctga catccaatat aggaccaaag atgcctcaac
     1081 ttggatccag gtccctcttg aagatacaat gtctcctcga acttccttca ctgtgcagga
     1141 cctcaagcct tttacagaat atgtgtttag gatccggtcc attaaggaca gtgggaaggg
     1201 ctactggagt gactggagtg aggaggctag tgggaccaca tacgaagaca gaccatccag
     1261 accaccaagt ttctggtata agacaaatcc atcccatggg caggaatata gatctgtacg
     1321 gctcatatgg aaggcactgc ctctttctga agccaatggg aaaatcttgg attatgaagt
     1381 gattcttacg cagtcaaagt ccgtctcaca aacgtacaca gtcactggca cagagctgac
     1441 cgtgaatctc accaatgacc gctatgtcgc gtctctagca gcaagaaaca aggtgggcaa
     1501 atcagctgca gctgtcctca ccatccccag cccccacgtc acagctgctt attctgtagt
     1561 gaatcttaaa gcatttccaa aagataacct gctctgggtg gaatggacac ctccacctaa
     1621 acccgtgagc aagtacatct tagagtggtg tgtgttgtca gagaacgcac cctgtgttga
     1681 agactggcag caggaagacg ctaccgtgaa tcggacccac ttgagaggac gcctcctgga
     1741 gagcaagtgc tatcaaatca cagtaactcc cgtattcgcc acggggcccg gaggctctga
     1801 gtccttgaag gcgtacctca aacaagccgc tcctgccaga ggaccgactg ttcggacaaa
     1861 gaaagtgggg aaaaatgaag ctgtcttagc gtgggaccag attcctgtgg acgaccagaa
     1921 tggcttcatt agaaactact ccatatctta cagaaccagc gtgggaaagg agatggttgt
     1981 gcatgtggat tcttctcaca cggagtacac gctgtcctct ctgagtagtg atacgttgta
     2041 catggtccga atggccgcgt acacagatga aggtgggaaa gatgggccgg aattcacttt
     2101 tacaacacca aagttcgctc aaggagaaat agaagccata gtcgtgcctg tgtgcttagc
     2161 cttcctcctg acaaccctgc tgggcgtctt gttctgcttt aacaaacgag acctaattaa
     2221 aaaacacatc tggcctaatg ttcctgatcc ttccaagagt catattgccc agtggtcacc
     2281 tcacaccccc ccaaggcaca attttaactc caaagatcaa atgtactcgg acggcaattt
     2341 cactgatgta agcgttgtgg aaatagaagc aaacaacaag aagccttgtc cagatgacct
     2401 gaagtccgtg gacctgttca agaaggagaa agtgagtaca gaagggcaca gcagtggcat
     2461 cgggggctct tcatgcatgt cctcctccag gcccagcatc tccagcaacg aggagaatga
     2521 gtctgctcag agcaccgcca gcacggtgca gtactccact gtggtgcaca gcggctacag
     2581 gcaccaggtc ccgtccgtgc aagtgttctc aaggtccgag tccacccagc ccctgctaga
     2641 ctcggaggag cggccagaag acctgcagct ggtggatagt gtagacggtg gggatgagat
     2701 cttgcccagg caaccgtatt tcaagcagaa ctgcagtcag cctgaagcct gtccagagat
     2761 ttcacatttt gaaaggtcaa accaggtttt gtccggcaat gaggaggatt ttgtcagact
     2821 gaagcagcag caggtttcag atcacatttc tcagccctat ggatccgagc aacggaggct
     2881 gtttcaggaa ggctctacag cggatgctct tggcacgggg gctgatggac agatggagag
     2941 atttgaatct gttggaatgg agaccacaat tgatgaagaa attcccaaaa gttacttgcc
     3001 acagactgta agacaaggtg gctacatgcc gcagtgaagg actggctcct gaacttcagc
     3061 aggaactgca aaataaagct aaagacgagt ggcttcagat gagaaacagt cctcactccc
     3121 tgaagatagg cattgcctct aaggacaaag tcacacctgg gccgtctcca ttccagagta
     3181 gctggaattc tccttcaagc actacatgaa ctgactttat cctctatagc tggaggactc
     3241 tgtgctcttt cagaatgttt gcactgccga aaacaaagtg tgtctgagtt tataaagctg
     3301 ttggtttgct acatagaaaa cgggggattt aaatgagcca caatgtcatg gcatcgttca
     3361 gctgggctgg ttttgatgag actgaccatc cagatgccag cgagaaggcc agcagcatca
     3421 tttaaaagtg ccctgtggca cagtgtccag attatgtcat ctagaagacg aaagaatgga
     3481 ggggtggctc gtttctgggt ctgtcagaga agcatggcct gctccttgct gttggtatcg
     3541 atgccggtta ctactgagga agaggataaa ctttaaagag aagcaacata gaagcacccg
     3601 ctttcttata gtcacctaca gcctcccaag aaactgctta ttattgaaaa tgtctttccg
     3661 agtcaatttc atccacccta tagtggacca ggctggcctc aaactcagag atctgtctgc
     3721 ctctgcctct gcctctgcct ccagagtacc gggatgaaag gcagtgcacc accactgctc
     3781 cacttacgaa gattgctgtt tttaaagact taagttgttg acatttttct gaacacacat
     3841 aaccacacca gggacagatg attctagaga ctggttgagg aagcacttta tccagaatgt
     3901 cttcaacttt aaattacttt aattgactcc accttgtttt gattttcaag aatagcaggg
     3961 tgtttgttga agggtggcat ttcccagagc ctcatgcagt cccagaacac acatcccaac
     4021 catgtcagcg accaccacaa tgacagaagt cctcctacag agctgaggaa gctggaaggg
     4081 tcctgctagt ttgcagggtg ggctttgaac ccacagccct gtgcatgcta gacattcact
     4141 ctaccgctga gctgctcctc cgcccggctc attatgtcat ctaggctctc gtgatcctcc
     4201 tggcccagct tcctgactgt ctgggactgt ggatgtgtgc tgtcacacac ccaaccaggt
     4261 ctttttaata tctgccattt atgaggtaga gtttttacac gacttaggac tatcttaaac
     4321 ctattccttc tagttgcttt attaaggaat agcctaggca tccagtgttt agcactaaag
     4381 ccattaatgt atttgtgcct aacttcccag tgtgacatgg aggtgggggc taaaggtaga
     4441 cactgggcag acaggaattg gctgagcgcc gttagaggct gatcactaag tgtgctcaca
     4501 ggaaaagggt tgaagtttca gagcatgggc acccagatca tttatagcgg ttaccacaca
     4561 gtgcctagga ggagttgata tgcacttagt tggatgcagt ttcacctttt actctcagaa
     4621 ggttgtttat attctacttg ctgatgtgtt atcatttata tttttatact gggtagtcct
     4681 tttctgtgtt ctttcacatg tataatcctc gtgagactgt acatgctttg ctctggtata
     4741 ttcagttgcc tccttggcaa aaccagcctg gaattgccaa aatgccggaa gtgaagggag
     4801 atggtgaaag tcgggcacag gaaggccagg tcaggggcag agagaccaga attcacacta
     4861 caaggctggc accattgcca ttcaagttgg acgtcaaagc ctgatcccag ttaggactga
     4921 gttttctatg tatatatctg ccaggaagtt aacacttgct gaatttctca tcttctcaca
     4981 gtaagcagtc tagttatggg actctatcca tgttcagctg tgacttccct catatcagac
     5041 agtggtgctg tgaacgttgc agtgtgaagt ctgtactggc tagggatggt agcccagcgt
     5101 gagttcaggc atgaacatag aggccactga aggaagagcc tcctggaagc aagttggcac
     5161 gttaaatccc agacagaaag tgtcccaggg agccagggcc tccgccagca gggagggggt
     5221 gtgctcactg caggaacgtt catttagaag atgtaccatg gagcacctcc ctttgctcta
     5281 agagaaaacc catcttaaag ttcatcttga atacagactt cgctcgagca tgttttagaa
     5341 taatctggat gctgtacctt gtaccttagg tagcagagaa agtaatctgg cgtctttctg
     5401 taaaaccgtc taataaagct agttctgccc gtgggctcgt attctttcgt gt
//
