LOCUS       NM_010559               3377 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus interleukin 6 receptor, alpha (Il6ra), transcript
            variant 1, mRNA.
ACCESSION   NM_010559
VERSION     NM_010559.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3377)
  AUTHORS   Chang,Y., Bach,L., Hasiuk,M., Wen,L., Elmzzahi,T., Tsui,C.,
            Gutierrez-Melo,N., Steffen,T., Utzschneider,D.T., Raj,T.,
            Jost,P.J., Heink,S., Cheng,J., Burton,O.T., Zeitrag,J.,
            Alterauge,D., Dahlstrom,F., Becker,J.C., Kastl,M., Symeonidis,K.,
            van Uelft,M., Becker,M., Reschke,S., Krebs,S., Blum,H.,
            Abdullah,Z., Paeschke,K., Ohnmacht,C., Neumann,C., Liston,A.,
            Meissner,F., Korn,T., Hasenauer,J., Heissmeyer,V., Beyer,M.,
            Kallies,A., Jeker,L.T. and Baumjohann,D.
  TITLE     TGF-beta specifies TFH versus TH17 cell fates in murine CD4+ T
            cells through c-Maf
  JOURNAL   Sci Immunol 9 (93), eadd4818 (2024)
   PUBMED   38427718
  REMARK    Erratum:[Sci Immunol. 2024 May 31;9(95):eadp3365. doi:
            10.1126/sciimmunol.adq3365.. PMID: 38820142]
REFERENCE   2  (bases 1 to 3377)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3377)
  AUTHORS   Guo,P., Lim,R.C., Rajawasam,K., Trinh,T., Sun,H. and Zhang,H.
  TITLE     A methylation-phosphorylation switch controls EZH2 stability and
            hematopoiesis
  JOURNAL   Elife 13, e86168 (2024)
   PUBMED   38346162
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3377)
  AUTHORS   Kang,S., Onishi,S., Ling,Z., Inoue,H., Zhang,Y., Chang,H., Zhao,H.,
            Wang,T., Okuzaki,D., Matsuura,H., Takamatsu,H., Oda,J. and
            Kishimoto,T.
  TITLE     Gp130-HIF1alpha axis-induced vascular damage is prevented by the
            short-term inhibition of IL-6 receptor signaling
  JOURNAL   Proc Natl Acad Sci U S A 121 (2), e2315898120 (2024)
   PUBMED   38165930
  REMARK    GeneRIF: Gp130-HIF1alpha axis-induced vascular damage is prevented
            by the short-term inhibition of IL-6 receptor signaling.
REFERENCE   5  (bases 1 to 3377)
  AUTHORS   Glass,J., Robinson,R.L., Greenway,G., Jones,G. and Sharma,S.
  TITLE     Diabetic Muller-Glial-Cell-Specific Il6ra Knockout Mice Exhibit
            Accelerated Retinal Functional Decline and Thinning of the Inner
            Nuclear Layer
  JOURNAL   Invest Ophthalmol Vis Sci 64 (15), 1 (2023)
   PUBMED   38038619
  REMARK    GeneRIF: Diabetic Muller-Glial-Cell-Specific Il6ra Knockout Mice
            Exhibit Accelerated Retinal Functional Decline and Thinning of the
            Inner Nuclear Layer.
REFERENCE   6  (bases 1 to 3377)
  AUTHORS   Jia,G.Q. and Gutierrez-Ramos,J.C.
  TITLE     Analysis of interleukin receptor gene expression in mouse fetal
            liver by quantitative polymerase chain reaction
  JOURNAL   Eur J Immunol 25 (7), 2096-2100 (1995)
   PUBMED   7621883
REFERENCE   7  (bases 1 to 3377)
  AUTHORS   Cosman,D.
  TITLE     The hematopoietin receptor superfamily
  JOURNAL   Cytokine 5 (2), 95-106 (1993)
   PUBMED   8392875
  REMARK    Review article
REFERENCE   8  (bases 1 to 3377)
  AUTHORS   Fiorillo,M.T., Toniatti,C., Van Snick,J. and Ciliberto,G.
  TITLE     Expression of the murine interleukin 6 receptor in hepatoma cells:
            the intracytoplasmic domain is not required for interleukin 6
            signal transduction
  JOURNAL   Eur J Immunol 22 (3), 799-804 (1992)
   PUBMED   1312474
REFERENCE   9  (bases 1 to 3377)
  AUTHORS   Saito,T., Yasukawa,K., Suzuki,H., Futatsugi,K., Fukunaga,T.,
            Yokomizo,C., Koishihara,Y., Fukui,H., Ohsugi,Y., Yawata,H. et al.
  TITLE     Preparation of soluble murine IL-6 receptor and anti-murine IL-6
            receptor antibodies
  JOURNAL   J Immunol 147 (1), 168-173 (1991)
   PUBMED   2051018
REFERENCE   10 (bases 1 to 3377)
  AUTHORS   Sugita,T., Totsuka,T., Saito,M., Yamasaki,K., Taga,T., Hirano,T.
            and Kishimoto,T.
  TITLE     Functional murine interleukin 6 receptor with the intracisternal A
            particle gene product at its cytoplasmic domain. Its possible role
            in plasmacytomagenesis
  JOURNAL   J Exp Med 171 (6), 2001-2009 (1990)
   PUBMED   2112585
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK141197.1, AK082270.1, BQ033304.1 and AC102392.8.
            
            On Jul 17, 2015 this sequence version replaced NM_010559.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082270.1, AK046337.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               AK141197.1         2-305
            305-911             AK082270.1         271-877
            912-1097            AK141197.1         913-1098
            1098-2562           AK082270.1         1065-2529
            2563-2650           BQ033304.1         22-109              c
            2651-2963           AK082270.1         2618-2930
            2964-2965           AC102392.8         55227-55228
            2966-3224           AK082270.1         2933-3191
            3225-3288           AC102392.8         55488-55551
            3289-3377           AK082270.1         3255-3343
FEATURES             Location/Qualifiers
     source          1..3377
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.19 cM"
     gene            1..3377
                     /gene="Il6ra"
                     /gene_synonym="CD126; IL-6R; IL-6R-alpha; IL-6RA; Il6r"
                     /note="interleukin 6 receptor, alpha"
                     /db_xref="GeneID:16194"
                     /db_xref="MGI:MGI:105304"
     exon            1..242
                     /gene="Il6ra"
                     /gene_synonym="CD126; IL-6R; IL-6R-alpha; IL-6RA; Il6r"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1540
                     /gene="Il6ra"
                     /gene_synonym="CD126; IL-6R; IL-6R-alpha; IL-6RA; Il6r"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; interleukin-6 receptor subunit alpha; IL-6R 1;
                     IL-6R subunit alpha; IL-6 receptor subunit alpha; IL-6
                     receptor alpha chain"
                     /codon_start=1
                     /product="interleukin-6 receptor subunit alpha isoform 1
                     precursor"
                     /protein_id="NP_034689.2"
                     /db_xref="CCDS:CCDS38496.1"
                     /db_xref="GeneID:16194"
                     /db_xref="MGI:MGI:105304"
                     /translation="MLTVGCTLLVALLAAPAVALVLGSCRALEVANGTVTSLPGATVT
                     LICPGKEAAGNVTIHWVYSGSQNREWTTTGNTLVLRDVQLSDTGDYLCSLNDHLVGTV
                     PLLVDVPPEEPKLSCFRKNPLVNAICEWRPSSTPSPTTKAVLFAKKINTTNGKSDFQV
                     PCQYSQQLKSFSCQVEILEGDKVYHIVSLCVANSVGSKSSHNEAFHSLKMVQPDPPAN
                     LVVSAIPGRPRWLKVSWQHPETWDPSYYLLQFQLRYRPVWSKEFTVLLLPVAQYQCVI
                     HDALRGVKHVVQVRGKEELDLGQWSEWSPEVTGTPWIAEPRTTPAGILWNPTQVSVED
                     SANHEDQYESSTEATSVLAPVQESSSMSLPTFLVAGGSLAFGLLLCVFIILRLKQKWK
                     SEAEKESKTTSPPPPPYSLGPLKPTFLLVPLLTPHSSGSDNTVNHSCLGVRDAQSPYD
                     NSNRDYLFPR"
     exon            243..479
                     /gene="Il6ra"
                     /gene_synonym="CD126; IL-6R; IL-6R-alpha; IL-6RA; Il6r"
                     /inference="alignment:Splign:2.1.0"
     exon            480..603
                     /gene="Il6ra"
                     /gene_synonym="CD126; IL-6R; IL-6R-alpha; IL-6RA; Il6r"
                     /inference="alignment:Splign:2.1.0"
     exon            604..788
                     /gene="Il6ra"
                     /gene_synonym="CD126; IL-6R; IL-6R-alpha; IL-6RA; Il6r"
                     /inference="alignment:Splign:2.1.0"
     exon            789..955
                     /gene="Il6ra"
                     /gene_synonym="CD126; IL-6R; IL-6R-alpha; IL-6RA; Il6r"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1097
                     /gene="Il6ra"
                     /gene_synonym="CD126; IL-6R; IL-6R-alpha; IL-6RA; Il6r"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1144
                     /gene="Il6ra"
                     /gene_synonym="CD126; IL-6R; IL-6R-alpha; IL-6RA; Il6r"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1214
                     /gene="Il6ra"
                     /gene_synonym="CD126; IL-6R; IL-6R-alpha; IL-6RA; Il6r"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1314
                     /gene="Il6ra"
                     /gene_synonym="CD126; IL-6R; IL-6R-alpha; IL-6RA; Il6r"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..3377
                     /gene="Il6ra"
                     /gene_synonym="CD126; IL-6R; IL-6R-alpha; IL-6RA; Il6r"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2995..3000
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il6ra"
                     /gene_synonym="CD126; IL-6R; IL-6R-alpha; IL-6RA; Il6r"
                     /note="hexamer: ATTAAA"
     polyA_site      3018
                     /gene="Il6ra"
                     /gene_synonym="CD126; IL-6R; IL-6R-alpha; IL-6RA; Il6r"
ORIGIN      
        1 cacaccgatc tgagccacgc cggggcgagc gctcgcagtg cgagctgagt gtggagcccg
       61 aggccgaggg cgactgctct cgctgcccca gtctgccggc cgcccggccc cggctgcgga
      121 gccgctctgc cgcccgccgt cccgcgtaga aggaagcatg ctgaccgtcg gctgcacgct
      181 gttggtcgcc ctgctggccg cgcccgcggt cgcgctggtc ctcgggagct gccgcgcgct
      241 ggaggtggca aatggcacag tgacaagcct gccaggggcc accgttaccc tgatttgccc
      301 cgggaaggaa gcagcaggca atgttaccat tcactgggtg tactctggct cacaaaacag
      361 agaatggact accacaggaa acacactggt tctgagggac gtgcagctca gcgacactgg
      421 ggactattta tgctccctga atgatcacct ggtggggact gtgcccttgc tggtggatgt
      481 tcccccagag gagcccaagc tctcctgctt ccggaagaac ccccttgtca acgccatctg
      541 tgagtggcgt ccgagcagca ccccctctcc aaccacgaag gctgtgctgt ttgcaaagaa
      601 aatcaacacc accaacggga agagtgactt ccaggtgccc tgtcagtatt ctcagcagct
      661 gaaaagcttc tcctgccagg tggagatcct ggagggtgac aaagtatacc acatagtgtc
      721 actgtgcgtt gcaaacagtg tgggaagcaa gtccagccac aacgaagcgt ttcacagctt
      781 aaaaatggtg cagccggatc cacctgccaa ccttgtggta tcagccatac ctggaaggcc
      841 gcgctggctc aaagtcagct ggcagcaccc tgagacctgg gacccgagtt actacttgct
      901 gcagttccag cttcgatacc gacctgtatg gtcaaaggag ttcacggtgt tgctgctccc
      961 ggtggcccag taccaatgcg tcatccatga tgccttgcga ggagtgaagc acgtggtcca
     1021 ggtccgtggg aaggaggagc ttgaccttgg ccagtggagc gaatggtccc cagaggtcac
     1081 gggcactcct tggatagcag agcccaggac caccccggca ggaatcctct ggaaccccac
     1141 acaggtctct gttgaagact ctgccaacca cgaggatcag tacgaaagtt ctacagaagc
     1201 aacgagtgtc ctcgccccag tgcaagaatc ctcgtccatg tccctgccca cattcctggt
     1261 agctggagga agcttggcgt ttgggttgct tctctgtgtc ttcatcatcc tgagactcaa
     1321 gcagaaatgg aagtcagagg ctgagaagga aagcaagacg acctctcctc cacccccacc
     1381 gtattccttg ggcccactga agccgacctt ccttctggtt cctctcctca ccccacacag
     1441 ctctgggtct gacaataccg taaaccacag ctgcctgggt gtcagggacg cacagagccc
     1501 ttatgacaac agcaacagag actacttatt ccccagataa tcatctggat ggtacctggc
     1561 agctggcagg gcaccacgag atcagcacac aagtttctca tgcgggtccc atccacctgg
     1621 ggtggggtgg ggcgggcggg gctgcagctt cactaaccca caagagctct gcacaggttc
     1681 tgagtaggtg cagctggtgc tgcataggct ctgaaggaag gaaggggctg tgaggaacac
     1741 aggccattgt gaagacagct tgtgatgact gaatagagat gcccgtcagc tccacatctg
     1801 atagtggctc acaagctgca ccctcaggag gcctcagaaa ggggctccaa aggctgcccc
     1861 agctgcctcg ctctgcctca ctgccccaag ccacctttta gctctcgaac tcctaaagtc
     1921 caagcacttt gccattctct ttccgaggcc actgaggccg ggtggaagct tggttccgat
     1981 ttccttctca acatctggaa agcagctggg cccggtggtg gtgactaata tctcagggcc
     2041 tgatggttta cgcgagtgac aatttctcac aagcagtttt taaatgtgaa tgatgacccc
     2101 aggcactgct ggctgcggag gcttcatttt cctcttcgat ctcaggactt caggcgaaaa
     2161 gcggagtgga agtagagagc ggatgggtgt ccaccgtcct catggtactt gcgggaggta
     2221 cagcctggaa aacacgtttc ctgtccccct actctcccag gagagggatg atggtagggg
     2281 gtgcctcttc cagggcggag agaactactt taccccagcc ttgcccattc tgatttcaac
     2341 tggactggag ctactaggaa agtcgacatt catgcaaaaa gaaaaaacgt taactagcaa
     2401 gaatgcactt tcattttggt ttttagagaa ctgttgcctg tttctctcaa gagtctggaa
     2461 gaggccgctc actgcacact actgtatgaa ccctcactgc ccaccctgga ggaccaagtg
     2521 cagtaacggt agcccaaaca ccaagtcaag tgaaaatcga gggaaaaaaa aaacaaacaa
     2581 gcaacaaaaa aaaaaaacca aaactaaact aaaaaacaaa tcaccccccc aaaaaaaaac
     2641 aaaaccaaaa accaaaaaaa acaaaaaaac aaaacaacaa caacaaaaaa aacccaaacc
     2701 aacccgctgt ttcctataac agaaaagcct ttggtttcat tttttatttt gatttttttg
     2761 tcttaaaaag tataaaaata gcctgtccat gctctgcttc agggaatgag cctgtgaaca
     2821 ctcccaggcg caggcaggaa gggtgtctgc ttcctgctac acctcactgc caccttggcc
     2881 ttccttgctt tacgtttgac tgagtggcct cagatgcttt cccctggggc tttgaggaat
     2941 ccagtgatgt tagtggtcac cgaggagacc acagagccac agtgtggtgc ttagattaaa
     3001 gtgacttctg caaccacagc accccacacc tgccgtctta ctgaactatg ccagtaactt
     3061 gccttttctg ccaccaccac gagacgagac gggcagagct cggaagctgt caccccatgc
     3121 cctctgcttg tccgctctag gggccactga cctaagcatt agttatttta ttttatttta
     3181 tttttttgtg ggttttgtac attttaggtc ctgttgctgt cttagaaaag gctctgtagg
     3241 ttgacagaaa atcaggccaa gtattcatgt tttgtttttt ttttttttcc ttctttcctc
     3301 ctttgctaag tttttgggac tcaagggtag caaaactgct gtgaaaggga aatttattaa
     3361 aaatgttaca gatcgtg
//
