LOCUS       NM_031168               1141 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus interleukin 6 (Il6), transcript variant 1, mRNA.
ACCESSION   NM_031168
VERSION     NM_031168.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1141)
  AUTHORS   Wei,W., Gao,X., Qian,J., Li,L., Zhao,C., Xu,L., Zhu,Y., Liu,Z.,
            Liu,N., Wang,X., Jin,Z., Liu,B., Xu,L., Dong,J., Zhang,S., Wang,J.,
            Zhang,Y., Yu,Y., Yan,Z., Yang,Y., Lu,J., Fang,Y., Yuan,N. and
            Wang,J.
  TITLE     Beclin 1 prevents ISG15-mediated cytokine storms to secure fetal
            hematopoiesis and survival
  JOURNAL   J Clin Invest 135 (3), e177375 (2025)
   PUBMED   39589832
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1141)
  AUTHORS   Mora,P., Laisne,M., Bourguignon,C., Rouault,P., Jaspard-Vinassa,B.,
            Maitre,M., Gadeau,A.P., Renault,M.A., Horng,S., Couffinhal,T. and
            Chapouly,C.
  TITLE     Astrocytic DLL4-NOTCH1 signaling pathway promotes neuroinflammation
            via the IL-6-STAT3 axis
  JOURNAL   J Neuroinflammation 21 (1), 258 (2024)
   PUBMED   39390606
  REMARK    GeneRIF: Astrocytic DLL4-NOTCH1 signaling pathway promotes
            neuroinflammation via the IL-6-STAT3 axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1141)
  AUTHORS   Zhao,Y., Yan,H., Liu,K., Ma,J., Sun,W., Lai,H., Li,H., Gu,J. and
            Huang,H.
  TITLE     Acetylcholine receptor-beta inhibition by interleukin-6 in skeletal
            muscles contributes to modulating neuromuscular junction during
            aging
  JOURNAL   Mol Med 30 (1), 171 (2024)
   PUBMED   39390392
  REMARK    GeneRIF: Acetylcholine receptor-beta inhibition by interleukin-6 in
            skeletal muscles contributes to modulating neuromuscular junction
            during aging.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1141)
  AUTHORS   Mao,Y., Meng,Y., Zou,K., Qin,N., Wang,Y., Yan,J., Chen,P.,
            Cheng,Y., Shi,W., Zhou,C., Chen,H., Sheng,J., Liu,X., Pan,J. and
            Huang,H.
  TITLE     Advanced paternal age exacerbates neuroinflammation in offspring
            via m6A modification-mediated intergenerational inheritance
  JOURNAL   J Neuroinflammation 21 (1), 249 (2024)
   PUBMED   39367406
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1141)
  AUTHORS   Abdollahzadeh,B., Cantale Aeo,N.M., Giordano,N., Orlando,A.,
            Basciani,M., Peruzzi,G., Grazioli,P., Screpanti,I., Felli,M.P. and
            Campese,A.F.
  TITLE     The NF-kappaB1/p50 Subunit Influences the Notch/IL-6-Driven
            Expansion of Myeloid-Derived Suppressor Cells in Murine T-Cell
            Acute Lymphoblastic Leukemia
  JOURNAL   Int J Mol Sci 25 (18), 9882 (2024)
   PUBMED   39337370
  REMARK    GeneRIF: The NF-kappaB1/p50 Subunit Influences the
            Notch/IL-6-Driven Expansion of Myeloid-Derived Suppressor Cells in
            Murine T-Cell Acute Lymphoblastic Leukemia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1141)
  AUTHORS   Chin,H., Mock,B., Kim,H.L., Kim,H. and Kozak,C.A.
  TITLE     The gene for the dihydropyridine-sensitive calcium channel alpha 2
            subunit (CCHL2A) maps to the proximal region of mouse chromosome 5
  JOURNAL   Genomics 13 (4), 1325-1327 (1992)
   PUBMED   1324224
REFERENCE   7  (bases 1 to 1141)
  AUTHORS   Okada,S., Nakauchi,H., Nagayoshi,K., Nakamura,M., Miura,Y. and
            Suda,T.
  TITLE     Synergistic effect of IL-3 and IL-6 on highly enriched murine
            hemopoietic progenitors
  JOURNAL   Exp Hematol 20 (5), 546-551 (1992)
   PUBMED   1350248
REFERENCE   8  (bases 1 to 1141)
  AUTHORS   Vandevoorde,V., Haegeman,G. and Fiers,W.
  TITLE     TNF-mediated IL6 gene expression and cytotoxicity are co-inducible
            in TNF-resistant L929 cells
  JOURNAL   FEBS Lett 302 (3), 235-238 (1992)
   PUBMED   1318227
REFERENCE   9  (bases 1 to 1141)
  AUTHORS   Fiorillo,M.T., Toniatti,C., Van Snick,J. and Ciliberto,G.
  TITLE     Expression of the murine interleukin 6 receptor in hepatoma cells:
            the intracytoplasmic domain is not required for interleukin 6
            signal transduction
  JOURNAL   Eur J Immunol 22 (3), 799-804 (1992)
   PUBMED   1312474
REFERENCE   10 (bases 1 to 1141)
  AUTHORS   Bodine,D.M., Orlic,D., Birkett,N.C., Seidel,N.E. and Zsebo,K.M.
  TITLE     Stem cell factor increases colony-forming unit-spleen number in
            vitro in synergy with interleukin-6, and in vivo in Sl/Sld mice as
            a single factor
  JOURNAL   Blood 79 (4), 913-919 (1992)
   PUBMED   1371079
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC112933.16 and AK150440.1.
            
            On Sep 30, 2015 this sequence version replaced NM_031168.1.
            
            Summary: This gene encodes a member of the interleukin family of
            cytokines that have important functions in immune response,
            hematopoiesis, inflammation and the acute phase response. The
            ectopic overexpression of the encoded protein in mice results in
            excessive plasma cells in circulation, leading to death. Mice
            lacking the encoded protein exhibit abnormalities in hepatic acute
            phase response, some immune mechanisms, bone resorption in response
            to estrogen, liver regeneration and wound healing. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150440.1, J03783.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AC112933.16        69228-69256
            30-838              AK150440.1         2-810
            839-839             AC112933.16        75787-75787
            840-1141            AK150440.1         812-1113
FEATURES             Location/Qualifiers
     source          1..1141
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 15.7 cM"
     gene            1..1141
                     /gene="Il6"
                     /gene_synonym="Il-6"
                     /note="interleukin 6"
                     /db_xref="GeneID:16193"
                     /db_xref="MGI:MGI:96559"
     exon            1..97
                     /gene="Il6"
                     /gene_synonym="Il-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..714
                     /gene="Il6"
                     /gene_synonym="Il-6"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; interleukin HP-1; B-cell hybridoma growth
                     factor"
                     /codon_start=1
                     /product="interleukin-6 isoform 1 precursor"
                     /protein_id="NP_112445.1"
                     /db_xref="CCDS:CCDS19153.1"
                     /db_xref="GeneID:16193"
                     /db_xref="MGI:MGI:96559"
                     /translation="MKFLSARDFHPVAFLGLMLVTTTAFPTSQVRRGDFTEDTTPNRP
                     VYTTSQVGGLITHVLWEIVEMRKELCNGNSDCMNNDDALAENNLKLPEIQRNDGCYQT
                     GYNQEICLLKISSGLLEYHSYLEYMKNNLKDNKKDKARVLQRDTETLIHIFNQEVKDL
                     HKIVLPTPISNALLTDKLESQKEWLRTKTIQFILKSLEEFLKVTLRSTRQT"
     exon            98..282
                     /gene="Il6"
                     /gene_synonym="Il-6"
                     /inference="alignment:Splign:2.1.0"
     exon            283..396
                     /gene="Il6"
                     /gene_synonym="Il-6"
                     /inference="alignment:Splign:2.1.0"
     exon            397..546
                     /gene="Il6"
                     /gene_synonym="Il-6"
                     /inference="alignment:Splign:2.1.0"
     exon            547..1141
                     /gene="Il6"
                     /gene_synonym="Il-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1038..1043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il6"
                     /gene_synonym="Il-6"
                     /note="hexamer: AATGAA"
     polyA_site      1072
                     /gene="Il6"
                     /gene_synonym="Il-6"
                     /note="major polyA site"
ORIGIN      
        1 aaatatgaga ctggggatgt ctgtagctca ttctgctctg gagcccacca agaacgatag
       61 tcaattccag aaaccgctat gaagttcctc tctgcaagag acttccatcc agttgccttc
      121 ttgggactga tgctggtgac aaccacggcc ttccctactt cacaagtccg gagaggagac
      181 ttcacagagg ataccactcc caacagacct gtctatacca cttcacaagt cggaggctta
      241 attacacatg ttctctggga aatcgtggaa atgagaaaag agttgtgcaa tggcaattct
      301 gattgtatga acaacgatga tgcacttgca gaaaacaatc tgaaacttcc agagatacaa
      361 agaaatgatg gatgctacca aactggatat aatcaggaaa tttgcctatt gaaaatttcc
      421 tctggtcttc tggagtacca tagctacctg gagtacatga agaacaactt aaaagataac
      481 aagaaagaca aagccagagt ccttcagaga gatacagaaa ctctaattca tatcttcaac
      541 caagaggtaa aagatttaca taaaatagtc cttcctaccc caatttccaa tgctctccta
      601 acagataagc tggagtcaca gaaggagtgg ctaaggacca agaccatcca attcatcttg
      661 aaatcacttg aagaatttct aaaagtcact ttgagatcta ctcggcaaac ctagtgcgtt
      721 atgcctaagc atatcagttt gtggacattc ctcactgtgg tcagaaaata tatcctgttg
      781 tcaggtatct gacttatgtt gttctctacg aagaactgac aatatgaatg ttgggacact
      841 attttaatta tttttaattt attgataatt taaataagta aactttaagt taatttatga
      901 ttgatattta ttatttttat gaagtgtcac ttgaaatgtt atatgttata gttttgaaat
      961 gataacctaa aaatctattt gatataaata ttctgttacc tagccagatg gtttcttgga
     1021 atgtataagt ttacctcaat gaattgctaa tttaaatatg tttttaaaga aatctttgtg
     1081 atgtattttt ataatgttta gactgtcttc aaacaaataa attatattat atttaaaaac
     1141 c
//
