LOCUS       NM_008370               3557 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus interleukin 5 receptor, alpha (Il5ra), mRNA.
ACCESSION   NM_008370
VERSION     NM_008370.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3557)
  AUTHORS   Lee,D., Jo,M.G., Min,K.Y., Choi,M.Y., Kim,Y.M., Kim,H.S. and
            Choi,W.S.
  TITLE     IL-10+ regulatory B cells mitigate atopic dermatitis by suppressing
            eosinophil activation
  JOURNAL   Sci Rep 14 (1), 18164 (2024)
   PUBMED   39107352
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3557)
  AUTHORS   Jeong,B.M., Walker,M.T., Rodriguez,R., Coden,M.E., Nagasaka,R.,
            Doan,T.C., Politanska,Y., Abdala-Valencia,H. and Berdnikovs,S.
  TITLE     More than neutrophils: Lin(+)Ly6G(+)IL-5Ralpha(+) multipotent
            myeloid cells (MMCs) are dominant in normal murine bone marrow and
            retain capacity to differentiate into eosinophils and monocytes
  JOURNAL   J Leukoc Biol 111 (1), 113-122 (2022)
   PUBMED   33857341
  REMARK    GeneRIF: More than neutrophils: Lin(+)Ly6G(+)IL-5Ralpha(+)
            multipotent myeloid cells (MMCs) are dominant in normal murine bone
            marrow and retain capacity to differentiate into eosinophils and
            monocytes.
REFERENCE   3  (bases 1 to 3557)
  AUTHORS   Gorski,S.A., Lawrence,M.G., Hinkelman,A., Spano,M.M., Steinke,J.W.,
            Borish,L., Teague,W.G. and Braciale,T.J.
  TITLE     Expression of IL-5 receptor alpha by murine and human lung
            neutrophils
  JOURNAL   PLoS One 14 (8), e0221113 (2019)
   PUBMED   31415658
  REMARK    GeneRIF: Expression of IL-5 receptor alpha by murine and human lung
            neutrophils.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3557)
  AUTHORS   Kim,H.S., Lee,M.B., Lee,D., Min,K.Y., Koo,J., Kim,H.W., Park,Y.H.,
            Kim,S.J., Ikutani,M., Takaki,S., Kim,Y.M. and Choi,W.S.
  TITLE     The regulatory B cell-mediated peripheral tolerance maintained by
            mast cell IL-5 suppresses oxazolone-induced contact
            hypersensitivity
  JOURNAL   Sci Adv 5 (7), eaav8152 (2019)
   PUBMED   31328158
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3557)
  AUTHORS   Bettigole,S.E., Lis,R., Adoro,S., Lee,A.H., Spencer,L.A.,
            Weller,P.F. and Glimcher,L.H.
  TITLE     The transcription factor XBP1 is selectively required for
            eosinophil differentiation
  JOURNAL   Nat Immunol 16 (8), 829-837 (2015)
   PUBMED   26147683
REFERENCE   6  (bases 1 to 3557)
  AUTHORS   Wilkie,T.M., Gilbert,D.J., Olsen,A.S., Chen,X.N., Amatruda,T.T.,
            Korenberg,J.R., Trask,B.J., de Jong,P., Reed,R.R., Simon,M.I. et
            al.
  TITLE     Evolution of the mammalian G protein alpha subunit multigene family
  JOURNAL   Nat Genet 1 (2), 85-91 (1992)
   PUBMED   1302014
  REMARK    Review article
REFERENCE   7  (bases 1 to 3557)
  AUTHORS   Gough,N.M. and Rakar,S.
  TITLE     Localization of the IL-5 receptor gene to the distal half of murine
            chromosome 6 using recombinant inbred strains of mice
  JOURNAL   Genomics 12 (4), 855-856 (1992)
   PUBMED   1572667
REFERENCE   8  (bases 1 to 3557)
  AUTHORS   Van der Heyden,J., Devos,R., Plaetinck,G., Fache,I., Fiers,W. and
            Tavernier,J.
  TITLE     Characterization of the murine IL-5 receptor complex with the use
            of a panel of monoclonal antibodies. Relationship to the murine
            IL-3 receptor
  JOURNAL   J Immunol 147 (10), 3413-3418 (1991)
   PUBMED   1940345
REFERENCE   9  (bases 1 to 3557)
  AUTHORS   Devos,R., Plaetinck,G., Van der Heyden,J., Cornelis,S.,
            Vandekerckhove,J., Fiers,W. and Tavernier,J.
  TITLE     Molecular basis of a high affinity murine interleukin-5 receptor
  JOURNAL   EMBO J 10 (8), 2133-2137 (1991)
   PUBMED   2065657
REFERENCE   10 (bases 1 to 3557)
  AUTHORS   Takaki,S., Tominaga,A., Hitoshi,Y., Mita,S., Sonoda,E.,
            Yamaguchi,N. and Takatsu,K.
  TITLE     Molecular cloning and expression of the murine interleukin-5
            receptor
  JOURNAL   EMBO J 9 (13), 4367-4374 (1990)
   PUBMED   2265612
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164169.8.
            
            On Nov 17, 2006 this sequence version replaced NM_008370.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D90205.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849375,
                                           SAMN00849376 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               AC164169.8         203046-203236       c
            192-253             AC164169.8         199718-199779       c
            254-290             AC164169.8         199272-199308       c
            291-375             AC164169.8         198463-198547       c
            376-521             AC164169.8         196851-196996       c
            522-660             AC164169.8         195333-195471       c
            661-814             AC164169.8         192559-192712       c
            815-1002            AC164169.8         192295-192482       c
            1003-1148           AC164169.8         189904-190049       c
            1149-1287           AC164169.8         185992-186130       c
            1288-1381           AC164169.8         170896-170989       c
            1382-1466           AC164169.8         169818-169902       c
            1467-3557           AC164169.8         164574-166664       c
FEATURES             Location/Qualifiers
     source          1..3557
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 49.19 cM"
     gene            1..3557
                     /gene="Il5ra"
                     /gene_synonym="CD125; CDw125; Il5r"
                     /note="interleukin 5 receptor, alpha"
                     /db_xref="GeneID:16192"
                     /db_xref="MGI:MGI:96558"
     exon            1..191
                     /gene="Il5ra"
                     /gene_synonym="CD125; CDw125; Il5r"
                     /inference="alignment:Splign:2.1.0"
     exon            192..253
                     /gene="Il5ra"
                     /gene_synonym="CD125; CDw125; Il5r"
                     /inference="alignment:Splign:2.1.0"
     exon            254..290
                     /gene="Il5ra"
                     /gene_synonym="CD125; CDw125; Il5r"
                     /inference="alignment:Splign:2.1.0"
     exon            291..375
                     /gene="Il5ra"
                     /gene_synonym="CD125; CDw125; Il5r"
                     /inference="alignment:Splign:2.1.0"
     CDS             303..1550
                     /gene="Il5ra"
                     /gene_synonym="CD125; CDw125; Il5r"
                     /note="interleukin-5 receptor subunit alpha; IL-5R subunit
                     alpha; IL-5 receptor subunit alpha; IL-5 receptor alpha
                     chain"
                     /codon_start=1
                     /product="interleukin-5 receptor subunit alpha precursor"
                     /protein_id="NP_032396.1"
                     /db_xref="CCDS:CCDS20396.1"
                     /db_xref="GeneID:16192"
                     /db_xref="MGI:MGI:96558"
                     /translation="MVPVLLILVGALATLQADLLNHKKFLLLPPVNFTIKATGLAQVL
                     LHWDPNPDQEQRHVDLEYHVKINAPQEDEYDTRKTESKCVTPLHEGFAASVRTILKSS
                     HTTLASSWVSAELKAPPGSPGTSVTNLTCTTHTVVSSHTHLRPYQVSLRCTWLVGKDA
                     PEDTQYFLYYRFGVLTEKCQEYSRDALNRNTACWFPRTFINSKGFEQLAVHINGSSKR
                     AAIKPFDQLFSPLAIDQVNPPRNVTVEIESNSLYIQWEKPLSAFPDHCFNYELKIYNT
                     KNGHIQKEKLIANKFISKIDDVSTYSIQVRAAVSSPCRMPGRWGEWSQPIYVGKERKS
                     LVEWHLIVLPTAACFVLLIFSLICRVCHLWTRLFPPVPAPKSNIKDLPVVTEYEKPSN
                     ETKIEVVHCVEEVGFEVMGNSTF"
     exon            376..521
                     /gene="Il5ra"
                     /gene_synonym="CD125; CDw125; Il5r"
                     /inference="alignment:Splign:2.1.0"
     exon            522..660
                     /gene="Il5ra"
                     /gene_synonym="CD125; CDw125; Il5r"
                     /inference="alignment:Splign:2.1.0"
     exon            661..814
                     /gene="Il5ra"
                     /gene_synonym="CD125; CDw125; Il5r"
                     /inference="alignment:Splign:2.1.0"
     exon            815..1002
                     /gene="Il5ra"
                     /gene_synonym="CD125; CDw125; Il5r"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1148
                     /gene="Il5ra"
                     /gene_synonym="CD125; CDw125; Il5r"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1287
                     /gene="Il5ra"
                     /gene_synonym="CD125; CDw125; Il5r"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1381
                     /gene="Il5ra"
                     /gene_synonym="CD125; CDw125; Il5r"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1466
                     /gene="Il5ra"
                     /gene_synonym="CD125; CDw125; Il5r"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..3557
                     /gene="Il5ra"
                     /gene_synonym="CD125; CDw125; Il5r"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaataattg gtaaacacag aaaatgtttc aatagaaaaa agaggaaaca gaacactgtg
       61 tagccctgtt atcagcagag acagagctaa cgctggggat accaaactag aagaagctca
      121 ctggacaggt cccggtatgc agttctattt ttgttgatgg ctctgtatct aatgtgttca
      181 tttgtaccaa ggatctaacc agggtcttcc agagtctgag caagcttctc ccactgagct
      241 acatcacagc cccctgttta ttccaagaag aaatacttac acttttccag cattcggcta
      301 ccatggtgcc tgtgttacta attcttgtgg gagctttggc aacactgcaa gctgacttac
      361 ttaatcacaa aaagttttta cttctaccac ctgtcaattt taccattaaa gccactggat
      421 tagctcaagt tcttttacac tgggacccaa atcctgacca agagcaaagg catgttgatc
      481 tagagtatca cgtgaaaata aatgccccac aagaagacga atatgatacc agaaagactg
      541 aaagcaaatg tgtgaccccc cttcatgaag gctttgcagc tagcgtgagg accattctga
      601 agagcagcca tacaactctg gccagcagtt gggtttctgc tgaactcaaa gctccaccag
      661 gatctcctgg aacctcggtt acgaatttaa cttgtaccac acacactgtt gtaagtagcc
      721 acacccactt aaggccatac caagtgtccc ttcgttgcac ctggcttgtt gggaaggatg
      781 cccctgagga cacacagtat ttcctatact acaggtttgg tgttttgact gaaaaatgcc
      841 aagaatacag cagagatgca ctgaacagaa atactgcatg ctggtttccc aggacattta
      901 tcaacagcaa agggtttgag cagcttgctg tgcacattaa tggctcaagc aagcgtgctg
      961 caatcaagcc ctttgatcag ctgttcagtc cacttgccat tgaccaagtg aatcctccaa
     1021 ggaatgtcac agtggaaatt gaaagcaatt ctctctatat acagtgggag aaaccacttt
     1081 ctgcctttcc agatcattgc tttaactatg agctgaaaat ttacaacaca aaaaatggtc
     1141 acattcagaa ggaaaaactg atcgccaata agttcatctc aaaaattgat gatgtttcta
     1201 catattccat tcaagtgaga gcagctgtga gctcaccttg cagaatgcca ggaaggtggg
     1261 gcgagtggag tcaacctatt tatgtgggaa aggaaaggaa gtccttggta gaatggcatc
     1321 tcattgtgct cccaacagcc gcctgcttcg tcttgttaat cttctcactc atctgcagag
     1381 tgtgtcatct atggaccagg ttgtttccac cggttccggc cccaaagagt aacatcaaag
     1441 atctccctgt ggttactgaa tatgagaaac cttcgaatga aaccaaaatt gaagttgtac
     1501 attgtgtgga agaggttgga tttgaagtca tgggaaattc cacgttttga tggcattttg
     1561 ccattctgaa atgaactcat acaggactcc gtgataagag caaggactgc tatttcttgg
     1621 caaggaggta tttcaaatga acactcagag ccaggcggtg gtggagctcg cctttaatac
     1681 cagcacctgg gatgcacaga tgggaggatt tctgagttcg aggccagctt ggtctataaa
     1741 gtgagttcca ggacagccag agctacacag agaaaccctg tctcgaaaaa acaaacaaac
     1801 aaacaaacaa aaatgaacac tcagtttgaa tgcaagtcac caacccatcc agacatgagt
     1861 caccaatgtc ccatttcata aagtgtgcat gcctcactca aacctccttg ctcacagcat
     1921 agcaccagac tcacccagag catgggcctt tggtttccta cccagagtac catgttatac
     1981 cagtgtgtct ttgaaagttg cttgacttac cttgaacttt ttgcacagga gacagttttt
     2041 ttaagctaat gtcacacatg tttactttgg gttaagttgc cagtggtagc actcagctac
     2101 agtgacagga ggaaaggata gaactcattg agagtgaacc caaattcaag actgtctttc
     2161 ctgaagcaag tgggagacac aatttcatgg tgcttttccc ctttgagttc tagaatagtt
     2221 ttctttctag aactgtgcct gtgtcttaaa gcataaggta acattgaggc aaaaacaaag
     2281 actatgtccc acatgtccct gtgttccata ggcctgttca aggaaatgtc taagccaaag
     2341 taagtttaag tcaccgtgcc tggggtgaaa aagatggttc agatgacgaa gaagcatgag
     2401 ggcctgagat tgatcaacca gcatcaagaa acaacaacaa caacagcagc agcaacaaca
     2461 aaacagtgca agaagcacat tcctataacc ccagagttgg gagataaaga caagaggatc
     2521 catgggaatt gtagttcaac cagtttagcc aattatgttt tctctaggtt cactgagaga
     2581 aatggtctta aaaatttaag gtggagagtg actaggcaga tcctctgata ctgacttctg
     2641 ccctaaatat gcatacacat gtacacacac aacacaaaga caccattccc tattgagaga
     2701 gaagacagaa gcttgttcaa ggattaaatt cttcaaggct tctaggtact ctggaaatga
     2761 cctgagaaag acattgaaaa taattctgct ttggaggtga ttgctggatc tagaatgtac
     2821 ttcccaaaga gatgtttgat gaaagagcct tcatggcaac ctgttggtca actcatgctt
     2881 agtcaattct aatctcttaa attagggttt cctatacata ttacaattgt ataaaaatgt
     2941 attctctaaa tatcttcatt aatgaagctg tatctatagg tctttttgat gggctgaaca
     3001 tagaagcaaa cacacttatg tgttgggaag aggaataagt agtgatagag ggacctagtg
     3061 gtggttattt tacatagtcc tgaagagcta aagacaatga aagaagaaat ggtactcaca
     3121 agagagagag ctatgtcggg gtcctgtcag ccaaatcttg ctagtatatg caatagtgtc
     3181 tgggtttggt ggttgtatat gggatggatc cctgggtggg gcagtctctg gatggtcttt
     3241 ccttccatca cagctctgaa atttgtctct gtaactcctt ccatgagtat tttgttcccc
     3301 attctaagaa gcagtgaagt atccacactt tggtcttcct tcttcttgag tttcatgtgt
     3361 tttgcaaatt gtgtgcctgg caaatacaga agcagatgct cacagtcatc tattggatga
     3421 aacacagggc ccctaatgaa ggagccagag aaagtaccca aggagctaaa agggtctgca
     3481 accctatagc aggaacaaca atatgaacta cccagcaacc ctcagaaatg taaatgaaga
     3541 aaatatctaa taaaaaa
//
