LOCUS       NM_010558               1534 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus interleukin 5 (Il5), mRNA.
ACCESSION   NM_010558
VERSION     NM_010558.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1534)
  AUTHORS   Rao,Z., Liu,S., Li,Z., Wang,Q., Gao,F., Peng,H., Ren,D., Zang,Y.,
            Li,H., Li,Y., Hu,Q., He,D. and Xu,H.
  TITLE     Alarmin-loaded extracellular lipid droplets induce airway
            neutrophil infiltration during type 2 inflammation
  JOURNAL   Immunity 57 (11), 2514-2529 (2024)
   PUBMED   39366382
REFERENCE   2  (bases 1 to 1534)
  AUTHORS   Bessell,E., Finlay,R.E., James,L.K., Ludewig,B., Harris,N.L.,
            Krebs,P., Hepworth,M.R. and Dubey,L.K.
  TITLE     Stromal cell and B cell dialogue potentiates IL-33-enriched
            lymphoid niches to support eosinophil recruitment and function
            during type 2 immunity
  JOURNAL   Cell Rep 43 (8), 114620 (2024)
   PUBMED   39141517
REFERENCE   3  (bases 1 to 1534)
  AUTHORS   AbuJabal,R., Ramakrishnan,R.K., Bajbouj,K. and Hamid,Q.
  TITLE     Role of IL-5 in asthma and airway remodelling
  JOURNAL   Clin Exp Allergy 54 (8), 538-549 (2024)
   PUBMED   38938056
  REMARK    GeneRIF: Role of IL-5 in asthma and airway remodelling.
            Review article
REFERENCE   4  (bases 1 to 1534)
  AUTHORS   Jorssen,J., Van Hulst,G., Mollers,K., Pujol,J., Petrellis,G.,
            Baptista,A.P., Schetters,S., Baron,F., Caers,J., Lambrecht,B.N.,
            Dewals,B.G., Bureau,F. and Desmet,C.J.
  TITLE     Single-cell proteomics and transcriptomics capture eosinophil
            development and identify the role of IL-5 in their lineage transit
            amplification
  JOURNAL   Immunity 57 (7), 1549-1566 (2024)
   PUBMED   38776917
REFERENCE   5  (bases 1 to 1534)
  AUTHORS   Shen,C., Wu,N., Chen,X., Peng,J., Feng,M., Wang,J. and Yu,Y.
  TITLE     Interleukin-5 alleviates cardiac remodelling via the STAT3 pathway
            in angiotensin II-infused mice
  JOURNAL   J Cell Mol Med 28 (13), e18493 (2024)
   PUBMED   38963241
  REMARK    GeneRIF: Interleukin-5 alleviates cardiac remodelling via the STAT3
            pathway in angiotensin II-infused mice.
REFERENCE   6  (bases 1 to 1534)
  AUTHORS   Dietrich,W., Katz,H., Lincoln,S.E., Shin,H.S., Friedman,J.,
            Dracopoli,N.C. and Lander,E.S.
  TITLE     A genetic map of the mouse suitable for typing intraspecific
            crosses
  JOURNAL   Genetics 131 (2), 423-447 (1992)
   PUBMED   1353738
REFERENCE   7  (bases 1 to 1534)
  AUTHORS   Kaupmann,K., Simon-Chazottes,D., Guenet,J.L. and Jockusch,H.
  TITLE     Wobbler, a mutation affecting motoneuron survival and gonadal
            functions in the mouse, maps to proximal chromosome 11
  JOURNAL   Genomics 13 (1), 39-43 (1992)
   PUBMED   1349581
REFERENCE   8  (bases 1 to 1534)
  AUTHORS   Buckwalter,M.S., Lossie,A.C., Scarlett,L.M. and Camper,S.A.
  TITLE     Localization of the human chromosome 5q genes Gabra-1, Gabrg-2,
            Il-4, Il-5, and Irf-1 on mouse chromosome 11
  JOURNAL   Mamm Genome 3 (10), 604-607 (1992)
   PUBMED   1358285
REFERENCE   9  (bases 1 to 1534)
  AUTHORS   Baldacci,P.A., Richoux,V., Renard,J.P., Guenet,J.L. and Babinet,C.
  TITLE     The locus Om, responsible for the DDK syndrome, maps close to Sigje
            on mouse chromosome 11
  JOURNAL   Mamm Genome 2 (2), 100-105 (1992)
   PUBMED   1347470
REFERENCE   10 (bases 1 to 1534)
  AUTHORS   Montgomery,R.A. and Dallman,M.J.
  TITLE     Analysis of cytokine gene expression during fetal thymic ontogeny
            using the polymerase chain reaction
  JOURNAL   J Immunol 147 (2), 554-560 (1991)
   PUBMED   1649220
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X06270.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X06270.1, BC125366.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1534
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 31.99 cM"
     gene            1..1534
                     /gene="Il5"
                     /gene_synonym="Il-5"
                     /note="interleukin 5"
                     /db_xref="GeneID:16191"
                     /db_xref="MGI:MGI:96557"
     exon            1..184
                     /gene="Il5"
                     /gene_synonym="Il-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..445
                     /gene="Il5"
                     /gene_synonym="Il-5"
                     /note="TRF; BCGF-II; B-cell growth factor II; T-cell
                     replacing factor; cytotoxic T-lymphocyte inducer;
                     eosinophil differentiation factor"
                     /codon_start=1
                     /product="interleukin-5 precursor"
                     /protein_id="NP_034688.1"
                     /db_xref="CCDS:CCDS24685.1"
                     /db_xref="GeneID:16191"
                     /db_xref="MGI:MGI:96557"
                     /translation="MRRMLLHLSVLTLSCVWATAMEIPMSTVVKETLTQLSAHRALLT
                     SNETMRLPVPTHKNHQLCIGEIFQGLDILKNQTVRGGTVEMLFQNLSLIKKYIDRQKE
                     KCGEERRRTRQFLDYLQEFLGVMSTEWAMEG"
     exon            185..217
                     /gene="Il5"
                     /gene_synonym="Il-5"
                     /inference="alignment:Splign:2.1.0"
     exon            218..346
                     /gene="Il5"
                     /gene_synonym="Il-5"
                     /inference="alignment:Splign:2.1.0"
     exon            347..1534
                     /gene="Il5"
                     /gene_synonym="Il-5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctcttcct ttgctgaagg ccagcgctga agacttcaga gtcatgagaa ggatgcttct
       61 gcacttgagt gttctgactc tcagctgtgt ctgggccact gccatggaga ttcccatgag
      121 cacagtggtg aaagagacct tgacacagct gtccgctcac cgagctctgt tgacaagcaa
      181 tgagacgatg aggcttcctg tccctactca taaaaatcac cagctatgca ttggagaaat
      241 ctttcagggg ctagacatac tgaagaatca aactgtccgt gggggtactg tggaaatgct
      301 attccaaaac ctgtcattaa taaagaaata cattgaccgc caaaaagaga agtgtggcga
      361 ggagagacgg aggacgaggc agttcctgga ttacctgcaa gagttccttg gtgtgatgag
      421 tacagagtgg gcaatggaag gctgaggctg agctgctcca tggtgacagg acttcacaat
      481 ttaagttaaa ttgtcaacag atgcaaaaac cccacaaaac tgtgcaaatg caagggatac
      541 catatgctgt ttccatttat atttatgtcc tgtagtcagt taaacctatc tatgtccata
      601 tatgcaaagt gtttaacctt tttgtatacg cataaaagaa attcctgtag cgcaggctgg
      661 cctcaaactg gtaatgtagc caaggataac cttgaatttc tgatcctcct gcctcctctt
      721 cctgaaggct gaggttacag acatgcacca ttgccactag ttcatgaagt gctggagatg
      781 gaacccaagg ctttgtgcat gttaccaact gagttatact ccctccccct catcctcttc
      841 gttgcatcag ggtctcaagt attccaggct gactttgaac tcagtgtgta gccaagggtg
      901 accctgaact cttggtccag atggacgcag gaggatcaca tacccaacct tagcatcctt
      961 tctcctagcc cctttagata gatgatactt aatgactctc ttgctgaggg atgccacacc
     1021 ggggcttcct gctcctatct aacttcaatt taatacccac tagtcaatct ctcctcaact
     1081 ccctgctact ctccccaaac tctagtaagc ccacttctat ttcttgggga gagagaaggt
     1141 tgacttttct tatgtcctat gtatgaatca gactgtgcca tgactgtgcc tctgtgcctg
     1201 gagcagctgg attttggaaa agaaaaggga catctccttg cagtgtgaat gagagccagc
     1261 cacatgctgg gccttacttc tccgtgtaac tgaacttaag aagcaaagta aataccacaa
     1321 ccttactacc ccatgccaac agaaagcata aaatggttgg gatgttattc aggtatcagg
     1381 gtcactggag aagcctcccc cagtttactc caggaaaaac agatgtatgc ttttatttaa
     1441 ttctgtaaga tgttcatatt atttatgatg gattcagtaa gttaatattt attacaacgt
     1501 atataatatt ctaataaagc agaagggaca actc
//
