LOCUS       NM_001008700            5133 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus interleukin 4 receptor, alpha (Il4ra), transcript
            variant 1, mRNA.
ACCESSION   NM_001008700
VERSION     NM_001008700.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5133)
  AUTHORS   Bessell,E., Finlay,R.E., James,L.K., Ludewig,B., Harris,N.L.,
            Krebs,P., Hepworth,M.R. and Dubey,L.K.
  TITLE     Stromal cell and B cell dialogue potentiates IL-33-enriched
            lymphoid niches to support eosinophil recruitment and function
            during type 2 immunity
  JOURNAL   Cell Rep 43 (8), 114620 (2024)
   PUBMED   39141517
REFERENCE   2  (bases 1 to 5133)
  AUTHORS   Cai,X.T., Jia,M., Heigl,T., Shamir,E.R., Wong,A.K., Hall,B.M.,
            Arlantico,A., Hung,J., Menon,H.G., Darmanis,S., Brightbill,H.D.,
            Garfield,D.A. and Rock,J.R.
  TITLE     IL-4-induced SOX9 confers lineage plasticity to aged adult lung
            stem cells
  JOURNAL   Cell Rep 43 (8), 114569 (2024)
   PUBMED   39088319
REFERENCE   3  (bases 1 to 5133)
  AUTHORS   Zhang,W., Pajulas,A., Niese,M., Zhou,H., Zhao,J., Akhtar,N.,
            Turner,M.J. and Kaplan,M.H.
  TITLE     Diminished gammadelta T Cells during Murine Allergic Skin
            Inflammation Is Mediated by IL-4 Signaling in Keratinocytes
  JOURNAL   J Immunol 213 (2), 125-134 (2024)
   PUBMED   38787155
  REMARK    GeneRIF: Diminished gammadelta T Cells during Murine Allergic Skin
            Inflammation Is Mediated by IL-4 Signaling in Keratinocytes.
REFERENCE   4  (bases 1 to 5133)
  AUTHORS   Billipp,T.E., Fung,C., Webeck,L.M., Sargent,D.B., Gologorsky,M.B.,
            Chen,Z., McDaniel,M.M., Kasal,D.N., McGinty,J.W., Barrow,K.A.,
            Rich,L.M., Barilli,A., Sabat,M., Debley,J.S., Wu,C., Myers,R.,
            Howitt,M.R. and von Moltke,J.
  TITLE     Tuft cell-derived acetylcholine promotes epithelial chloride
            secretion and intestinal helminth clearance
  JOURNAL   Immunity 57 (6), 1243-1259 (2024)
   PUBMED   38744291
REFERENCE   5  (bases 1 to 5133)
  AUTHORS   Alvarez-Argote,S., Almeida,V.A., Knas,M.C., Buday,S.L.,
            Patterson,M. and O'Meara,C.C.
  TITLE     Global IL4Ralpha blockade exacerbates heart failure after an
            ischemic event in mice and humans
  JOURNAL   Am J Physiol Heart Circ Physiol 326 (5), H1080-H1093 (2024)
   PUBMED   38426866
  REMARK    GeneRIF: Global IL4Ralpha blockade exacerbates heart failure after
            an ischemic event in mice and humans.
REFERENCE   6  (bases 1 to 5133)
  AUTHORS   Lock,L.F., Pines,J., Hunter,T., Gilbert,D.J., Gopalan,G.,
            Jenkins,N.A., Copeland,N.G. and Donovan,P.J.
  TITLE     A single cyclin A gene and multiple cyclin B1-related sequences are
            dispersed in the mouse genome
  JOURNAL   Genomics 13 (2), 415-424 (1992)
   PUBMED   1535334
REFERENCE   7  (bases 1 to 5133)
  AUTHORS   Niswander,L. and Martin,G.R.
  TITLE     Fgf-4 expression during gastrulation, myogenesis, limb and tooth
            development in the mouse
  JOURNAL   Development 114 (3), 755-768 (1992)
   PUBMED   1618140
REFERENCE   8  (bases 1 to 5133)
  AUTHORS   Wrighton,N., Campbell,L.A., Harada,N., Miyajima,A. and Lee,F.
  TITLE     The murine interleukin-4 receptor gene: genomic structure,
            expression and potential for alternative splicing
  JOURNAL   Growth Factors 6 (2), 103-118 (1992)
   PUBMED   1534014
REFERENCE   9  (bases 1 to 5133)
  AUTHORS   Pritchard,M.A., Baker,E., Whitmore,S.A., Sutherland,G.R.,
            Idzerda,R.L., Park,L.S., Cosman,D., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. et al.
  TITLE     The interleukin-4 receptor gene (IL4R) maps to 16p11.2-16p12.1 in
            human and to the distal region of mouse chromosome 7
  JOURNAL   Genomics 10 (3), 801-806 (1991)
   PUBMED   1679753
REFERENCE   10 (bases 1 to 5133)
  AUTHORS   Suzuki,H., Chung,F.Z., Palmer,E., Sasaki,T., Ohara,N., Taylor,B.A.
            and Ohara,J.
  TITLE     Gene mapping of mouse IL-4 receptor: the loci of interleukin 4
            (IL-4) receptor gene and lymphocyte function associated antigen 1
            (LFA-1) gene are closely linked on chromosome 7
  JOURNAL   Immunogenetics 34 (4), 252-256 (1991)
   PUBMED   1680807
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK159375.1 and BC112911.1.
            
            On Jun 3, 2018 this sequence version replaced NM_001008700.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC112911.1, AK137827.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AK159375.1         2-12
            12-5133             BC112911.1         1-5122
FEATURES             Location/Qualifiers
     source          1..5133
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 68.94 cM"
     gene            1..5133
                     /gene="Il4ra"
                     /gene_synonym="CD124; Il4r"
                     /note="interleukin 4 receptor, alpha"
                     /db_xref="GeneID:16190"
                     /db_xref="MGI:MGI:105367"
     exon            1..58
                     /gene="Il4ra"
                     /gene_synonym="CD124; Il4r"
                     /inference="alignment:Splign:2.1.0"
     exon            59..234
                     /gene="Il4ra"
                     /gene_synonym="CD124; Il4r"
                     /inference="alignment:Splign:2.1.0"
     exon            235..322
                     /gene="Il4ra"
                     /gene_synonym="CD124; Il4r"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..2685
                     /gene="Il4ra"
                     /gene_synonym="CD124; Il4r"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; interleukin-4 receptor subunit alpha;
                     IL-4R-alpha; IL-4R subunit alpha; IL-4 receptor subunit
                     alpha; IL-4 receptor alpha chain"
                     /codon_start=1
                     /product="interleukin-4 receptor subunit alpha isoform 1
                     precursor"
                     /protein_id="NP_001008700.1"
                     /db_xref="CCDS:CCDS40121.1"
                     /db_xref="GeneID:16190"
                     /db_xref="MGI:MGI:105367"
                     /translation="MGRLCTKFLTSVGCLILLLVTGSGSIKVLGEPTCFSDYIRTSTC
                     EWFLDSAVDCSSQLCLHYRLMFFEFSENLTCIPRNSASTVCVCHMEMNRPVQSDRYQM
                     ELWAEHRQLWQGSFSPSGNVKPLAPDNLTLHTNVSDEWLLTWNNLYPSNNLLYKDLIS
                     MVNISREDNPAEFIVYNVTYKEPRLSFPINILMSGVYYTARVRVRSQILTGTWSEWSP
                     SITWYNHFQLPLIQRLPLGVTISCLCIPLFCLFCYFSITKIKKIWWDQIPTPARSPLV
                     AIIIQDAQVPLWDKQTRSQESTKYPHWKTCLDKLLPCLLKHRVKKKTDFPKAAPTKSL
                     QSPGKAGWCPMEVSRTVLWPENVSVSVVRCMELFEAPVQNVEEEEDEIVKEDLSMSPE
                     NSGGCGFQESQADIMARLTENLFSDLLEAENGGLGQSALAESCSPLPSGSGQASVSWA
                     CLPMGPSEEATCQVTEQPSHPGPLSGSPAQSAPTLACTQVPLVLADNPAYRSFSDCCS
                     PAPNPGELAPEQQQADHLEEEEPPSPADPHSSGPPMQPVESWEQILHMSVLQHGAAAG
                     STPAPAGGYQEFVQAVKQGAAQDPGVPGVRPSGDPGYKAFSSLLSSNGIRGDTAAAGT
                     DDGHGGYKPFQNPVPNQSPSSVPLFTFGLDTELSPSPLNSDPPKSPPECLGLELGLKG
                     GDWVKAPPPADQVPKPFGDDLGFGIVYSSLTCHLCGHLKQHHSQEEGGQSPIVASPGC
                     GCCYDDRSPSLGSLSGALESCPEGIPPEANLMSAPKTPSNLSGEGKGPGHSPVPSQTT
                     EVPVGALGIAVS"
     exon            323..464
                     /gene="Il4ra"
                     /gene_synonym="CD124; Il4r"
                     /inference="alignment:Splign:2.1.0"
     exon            465..616
                     /gene="Il4ra"
                     /gene_synonym="CD124; Il4r"
                     /inference="alignment:Splign:2.1.0"
     exon            617..768
                     /gene="Il4ra"
                     /gene_synonym="CD124; Il4r"
                     /inference="alignment:Splign:2.1.0"
     exon            769..925
                     /gene="Il4ra"
                     /gene_synonym="CD124; Il4r"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1025
                     /gene="Il4ra"
                     /gene_synonym="CD124; Il4r"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1104
                     /gene="Il4ra"
                     /gene_synonym="CD124; Il4r"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1154
                     /gene="Il4ra"
                     /gene_synonym="CD124; Il4r"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..5105
                     /gene="Il4ra"
                     /gene_synonym="CD124; Il4r"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3579..3584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il4ra"
                     /gene_synonym="CD124; Il4r"
                     /note="hexamer: AATAAA"
     polyA_site      3599
                     /gene="Il4ra"
                     /gene_synonym="CD124; Il4r"
                     /note="major polyA site"
     regulatory      5084..5089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il4ra"
                     /gene_synonym="CD124; Il4r"
                     /note="hexamer: ATTAAA"
     polyA_site      5105
                     /gene="Il4ra"
                     /gene_synonym="CD124; Il4r"
ORIGIN      
        1 ggggcgaggt ccttctcgca ggaaagcccc gcgcggcgcg tggagcctga actcgcaggt
       61 tctggctgga cttctcgaag ctgaggagaa gcagagggac ctggcttctg attttggatc
      121 tgcgtgcttg ctggttctgg cgcctgctgg tcttgttcct gtaacctagg actcggggct
      181 tgcacatgct ttttttttga agttgctgga gagggagccc aggaccttgt gcaggcacct
      241 tttgtgtccc caatggggcg gctttgcacc aagttcctga cctctgtggg ctgtctgatt
      301 ttgctgttgg tgactggatc tgggagcatc aaggtcctgg gtgagcccac ctgcttctct
      361 gactacatcc gcacttccac gtgtgagtgg ttcctggata gcgctgtgga ctgcagttct
      421 cagctctgcc tacactacag gctgatgttc ttcgagttct ctgaaaacct cacatgcatc
      481 ccgaggaaca gtgccagcac tgtgtgtgtg tgccacatgg aaatgaatag gccggtccaa
      541 tcagacagat accagatgga actgtgggct gagcacagac agctgtggca gggctccttc
      601 agccccagtg gtaatgtgaa gcccctagct ccagacaacc tcacactcca caccaatgtg
      661 tccgacgaat ggctgctgac ctggaataac ctgtacccat cgaacaactt actgtacaaa
      721 gacctcatct ccatggtcaa catctccaga gaggacaacc ctgcagaatt catagtctat
      781 aatgtgacct acaaggaacc caggctgagc ttcccgatca acatcctgat gtcaggggtc
      841 tactatacgg cgcgtgtgag ggtcagatcc cagatactca ctggcacctg gagtgagtgg
      901 agtcctagca tcacgtggta caaccacttc cagctgcccc tgatacagcg ccttccactg
      961 ggggtcacca tctcctgcct ctgcatcccg ttgttttgcc tgttctgtta cttcagcatt
     1021 accaagatta agaagatatg gtgggaccag attcccaccc cagcacgcag tcccttggtg
     1081 gccatcatca ttcaggatgc acaggtgccc ctctgggata agcagacccg aagccaggag
     1141 tcaaccaagt acccgcactg gaaaacttgt ctagacaagc tgctgccttg cttgctgaag
     1201 cacagagtaa agaagaagac agacttcccg aaggctgccc caaccaagtc tctccagagt
     1261 cctggaaagg caggctggtg tcccatggag gtcagcagga ccgtcctctg gccagagaat
     1321 gttagtgtca gtgtggtgcg ctgtatggag ctgtttgagg ccccagtaca gaatgtggag
     1381 gaggaagaag atgagatagt caaagaggac ctgagcatgt cacctgagaa cagcggaggc
     1441 tgcggcttcc aggagagcca ggcagacatc atggctcggc tcactgagaa cctgttttcc
     1501 gacttgttgg aggctgagaa tgggggcctt ggccagtcag ccttggcaga gtcatgctcc
     1561 cctctgcctt caggaagtgg gcaggcttct gtatcctggg cctgcctccc catggggccc
     1621 agtgaggagg ccacatgcca ggtcacagag cagccttcac acccaggccc tctttcaggc
     1681 agcccagccc agagtgcacc tactctggct tgcacgcagg tcccacttgt ccttgcagac
     1741 aatcctgcct accggagttt tagtgactgc tgtagcccgg ccccaaatcc tggagagctg
     1801 gctccagagc agcagcaggc tgatcatctg gaagaagagg agcctccaag cccggctgac
     1861 ccccattctt cagggccacc aatgcagcca gtggagagct gggagcagat ccttcacatg
     1921 agtgtcctgc agcatggggc agctgctggc tccaccccag cccctgccgg tggctaccag
     1981 gagtttgtgc aggcagtgaa gcagggtgcc gcccaggatc ctggggtgcc tggtgtcagg
     2041 ccttctggag accccggtta caaggccttc tcgagcctgc tcagcagcaa tggcatccgc
     2101 ggggacacag cagcagcggg gactgacgat gggcatggag gctacaagcc cttccagaat
     2161 cctgttccta accagtcccc tagctccgtg cccttattta ctttcggact agacacggag
     2221 ctgtcaccca gtcctctgaa ctcagaccca cccaaaagcc ccccagaatg ccttggtctg
     2281 gagctggggc tcaaaggagg tgactgggtg aaggcccctc ctcctgcaga tcaggtgccc
     2341 aagccctttg gggatgacct gggctttggt attgtgtact cgtccctcac ttgccacttg
     2401 tgtggccacc tgaagcaaca ccacagccag gaggaaggtg gccagagccc catcgttgct
     2461 agccctggct gtggctgctg ctacgatgac agatcaccat ccctggggag cctctcgggg
     2521 gccttggaaa gctgtcctga gggaatacca ccagaagcca acctcatgtc agcacccaag
     2581 acaccctcaa acttgtcagg ggagggcaag ggccctggtc actctcctgt tcccagccag
     2641 acgaccgagg tgcctgtggg cgccctgggc attgctgttt cttaggtgag tgagtgtgct
     2701 gttgttgctg aggtctgtgc tgaggccagg gttcctccaa gccagggaag tacttcctgg
     2761 gagacagccc agctggcagg tttcccagaa atccagagaa tggtgaattg aagatgtaaa
     2821 cttggcctga ccctggacgc tcggagcctg gctgtctcct cttccactgg cctgggctct
     2881 cctccctccc aagggataca ggggctcact gtgcttggtc ccacagcagt gctgacgttc
     2941 ctaagtcctg ggctttccta gctgatgttg tcctacctac tcagtcccat tttgtccacc
     3001 gaatagacct gtcactcaag gctctcagcg gtcctgccat agctgctgga cgctcccagc
     3061 tggaagctgg gcctagaaac tcacagatgg cctggcagtg gcatgggagg ccctaaaaat
     3121 tagtggaaat tttgagagag gacaggtatt gccccacaga ggccattcat tgaacagcca
     3181 ggactgggac tagaggcaga gcctgctgtc ctccgctcag ttgtagaaag caacaaggac
     3241 acaaacttga ttgcccaaag tcactgccag ttacccacat atgaccagaa gccagggctc
     3301 ctgggatgtg gaagataaac aaacacagtt gccgggtggc agggcccagc gggcacgata
     3361 actggcagtc aaggcgatac ctcgagggaa ctgtggggct ggtcctggtt ggtggtcagg
     3421 tggtagggat agcagatggc agactttggt gagtgagtga gtctgactgt gttctggaag
     3481 atgggaccgg gctcagcact gtctgctcac gtccccactg ttgcaacacc tagtctgttt
     3541 gcaaggagga caggacaggt cacatggagc tttatgtcaa taaagtcttt atcttgtcag
     3601 gtttccttta ctatacacac gccgagccca cagtgcacga aagctgaaat gtgcaggcag
     3661 ggggttgggg aagtggggag acaaggcccc agcagttggt ttaagggaat gacttgggaa
     3721 tggggcagag ctgtggctac tccatctctc atccttaccc tcctgctacc acagcttgtg
     3781 cccatgtgtg cctgctcagg ggaggggtcc tcctctttcc ctctccttta ggcagagtgc
     3841 tagaggtgtt ggatgctcct tagcacgcag agggcgtgac actggctgct aagtgttgtt
     3901 gaatgtgtca aggcattgac atcagtaggc cccacatctt aggcagggga tttggggtgt
     3961 ggcaacctgc caggccagca gagaacttga atatgatgtt cagaaggaaa gacagagaca
     4021 ggtcacttag ggaggcttga aggaggccac ttttgagatg agcccgtggt atctgcaaaa
     4081 aagcctggaa gaactcagaa catgcagcag atggctcatg tctgaagttt gaggcacagg
     4141 gatctggtgt ggtcacagca tcagagagaa gggtcctggc atgatgggga ctggtgtgca
     4201 gttggatact ggtattctgc cttagttctg cctcttgaga ggtggtccag tagaagccag
     4261 cctcagactt tcacatctca gaacagtctt ttcaaagaca aggtctcagt gtggctcaga
     4321 cgggcctcta gcatcactcg gtctcctgag tgctgggatc acaggtgtgt gctactacac
     4381 ccagcttccc agagcagtct taccacagcc cctaagcagg ggaggagagg aaacggagcc
     4441 atccaagatc tacctcctgt gggcatccct cctgcctggc tgaaggagaa gtctgggttt
     4501 aaaatcccca ttgctcagat ttgtatcctg gagggaagtg actcccacag gaatgaactg
     4561 actgtcccag gaaattcttc ccgctgtgcc tttagaactt cctctgtaaa gtacctccct
     4621 tcagctggtg gtgcctgtct ttaacagtgg ctgacagcca gggagtttga ggctagccta
     4681 ggctttgaca gtgagatcct gttcaataaa cgcagcttcc cagtccggca cttgaccttc
     4741 aagctctgac ctctggatta gcccaggatt tcttcactgg tcctccacct tccaccccct
     4801 tccactgctt atacccgctc ccatcatttc caacccagga agctgctaag atctatgtgg
     4861 tagccctggc tccattacca ccctctcccc atctcctggg tgactgaggg aactaaggta
     4921 caagcccgag gaacttggga ttccctgccc tgctgttacc ttgcctcctg tctgccatca
     4981 ttaacatagg aggtgccagc ctgtgccgtc ctggctccca tactcactac ctaaggctac
     5041 ctgttgggaa ttccaaccct caccagtccc atctcttcat tctattaaaa ttacttatca
     5101 agcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
