LOCUS       NM_001171024            2320 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus interleukin 4 induced 1B (Il4i1b), mRNA.
ACCESSION   NM_001171024
VERSION     NM_001171024.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2320)
  AUTHORS   Seddigh,P., Bracht,T., Molinier-Frenkel,V., Castellano,F.,
            Kniemeyer,O., Schuster,M., Weski,J., Hasenberg,A., Kraus,A.,
            Poschet,G., Hager,T., Theegarten,D., Opitz,C.A., Brakhage,A.A.,
            Sitek,B., Hasenberg,M. and Gunzer,M.
  TITLE     Quantitative Analysis of Proteome Modulations in Alveolar
            Epithelial Type II Cells in Response to Pulmonary Aspergillus
            fumigatus Infection
  JOURNAL   Mol Cell Proteomics 16 (12), 2184-2198 (2017)
   PUBMED   28951444
  REMARK    GeneRIF: Data showed proteome changes in alveolar epithelial cells
            type II exposed to an infection with A. fumigatus with IL4I1
            showing the most prominent increase in abundance both, in terms of
            relative abundance as well as activity. Also, in the infected
            lungs, there was levels of IL4I1 metabolic products.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY087056.1, AK133082.1 and BG276482.1.
            
            Summary: This locus represents naturally-occurring readthrough
            transcription between Nup62 (nucleoporin 62) and Il4i1 (interleukin
            4 induced 1). It encodes a protein sharing similarity with the
            protein encoded by Il4i1, but with a longer and distinct
            N-terminus. [provided by RefSeq, Aug 2015].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133082.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 14204, 18226
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BY087056.1         2-27
            27-1661             AK133082.1         2-1636
            1662-2061           BG276482.1         107-506
            2062-2320           AK133082.1         2037-2295
FEATURES             Location/Qualifiers
     source          1..2320
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7"
     gene            1..2320
                     /gene="Il4i1b"
                     /gene_synonym="Fig1; Gm21948; Il4i1; LAAO; LAO; mFIG1;
                     Nup62-il4i1"
                     /note="interleukin 4 induced 1B"
                     /db_xref="GeneID:100328588"
                     /db_xref="MGI:MGI:5439399"
     exon            1..114
                     /gene="Il4i1b"
                     /gene_synonym="Fig1; Gm21948; Il4i1; LAAO; LAO; mFIG1;
                     Nup62-il4i1"
                     /inference="alignment:Splign:2.1.0"
     exon            115..180
                     /gene="Il4i1b"
                     /gene_synonym="Fig1; Gm21948; Il4i1; LAAO; LAO; mFIG1;
                     Nup62-il4i1"
                     /inference="alignment:Splign:2.1.0"
     exon            181..322
                     /gene="Il4i1b"
                     /gene_synonym="Fig1; Gm21948; Il4i1; LAAO; LAO; mFIG1;
                     Nup62-il4i1"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..2202
                     /gene="Il4i1b"
                     /gene_synonym="Fig1; Gm21948; Il4i1; LAAO; LAO; mFIG1;
                     Nup62-il4i1"
                     /EC_number="1.4.3.2"
                     /note="L-amino-acid oxidase; Interleukin-4-induced protein
                     1; Protein Fig-1; IL4-induced protein 1"
                     /codon_start=1
                     /product="L-amino-acid oxidase precursor"
                     /protein_id="NP_001164495.1"
                     /db_xref="GeneID:100328588"
                     /db_xref="MGI:MGI:5439399"
                     /translation="MGARRAPQRPPCTLRLVLAATLLGLAGSLDWKAASSLNPIEKCM
                     EDHDYEQLLKVVTLGLNRTSKPQKVVVVGAGVAGLVAAKMLSDAGHKVTILEADNRIG
                     GRIFTFRDEKTGWIGELGAMRMPSSHRILHKLCRTLGLNLTQFTQYDENTWTEVHNVK
                     LRNYVVEKMPEKLGYNLNNRERGHSPEDIYQMALNKAFKDLKALGCKKAMNKFNKHTL
                     LEYLLEEGNLSRPAVQLLGDVMSEEGFFYLSFAEALRAHACLSDRLRYSRIVGGWDLL
                     PRALLSSLSGALLLNAPVVSITQGRNDVRVHIATSLHSEKTLTADVVLLTASGPALQR
                     ITFSPPLTRKRQEALRALHYVAASKVFLSFRRPFWHEEHIEGGHSNTDRPSRLIFYPA
                     QGEGSLLLASYTWSDAAAPFAGLSTDQTLRLVLQDVAALHGPVVFRLWDGRGVVKRWA
                     EDPHSQGGFVVQPPLYGREAEDYDWSAPFGRIYFAGEHTALPHGWVETAVKSGLRAAV
                     RINNNYGYGEVDPQMMEHAYAEANYLDQYPEGERPEEQQAREEVSPDEQEPSHKHLLV
                     ETSPEGQQHAFVEAIPELQGHVFVETVPQEKGHAHQNIYPSEHVQVHGEVIPEWHGHG
                     GSGTPQMHRVGDHS"
     exon            323..558
                     /gene="Il4i1b"
                     /gene_synonym="Fig1; Gm21948; Il4i1; LAAO; LAO; mFIG1;
                     Nup62-il4i1"
                     /inference="alignment:Splign:2.1.0"
     exon            559..671
                     /gene="Il4i1b"
                     /gene_synonym="Fig1; Gm21948; Il4i1; LAAO; LAO; mFIG1;
                     Nup62-il4i1"
                     /inference="alignment:Splign:2.1.0"
     exon            672..873
                     /gene="Il4i1b"
                     /gene_synonym="Fig1; Gm21948; Il4i1; LAAO; LAO; mFIG1;
                     Nup62-il4i1"
                     /inference="alignment:Splign:2.1.0"
     exon            874..942
                     /gene="Il4i1b"
                     /gene_synonym="Fig1; Gm21948; Il4i1; LAAO; LAO; mFIG1;
                     Nup62-il4i1"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1079
                     /gene="Il4i1b"
                     /gene_synonym="Fig1; Gm21948; Il4i1; LAAO; LAO; mFIG1;
                     Nup62-il4i1"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..2301
                     /gene="Il4i1b"
                     /gene_synonym="Fig1; Gm21948; Il4i1; LAAO; LAO; mFIG1;
                     Nup62-il4i1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2281..2286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il4i1b"
                     /gene_synonym="Fig1; Gm21948; Il4i1; LAAO; LAO; mFIG1;
                     Nup62-il4i1"
                     /note="hexamer: AATAAA"
     polyA_site      2301
                     /gene="Il4i1b"
                     /gene_synonym="Fig1; Gm21948; Il4i1; LAAO; LAO; mFIG1;
                     Nup62-il4i1"
                     /note="major polyA site"
ORIGIN      
        1 agttggcgag ggaggggcga gcggttactc actccatggc ggcgaaaagg cgaggaggca
       61 acggcggcgg cggcctcggc tgaagagacg gtgtgagcgg agagtgaagg cgcggaagaa
      121 cacaggcaga tgccctgcct tgctgaccgg tctcattaaa tcaccatgaa gacagcaaag
      181 gacctggctt ctctggccta gcaaggctgt aggagaaagc tatcattcat cctggttctg
      241 cctgcgctaa aggatgacct cagttccagg ctgaccagca aggccatggg cgccaggaga
      301 gccccacaaa gaccaccatg caccctgcgt cttgtcctgg cggccaccct ccttggtctg
      361 gcaggctctc tggactggaa ggcagcctcc agcttgaacc ctattgagaa gtgtatggag
      421 gaccacgatt atgagcagct actcaaggtg gtgaccttgg gcctcaatcg gacttcgaag
      481 ccccagaagg tggtagtggt tggtgcaggc gtggcagggc tggtagcagc caagatgctc
      541 agtgatgcag gacacaaggt caccatcctg gaggcagata acaggattgg gggccgtatc
      601 ttcactttcc gggatgagaa gacaggctgg ataggggagc ttggggccat gcgaatgccc
      661 agctctcaca ggatcttgca caagctctgc aggaccctgg gcctcaacct gactcagttc
      721 acacagtatg atgagaacac gtggacggag gtgcataatg tgaagctgcg aaactatgtg
      781 gtggagaaga tgccagaaaa gctgggctac aacctgaaca acagggaaag gggccattcc
      841 ccagaggaca tctaccagat ggcactcaac aaggccttca aagacctcaa ggccttgggc
      901 tgcaagaaag ccatgaataa gttcaacaag catacgcttc tggaatacct cctcgaggag
      961 ggcaacctgt cccggccggc tgtgcagctc ctgggagatg tgatgtccga ggagggcttc
     1021 ttctacctca gctttgcaga agccttacgt gcgcacgcct gcctgagcga tagactccgg
     1081 tacagccgca tcgtaggtgg ctgggacctg cttccgcgag ctctgctgag ctcactgtcc
     1141 ggggcgctgc tactgaacgc gcctgtggtg tcgatcactc aggggaggaa cgatgtgcgc
     1201 gtgcacattg ccacctcgct tcacagcgag aagacgctga cagccgacgt ggtgctgctg
     1261 actgccagtg gacccgcgct gcagcgcatt accttctcgc cgcccttgac tcgcaagagg
     1321 caggaggcac tgcgcgcgct tcactacgta gcagccagca aggtttttct gagtttccgt
     1381 cggcccttct ggcacgagga gcacatcgag ggcggccact ccaacactga ccgcccatcg
     1441 cgcctcatat tctatcccgc gcagggcgag ggctcactgc ttctggcctc ctacacgtgg
     1501 tcggacgctg cagccccctt cgctggactg agcaccgacc agaccctgcg tttggtgctc
     1561 caggacgtgg cggccctgca cgggcctgtg gtgttccggc tgtgggacgg caggggtgtg
     1621 gtcaagcgct gggcagagga cccgcatagc cagggaggct tcgtggtgca gccgccattg
     1681 tacgggcgcg aggctgagga ctatgactgg tcagccccct tcggccgcat ttacttcgcg
     1741 ggcgagcaca cagctctccc gcatggctgg gtagagaccg ctgtcaagtc cgggttgcgg
     1801 gccgcggtga gaatcaataa taactatggg tacggggagg tcgaccccca gatgatggag
     1861 catgcatatg cagaggccaa ctatctggac cagtatcctg aaggggagag gcccgaggag
     1921 cagcaggcgc gggaagaagt cagcccagat gaacaggagc cctctcacaa acacttgttg
     1981 gtggaaacga gccccgaggg gcagcaacac gcgtttgtgg aggccattcc cgagctgcag
     2041 ggacacgtgt tcgtggagac tgtcccccag gagaaggggc acgcccacca gaatatatat
     2101 ccttcggagc atgtacaggt gcatggggaa gtcatccctg agtggcatgg tcatggggga
     2161 tctggcaccc cgcaaatgca ccgagtgggg gaccactcct aatcgcaaag aggaagtgag
     2221 cacccagctc ctaagccagc cctcttcagg gcagacagac cacctacact aatagcccac
     2281 aataaagtta tttttgttaa aaaaaaaaaa aaaaaaaaaa
//
