LOCUS       NM_010215               2059 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus interleukin 4 induced 1 (Il4i1), mRNA.
ACCESSION   NM_010215
VERSION     NM_010215.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2059)
  AUTHORS   Bekkat,F., Seradj,M., Lengagne,R., Fiore,F., Kato,M., Lucas,B.,
            Castellano,F., Molinier-Frenkel,V., Richard,Y. and
            Prevost-Blondel,A.
  TITLE     Upregulation of IL4-induced gene 1 enzyme by B2 cells during
            melanoma progression impairs their antitumor properties
  JOURNAL   Eur J Immunol 54 (4), e2350615 (2024)
   PUBMED   38400692
  REMARK    GeneRIF: Upregulation of IL4-induced gene 1 enzyme by B2 cells
            during melanoma progression impairs their antitumor properties.
REFERENCE   2  (bases 1 to 2059)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2059)
  AUTHORS   Hu,J., Melchor,G.S., Ladakis,D., Reger,J., Kim,H.W.,
            Chamberlain,K.A., Shults,N.V., Oft,H.C., Smith,V.N., Rosko,L.M.,
            Li,E., Baydyuk,M., Fu,M.M., Bhargava,P. and Huang,J.K.
  TITLE     Myeloid cell-associated aromatic amino acid metabolism facilitates
            CNS myelin regeneration
  JOURNAL   NPJ Regen Med 9 (1), 1 (2024)
   PUBMED   38167866
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2059)
  AUTHORS   Qasimi,M.I., Fukuzawa,S., Suenaga,K., Kambe,J., Li,C., Tomonaga,S.,
            Kawase,T., Tsukahara,T., Hirayama,K., Inoue,R., Yamamoto,Y. and
            Nagaoka,K.
  TITLE     L-amino acid oxidase-1 is involved in the gut-liver axis by
            regulating 5-aminolevulinic acid production in mice
  JOURNAL   J Vet Med Sci 85 (6), 672-679 (2023)
   PUBMED   37150613
  REMARK    GeneRIF: L-amino acid oxidase-1 is involved in the gut-liver axis
            by regulating 5-aminolevulinic acid production in mice.
REFERENCE   5  (bases 1 to 2059)
  AUTHORS   Gao,Y., Wang,N. and Jia,D.
  TITLE     JMJD3 downregulates IL4i1 aggravating lipopolysaccharide-induced
            acute lung injury via H3K27 and H3K4 demethylation
  JOURNAL   Environ Toxicol 38 (4), 754-769 (2023)
   PUBMED   36537648
  REMARK    GeneRIF: JMJD3 downregulates IL4i1 aggravating
            lipopolysaccharide-induced acute lung injury via H3K27 and H3K4
            demethylation.
REFERENCE   6  (bases 1 to 2059)
  AUTHORS   Roopenian,D.C., Christianson,G.J., Davis,A.P., Zuberi,A.R. and
            Mobraaten,L.E.
  TITLE     The genetic origin of minor histocompatibility antigens
  JOURNAL   Immunogenetics 38 (2), 131-140 (1993)
   PUBMED   7683307
REFERENCE   7  (bases 1 to 2059)
  AUTHORS   Roopenian,D.C.
  TITLE     What are minor histocompatibility loci? A new look at an old
            question
  JOURNAL   Immunol Today 13 (1), 7-10 (1992)
   PUBMED   1531413
  REMARK    Review article
REFERENCE   8  (bases 1 to 2059)
  AUTHORS   Davis,A.P. and Roopenian,D.C.
  TITLE     Complexity at the mouse minor histocompatibility locus H-4
  JOURNAL   Immunogenetics 31 (1), 7-12 (1990)
   PUBMED   2137109
REFERENCE   9  (bases 1 to 2059)
  AUTHORS   Roopenian,D.C. and Davis,A.P.
  TITLE     Responses against antigens encoded by the H-3 histocompatibility
            locus: antigens stimulating class I MHC- and class II
            MHC-restricted T cells are encoded by separate genes
  JOURNAL   Immunogenetics 30 (5), 335-343 (1989)
   PUBMED   2530167
REFERENCE   10 (bases 1 to 2059)
  AUTHORS   Graff,R.J. and Bailey,D.W.
  TITLE     The non-H-2 histocompatibility loci and their antigens
  JOURNAL   Transplant Rev 15, 26-49 (1973)
   PUBMED   4130130
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK151731.1, AK150582.1 and U70429.1.
            
            On Jul 22, 2009 this sequence version replaced NM_010215.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U70429.1, AK151731.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AK151731.1         3-6
            5-2044              AK150582.1         2-2041
            2045-2059           U70429.1           2045-2059
FEATURES             Location/Qualifiers
     source          1..2059
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.93 cM"
     gene            1..2059
                     /gene="Il4i1"
                     /gene_synonym="Fig1; Fig1-ps; H-4; H-46; H4; H46; LAAO;
                     LAO; mIL4I1"
                     /note="interleukin 4 induced 1"
                     /db_xref="GeneID:14204"
                     /db_xref="MGI:MGI:109552"
     exon            1..29
                     /gene="Il4i1"
                     /gene_synonym="Fig1; Fig1-ps; H-4; H-46; H4; H46; LAAO;
                     LAO; mIL4I1"
                     /inference="alignment:Splign:2.1.0"
     exon            30..63
                     /gene="Il4i1"
                     /gene_synonym="Fig1; Fig1-ps; H-4; H-46; H4; H46; LAAO;
                     LAO; mIL4I1"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1943
                     /gene="Il4i1"
                     /gene_synonym="Fig1; Fig1-ps; H-4; H-46; H4; H46; LAAO;
                     LAO; mIL4I1"
                     /EC_number="1.4.3.2"
                     /EC_number="1.4.3.25"
                     /note="L-amino-acid oxidase; interleukin-four induced
                     protein-1; interleukin-four induced gene-1 protein;
                     protein Fig-1; IL4-induced protein 1;
                     interleukin-4-induced protein 1; interleukin-four induced
                     gene 1; histocompatibility 46"
                     /codon_start=1
                     /product="L-amino-acid oxidase precursor"
                     /protein_id="NP_034345.2"
                     /db_xref="CCDS:CCDS21217.1"
                     /db_xref="GeneID:14204"
                     /db_xref="MGI:MGI:109552"
                     /translation="MAGLALRLVLAATLLGLAGSLDWKAASSLNPIEKCMEDHDYEQL
                     LKVVTLGLNRTSKPQKVVVVGAGVAGLVAAKMLSDAGHKVTILEADNRIGGRIFTFRD
                     EKTGWIGELGAMRMPSSHRILHKLCRTLGLNLTQFTQYDENTWTEVHNVKLRNYVVEK
                     MPEKLGYNLNNRERGHSPEDIYQMALNKAFKDLKALGCKKAMNKFNKHTLLEYLLEEG
                     NLSRPAVQLLGDVMSEEGFFYLSFAEALRAHACLSDRLRYSRIVGGWDLLPRALLSSL
                     SGALLLNAPVVSITQGRNDVRVHIATSLHSEKTLTADVVLLTASGPALQRITFSPPLT
                     RKRQEALRALHYVAASKVFLSFRRPFWHEEHIEGGHSNTDRPSRLIFYPAQGEGSLLL
                     ASYTWSDAAAPFAGLSTDQTLRLVLQDVAALHGPVVFRLWDGRGVVKRWAEDPHSQGG
                     FVVQPPLYGREAEDYDWSAPFGRIYFAGEHTALPHGWVETAVKSGLRAAVRINNNYGY
                     GEVDPQMMEHAYAEANYLDQYPEGERPEEQQAREEVSPDEQEPSHKHLLVETSPEGQQ
                     HAFVEAIPELQGHVFVETVPQEKGHAHQNIYPSEHVQVHGEVIPEWHGHGGSGTPQMH
                     RVGDHS"
     exon            64..299
                     /gene="Il4i1"
                     /gene_synonym="Fig1; Fig1-ps; H-4; H-46; H4; H46; LAAO;
                     LAO; mIL4I1"
                     /inference="alignment:Splign:2.1.0"
     exon            300..412
                     /gene="Il4i1"
                     /gene_synonym="Fig1; Fig1-ps; H-4; H-46; H4; H46; LAAO;
                     LAO; mIL4I1"
                     /inference="alignment:Splign:2.1.0"
     exon            413..614
                     /gene="Il4i1"
                     /gene_synonym="Fig1; Fig1-ps; H-4; H-46; H4; H46; LAAO;
                     LAO; mIL4I1"
                     /inference="alignment:Splign:2.1.0"
     exon            615..683
                     /gene="Il4i1"
                     /gene_synonym="Fig1; Fig1-ps; H-4; H-46; H4; H46; LAAO;
                     LAO; mIL4I1"
                     /inference="alignment:Splign:2.1.0"
     exon            684..820
                     /gene="Il4i1"
                     /gene_synonym="Fig1; Fig1-ps; H-4; H-46; H4; H46; LAAO;
                     LAO; mIL4I1"
                     /inference="alignment:Splign:2.1.0"
     exon            821..2047
                     /gene="Il4i1"
                     /gene_synonym="Fig1; Fig1-ps; H-4; H-46; H4; H46; LAAO;
                     LAO; mIL4I1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2022..2027
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il4i1"
                     /gene_synonym="Fig1; Fig1-ps; H-4; H-46; H4; H46; LAAO;
                     LAO; mIL4I1"
                     /note="hexamer: AATAAA"
     polyA_site      2042
                     /gene="Il4i1"
                     /gene_synonym="Fig1; Fig1-ps; H-4; H-46; H4; H46; LAAO;
                     LAO; mIL4I1"
                     /note="major polyA site"
ORIGIN      
        1 ctctgcagtc ctgcccaaga gagctgaaga cagcagctgc cacttgagcc atggctgggc
       61 tggccctgcg tcttgtcctg gcggccaccc tccttggtct ggcaggctct ctggactgga
      121 aggcagcctc cagcttgaac cctattgaga agtgtatgga ggaccacgat tatgagcagc
      181 tactcaaggt ggtgaccttg ggcctcaatc ggacttcgaa gccccagaag gtggtagtgg
      241 ttggtgcagg cgtggcaggg ctggtagcag ccaagatgct cagtgatgca ggacacaagg
      301 tcaccatcct ggaggcagat aacaggattg ggggccgtat cttcactttc cgggatgaga
      361 agacaggctg gataggggag cttggggcca tgcgaatgcc cagctctcac aggatcttgc
      421 acaagctctg caggaccctg ggcctcaacc tgactcagtt cacacagtat gatgagaaca
      481 cgtggacgga ggtgcataat gtgaagctgc gaaactatgt ggtggagaag atgccagaaa
      541 agctgggcta caacctgaac aacagggaaa ggggccattc cccagaggac atctaccaga
      601 tggcactcaa caaggccttc aaagacctca aggccttggg ctgcaagaaa gccatgaata
      661 agttcaacaa gcatacgctt ctggaatacc tcctcgagga gggcaacctg tcccggccgg
      721 ctgtgcagct cctgggagat gtgatgtccg aggagggctt cttctacctc agctttgcag
      781 aagccttacg tgcgcacgcc tgcctgagcg atagactccg gtacagccgc atcgtaggtg
      841 gctgggacct gcttccgcga gctctgctga gctcactgtc cggggcgctg ctactgaacg
      901 cgcctgtggt gtcgatcact caggggagga acgatgtgcg cgtgcacatt gccacctcgc
      961 ttcacagcga gaagacgctg acagccgacg tggtgctgct gactgccagt ggacccgcgc
     1021 tgcagcgcat taccttctcg ccgcccttga ctcgcaagag gcaggaggca ctgcgcgcgc
     1081 ttcactacgt agcagccagc aaggtttttc tgagtttccg tcggcccttc tggcacgagg
     1141 agcacatcga gggcggccac tccaacactg accgcccatc gcgcctcata ttctatcccg
     1201 cgcagggcga gggctcactg cttctggcct cctacacgtg gtcggacgct gcagccccct
     1261 tcgctggact gagcaccgac cagaccctgc gtttggtgct ccaggacgtg gcggccctgc
     1321 acgggcctgt ggtgttccgg ctgtgggacg gcaggggtgt ggtcaagcgc tgggcagagg
     1381 acccgcatag ccagggaggc ttcgtggtgc agccgccatt gtacgggcgc gaggctgagg
     1441 actatgactg gtcagccccc ttcggccgca tttacttcgc gggcgagcac acagctctcc
     1501 cgcatggctg ggtagagacc gctgtcaagt ccgggttgcg ggccgcggtg agaatcaata
     1561 ataactatgg gtacggggag gtcgaccccc agatgatgga gcatgcatat gcagaggcca
     1621 actatctgga ccagtatcct gaaggggaga ggcccgagga gcagcaggcg cgggaagaag
     1681 tcagcccaga tgaacaggag ccctctcaca aacacttgtt ggtggaaacg agccccgagg
     1741 ggcagcaaca cgcgtttgtg gaggccattc ccgagctgca gggacacgtg ttcgtggaga
     1801 ctgtccccca ggagaagggg cacgcccacc agaatatata tccttcggag catgtacagg
     1861 tgcatgggga agtcatccct gagtggcatg gtcatggggg atctggcacc ccgcaaatgc
     1921 accgagtggg ggaccactcc taatcgcaaa gaggaagtga gcacccagct cctaagccag
     1981 ccctcttcag ggcagacaga ccacctacac taatagccca caataaagtt atttttgtta
     2041 aaccacaaaa aaaaaaaaa
//
