LOCUS       NM_001418459             943 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus interleukin 3 receptor, alpha chain (Il3ra),
            transcript variant 25, mRNA.
ACCESSION   NM_001418459
VERSION     NM_001418459.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 943)
  AUTHORS   Hou,Z., Ren,Y., Zhang,X., Huang,D., Yan,F., Sun,W., Zhang,W.,
            Zhang,Q., Fu,X., Lang,Z., Chu,C., Zou,B., Gao,B., Jin,B., Kang,Z.,
            Liu,Q. and Yan,J.
  TITLE     EP300-ZNF384 transactivates IL3RA to promote the progression of
            B-cell acute lymphoblastic leukemia
  JOURNAL   Cell Commun Signal 22 (1), 211 (2024)
   PUBMED   38566191
  REMARK    GeneRIF: EP300-ZNF384 transactivates IL3RA to promote the
            progression of B-cell acute lymphoblastic leukemia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 943)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 943)
  AUTHORS   Ullrich,K.A., Derdau,J., Baltes,C., Battistella,A., Rosso,G.,
            Uderhardt,S., Schulze,L.L., Liu,L.J., Dedden,M., Spocinska,M.,
            Kainka,L., Kubankova,M., Muller,T.M., Schmidt,N.M., Becker,E., Ben
            Brahim,O., Atreya,I., Finotto,S., Prots,I., Wirtz,S., Weigmann,B.,
            Lopez-Posadas,R., Atreya,R., Ekici,A.B., Lautenschlager,F.,
            Guck,J., Neurath,M.F. and Zundler,S.
  TITLE     IL-3 receptor signalling suppresses chronic intestinal inflammation
            by controlling mechanobiology and tissue egress of regulatory T
            cells
  JOURNAL   Gut 72 (11), 2081-2094 (2023)
   PUBMED   37541770
REFERENCE   4  (bases 1 to 943)
  AUTHORS   Feng,L., Li,C., Zeng,L.W., Gao,D., Sun,Y.H., Zhong,L., Lin,H.,
            Shu,H.B. and Li,S.
  TITLE     MARCH3 negatively regulates IL-3-triggered inflammatory response by
            mediating K48-linked polyubiquitination and degradation of
            IL-3Ralpha
  JOURNAL   Signal Transduct Target Ther 7 (1), 21 (2022)
   PUBMED   35075102
  REMARK    GeneRIF: MARCH3 negatively regulates IL-3-triggered inflammatory
            response by mediating K48-linked polyubiquitination and degradation
            of IL-3Ralpha.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 943)
  AUTHORS   McAlpine,C.S., Park,J., Griciuc,A., Kim,E., Choi,S.H., Iwamoto,Y.,
            Kiss,M.G., Christie,K.A., Vinegoni,C., Poller,W.C., Mindur,J.E.,
            Chan,C.T., He,S., Janssen,H., Wong,L.P., Downey,J., Singh,S.,
            Anzai,A., Kahles,F., Jorfi,M., Feruglio,P.F., Sadreyev,R.I.,
            Weissleder,R., Kleinstiver,B.P., Nahrendorf,M., Tanzi,R.E. and
            Swirski,F.K.
  TITLE     Astrocytic interleukin-3 programs microglia and limits Alzheimer's
            disease
  JOURNAL   Nature 595 (7869), 701-706 (2021)
   PUBMED   34262178
REFERENCE   6  (bases 1 to 943)
  AUTHORS   Hara,T., Ichihara,M., Takagi,M. and Miyajima,A.
  TITLE     Interleukin-3 (IL-3) poor-responsive inbred mouse strains carry the
            identical deletion of a branch point in the IL-3 receptor alpha
            subunit gene
  JOURNAL   Blood 85 (9), 2331-2336 (1995)
   PUBMED   7727767
REFERENCE   7  (bases 1 to 943)
  AUTHORS   Ichihara,M., Hara,T., Takagi,M., Cho,L.C., Gorman,D.M. and
            Miyajima,A.
  TITLE     Impaired interleukin-3 (IL-3) response of the A/J mouse is caused
            by a branch point deletion in the IL-3 receptor alpha subunit gene
  JOURNAL   EMBO J 14 (5), 939-950 (1995)
   PUBMED   7889941
REFERENCE   8  (bases 1 to 943)
  AUTHORS   Miyajima,I., Levitt,L., Hara,T., Bedell,M.A., Copeland,N.G.,
            Jenkins,N.A. and Miyajima,A.
  TITLE     The murine interleukin-3 receptor alpha subunit gene: chromosomal
            localization, genomic structure, and promoter function
  JOURNAL   Blood 85 (5), 1246-1253 (1995)
   PUBMED   7858255
REFERENCE   9  (bases 1 to 943)
  AUTHORS   Mueller,D.L., Chen,Z.M., Schwartz,R.H., Gorman,D.M. and
            Kennedy,M.K.
  TITLE     Subset of CD4+ T cell clones expressing IL-3 receptor alpha-chains
            uses IL-3 as a cofactor in autocrine growth
  JOURNAL   J Immunol 153 (7), 3014-3027 (1994)
   PUBMED   7522247
REFERENCE   10 (bases 1 to 943)
  AUTHORS   Hara,T. and Miyajima,A.
  TITLE     Two distinct functional high affinity receptors for mouse
            interleukin-3 (IL-3)
  JOURNAL   EMBO J 11 (5), 1875-1884 (1992)
   PUBMED   1582416
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025689.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.1697172.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               CT025689.6         97651-97757
            108-286             CT025689.6         98255-98433
            287-416             CT025689.6         100488-100617
            417-649             CT025689.6         101280-101512
            650-752             CT025689.6         103162-103264
            753-819             CT025689.6         106252-106318
            820-943             CT025689.6         106615-106738
FEATURES             Location/Qualifiers
     source          1..943
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 7.08 cM"
     gene            1..943
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /note="interleukin 3 receptor, alpha chain"
                     /db_xref="GeneID:16188"
                     /db_xref="MGI:MGI:96553"
     exon            1..107
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            108..286
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..876
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /note="isoform 10 precursor is encoded by transcript
                     variant 25; interleukin-3 receptor subunit alpha; IL-3RA;
                     IL-3R-alpha; IL-3R subunit alpha; IL-3 receptor subunit
                     alpha; interleukin-3 receptor class II alpha chain; Il-3
                     alpha subunit; IL-3 receptor alpha chain"
                     /codon_start=1
                     /product="interleukin-3 receptor subunit alpha isoform 10
                     precursor"
                     /protein_id="NP_001405388.1"
                     /db_xref="GeneID:16188"
                     /db_xref="MGI:MGI:96553"
                     /translation="MAANLWLILGLLASHSSDLDGDHEAAAQDLRCWVHEGQLSCQWE
                     RGPKATGDVHYRMFWRDVRLGPAHNRECPHYHSLDVNTAGPAPHGGHEGCTLDLDTVL
                     GSTPNSPDLVPQVTITVNGSGRAGPVPCMDNTVDLQRAVCPPEVMPVKTALVTSVATV
                     LGAGLVAAGLLLWWRKSLLYRLCPPIPRLRLPLAGEMVVWEPALEDCEVTPVTDA"
     exon            287..416
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            417..649
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            650..752
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            753..819
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            820..943
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      920..925
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /note="hexamer: AATAAA"
     polyA_site      943
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /note="major polyA site"
ORIGIN      
        1 ctctggggtc acgggcaggg tcgcagtcct ctgccctgta agcagttccg acccccagac
       61 ccccgaggac aggaacggac gccgccagcg ccgtgggcgc cactcaggaa ccagaagcat
      121 cgtgaagggg tcgggatcag gaggtggagt ccgcttgcgc cccggccccg cccctcacgc
      181 cccggccccg cccccaggcc tccgaggctc cagccccgcc ctcctatcat ggccgccaac
      241 ctgtggctca tcctggggct cctggcatcc cactcttcag atctggatgg cgaccacgag
      301 gccgcagccc aggacctgcg ctgctgggtg catgaggggc agctgagctg ccaatgggag
      361 cggggtccga aagcaacggg tgacgtgcac taccggatgt tctggcgtga tgtgcggctc
      421 ggtcctgccc acaaccgcga gtgtccacac taccacagcc ttgatgtcaa caccgctggc
      481 cccgcccctc atggtggcca tgaaggctgc acccttgacc tcgacactgt ccttggctcc
      541 acccccaaca gccctgacct tgtcccccag gtcaccatca ccgtcaacgg cagtggccgc
      601 gctggccccg tgccctgcat ggacaacact gtggacctgc agcgcgcagt ctgcccccca
      661 gaggtgatgc ctgtgaagac agccttggtg acttcagtgg ctacggtgct gggggcaggg
      721 ctcgtggcag ctgggctcct gctgtggtgg aggaagtcgc tgctctaccg cctgtgccca
      781 cccattccac gcctgcgcct gcccttggca ggggagatgg tcgtgtggga accagctctt
      841 gaagactgcg aggtgacgcc tgtgacagac gcctgagaac tgtgtggggg ctggggcata
      901 gggagcggtg ggcggggtca ataaagtgcg tggattcctg gga
//
