LOCUS       NM_001418436            1396 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus interleukin 3 receptor, alpha chain (Il3ra),
            transcript variant 8, mRNA.
ACCESSION   NM_001418436
VERSION     NM_001418436.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1396)
  AUTHORS   Hou,Z., Ren,Y., Zhang,X., Huang,D., Yan,F., Sun,W., Zhang,W.,
            Zhang,Q., Fu,X., Lang,Z., Chu,C., Zou,B., Gao,B., Jin,B., Kang,Z.,
            Liu,Q. and Yan,J.
  TITLE     EP300-ZNF384 transactivates IL3RA to promote the progression of
            B-cell acute lymphoblastic leukemia
  JOURNAL   Cell Commun Signal 22 (1), 211 (2024)
   PUBMED   38566191
  REMARK    GeneRIF: EP300-ZNF384 transactivates IL3RA to promote the
            progression of B-cell acute lymphoblastic leukemia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1396)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1396)
  AUTHORS   Ullrich,K.A., Derdau,J., Baltes,C., Battistella,A., Rosso,G.,
            Uderhardt,S., Schulze,L.L., Liu,L.J., Dedden,M., Spocinska,M.,
            Kainka,L., Kubankova,M., Muller,T.M., Schmidt,N.M., Becker,E., Ben
            Brahim,O., Atreya,I., Finotto,S., Prots,I., Wirtz,S., Weigmann,B.,
            Lopez-Posadas,R., Atreya,R., Ekici,A.B., Lautenschlager,F.,
            Guck,J., Neurath,M.F. and Zundler,S.
  TITLE     IL-3 receptor signalling suppresses chronic intestinal inflammation
            by controlling mechanobiology and tissue egress of regulatory T
            cells
  JOURNAL   Gut 72 (11), 2081-2094 (2023)
   PUBMED   37541770
REFERENCE   4  (bases 1 to 1396)
  AUTHORS   Feng,L., Li,C., Zeng,L.W., Gao,D., Sun,Y.H., Zhong,L., Lin,H.,
            Shu,H.B. and Li,S.
  TITLE     MARCH3 negatively regulates IL-3-triggered inflammatory response by
            mediating K48-linked polyubiquitination and degradation of
            IL-3Ralpha
  JOURNAL   Signal Transduct Target Ther 7 (1), 21 (2022)
   PUBMED   35075102
  REMARK    GeneRIF: MARCH3 negatively regulates IL-3-triggered inflammatory
            response by mediating K48-linked polyubiquitination and degradation
            of IL-3Ralpha.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1396)
  AUTHORS   McAlpine,C.S., Park,J., Griciuc,A., Kim,E., Choi,S.H., Iwamoto,Y.,
            Kiss,M.G., Christie,K.A., Vinegoni,C., Poller,W.C., Mindur,J.E.,
            Chan,C.T., He,S., Janssen,H., Wong,L.P., Downey,J., Singh,S.,
            Anzai,A., Kahles,F., Jorfi,M., Feruglio,P.F., Sadreyev,R.I.,
            Weissleder,R., Kleinstiver,B.P., Nahrendorf,M., Tanzi,R.E. and
            Swirski,F.K.
  TITLE     Astrocytic interleukin-3 programs microglia and limits Alzheimer's
            disease
  JOURNAL   Nature 595 (7869), 701-706 (2021)
   PUBMED   34262178
REFERENCE   6  (bases 1 to 1396)
  AUTHORS   Hara,T., Ichihara,M., Takagi,M. and Miyajima,A.
  TITLE     Interleukin-3 (IL-3) poor-responsive inbred mouse strains carry the
            identical deletion of a branch point in the IL-3 receptor alpha
            subunit gene
  JOURNAL   Blood 85 (9), 2331-2336 (1995)
   PUBMED   7727767
REFERENCE   7  (bases 1 to 1396)
  AUTHORS   Ichihara,M., Hara,T., Takagi,M., Cho,L.C., Gorman,D.M. and
            Miyajima,A.
  TITLE     Impaired interleukin-3 (IL-3) response of the A/J mouse is caused
            by a branch point deletion in the IL-3 receptor alpha subunit gene
  JOURNAL   EMBO J 14 (5), 939-950 (1995)
   PUBMED   7889941
REFERENCE   8  (bases 1 to 1396)
  AUTHORS   Miyajima,I., Levitt,L., Hara,T., Bedell,M.A., Copeland,N.G.,
            Jenkins,N.A. and Miyajima,A.
  TITLE     The murine interleukin-3 receptor alpha subunit gene: chromosomal
            localization, genomic structure, and promoter function
  JOURNAL   Blood 85 (5), 1246-1253 (1995)
   PUBMED   7858255
REFERENCE   9  (bases 1 to 1396)
  AUTHORS   Mueller,D.L., Chen,Z.M., Schwartz,R.H., Gorman,D.M. and
            Kennedy,M.K.
  TITLE     Subset of CD4+ T cell clones expressing IL-3 receptor alpha-chains
            uses IL-3 as a cofactor in autocrine growth
  JOURNAL   J Immunol 153 (7), 3014-3027 (1994)
   PUBMED   7522247
REFERENCE   10 (bases 1 to 1396)
  AUTHORS   Hara,T. and Miyajima,A.
  TITLE     Two distinct functional high affinity receptors for mouse
            interleukin-3 (IL-3)
  JOURNAL   EMBO J 11 (5), 1875-1884 (1992)
   PUBMED   1582416
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025689.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13862062.11103.1,
                                           SRR13422586.503599.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               CT025689.6         97651-97757
            108-196             CT025689.6         98345-98433
            197-351             CT025689.6         99159-99313
            352-475             CT025689.6         100066-100189
            476-605             CT025689.6         100488-100617
            606-838             CT025689.6         101280-101512
            839-957             CT025689.6         101933-102051
            958-987             CT025689.6         102183-102212
            988-1102            CT025689.6         102295-102409
            1103-1205           CT025689.6         103162-103264
            1206-1272           CT025689.6         106252-106318
            1273-1396           CT025689.6         106615-106738
FEATURES             Location/Qualifiers
     source          1..1396
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 7.08 cM"
     gene            1..1396
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /note="interleukin 3 receptor, alpha chain"
                     /db_xref="GeneID:16188"
                     /db_xref="MGI:MGI:96553"
     exon            1..107
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            108..196
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..1329
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 8; interleukin-3 receptor subunit alpha; IL-3RA;
                     IL-3R-alpha; IL-3R subunit alpha; IL-3 receptor subunit
                     alpha; interleukin-3 receptor class II alpha chain; Il-3
                     alpha subunit; IL-3 receptor alpha chain"
                     /codon_start=1
                     /product="interleukin-3 receptor subunit alpha isoform 3
                     precursor"
                     /protein_id="NP_001405365.1"
                     /db_xref="GeneID:16188"
                     /db_xref="MGI:MGI:96553"
                     /translation="MAANLWLILGLLASHSSDLAAVREAPPTAVTTPIQNLHIDPAHY
                     TLSWDPAPGADITTGAFCRKGRDIFVWADPGLARCSFQSLSLCHVTNFTVFLGKDRAV
                     AGSIQFPPDDDGDHEAAAQDLRCWVHEGQLSCQWERGPKATGDVHYRMFWRDVRLGPA
                     HNRECPHYHSLDVNTAGPAPHGGHEGCTLDLDTVLGSTPNSPDLVPQVTITVNGSGRA
                     GPVPCMDNTVDLQRAEVLAPPTLTVECNGSEAHARWVARNRFHHGLLGYTLQVNQSSR
                     SEPQEYNVSIPHFWVPNAGAISFRVKSRSEVYPRKLSSWSEAWGLVCPPEVMPVKTAL
                     VTSVATVLGAGLVAAGLLLWWRKSLLYRLCPPIPRLRLPLAGEMVVWEPALEDCEVTP
                     VTDA"
     exon            197..351
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            352..475
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            476..605
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            606..838
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            839..957
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..987
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1102
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1205
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1272
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1396
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1373..1378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /note="hexamer: AATAAA"
     polyA_site      1396
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /note="major polyA site"
ORIGIN      
        1 ctctggggtc acgggcaggg tcgcagtcct ctgccctgta agcagttccg acccccagac
       61 ccccgaggac aggaacggac gccgccagcg ccgtgggcgc cactcaggcc tccgaggctc
      121 cagccccgcc ctcctatcat ggccgccaac ctgtggctca tcctggggct cctggcatcc
      181 cactcttcag atctggctgc ggtccgtgag gctccaccca ctgctgtgac cacgcccatc
      241 cagaacctgc atatcgaccc cgcccactac acactgagct gggaccccgc ccccggcgct
      301 gacatcacga caggggcttt ttgcaggaag ggcagggaca tctttgtctg ggctgacccc
      361 gggcttgccc gctgctcatt ccagtcgctc tccctctgcc atgtgaccaa cttcaccgtc
      421 ttcctgggga aggacagggc tgtggcagga tccatccagt tccccccaga tgatgatggc
      481 gaccacgagg ccgcagccca ggacctgcgc tgctgggtgc atgaggggca gctgagctgc
      541 caatgggagc ggggtccgaa agcaacgggt gacgtgcact accggatgtt ctggcgtgat
      601 gtgcggctcg gtcctgccca caaccgcgag tgtccacact accacagcct tgatgtcaac
      661 accgctggcc ccgcccctca tggtggccat gaaggctgca cccttgacct cgacactgtc
      721 cttggctcca cccccaacag ccctgacctt gtcccccagg tcaccatcac cgtcaacggc
      781 agtggccgcg ctggccccgt gccctgcatg gacaacactg tggacctgca gcgcgcagag
      841 gtcctggccc cgcccacgtt gacagtggag tgcaacggct ctgaggccca tgcccgatgg
      901 gtcgcgcgga acagattcca ccatggcctc cttgggtaca ccctgcaggt caaccagagc
      961 tcccgctcag agccacagga atacaatgtc tccatccccc acttctgggt ccccaacgct
     1021 ggtgccatct ccttccgggt caagtcgagg tcagaggttt accctcggaa gctcagcagc
     1081 tggagcgaag cctggggcct cgtctgcccc ccagaggtga tgcctgtgaa gacagccttg
     1141 gtgacttcag tggctacggt gctgggggca gggctcgtgg cagctgggct cctgctgtgg
     1201 tggaggaagt cgctgctcta ccgcctgtgc ccacccattc cacgcctgcg cctgcccttg
     1261 gcaggggaga tggtcgtgtg ggaaccagct cttgaagact gcgaggtgac gcctgtgaca
     1321 gacgcctgag aactgtgtgg gggctggggc atagggagcg gtgggcgggg tcaataaagt
     1381 gcgtggattc ctggga
//
