LOCUS       NM_001418425            1792 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus interleukin 3 receptor, alpha chain (Il3ra),
            transcript variant 3, mRNA.
ACCESSION   NM_001418425
VERSION     NM_001418425.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1792)
  AUTHORS   Hou,Z., Ren,Y., Zhang,X., Huang,D., Yan,F., Sun,W., Zhang,W.,
            Zhang,Q., Fu,X., Lang,Z., Chu,C., Zou,B., Gao,B., Jin,B., Kang,Z.,
            Liu,Q. and Yan,J.
  TITLE     EP300-ZNF384 transactivates IL3RA to promote the progression of
            B-cell acute lymphoblastic leukemia
  JOURNAL   Cell Commun Signal 22 (1), 211 (2024)
   PUBMED   38566191
  REMARK    GeneRIF: EP300-ZNF384 transactivates IL3RA to promote the
            progression of B-cell acute lymphoblastic leukemia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1792)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1792)
  AUTHORS   Ullrich,K.A., Derdau,J., Baltes,C., Battistella,A., Rosso,G.,
            Uderhardt,S., Schulze,L.L., Liu,L.J., Dedden,M., Spocinska,M.,
            Kainka,L., Kubankova,M., Muller,T.M., Schmidt,N.M., Becker,E., Ben
            Brahim,O., Atreya,I., Finotto,S., Prots,I., Wirtz,S., Weigmann,B.,
            Lopez-Posadas,R., Atreya,R., Ekici,A.B., Lautenschlager,F.,
            Guck,J., Neurath,M.F. and Zundler,S.
  TITLE     IL-3 receptor signalling suppresses chronic intestinal inflammation
            by controlling mechanobiology and tissue egress of regulatory T
            cells
  JOURNAL   Gut 72 (11), 2081-2094 (2023)
   PUBMED   37541770
REFERENCE   4  (bases 1 to 1792)
  AUTHORS   Feng,L., Li,C., Zeng,L.W., Gao,D., Sun,Y.H., Zhong,L., Lin,H.,
            Shu,H.B. and Li,S.
  TITLE     MARCH3 negatively regulates IL-3-triggered inflammatory response by
            mediating K48-linked polyubiquitination and degradation of
            IL-3Ralpha
  JOURNAL   Signal Transduct Target Ther 7 (1), 21 (2022)
   PUBMED   35075102
  REMARK    GeneRIF: MARCH3 negatively regulates IL-3-triggered inflammatory
            response by mediating K48-linked polyubiquitination and degradation
            of IL-3Ralpha.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1792)
  AUTHORS   McAlpine,C.S., Park,J., Griciuc,A., Kim,E., Choi,S.H., Iwamoto,Y.,
            Kiss,M.G., Christie,K.A., Vinegoni,C., Poller,W.C., Mindur,J.E.,
            Chan,C.T., He,S., Janssen,H., Wong,L.P., Downey,J., Singh,S.,
            Anzai,A., Kahles,F., Jorfi,M., Feruglio,P.F., Sadreyev,R.I.,
            Weissleder,R., Kleinstiver,B.P., Nahrendorf,M., Tanzi,R.E. and
            Swirski,F.K.
  TITLE     Astrocytic interleukin-3 programs microglia and limits Alzheimer's
            disease
  JOURNAL   Nature 595 (7869), 701-706 (2021)
   PUBMED   34262178
REFERENCE   6  (bases 1 to 1792)
  AUTHORS   Hara,T., Ichihara,M., Takagi,M. and Miyajima,A.
  TITLE     Interleukin-3 (IL-3) poor-responsive inbred mouse strains carry the
            identical deletion of a branch point in the IL-3 receptor alpha
            subunit gene
  JOURNAL   Blood 85 (9), 2331-2336 (1995)
   PUBMED   7727767
REFERENCE   7  (bases 1 to 1792)
  AUTHORS   Ichihara,M., Hara,T., Takagi,M., Cho,L.C., Gorman,D.M. and
            Miyajima,A.
  TITLE     Impaired interleukin-3 (IL-3) response of the A/J mouse is caused
            by a branch point deletion in the IL-3 receptor alpha subunit gene
  JOURNAL   EMBO J 14 (5), 939-950 (1995)
   PUBMED   7889941
REFERENCE   8  (bases 1 to 1792)
  AUTHORS   Miyajima,I., Levitt,L., Hara,T., Bedell,M.A., Copeland,N.G.,
            Jenkins,N.A. and Miyajima,A.
  TITLE     The murine interleukin-3 receptor alpha subunit gene: chromosomal
            localization, genomic structure, and promoter function
  JOURNAL   Blood 85 (5), 1246-1253 (1995)
   PUBMED   7858255
REFERENCE   9  (bases 1 to 1792)
  AUTHORS   Mueller,D.L., Chen,Z.M., Schwartz,R.H., Gorman,D.M. and
            Kennedy,M.K.
  TITLE     Subset of CD4+ T cell clones expressing IL-3 receptor alpha-chains
            uses IL-3 as a cofactor in autocrine growth
  JOURNAL   J Immunol 153 (7), 3014-3027 (1994)
   PUBMED   7522247
REFERENCE   10 (bases 1 to 1792)
  AUTHORS   Hara,T. and Miyajima,A.
  TITLE     Two distinct functional high affinity receptors for mouse
            interleukin-3 (IL-3)
  JOURNAL   EMBO J 11 (5), 1875-1884 (1992)
   PUBMED   1582416
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025689.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422591.397688.1,
                                           SRR12282455.22351836.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               CT025689.6         97651-97757
            108-502             CT025689.6         98039-98433
            503-747             CT025689.6         99069-99313
            748-871             CT025689.6         100066-100189
            872-1001            CT025689.6         100488-100617
            1002-1234           CT025689.6         101280-101512
            1235-1353           CT025689.6         101933-102051
            1354-1383           CT025689.6         102183-102212
            1384-1498           CT025689.6         102295-102409
            1499-1601           CT025689.6         103162-103264
            1602-1668           CT025689.6         106252-106318
            1669-1792           CT025689.6         106615-106738
FEATURES             Location/Qualifiers
     source          1..1792
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 7.08 cM"
     gene            1..1792
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /note="interleukin 3 receptor, alpha chain"
                     /db_xref="GeneID:16188"
                     /db_xref="MGI:MGI:96553"
     exon            1..107
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            108..502
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             445..1725
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 3; interleukin-3 receptor subunit alpha; IL-3RA;
                     IL-3R-alpha; IL-3R subunit alpha; IL-3 receptor subunit
                     alpha; interleukin-3 receptor class II alpha chain; Il-3
                     alpha subunit; IL-3 receptor alpha chain"
                     /codon_start=1
                     /product="interleukin-3 receptor subunit alpha isoform 1
                     precursor"
                     /protein_id="NP_001405354.1"
                     /db_xref="GeneID:16188"
                     /db_xref="MGI:MGI:96553"
                     /translation="MAANLWLILGLLASHSSDLEWCQSKPRHLPQLWMMSPVTQAPPH
                     LPLTTAAVREAPPTAVTTPIQNLHIDPAHYTLSWDPAPGADITTGAFCRKGRDIFVWA
                     DPGLARCSFQSLSLCHVTNFTVFLGKDRAVAGSIQFPPDDDGDHEAAAQDLRCWVHEG
                     QLSCQWERGPKATGDVHYRMFWRDVRLGPAHNRECPHYHSLDVNTAGPAPHGGHEGCT
                     LDLDTVLGSTPNSPDLVPQVTITVNGSGRAGPVPCMDNTVDLQRAEVLAPPTLTVECN
                     GSEAHARWVARNRFHHGLLGYTLQVNQSSRSEPQEYNVSIPHFWVPNAGAISFRVKSR
                     SEVYPRKLSSWSEAWGLVCPPEVMPVKTALVTSVATVLGAGLVAAGLLLWWRKSLLYR
                     LCPPIPRLRLPLAGEMVVWEPALEDCEVTPVTDA"
     exon            503..747
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            748..871
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1001
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1234
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1353
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1383
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1498
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1601
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1668
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1792
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1769..1774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /note="hexamer: AATAAA"
     polyA_site      1792
                     /gene="Il3ra"
                     /gene_synonym="CD123; CDw123; SUT-1"
                     /note="major polyA site"
ORIGIN      
        1 ctctggggtc acgggcaggg tcgcagtcct ctgccctgta agcagttccg acccccagac
       61 ccccgaggac aggaacggac gccgccagcg ccgtgggcgc cactcagcat cctccagcct
      121 ccgtttctgc ttccggtcac cgctgccatc cctctgcctt gtcatctgca ctgatggaca
      181 tgctcctgcc tcatgctgtt cactcctggg catacccata cccctgcctc gcgatgtgac
      241 actggggaca gtgaagctga ggcaggggga taaccgcgag tgagcagctg aggcagggga
      301 atgaccgcaa tggaccatga caggaaccag aagcatcgtg aaggggtcgg gatcaggagg
      361 tggagtccgc ttgcgccccg gccccgcccc tcacgccccg gccccgcccc caggcctccg
      421 aggctccagc cccgccctcc tatcatggcc gccaacctgt ggctcatcct ggggctcctg
      481 gcatcccact cttcagatct ggaatggtgt caatcaaagc ccaggcacct cccacaactg
      541 tggatgatgt cacctgtcac tcaagcccca ccccacctcc ccttgacaac agctgcggtc
      601 cgtgaggctc cacccactgc tgtgaccacg cccatccaga acctgcatat cgaccccgcc
      661 cactacacac tgagctggga ccccgccccc ggcgctgaca tcacgacagg ggctttttgc
      721 aggaagggca gggacatctt tgtctgggct gaccccgggc ttgcccgctg ctcattccag
      781 tcgctctccc tctgccatgt gaccaacttc accgtcttcc tggggaagga cagggctgtg
      841 gcaggatcca tccagttccc cccagatgat gatggcgacc acgaggccgc agcccaggac
      901 ctgcgctgct gggtgcatga ggggcagctg agctgccaat gggagcgggg tccgaaagca
      961 acgggtgacg tgcactaccg gatgttctgg cgtgatgtgc ggctcggtcc tgcccacaac
     1021 cgcgagtgtc cacactacca cagccttgat gtcaacaccg ctggccccgc ccctcatggt
     1081 ggccatgaag gctgcaccct tgacctcgac actgtccttg gctccacccc caacagccct
     1141 gaccttgtcc cccaggtcac catcaccgtc aacggcagtg gccgcgctgg ccccgtgccc
     1201 tgcatggaca acactgtgga cctgcagcgc gcagaggtcc tggccccgcc cacgttgaca
     1261 gtggagtgca acggctctga ggcccatgcc cgatgggtcg cgcggaacag attccaccat
     1321 ggcctccttg ggtacaccct gcaggtcaac cagagctccc gctcagagcc acaggaatac
     1381 aatgtctcca tcccccactt ctgggtcccc aacgctggtg ccatctcctt ccgggtcaag
     1441 tcgaggtcag aggtttaccc tcggaagctc agcagctgga gcgaagcctg gggcctcgtc
     1501 tgccccccag aggtgatgcc tgtgaagaca gccttggtga cttcagtggc tacggtgctg
     1561 ggggcagggc tcgtggcagc tgggctcctg ctgtggtgga ggaagtcgct gctctaccgc
     1621 ctgtgcccac ccattccacg cctgcgcctg cccttggcag gggagatggt cgtgtgggaa
     1681 ccagctcttg aagactgcga ggtgacgcct gtgacagacg cctgagaact gtgtgggggc
     1741 tggggcatag ggagcggtgg gcggggtcaa taaagtgcgt ggattcctgg ga
//
