LOCUS       NM_019451               1759 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Mus musculus interleukin 36 receptor antagonist (Il36rn),
            transcript variant 2, mRNA.
ACCESSION   NM_019451
VERSION     NM_019451.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1759)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1759)
  AUTHORS   Hasegawa,Y., Iwata,Y., Fukushima,H., Tanaka,Y., Watanabe,S.,
            Saito,K., Ito,H., Sugiura,M., Akiyama,M. and Sugiura,K.
  TITLE     Neutrophil extracellular traps are involved in enhanced contact
            hypersensitivity response in IL-36 receptor antagonist-deficient
            mice
  JOURNAL   Sci Rep 12 (1), 13384 (2022)
   PUBMED   35927298
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1759)
  AUTHORS   Yang,W., Dong,H.P., Wang,P., Xu,Z.G., Xian,J., Chen,J., Wu,H.,
            Lou,Y., Lin,D. and Zhong,B.
  TITLE     IL-36gamma and IL-36Ra Reciprocally Regulate Colon Inflammation and
            Tumorigenesis by Modulating the Cell-Matrix Adhesion Network and
            Wnt Signaling
  JOURNAL   Adv Sci (Weinh) 9 (10), e2103035 (2022)
   PUBMED   35119210
REFERENCE   4  (bases 1 to 1759)
  AUTHORS   Tanaka,Y., Iwata,Y., Saito,K., Fukushima,H., Watanabe,S.,
            Hasegawa,Y., Akiyama,M. and Sugiura,K.
  TITLE     Cutaneous ischemia-reperfusion injury is exacerbated by IL-36
            receptor antagonist deficiency
  JOURNAL   J Eur Acad Dermatol Venereol 36 (2), 295-304 (2022)
   PUBMED   34699104
  REMARK    GeneRIF: Cutaneous ischemia-reperfusion injury is exacerbated by
            IL-36 receptor antagonist deficiency.
REFERENCE   5  (bases 1 to 1759)
  AUTHORS   Wang,P., Yang,W., Guo,H., Dong,H.P., Guo,Y.Y., Gan,H., Wang,Z.,
            Cheng,Y., Deng,Y., Xie,S., Yang,X., Lin,D. and Zhong,B.
  TITLE     IL-36gamma and IL-36Ra Reciprocally Regulate NSCLC Progression by
            Modulating GSH Homeostasis and Oxidative Stress-Induced Cell Death
  JOURNAL   Adv Sci (Weinh) 8 (19), e2101501 (2021)
   PUBMED   34369094
REFERENCE   6  (bases 1 to 1759)
  AUTHORS   Debets,R., Timans,J.C., Homey,B., Zurawski,S., Sana,T.R., Lo,S.,
            Wagner,J., Edwards,G., Clifford,T., Menon,S., Bazan,J.F. and
            Kastelein,R.A.
  TITLE     Two novel IL-1 family members, IL-1 delta and IL-1 epsilon,
            function as an antagonist and agonist of NF-kappa B activation
            through the orphan IL-1 receptor-related protein 2
  JOURNAL   J Immunol 167 (3), 1440-1446 (2001)
   PUBMED   11466363
REFERENCE   7  (bases 1 to 1759)
  AUTHORS   Barton,J.L., Herbst,R., Bosisio,D., Higgins,L. and Nicklin,M.J.
  TITLE     A tissue specific IL-1 receptor antagonist homolog from the IL-1
            cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities
  JOURNAL   Eur J Immunol 30 (11), 3299-3308 (2000)
   PUBMED   11093146
REFERENCE   8  (bases 1 to 1759)
  AUTHORS   Kumar,S., McDonnell,P.C., Lehr,R., Tierney,L., Tzimas,M.N.,
            Griswold,D.E., Capper,E.A., Tal-Singer,R., Wells,G.I., Doyle,M.L.
            and Young,P.R.
  TITLE     Identification and initial characterization of four novel members
            of the interleukin-1 family
  JOURNAL   J Biol Chem 275 (14), 10308-10314 (2000)
   PUBMED   10744718
REFERENCE   9  (bases 1 to 1759)
  AUTHORS   Smith,D.E., Renshaw,B.R., Ketchem,R.R., Kubin,M., Garka,K.E. and
            Sims,J.E.
  TITLE     Four new members expand the interleukin-1 superfamily
  JOURNAL   J Biol Chem 275 (2), 1169-1175 (2000)
   PUBMED   10625660
REFERENCE   10 (bases 1 to 1759)
  AUTHORS   Mulero,J.J., Pace,A.M., Nelken,S.T., Loeb,D.B., Correa,T.R.,
            Drmanac,R. and Ford,J.E.
  TITLE     IL1HY1: A novel interleukin-1 receptor antagonist gene
  JOURNAL   Biochem Biophys Res Commun 263 (3), 702-706 (1999)
   PUBMED   10512743
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK009741.1, AI413231.1 and CJ067640.1.
            
            On Mar 27, 2009 this sequence version replaced NM_019451.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ250429.1, AF200495.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1048              AK009741.1         3-1050
            1049-1406           AI413231.1         1-358               c
            1407-1759           CJ067640.1         121-473
FEATURES             Location/Qualifiers
     source          1..1759
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 16.31 cM"
     gene            1..1759
                     /gene="Il36rn"
                     /gene_synonym="Fil1delta; If36rn; Il-1h3; IL-36Ra; Il1f5;
                     Il1hy1"
                     /note="interleukin 36 receptor antagonist"
                     /db_xref="GeneID:54450"
                     /db_xref="MGI:MGI:1859325"
     exon            1..260
                     /gene="Il36rn"
                     /gene_synonym="Fil1delta; If36rn; Il-1h3; IL-36Ra; Il1f5;
                     Il1hy1"
                     /inference="alignment:Splign:2.1.0"
     exon            261..346
                     /gene="Il36rn"
                     /gene_synonym="Fil1delta; If36rn; Il-1h3; IL-36Ra; Il1f5;
                     Il1hy1"
                     /inference="alignment:Splign:2.1.0"
     exon            347..474
                     /gene="Il36rn"
                     /gene_synonym="Fil1delta; If36rn; Il-1h3; IL-36Ra; Il1f5;
                     Il1hy1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..1759
                     /gene="Il36rn"
                     /gene_synonym="Fil1delta; If36rn; Il-1h3; IL-36Ra; Il1f5;
                     Il1hy1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcagacaa ccacaggctc ctacctggag aaaagggcag atctgatgga tgctttgtgg
       61 gctctttcct gacttccaga tccagaatcg cctgcttcac acaggctagt cacatactga
      121 caggctctgg agcctgcttt ctacttaggt ctcaaatttt ccagccttgt ctttgcctaa
      181 aatttcctgc tgtttatttc aaaatagggt ctacatactg tggagctcat gatggttctg
      241 agtggggcac tatgcttccg aatgaaggat tcagccttga aggtactgta tctgcacaat
      301 aaccagctgc tggctggagg actgcacgca gagaaggtca ttaaaggtga ggagatcagt
      361 gttgtcccaa atcgggcact ggatgccagt ctgtcccctg tcatcctggg cgttcaagga
      421 ggaagccagt gcctatcttg tgggacagag aaagggccaa ttctgaaact tgagccagtg
      481 aacatcatgg agctctacct cggggccaag gaatcaaaga gcttcacctt ctaccggcgg
      541 gatatgggtc ttacctccag cttcgaatcc gctgcctacc caggctggtt cctctgcacc
      601 tcaccggaag ctgaccagcc tgtcaggctc actcagatcc ctgaggaccc cgcctgggat
      661 gctcccatca cagacttcta ctttcagcag tgtgactagg gctgcgtggt ccccaaaact
      721 ccataagcag aggcagagta ggcagtggcg gctcctgata gaggatagag agacagagga
      781 gctccacagt aggtggctta ctcctctcct tccctactgg actcccgctt ctgacctaag
      841 gcacacagac actctcttct cctgcatccc agtgctggta aatcttctgg tatttggagc
      901 tcaatgtgta gattctttca gattggatgg tactacctct ggtgtggaac ccaatagaaa
      961 ccacgtagga ccaacaaaga gcaacataaa agattcttgg gtgaagaaga ggtgggaact
     1021 gttcatacat agtaagatct gacacagtac ctcagaagtc ctgccattcc ttatgttctg
     1081 gagaaagtgg agggggggtc accaagactt tctctggctg gctgggccct ttccctcaac
     1141 ctttctgaca tctgcagcct ctctcattct tgccttcatt ctctggccct gaaccgagag
     1201 ggtgatatca ggatagctga cagaagatga ccaggcacac tgtcctggtt tgaaaccaga
     1261 ggggacaata aaaaaccctg attctggtct ctactcacat aaaaagaagc ttgtgaacat
     1321 taagtgggaa gagattgcta ctaaataaca taccttgtaa tttcatctta attaaaatat
     1381 acttctctat attatatatt ttaaaaggga tctggagtgt ttacatcaat tgtagccatg
     1441 tccaggtggg ggcaagagag gtgactttct atttgtgtct attacctttt ccattatgga
     1501 ggtgggttat ttgcataata ataaaaagag atcactatag agggaagtga agcagaccta
     1561 gtttctggtc atcctcacca tctgctagag agaaatccaa actgagctca ttggttctaa
     1621 gtggcaggag cagggagcaa gaggcagact ccagaaaagc taggaagaat gtgaagggtt
     1681 tatctcctgg gtaagggatt tacagaagaa ataaagaata gaagaaaaaa gtagagggag
     1741 aaatggaggg aggaagggg
//
